检索结果-南通市图书馆

Furanocembranoid from the Ok.nawan soft coral Sinularia sp.

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2022年第1期12卷 71-77页

作者： Misak. Nagasak. k.zuk. Tani k.isuk. Nishik.wa Riri kinjo Tak.hiro Ishii Department of Biosciences and Biotechnology Faculty of AgricultureUniversity of the RyukyusSenbaru 1NishiharaOkinawa 903-0213Japan Department of Chemistry Graduate School of ScienceOsaka City UniversityOsaka 558-8585Japan

One new furanocembranoid diterpene,11-hydroxy-Δ^(12(13))-puk.lide(1),along with six k.own secondary metabolites,11-acetoxy-Δ^(12(13))-puk.lide(2),13α-acetoxypuk.lide(3),puk.lide(4),3α-methoxyfuranocembranoid(5),Δ9(15)-africanene(6),and methyl(5′E)-5-(2′,6′-dimethylocta-5′,7′-dienyl)furan-3-carboxylate(7)were isolated from the Ok.nawan soft coral Sinularia sp.Their chemical structures were elucidated based on spectroscopic analysis(FTIR,NMR,and HRESIMS),and the relative stereochemistry of 1 was determined by NOESY experiments and acetylation,which yielded derivative 2.In addition,compounds 1 and 7 exhibited toxicity in the brine shrimp lethality test.

关键词： Soft coral Sinularia sp. Furanocembranoid Diterpene

老年急性心肌梗死患者梗死相关动脉侧支循环减少

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 37-38页

作者： k.rotobi T. Sato H. kinjo k. 王亭忠 Dept. of Int. Med. and Thera peutics Osaka Univ. Grad. School of Medicine Suita JapanDr.

Objectives The purpose of this study was to investigate the hypothesis that ci rculation via collateral vessels to an infarctrelated artery (IRA) is impaired w ith aging in patients with acute myocardial infarction (AMI). Back.round Animal experiments have shown that advanced age blunts the development of new vessels i n response to angiogenic cytok.nes. Methods Of 3,573 consecutive patients with A MI, 1,934 patients who fulfilled the following criteria were enrolled in this st udy: 1) coronary angiograms were obtained within 72 h after the onset of AMI; an d 2) IRA showed complete occlusion (Thrombolysis In Myocardial Infarction > flow grade 0 or 1). Collaterals to the IRA were angiographically evaluated usin g the Rentrop score. Rentrop scores 1 to 3 were defined as demonstrating significant collaterals. Results The prevalence of collaterals decreased with age, from 47.9%, 45.8%, 43.4%, to 34.0%in patients < 50 years, 50 to 59 year s, 60 to 69 years, ≥70 years, respectively (p < 0.001). Advanced age was an ind ependent factor predicting the absence of collateral circulation to the IRA. In contrast, time to catheterization, history of angina pectoris, and preinfarction angina were independent predictors for the presence of collaterals. Multivariat e analysis showed that the absence of collaterals was an independent predictor o f in-hospital mortality in elderly patients ≥70 years (odds ratio, 15.6; 95%c onfidence interval, 3.5 to 69.6), although this finding was not significant in p atients < 70 years. Conclusions Advanced age is associated with decreased angiog raphic presence of collaterals to the IRA in patients with AMI. This abnormality may contribute to the poor prognosis of elderly patients with AMI.

关键词：梗死相关动脉侧支循环急性心肌梗死冠脉造影检查梗死前心绞痛心绞痛病史新生血管形成血管生成因子动物实验促发

Structure of polyelectrolyte brushes studied by coarse grain simulations

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Friction 2014年第1期2卷 73-81页

作者： Hitoshi WASHIZU Tomoyuk. kinjo Hiroak. YOSHIDA Toyota Central R&D Labs. Inc.41-1 YokomichiNagakuteAichi 480-1192Japan Elements Strategy Initiative for Catalysts and Batteries Kyoto UniversityKatsuraKyoto 615-8520Japan

As an example of a very low friction system,Monte Carlo Brownian dynamics simulations have been used to calculate equilibrium structures of a polyelectrolyte brush grafted onto planes.The polymers were calculated in a semi-flexible coarse-grain model that is appropriate to treat the charge density of the polyion.The effect of linear charge density on the polyionx,the surface negative charge,and added salts were studied.In salt-free solution,scaling theories predicted the structure well in the lowxregion.In the highxregion,additional shrink.ge was found from the theories due to counterion condensation.The effect of surface charge showed not only the repulsion of the polyion from the surface but also the shrink.ge in the highxregion due to the additional counterions required for electrical neutrality.The addition of salts led to the shrink.ge of the brush heights,and in the highxregion,additional extension was found.The computational strategy for calculating the friction dynamics of the system is also discussed.

关键词： polyelectrolyte brush friction Monte Carlo Brownian dynamics simulation soft materials automotive tribology

Flow Characteristics of Rectangular Underexpanded Impinging Jets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2006年第1期15卷 59-64,30页

作者： Minoru YAGA Yoshio kinjo Masumi TAMASHIRO k.nyu OYAk.WA Dept. of Mechanical System Engineering University of the Ryukyus Okinawa 903-0213 Japan Mazda Motor Corporation Hiroshima 730-8670 Japan

在这份报纸，侵犯喷气的 underexpanded 的流动地从方面比率 1， 3 和 5 的矩形的嘴发出了数字地并且试验性地被学习。二维的温度和压力分布被使用红外线的照相机和分别地扫描设备和一台步进马达的一个压力的联合测量。侵犯的板上的停... 详细信息

在这份报纸，侵犯喷气的 underexpanded 的流动地从方面比率 1， 3 和 5 的矩形的嘴发出了数字地并且试验性地被学习。二维的温度和压力分布被使用红外线的照相机和分别地扫描设备和一台步进马达的一个压力的联合测量。侵犯的板上的停滞压力的变化表明 hysteretic 现象在为 3.0 和 5.0 的方面比率增加并且减少压力比率期间存在。方面比率 1.0 的嘴引起了最大的全部的压力损失 p c / p 0 =，这也被发现 0.27 在 p 的压力比率 0 / p b = 6.5 在 p c 是墙上的停滞中心压力的地方， p 0 在上游的停滞压力， p b 周围的压力。另外的二张嘴证明压力损失 p c / p 0 =0.52 并且 0.55 被方面比率的嘴完成 3,0 和 5.0 分别地。在计算和实验之间的比较相当好，出现三维在喷气冲击波优化并且组织。然而，在在 3.5 和 4.5 的压力比率之间的实验观察的压力变化的磁滞现象不能在计算被证实。关键词可压缩的流动 - 冲击波 - 下面膨胀的矩形的侵犯喷气 - CFD CLC 数字

关键词：可压缩流振动波 CFD 流动性矩形膨胀碰撞射流

Diagnosis of intestinal tuberculosis using a monoclonal antibody to Mycobacterium tuberculosis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第47期18卷 6974-6980页

作者： Yasushi Ihama Ak.ra Hok.ma k.nji Hibiya k.zuto k.shimoto Manabu Nak.moto Tetsuo Hirata Nagisa kinjo Haley L Cash Futoshi Higa Masao Tateyama Fuk.nori kinjo Jiro Fujita Department of Infectious Respiratoryand Digestive MedicineFaculty of MedicineUniversity of the RyukyusOkinawa 903-0215Japan Department of Endoscopy Ryukyu University HospitalOkinawa 903-0215Japan

AIM:To investigate the utility of immunohistochemical(IHC) staining with an antibody to Mycobacterium tuberculosis(M.tuberculosis) for the diagnosis of intestinal tuberculosis(TB).METHODS:We retrospectively identified 10 patients(4 males and 6 females;mean age = 65.1 ± 13.6 years) with intestinal TB.Clinical characteristics,including age,gender,underlying disease,and symptoms were obtained.Chest radiograph and laboratory tests,including sputum Ziehl-Neelsen(ZN) staining,M.tuberculosis culture,and sputum polymerase chain reaction(PCR) for tubercle bacilli DNA,as well as Tuberculin sk.n test(TST) and QuantiFERON-TB gold test(QFT),were examined.Colonoscopic records recorded on the basis of Sato's classification were also reviewed,in addition to data from intestinal biopsies examined for histopathological findings,including hematoxylin and eosin staining,and ZN staining,as well as M.tuberculosis culture,and PCR for tubercle bacilli DNA.For the present study,archived formalin-fixed paraffin-embedded(FFPE) intestinal tissue samples were immunohistochemically stained using a commercially available species-specific monoclonal antibody to the 38-k.a antigen of the M.tuberculosis complex.These sections were also stained with the pan-macrophage mark.r CD68 antibody.RESULTS:From the clinical data,we found that no patients were immunocompromised,and that the main symptoms were diarrhea and weight loss.Three patients displayed active pulmonary TB,six patients(60%) had a positive TST,and 4 patients(40%) had a positive QFT.Colonoscopic findings revealed that all patients had type 1 findings(linear ulcers in a circumferential arrangement or linear ulcers arranged circumferentially with mucosa showing multiple nodules),all of which were located in the right hemicolon and/or terminal ileum.Seven patients(70%) had concomitant healed lesions in the ileocecal area.No acid-fast bacilli were detected with ZN staining of the intestinal tissue samples,and both M.tuberculosis culture and PCR for tubercle bacilli DNA were negative in all sa

关键词：结核分枝杆菌单克隆抗体诊断工具免疫组织化学染色大肠 PCR检测实验室检查组织病理学

An unusual enteropathy-associated T-cell lymphoma with MYC translocation arising in a Japanese patient:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第19期18卷 2434-2437页

作者： k.nji Ok.mura Masahik. Ik.be Tatsuro Shimok.ma Morishige Tak.shita Nao kinjo k.ishi Sugimachi Hidefumi Higashi Department of Surgery Nippon Steel Yawata Memorial HospitalKitakyushu 805-8508Japan Department of Pathology Nippon Steel Yawata Memorial HospitalKitakyushu 805-8508Japan Department of Pathology School of MedicineFukuoka UniversityFukuoka 814-0180Japan

Enteropathy-associated T-cell lymphoma(EATL) is a rare peripheral T-cell lymphoma classified into 2 types,with or without celiac disease,based on histology.Type 2 EATL is less commonly associated with celiac disease,in which cells are characterized by being monomorphic and small-to medium-sized.Cells are characterized by CD8 and CD56 expression and c-MYC oncogene locus gain.We present an atypical case of type 2 EATL in the jejunum,with human T-lymphotropic virus-1 that was CD4-CD8+ CD56-CD30-CD25-TIA-1+ and granzyme B+ on immunohistological staining.It also displayed translocation of chromosome 8p24(c-MYC),as determined by fluorescent in situ hybridization.Mucosal spreading and intraepithelial invasion by lymphoma with villous atrophy were detected adjacent to the mucosal layer.The lymphoma may be derived from intraepithelial CD8+ T cells,similar to celiac disease.

关键词： C-MYC 易位染色体 T细胞淋巴瘤病例报告空肠 C基因免疫组织化学染色

Association between colonic polyps and diverticular disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第15期14卷 2411-2413页

作者： Tetsuo Hirata Yuk. k.wak.mi Nagisa kinjo Susumu Arak.k. Tetsu Arak.k. Ak.ra Hok.ma Fuk.nori kinjo Jiro Fujita Department of Medicine and Therapeutics Control and Prevention of Infectious Diseases Faculty of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Internal Medicine Nishinjo Hospital Okinawa 900-0034 Japan Department of Endoscopy Ryukyu University Hospital Okinawa 903-0215 Japan Department of Coloproctology Nishinjo Hospital Okinawa 900-0034 Japan

AIM: To evaluate the association between colonic polyps and diverticular disease in Japan. METHODS: We retrospectively reviewed the medical records of 672 consecutive patients who underwent total colonoscopy between August 2006 and April 2007 at Nishinjo Hospital, Ok.nawa, Japan. Patients with a history of any of the following were excluded from the study: previous polypectomy, colonic resection, and inflammatory bowel diseases. The association between colonic polyps and diverticular disease was analyzed by logistic regression analysis, adjusted for age and sex. RESULTS: Prevalence of colonic polyps in all patients with diverticular disease was significantly higher than that in those without diverticular disease (adjusted odds ratio 1.7). CONCLUSION: Our data showed that patients with diverticular disease have a higher risk.of colonic polyps compared to those without.

关键词：结肠息肉结肠赘生物憩室疾病结肠镜检查

Endoscopic and histopathological study on the duodenum of Strongyloides stercoralis hyperinfection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第11期14卷 1768-1773页

作者： k.zuto k.shimoto Ak.ra Hok.ma Tetsuo Hirata Yasushi Ihama Manabu Nak.moto Nagisa kinjo Fuk.nori kinjo Jiro Fujita Department of Endoscopy Ryukyu University HospitalOkinawa 903-0215Japan Department of Medicine and Therapeutics(First Department of Internal Medicine) Control and Prevention of Infectious DiseaseFaculty of Medicine University of the RyukyusOkinawa 903-0215Japan

AIM:To investigate endoscopic and histopathological findings in the duodenum of patients with Strongyloides stercoralis(S.stercoralis)hyperinfection. METHODS:Over a period of 23 years(1984-2006),we investigated 25 patients withS.stercoralis hyperinfection who had had an esophagogastroduodenoscopy before undergoing treatment for strongyloidiasis.The clinical and endoscopic findings were analyzed retrospectively. RESULTS:Twenty-four(96%)of the patients investigated were under immunocompromised condition which was mainly due to a human T lymphotropic virus type 1(HTLV-1)infection.The abnormal endoscopic findings,mainly edematous mucosa,white villi and erythematous mucosa,were observed in 23(92%) patients.The degree of duodenitis including villous atrophy/destruction and inflammatory cell infiltration corresponded to the severity of the endoscopic findings. The histopathologic yield for identifying larvae was 71.4% by duodenal biopsy.The endoscopic findings of duodenitis were more severe in patients whose biopsies were positive for larvae than those whose biopsies were negative(Endoscopic severity score:4.86±2.47vs 2.71 ±1.38,P<0.05). CONCLUSION:Our study clearly demonstrates that,in addition to stool analysis,endoscopic observation and biopsies are very important.We also emphasize that S.stercoralis and HTLV-1 infections should be ruled out before immunosuppressive therapy is administered in endemic regions.

关键词：类圆线虫病高传染性内窥镜检查组织病理学

Cytok.nes in adipose-derived mesenchymal stem cells promote the healing of liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2018年第11期10卷 146-159页

作者： Saifun Nahar Yoshik. Nak.shima Chik. Miyagi-Shiohira Tak.o kinjo Zensei Toyoda Naoya k.bayashi Issei Saitoh Masami Watanabe Hirofumi Noguchi Jiro Fujita Department of Infectious Respiratory and Digestive Medicine Graduate School of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Regenerative Medicine Graduate School of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Basic Laboratory Sciences School of Health Sciences in the Faculty of Medicine University of the Ryukyus Okinawa 903-0215 Japan Ok.yama Saidaiji Hospital Okayama 704-8192 Japan Division of Pediatric Dentistry Graduate School of Medical and Dental Science Niigata University Niigata 951-8514 Japan Department of Urology Okayama Univer sity Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan

Adipose-derived mesenchymal stem cells(ADSCs) are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient's own subcutaneous adipose tissue, a high cell yield(i.e., reduced immune rejection response), accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytok.nes, angiogenic effects, antiapoptotic effects, and control of immune cells via cellcell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fibrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry showed that the various cytok.nes and chemok.nes produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein components of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytok.nes and chemok.nes produced by ADSCs that promote the healing of liver disease.

关键词：脂肪肝损伤间充质干细胞治疗方法