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丙二醇对利扎曲普坦普鲁兰多糖/麦芽糖糊精口腔速溶膜剂制剂学性质的影响

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当代化工 2020年第11期49卷 2379-2382页

作者： kiramat Ali shah 高彬彬李洁琼崔京浩苏州大学药学院苏州215123

为考察增塑剂丙二醇对利扎曲普坦普鲁兰多糖/麦芽糖糊精口腔速溶膜剂制剂学性质的影响,采用溶液浇铸法制备利扎曲普坦的口腔速溶膜剂(RZT-OFDF),成膜材料为普鲁兰和麦芽糖糊精的混合物(3∶1),添加不同质量分数的丙二醇(15%~30%)考察对RZ... 详细信息

为考察增塑剂丙二醇对利扎曲普坦普鲁兰多糖/麦芽糖糊精口腔速溶膜剂制剂学性质的影响,采用溶液浇铸法制备利扎曲普坦的口腔速溶膜剂(RZT-OFDF),成膜材料为普鲁兰和麦芽糖糊精的混合物(3∶1),添加不同质量分数的丙二醇(15%~30%)考察对RZT-OFDF制剂学性质的影响。通过转篮法,考察RZT-OFDF在人工唾液中的释放度。结果表明:RZT-OFDF成膜性良好,表面光滑。随着丙二醇质量分数的增加,RZT-OFDF的含水量有一定增加的趋势,崩解时间略有缩短。丙二醇质量分数对弯曲次数、抗拉强度、拉伸百分率有显著影响。RZT-OFDF的释放速度快于市售片剂。因此,增塑剂丙二醇可显著改变RZT-OFDF的机械性能。

关键词：口腔速溶膜剂普鲁兰麦芽糖糊精丙二醇溶剂浇铸法

let-7a荷载AS1411与lipidoid共修饰阳离子脂质复合物的制备

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当代化工 2019年第12期48卷 2817-2819,2823页

作者：仲婷婷李言高彬彬李洁琼 kiramat Ali shah 曹青日崔京浩苏州大学药学院江苏苏州215123

构建了let-7a荷载AS1411与lipidoid共修饰阳离子脂质复合物,并对其理化性质进行考察。合成荷正电荷类脂质材料N,N’-二油酰三羟甲基氨基甲烷(2-氨基乙基)胺(Lipidoid),然后结合乙醇注入法与静电吸附法,制备荷载let-7a的AS1411与lipidoi... 详细信息

构建了let-7a荷载AS1411与lipidoid共修饰阳离子脂质复合物,并对其理化性质进行考察。合成荷正电荷类脂质材料N,N’-二油酰三羟甲基氨基甲烷(2-氨基乙基)胺(Lipidoid),然后结合乙醇注入法与静电吸附法,制备荷载let-7a的AS1411与lipidoid共修饰阳离子脂质复合物(let-7a/AS1411-Lipoplex),评价其制剂学性质。通过薄层色谱法(TLC)、核磁共振法(~1H-NMR)、傅里叶转变红外法(FT-IR)和液质联用仪(LC-MS)法验证了Lipidoid的结构。所制得let-7a/AS1411-Lipoplex大小规整,平均粒径为70nm,Zeta电位为30mV,AS1411-Lipoplex明显改善let-7a在血清中降解。成功构建可高效荷载let-7a的适配体(AS1411)与lipidoid共修饰的脂质复合物,为后续研究打下基础。

关键词： let-7a 适配体类脂多胺阳离子脂质复合物

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盐酸多奈哌齐口腔速溶膜剂的制备与评价

全科口腔医学电子杂志 2019年第6期6卷 25-25,27页

作者：孙元永巴登措姆仲婷婷高彬彬李洁琼 kiramat Ali shah 崔京浩苏州大学药学院江苏苏州215123 礼来苏州制药有限公司(湖东分公司) 江苏苏州215122

盐酸多奈哌齐(DPL)为一种胆碱酯酶抑制剂,应用于老年痴呆患者的临床治疗中能够取得较为理想的疗效[1]。DPL的已上市制剂为口服片剂,应用于老年痴呆患者的临床治疗中,对患者精神状态的改善、生活能力的提高均有重要价值。口服片剂的服用... 详细信息

盐酸多奈哌齐(DPL)为一种胆碱酯酶抑制剂,应用于老年痴呆患者的临床治疗中能够取得较为理想的疗效[1]。DPL的已上市制剂为口服片剂,应用于老年痴呆患者的临床治疗中,对患者精神状态的改善、生活能力的提高均有重要价值。口服片剂的服用,一般要求患者的自主意识高,但因其外形、大小、口味等引起的吞咽困难等问题,现已成为导致患者依从性差的主要原因[2,3]。

关键词：盐酸多奈哌齐胆碱酯酶抑制剂口腔速溶膜剂

Constraints and Opportunities for Sustainable Livelihoods and Cash Income Generation from NTFPs in the Mountains of Northern Parts of Pakistan

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云南植物研究 2010年第2期32卷 167-176页

作者： Hassan Sher Jehangir Khan kiramat Khan Hazrat Sher Muhammad Elyemeni Department of Botany King Saud University Rydah Food and Agriculture Organization of the United Nation Pakistan Office Department of Environmental Sciences COMSATS UniversityAbbottabad Campus Department of Botany Kohat University of Science and Technology

Pakistan′s forest resource base is mostly found in the mountains of the North-West Frontier Province (NWFP) supporting the livelihood of the rural poor and providing different ecological *** present study was,therefore,initiated with the aim to evaluate different constraints and opportunities for sustainable livelihoods and cash income generation from NTFPs in the mountainous area of NWFP,Pakistan during *** was collected through questionnaire and interviews during field trips.A total of 117 NTFPs species have been recorded which are being used locally for various purposes such as fuel wood,fodder,medicinal plants,vegetables,mushroom,agricultural tools making,furniture,thatching,shade,fencing/poles,ornamental purpose and animal *** majority of plants are multi-functional like Pinus wallichiana provides timber,firewood,torch wood,the leaves/small branches are used as thatch for roofing,split logs are used for fencing and the decomposed needles are collected as humus for agricultural *** products were widely used by the indigenous community supporting their *** study proposes protection and sustainable management of these valuable resources for rural livelihoods,which might be useful for developing regional strategies of sustainable management of forest resources.

关键词： Livelihood Forest resources Communities Management Unsustainable use Opportunity

Genetic analysis of maturity and flowering characteristics in maize(Zea mays L.)

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Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 621-626页

作者： Hassan Sher Muhammad Iqbal kiramat Khan Muhammad yasir Hameed-ur-Rahman Centre of Botany and Biodiversity Conservation University of Swat Cereal Crops Research Institute(CCRI) Pirsabak Department of Environmental Sciences COMSATS Institute of Information Technology(CUT)Abbottabad

Objective:To elucidate the pattern of inheritance and determine the relative magnitude of various genetic effects for maturity and flowering attributes in subtropical ***: Four white grain maize inbred lines from flint group of corn,two with late maturity and two with early maturity,were *** contrasting inbred lines were crossed to form four *** generations(P_1,P_2,F_1,F_2,BC_1,and BC_2) were developed for each individual *** were evaluated in triplicate trial for two consecutive ***:Roth dominance gene action and epistatic interaction played major role in governing inheritance of days to pollen shedding, 50%silking,anlbesis silking interval and ***:Preponderance of dominance gene action for these traits indicated their usefulness in hybrid programs of subtropical maize.

关键词： Genetic analysis Maize Maturity Generation means