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Phytochemical screening, hepatoprotective and antioxidant effects of leaf extracts of <i>Zapoteca portoricensis</i>

Advances in Biological Chemistry 2014年第1期4卷 35-39页

作者： kingsley nwonu agbafor Moses Eje Ogbanshi Emmanuel Iroha Akubugwo Biochemistry Department Abia State University Uturu Nigeria Biochemistry Department Ebonyi State University Abakaliki Nigeria

Fresh leaves of Zapoteca portoricensis are used in Eastern Nigeria for management/treatment of various disorders without any scientific basis. Hepatoprotective and antioxidant properties in albino rats, and phytochemical composition of distilled water and ethanol leaf extracts were studied. Fifty-five animals were placed in eleven groups (A-K) of five in each. Different doses (100, 200, 400 and 600 mg/kg body weight) of the extracts, 20 mg/kg body weight of vitamin C (standard antioxidant) and distilled water were orally administered to groups A-H, I and J-K respectively for six consecutive days. On the seventh day, 2.5 ml/kg body weight of carbon tetrachloride (CCl4) was given intraperitoneally to groups A-J, while group K received distilled. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were used to study hepatoprotective effect. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) levels in the liver were monitored to assess antioxidant activity. Phytochemical analysis revealed the presence of alkaloids, tannins, saponins, flavonoids, anthraquinones, terpenoids and cardiac glycosides in the extracts. Pretreatment of the rats with the extracts produced a significant decrease (p < 0.05) in ALT, AST, GGT and MDA, while the activity of SOD and CAT increased significantly (p < 0.05) relative to the positive control. These results, which were dose-dependent, are indicative of hepatoprotective and antioxidants potentials of the extracts, and may be due to their phytoconstituents.

关键词： Albino Rats Carbon Tetrachloride Zapoteca portoricensis Phytochemicals Liver Enzymes Antioxidant Activity

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Association of Obesity and Dyslipidaemia with Type 2 Diabetes in Outpatients of Enugu State University Teaching Hospital （ESUTH）in Enugu Nigeria

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Journal of Life Sciences 2018年第2期12卷 92-99页

作者： Godwill Azeh Engwa Amanda Okolie Friday Nweke Nwalo Emmanuela Akaniro-Ejim Marian N.Unachukwu Micheal Ndidiamaka Ozofor kingsley N. agbafor Benjamin Ewa Ubi Department of Chemical Sciences Godfrey Okoye University P. M. B 01014 Thinkers Comer Enugu Nigeria Department of Biotechnology Federal University Ndufu-Alike Ikwo (FUNAI) P. M. B. 1010 Abakaliki Nigeria Department of Biotechnology Godfrey Okoye University P. M. B 01014 Thinkers Corner Enugu Nigeria Department of Microbiology Godfrey Okoye University P. M. B 01014 Thinkers Comer Enugu Nigeria Department of Computer Science and Mathematics Godfrey Okoye University P. M. B 01014 Thinkers Corner Enugu Nigeria Department of Biochemistry Ebonyi State University P. M. B 53 Abakaliki Nigeria Department ofBiotechnology Ebonyi State University P. M. B 53 Abakaliki Nigeria

Obesity is known to be a major risk factor of type 2 diabetes （T2D） and responsible for most lipid abnormalities associated with the disease but limited data on such association are available for diabetic patients of Igbo ethnicity in the South East region of Nigeria. A case-control study involving 72 T2D patients and 75 non-diabetic （ND） patients （control） ofIgbo ethnicity was conducted. Demographic and anthropometric data were obtained followed by blood collection for the determination of fasting blood sugar （FBS）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL） and low density lipoprotein （LDL）. Obesity based on waist circumference （WC） was significantly higher （p 〈 0.001） in T2D patients compared to their non-diabetic counterparts. Similarly, TC, TG and LDL levels were significantly （p 〈 0.001） higher in T2D patients while HDL was significantly lower （p 〈 0.001） in T2D patients compared to the control. The proportion of dyslipidaemia characterized by high TC, high TG, high LDL and low HDL was significantly higher （p 〈 0.001） in T2D patients. BMI correlated positively （p 〈 0.05） with WC, TC, and LDL while FBS correlated positively （p 〈 0.05） with TG but negatively with HDL. In conclusion, dyslipidaemia characterised by hypercholesterolaemia, hypertriglyceridaemia, elevated LDL and reduced HDL, as well as obesity were associated with T2D and correlated with FBS in this population.

关键词： Type 2 diabetes obesity Igbo dyslipidaemia Enugu.

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In vivo antiplasmodial activity of Bombax buonopozense root bark aqueous extract in mice infected by Plasmodium berghei

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Journal of Traditional Chinese Medicine 2017年第4期37卷 431-435页

作者： Akuodor Godwin Christian Ezeonu Chinonyelum Thecla Essien Augustine Dick Asika Ebere Chile Chilaka kingsley Chimsorom Nwachukwu Daniel Ckukwu Nwobodo Ndubuisi Nwobodo Department of Pharmacology and Therapeutics Faculty of Medicine Ebonyi State UniversityAbakaliki P.M.B. 053 Nigeria Department of Paediatrics Faculty of Medicine Ebonyi State University Abakaliki RM.B.053 Nigeria Department of Pharmacology College of Medical Sciences University of Calabar Calabar P.M.B. 1115 Nigeria Department of Pharmacology and Therapeutics College of Health Sciences Nnamdi Azikiwe University Awka P.M.B. 5025 Nigeria Department of Physiology College of Medicine University of Nigeria Enugu P.M.B. 1011 Nigeria

OBJECTIVE: To evaluate the in vivo antiplasmodial activity and the oral acute toxicity of the Bombax buonopozense root bark aqueous ***: The in vivo antiplasmodial activity of the root bark aqueous extract of Bombax buonopozense against early and established rodent malaria infections in chloroquine sensitive Plasmodium berghei strain in mice was investigated, and oral acute toxicity of the aqueous root bark extract of Bombax buonopozense was also evaluated in ***: The findings of this study revealed significant(P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract(50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The aqueous extract was found no toxicity in mice and the oral LD50 was determined to be greater than 5000 mg/***: Bombax buonopozense root bark aqueous extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents.

关键词： Plasmodium berghei Bombax Plant extracts Phytochemicals Toxicity tests, acute

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