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Proximate analyses,in vitro antioxidant activity and GC-MS analyses of fermented Pentaclethra macrophylla seeds

Life Research 2024年第3期7卷 2-8页

作者： Ikechukwu Okoro Parker joshua Innocent Okagu Christian Amah Nnamani Ikenna Nene Chiaka-Onyemeze Emeka Anaduaka David Obasi Prince Okoroh Daniel Orieke Victor Ogugua Department of Medical Biochemistry College of Health SciencesDavid Umahi Federal University of Health SciencesUburuNigeria Department of Biochemistry University of NigeriaNsukkaNigeria Department of Biochemistry State University of Medical and Applied SciencesIgbo-EnoNigeria Department of Medical Laboratory Sciences State University of Medical and Applied SciencesIgbo-EnoNigeria

The present study assessed the proximate composition,in vitro antioxidant activity and GC-MS analyses of fermented Pentaclethra macrophylla seeds extract(FPMSE).The in vitro antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazl(DPPH)while Gas Chromatography-Mass Spectrophotometry(GC-MS)technique was used to identify the volatile compounds in *** revealed a dose dependent percentage inhibition of the extract on DPPH *** composition of FPMSE constitutes respectively;ash(0.33±0.12%),protein(2.19±0.08%),fats and oil(80.60±0.00%),carbohydrate(16.88±0.00%)while moisture and fibre were not ***,the pulverised sample constitute respectively;ash(1.27±0.58%),protein(10.51±0.60%),moisture(8.27±0.12%),fats and oil(32.33±0.12%),fibre(7.27±0.12%)and carbohydrate(40.35±0.00%).GC-MS analyses revealed fourteen(14)fatty acids including Octadecanoic acid(1.95%),Benzyloxymethylimine(43.89%),2-Allylpent-4-enoic acid benzyl ester(26.25%),Hexadecanoic acid,methyl ester(1.09%),Oleic Acid(0.25%),9,12-Octadecadienoic acid,methyl ester(Omega-6-fatty acid)(1.52%).The bioactive compounds identified in FPMSE could contribute to the pharmacological properties of *** seeds and hence,could be of considerable interest for the development of new drugs.

关键词： Pentaclethra macrophylla in vitro antioxidant GC-MS fatty acids

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Recurrent gene flow between Neanderthals and modern humans over the past 200,000 years

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四川生理科学杂志 2024年第7期46卷 1621-1621页

作者： Liming Li Troy J. Comi Rob F. Bierman joshua M. Akey Department of Medical Genetics and Developmental Biology School of Medicine The Key Laboratory of Developmental Genes and Human Diseases Ministry of Education Southeast University Nanjing 210009 China. The Lewis-Sigler Institute for Integrative Genomics Princeton University Princeton NJ 08540 USA.

Although it is well known that the ancestors of modern humans and Neanderthals admixed,the effects of gene flow on the Neanderthal genome are not well *** develop methods to estimate the amount of human-introgressed s... 详细信息

关键词： flow modern apply

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DEEP:Getting to Know Gin

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城市漫步（GBA版） 2024年第6期 31-31页

作者： joshua Cawthorpe 不详

Tucked away on a quiet laneway onlya stone's throw from Guangzhou'sTaikoo Hui is *** warm and intimate space is one ofthe city's well-kept secrets as it calls only themost dedicated epicureans. On the menu:craft gin and craft beer. DEEP'S owner AnnChi explains that the two choices on offerboth represent the fengwei (风味) or speciallocal flavor that emerges from carefullychosen ingredients.

关键词： DEE craft Guangzhou

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L-Arginine Supplementation Mitigates Dichlorvos-Induced Haematocardiotoxicity, and Oxidative Stress in Male Wistar Rats

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Open Journal of Applied Sciences 2024年第7期14卷 1886-1903页

作者： Waidi Adeoye Saka Yusuff Dimeji Igbayilola Jabba Hamidu Lawan Taoheed Kolawole Muftaudeen Ridwanullahi Adejumo Tolulope Deborah Alu Mary Ikuomola joshua Tinuade Ojelere Victor Odufa Adegoke Department of Physiology College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Oyo State Nigeria Department of Human Physiology College of Medicine and Health Sciences Baze University Abuja Nigeria Department of Biological Sciences Faculty of Computing and Applied Sciences Baze University Abuja Nigeria

Due to its toxicity, dichlorvos—a common organophosphate pesticide—poses significant risks to human health. This study utilized male Wistar rats to explore the potential protective effects of L-arginine supplementation against dichlorvos-induced toxicity, focusing on cardiotoxicity, haematotoxicity and oxidative stress. The rats were divided into four groups: Control, L-arginine (L), Dichlorvos (D), and L-arginine + Dichlorvos (L + D). Dichlorvos was administered to the D group, L-arginine (100 mg/kg) to the L group, and both L-arginine and dichlorvos to the L + D group. The study evaluated various parameters, including cardiovascular, oxidative stress markers, and haematological indices. Significant changes in haematological parameters such as haemoglobin (Hb), haematocrit (HCT), and red blood cell count (RBC) indicated haematotoxicity after dichlorvos administration. Additionally, elevated cardiac markers, including lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB), suggested cardiotoxic effects. Exposure to dichlorvos also resulted in decreased antioxidant enzyme levels and increased oxidative stress indicators like malondialdehyde (MDA). Remarkably, L-arginine supplementation mitigated the damage caused by dichlorvos. It normalized the altered haematological parameters, demonstrating its protective effect against haematotoxicity. The rise in cardiac markers was reduced with L-arginine supplementation, indicating protection against cardiotoxicity. Moreover, L-arginine significantly decreased oxidative stress, as evidenced by lower MDA levels and restored antioxidant enzyme activity. In conclusion, L-arginine supplementation in male Wistar rats showed promising protective effects against dichlorvos-induced cardiotoxicity, haematotoxicity and oxidative stress. This suggests that L-arginine may offer a beneficial intervention to mitigate the adverse effects of dichlorvos on blood and heart health, paving the way for potential treatments for pesticide poison

关键词： Dichlorvos L-Arginine Cardiovascular Function Haematological Parameters Oxidative Stress

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First-Principles Investigation of Charge Transfer Mechanism of B-Doped 3C-SiC Semiconductor Material

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World Journal of Condensed Matter Physics 2024年第2期14卷 35-44页

作者： Abdullahi Alkali Dauda Muhammad Yusuf Onimisi Adeyemi joshua Owolabi Hameed Adeneyi Lawal Hassan Muhammad Gambo Bashir Mohammed Aliyu Surajo Bala Muhammad Lamido Madugu Muhammad Abdurrahman Nainna Johnson Akinade Bamikole Physics Department Faculty of Science Air Force Institute of Technology Kaduna Nigeria Physics Department Faculty of Science Nigeria Defence Academy Kaduna Nigeria Physics Department Umaru Musa Yar&#8217adua University Batagarawa Nigeria Physics Department Faculty of Science Gombe State University Gombe Nigeria Physics Department Federal University of Lafia Lafia Nigeria

This study delves into the charge transfer mechanism of boron (B)-doped 3C-SiC through first-principles investigations. We explore the effects of B doping on the electronic properties of 3C-SiC, focusing on a 12.5% impurity concentration. Our comprehensive analysis encompasses structural properties, electronic band structures, and charge density distributions. The optimized lattice constant and band gap energy of 3C-SiC were found to be 4.373 Å and 1.36 eV respectively, which is in agreement with previous research (Bui, 2012;Muchiri et al., 2018). Our results show that B doping narrows the band gap, enhances electrical conductivity, and influences charge transfer interactions. The charge density analysis reveals substantial interactions between B dopants and surrounding carbon atoms. This work not only enhances our understanding of the material’s electronic properties, but also highlights the importance of charge density analysis for characterizing charge transfer mechanisms and their implications in the 3C-SiC semiconductors.

关键词： First-Principles Calculations DFT Boron (B)-Doped 3C-SiC Charge Transfer

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突发性感音神经性听力损失患者高压氧治疗的临床意义

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听力学及言语疾病杂志 2024年第3期32卷 289-289页

作者：焦沃尔(摘译) 陈始明(审校) joshua TG Ayub A Wijesinghe P 武汉大学人民医院耳鼻咽喉头颈外科武汉430060 武汉大学耳鼻咽喉头颈外科研究所不详

本研究通过Meta分析系统回顾已有文献,研究HBOT是否可以作为SSNHL患者单一治疗手段或补充疗法。研究对2000年1月到2020年4月期间的10个国际数据库进行系统回顾,检索词包括:高压氧、突发性听力损失、感音神经性听力损失以及相关缩写词。... 详细信息

本研究通过Meta分析系统回顾已有文献,研究HBOT是否可以作为SSNHL患者单一治疗手段或补充疗法。研究对2000年1月到2020年4月期间的10个国际数据库进行系统回顾,检索词包括:高压氧、突发性听力损失、感音神经性听力损失以及相关缩写词。研究纳入了将HBOT作为单一或联合疗法并与其他疗法(例如激素口服、静脉输注以及鼓室内给药或使用安慰剂)进行比较的文章,并排除非英语及无法获得全文的文章。提取的主要指标包括:听力损失的严重程度,HBOT的次数和持续时间,其他治疗细节(即药物类型、给药方法、剂量和治疗开始时间),治疗前后PTA,患者听力恢复比例,治疗相关的不良反应。共检索到826篇文献,除去358篇重复文献以及468篇文献不符合纳入标准,最后有3篇文献共150例SSNHL患者进行了评估。Cho等纳入60例≥70 dB HL的SSNHL患者,对照组(30例)采用激素口服和鼓室内给药的方式,联合治疗组(30例)在此基础上加上HBOT[持续10 d,每天在2.5个绝对大气压(ATA)下进行60 min]。Kraj ovi ová等纳入了68例中度听力损失(41~60 dB HL)的SSNHL患者,对照组(21例)采用激素静脉给药和口服、口服扩血管药物的方式,联合治疗组(47例)在此基础上加上HBOT(持续10 d,每天在2个ATA下进行90 min)。Khater等招募22例SSNHL患者(未描述听力损失程度),对照组(11例)采用激素口服和鼓室内给药、口服抗病毒药物的方式,联合治疗组(11例)在此基础上加上HBOT(持续20 d,每天在2个ATA下进行60 min)。

关键词：绝对大气压听力损失程度扩血管药物其他疗法联合疗法高压氧治疗听力恢复抗病毒药物

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Influence of climate fluctuations on Pinus palustris growth and drought resilience

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Forest Ecosystems 2023年第6期10卷 681-689页

作者： Joao Campoa joshua Puhlick CENSE–Center for Environmental and Sustainability Research CHANGE-Global Change and Sustainability InstituteDepartment of Environmental Sciences and EngineeringNOVA School of Science and TechnologyNOVA University LisbonCampus de Caparica2829-516 CaparicaPortugal The Jones Center at Ichauway 3988 Jones Center Drive39870NewtonGAUSA

The longleaf pine(Pinus palustris Mill.)ecosystem is an endangered ecosystem in the southeastern USA,and efforts to restore the species are ***,in recent decades,the region has experienced drastic fluctuations between wet and dry growing season conditions from year to year,and it is not fully understood how these fluctuations have influenced the growth of *** address this topic,we cored *** trees in woodlands of southwest Georgia and used dendrochronology techniques to determine how climate fluctuations have influenced the growth and drought resilience of *** also cored slash pine(Pinus elliottii Engelm.)trees in the same woodlands to compare growth between *** *** growth was less impacted by adverse climate conditions compared to ***,the strength of correlations between *** growth and temperature,precipitation,and Palmer Drought Severity Index(PDSI)changed over *** recent decades,climate conditions during the growing season became more influential on *** growth than the previous year's *** is concerning given that drought severity during the growing season has been *** results also indicate that *** was less resilient to droughts during the 2000s and 2010s than to those of the *** this new climate paradigm,our results suggest that *** might be more susceptible to growth reductions and less resistant to droughts than once *** work highlights the importance of understanding the impact of novel climate conditions on *** and has implications for restoration efforts,such as using silvicultural treatments that reduce tree vulnerability to drought(e.g.,thinning)and promote other climate-adapted species in mixture with ***.

关键词： Longleaf pine Slash pine Pinus elliottii Climate change Dendrochronology Dendroclimatology Forest disturbances

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How a systems perspective can help us with the interdisciplinarity puzzle

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Journal of Data and Information Science 2023年第1期8卷 2-8页

作者： joshua Eykens ECOOM-UAntwerpen Middelheimlaan 1 2020 AntwerpBelgium

1 Introduction The future of scientific knowledge production is by many envisioned as an interdisciplinary *** an increasing extent knowledge generated within separate disciplines will be integrated to develop effecti... 详细信息

关键词： knowledge today tomorrow

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Lethal means and suicide prevention among military veterans

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Military Medical Research 2023年第1期10卷 139-140页

作者： joshua Levine Leo Sher Veterans’Administration New York Harbor Healthcare System BrooklynNY 11209USA James J.Peters Veterans’Administration Medical Center BronxNY 10468USA

Dear Editor,Suicide amongst the military veteran population is a significant *** VeteranSuicidePreventionAnnualReportrevealedthat6261 died by suicide in 2019[1]. The lingering effects of the coronavirus disease 2019 (... 详细信息

关键词： Suicide Depression Public health Lethal means Military veterans

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Vaccine-associated myocarditis:a case report and summary of the literature

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World Journal of Emergency Medicine 2022年第6期13卷 485-487页

作者： joshua Davis Lauren Jennings University of Kansas School of Medicine Wichita 67214USA Vituity Wichita 67214USA American Red Cross in Hazelwood Missouri 63042USA

Dear editor,Myocarditis is a known complication of vaccines for COVID-19,particularly mRNA *** it is rare,the exact incidence of vaccine-associated myocarditis is *** of personal choice in vaccination decisions often cite the risk of myocarditis as a reason one might choose not to receive the COVID-19 ***,we describe a case of focal myocarditis associated with the Pfizer-BioNTech COVID-19 vaccine and review the literature on the incidence and risk of COVID-19 vaccine-associated myocarditis.

关键词： myocarditis vaccine Pfizer

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