检索结果-南通市图书馆

Kaempferia parviflora ethanol extract improves self-assessed sexual health in men:a pilot study

Journal of Integrative Medicine 2018年第4期16卷 249-254页

作者： Richard A.Stein kira schmid Jowell Bolivar Andrew G.Swick Steven V.Joyal Steven P.Hirsh Life Extension 3600 West Commercial BlvdFort tauderdaleFL 33309USA Life Extension Clinical Research Inc.5990 North Federal HighwayFort LauderdaleFL 33308USA

Background： Sexual health positively correlates with overall wellbeing. Existing therapeutics to enhance male sexual health are limited by factors that include responsiveness, adherence and adverse effects. As the population ages, safe and effective interventions that preserve male sexual function are needed. Published research suggests that various preparations of Kaempferia parviflora, a plant in the Zingiberaceae （ginger） family, support cardiovascular health and may ameliorate erectile function. Objective： The aim of this study was to examine the effects of KaempMaxTM, an ethanol extract of the K. parvi]lora rhizome, on erectile function in healthy middle-aged and older men. Design, setting, participants and interventions： We conducted an open-label, one-arm study on 14 generally healthy males aged 50-68 years with self-reported mild erectile dysfunction, who were not using pre- scription treatments. Participants took 100 mg KaempMaxTM daily for 30 days. Main outcome measures： Evaluations were conducted at baseline and on the final study assessment. Primary efficacy analyses included the International Index of Erectile Function （IIEF）; secondary efficacy analyses included the Global Assessment Question about erectile function. Results： Thirteen participants completed the 30-day study. Supplementation with KaempMaxTM resulted in statistically significant improvements in erectile function, intercourse satisfaction and total scores on the IIEF questionnaire. KaempMaxTM was well tolerated and exhibited an excellent safety profile. Conclusion： Our results suggest that KaempMaxTM may improve erectile function in healthy middle-aged and older men. While the effects were not as pronounced as what might be seen with prescription med- ication, most participants found them satisfactory. Additional, longer and placebo-controlled clinical tri- als will be needed. Trial registration： *** identifier Ncr03389867.

关键词： Sexual health Kaempferia parviflom Complementary therapies KaempMax^TM Global Assessment QuestionInternational Index of Erectile Function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functional dissimilarity in mixed forests promotes stem radial growth by mitigating tree water deficit

引用

National Science Review 2024年第3期11卷 55-57页

作者：张宏图艾尤尔.亥热提白云旻郭焱培李珊 Bernhard schmid Helge Bruelheide 马克平唐志尧 Institute of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface Processes of Ministry of EducationPeking University College of Geography and Tourism Xinjiang Normal University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences Department of Geography Remote Sensing LaboratoriesUniversity of Zurich Institute of Biology/Geobotany and Botanical Garden Martin Luther University Halle-Wittenberg German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig

Tree growth is a key component of forest ecosystem functioning and is wellknown to be limited by water availability[1]. It is acknowledged that composition and diversity of co-occurring tree species can mitigate the influence of drought on tree growth through the resource complementarity for water use via niche partitioning and facilitation between different species [2,3].

关键词： RESILIENCE

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Towards greener polymers:Trends in the German chemical industry

引用

Green Carbon 2024年第1期2卷 33-44页

作者： Adam W.Franz Stefan Buchholz Rolf W.Albach Rolf schmid BASF SE Ludwigshafen 67056Germany Evonik Operations GmbH Hanau 63457Germany Association for Chemistry and Economics German Chemical SocietyFrankfurt am Main 60444Germany Stuttgart University and Bio4Business Stuttgart 70569Germany

Global plastics production is expected to exceed 400 million tons and reach 600 million tons by *** synthesis currently accounts for approximately 3%of global greenhouse gas *** 60%of all polymers are produced for *** include shopping bags,packaging materials,mulch films,and soluble polymers for cosmetics and other ***,only a portion of single-use plastic is recycled or disposed of in incinerators or *** estimated 20%is not disposed of properly and pollutes the global environment,especially the *** response to these challenges,the United Nations,European Union,and many nation-states are developing regulatory frameworks that encourage the chemical industry to produce plastics with a smaller environmental footprint and often support this through research *** solutions include:(1)the use of green energy,green hydrogen,bio-based feedstocks,or CO_(2) in synthesis;(2)the reuse or recycling of plastics through conversion or pyrolysis;and(3)the production of biodegradable *** German chemical industry contributes approximately one-third of polymer production in the *** is embedded in the EU regulatory and research landscape and anchored in the European Green Deal,which aims for carbon neutrality by *** this paper,we describe how BASF and Evonik,two leading German chemical companies with strong but different polymer portfolios,respond to the call for greener polymers and how technologies are being developed to make polyurethanes,a particularly important and difficult-to-recycle family of elastomers and duromers,renewable and *** the environmental footprint of plastics requires not only innovative materials but also proper governance,regulatory and collection systems,and public willingness to *** an international comparison of these competencies,expressed by the"polymer management index"(PMI),Germany achieved a top position.

关键词： Plastics recycling Biobased plastics Biodegradable plastics Polymer management index European Green Deal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Can DyeCycling break the photobleaching limit in single-molecule FRET?

引用

Nano Research 2022年第11期15卷 9818-9830页

作者： Benjamin Vermeer Sonja schmid NanoDynamicsLab Laboratory of BiophysicsWageningen UniversityStippeneng 46708WE WageningenThe Netherlands

Biomolecular systems,such as proteins,crucially rely on dynamic processes at the *** biomolecular nanodynamics is therefore key to obtaining a mechanistic understanding of the energies and molecular driving forces that controlbiomolecular ***-molecule fluorescence resonance energy transfer(smFRET)is a powerful technique to observe inreal-time how a single biomolecule proceeds through its functional cycle involving a sequence of distinct structural ***,this technique is fundamentally limited by irreversible photobleaching,causing the untimely end of the experiment andthus,a narrow temporal bandwidth of≤3 orders of ***,we introduce“DyeCycling”,a measurement scheme withwhich we aim to break the photobleaching limit in *** introduce the concept of spontaneous dye replacement bysimulations,and as an experimental proof-of-concept,we demonstrate the intermittent observation of a single biomolecule forone hour with a time resolution of ***,DyeCycling can provide>100-fold more information per singlemolecule than conventional *** discuss the experimental implementation of DyeCycling,its current and fundamentallimitations,and specific biological use *** its general simplicity and versatility,DyeCycling has the potential torevolutionize the field of time-resolved smFRET,where it may serve to unravel a wealth of biomolecular dynamics by bridgingfrom milliseconds to the hour range.

关键词： biomolecular dynamics single-molecule fluorescence resonance energy transfer(smFRET) photobleaching conformational changes single-molecule kinetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prospect of gastroenterology and hepatology in the next century

引用

World Journal of Gastroenterology 1999年第3期5卷 185-190页

作者： Rudi schmid University of California 美国

The task of predicting what Gastroenterology and Hepatology may look like in the coming century is a great personal challenge and at the same time an awe-inspiring assignment. Not only have these two medical specialties become very large and diversified but there are so many new discoveries and ideas that it is a capricious undertaking to attempt fore-telling which of them may become part of the next century′s medical practice. I therefore will take the personal privilege of being highly selective, choosing only topics for discussion which I believe have a distinct potential of generating novel scientific concepts, fresh approaches or new therapeutic modalities.

关键词： Prospect of gastroenterology and hepatology in the next century

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transient thermal analysis as measurement method for IC package structural integrity

引用

Chinese Physics B 2015年第6期24卷 47-64页

作者： Alexander Han Maximilian schmid E Liu Gordon Elger Technische Hochschule Ingolstadt

Practices of IC package reliability testing are reviewed briefly, and the application of transient thermal analysis is examined in great depth. For the design of light sources based on light emitting diode （LED） efficient and accurate reliability testing is required to realize the potential lifetimes of 105 h. Transient thermal analysis is a standard method to determine the transient thermal impedance of semiconductor devices, e.g. power electronics and LEDs. The temperature of the semiconductor junctions is assessed by time-resolved measurement of their forward voltage （Vf）. The thermal path in the IC package is resolved by the transient technique in the time domain. This enables analyzing the structural integrity of the semiconductor package. However, to evaluate thermal resistance, one must also measure the dissipated energy of the device （i.e., the thermal load） and the k-factor. This is time consuming, and measurement errors reduce the accuracy. To overcome these limitations, an innovative approach, the relative thermal resistance method, was developed to reduce the measurement effort, increase accuracy and enable automatic data evaluation. This new way of evaluating data simplifies the thermal transient analysis by eliminating measurement of the k-factor and thermal load, i.e. measurement of the lumen flux for LEDs, by normalizing the transient Vf data. This is especially advantageous for reliability testing where changes in the thermal path, like cracks and delaminations, can be determined without measuring the k-factor and thermal load. Different failure modes can be separated in the time domain. The sensitivity of the method is demonstrated by its application to high- power white InGaN LEDs. For detailed analysis and identification of the failure mode of the LED packages, the transient signals are simulated by time-resolved finite element （FE） simulations. Using the new approach, the transient thermal analysis is enhanced to a powerful tool for reliability

关键词： transient thermal analysis thermal resistance reliability light emitting diode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ecological intensification of agriculture through biodiversity management:introduction

引用

Journal of Plant Ecology 2023年第6期16卷 1-4页

作者： Bernhard schmid Christian Schöb Department of Geography Remote Sensing LaboratoriesUniversity of ZurichWinterthurerstrasse 1908057 ZürichSwitzerland Universidad Rey Juan Carlos Calle Tulipán s/n28933 MóstolesSpain

A major feature of humans is that they can attain much higher population densities than any non-domestic animal species of similar body size(Damuth 1987).This is most likely due to the invention of agriculture(Herrera and Garcia-Bertrand 2018),which allowed humans to manage ecosystems in such a way that as much biomass as possible is converted into food(Vitousek et al.1986).

关键词： Ecological likely agriculture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diagnostic approaches for cholangiocarcinoma

引用

World Journal of Gastroenterology 2008年第26期14卷 4131-4136页

作者： Andreas Weber Roland M schmid Christian Prinz Department of Internal Medicine Ⅱ Technical University of MunichMunich 81675Germany

Cholangiocarcinomas arise from the epithelial cells of the bile ducts and are associated with poor prognosis. Despite new diagnostic approaches, the definite diagnosis of this malignancy continues to be challenging. Cholangiocarcinomas often grow longitudinally along the bile duct rather than in a radial direction. Thus, large tumor masses are frequently absent and imaging techniques, including ultrasound, CT, and MRI have only limited sensitivity. Tissue collection during endoscopic (ERCP) and/or percutaneous transhepatic (PTC) procedures are usually used to confirm a definitive diagnosis of cholangiocarcinoma. However, forceps biopsy and brush cytology provide positive results for malignancy in about only 50% of patients. Percutaneous and peroral cholangioscopy using fiber-optic techniques were therefore developed for direct visualization of the biliary tree, yielding additional information about endoscopic appearance and tumor extension, as well as a guided biopsy acquistion. Finally, endoscopic ultrasonography (EUS) complements endoscopic and percutaneous approaches and may provide a tissue diagnosis of tumors in the biliary region through fine-needle aspiration. In the future, new techniques allowing for early detection, including molecular markers, should be developed to improve the diagnostic sensitivity in this increasing tumor entity.

关键词： Diagnosis Brush cytology Forceps biopsy Cholangiocarcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Male-mediated developmental toxicity

引用

Asian Journal of Andrology 2014年第1期16卷 81-88页

作者： Diana Andersonl Thomas E schmid Adolf Baumgartner Division of Medical Sciences School of Life Sciences University of Bradford Bradford West Yorkshire BD UK Department of Radiation Oncology Klinikum rechts der Isar Technische Universit~t MOnchen Munich Germany.

Male-mediated developmental toxicity has been of concern for many years. The public became aware of male-mediated developmental toxicity in the early 1990s when it was reported that men working at Sellafield might be causing leukemia in their children. Human and animal studies have contributed to our current understanding of male-mediated effects. Animal studies in the 1980s and 1990s suggested that genetic damage after radiation and chemical exposure might be transmitted to offspring. With the increasing understanding that there is histone retention and modification, protamine incorporation into the chromatin and DNA methylation in mature sperm and that spermatozoal RNA transcripts can play important roles in the epigenetic state of sperm, heritable studies began to be viewed differently. Recent reports using molecular approaches have demonstrated that DNA damage can be transmitted to babies from smoking fathers, and expanded simple tandem repeats minisatellite mutations were found in the germline of fathers who were exposed to radiation from the Chernobyl nuclear power plant disaster. In epidemiological studies, it is possible to clarify whether damage is transmitted to the sons after exposure of the fathers. Paternally transmitted damage to the offspring is now recognized as a complex issue with genetic as well as epigenetic components.

关键词： genetic and epigenetic effects human exposure to chemicals and radiation male-mediated animal studies paternalexposure to chemicals and radiation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distribution of Debris Flows in Glacier National Park,Montana,U.S.A.

引用

Journal of Mountain Science 2008年第4期5卷 318-326页

作者： WILKERSON Forrest D. schmid Ginger L. Department of Geography 7 Armstrong HallMinnesota State UniversityMankatoMN 56001USA

The spectacular scenery of Glacier National Park is the result of glacial erosion as well as post-glacial mass wasting processes. Debris flow magnitude and frequency have been established through extensive fieldwork across seven separate drainage basins in the eastern portion of the park. This paper summarizes the investigation of the hypotheses that debris flow distribution in the Glacier National Park, east of the Continental Divide is （a） not random; and Co） concentrated adjacent to the Continental Divide. The location of 2317 debris flows were identified and mapped from sixty-three 1-m resolution Digital Orthophoto Quarter Quadrangles and their spatial distribution was then analyzed using ArcView Spatial Analyst GIS software. The GIS analysis showed that the debris flows are not randomly distributed nor are they concentrated directly adjacent to the Divide. While the Continental Divide provides orographic enhancement of precipitation directly adjacent to the Divide, the debris flows are not concentrated there due to a lack of available weathered regolith. The most recent Little Ice Age glaciation removed the debris directly adjacent to the Divide, and without an adequate debris supply, these steep slopes experience few debris flows. Both abundant water and an adequate debris supply are necessary to initiate slope failure, resulting in a clustering of debris flows at the break in slope where valley walls contact talus slopes. A variety of summer storm and antecedent moisture conditions initiate slope failures in the Glacier National Park, with no distinct meteorological threshold. With over two million visitorsevery year, and millions of dollars of park infrastructure at risk, identifying the hazard of debris flows is essential to future park management plans.

关键词： Debris flows remote sensing GIS GlacierNational Park USA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：