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Examining patterns of traditional chinese medicine use in pediatric oncology: A systematic review, meta-analysis and data-mining study

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Journal of Integrative Medicine 2022年第5期20卷 402-415页

作者： Chun Sing Lam Li Wen Peng Lok Sum Yang ho Wing Janessa Chou Chi-Kong Li Zhong Zuo ho-Kee Koon Yin Ting cheung School of Pharmacy Faculty of Medicinethe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of Medicinethe Chinese University of Hong KongHong KongChina hong Kong Hub of Paediatric Excellence the Chinese University of Hong KongHong KongChina Department of Paediatrics&Adolescent Medicine Hong Kong Children’s HospitalHong KongChina School of Chinese Medicine Faculty of Medicinethe Chinese University of Hong KongHong KongChina

Background Traditional Chinese medicine(TCM)is becoming a popular complementary approach in pediatric ***,few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric *** We explored the patterns of TCM use and its efficacy in children with cancer,using a systematic review,meta-analysis and data mining *** strategy We conducted a search of five English(Allied and Complementary Medicine Database,Embase,PubMed,Cochrane Central Register of Controlled Trials,and ***)and four Chinese databases(Wanfang Data,China National Knowledge Infrastructure,Chinese Biomedical Literature Database,and VIP Chinese Science and Technology Periodicals Database)for clinical studies published before October 2021,using keywords related to“pediatric,”“cancer,”and“TCM.”Inclusion criteria We included studies which were randomized controlled trials(RCTs)or observational clinical studies,focused on patients agedho had been diagnosed with cancer,and included at least one group of subjects receiving TCM *** extraction and analysis The methodological quality of RCTs and observational studies was assessed using the six-item Jadad scale and the Effective Public Healthcare Panacea Project Quality Assessment Tool,***-analysis was used to evaluate the efficacy of combining TCM with *** outcomes included the treatment response rate and occurrence of cancer-related *** rule mining(ARM)was used to investigate the associations among medicinal herbs and patient *** The fifty-four studies included in this analysis were comprised of RCTs(63.0%)and observational studies(37.0%).Most RCTs focused on hematological malignancies(41.2%).The study outcomes included chemotherapy-induced toxicities(76.5%),infection rate(35.3%),and response,survival or relapse rate(23.5%).The methodological quality of most of the RCTs(82.4%)and observational studies(80.0%)was r

关键词： Traditional Chinese Medicine Herbal medicine Pediatric oncology Data mining Associate rule mining Chemotherapy

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A red herring: An unusual case of pneumothorax

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World Journal of Emergency Medicine 2021年第2期12卷 160-161页

作者： Joseph H.Walline Koon-ho cheung Priscilla P.Song Colin A.Graham Accident and Emergency Medicine Academic Unit Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina Department of Accident and Emergency Medicine Prince of Wales HospitalHong Kong Hospital AuthorityHong KongChina Centre for the Humanities and Medicine the University of Hong KongHong KongChina

Dear editor,A 67-year-old Chinese man presented to our emergency department (ED) complaining of right-sided chest wall *** noticed these symptoms three hours prior to arrival. He denied any shortness of breath or recent injury. Past medical history was significant only for hypertension. Social history was significant for a history of smoking (40 packs per year).

关键词： sided editor hypertension

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A newly discovered active contact binary in the field of NGC 1348

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Research in Astronomy and Astrophysics 2012年第1期12卷 93-103页

作者： Xiang-Song Fang Sheng-hong Gu ho-Keung Hui Chi-Tai Kwok Bill Yeung Kam-cheung Leung National Astronomical Observatories / Yunnan Observatory Chinese Academy of SciencesKunming 650011 China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650011 China Graduate University of Chinese Academy of Sciences Beijing 100049 China hokoon Nature Education cum Astronomical Centre Sik Sik-Yuen Hong Kong China hong Kong Astronomical Society Hong Kong China

We present a CCD photometry study of a newly discovered active eclipsing binary in the field of open cluster NGC 1348 based on the first time-series photometric observation. From the minimum times, we determined an orbital period of P = 0.691363 d. Among our datasets, the BV（.RI）c light curves obtained in November 2008 were analyzed using the Wilson-Devinney light curve modeling tech- nique. Because of the uncertainty of the membership of this binary in open cluster NGC 1348, we have analyzed the photometric data in two cases with different primary effective temperatures： Case A （T1 = 7750K） and Case B （T1 = 5250K）. Our anal- yses reveal that, for Case A, it is a deep （f 〉 70%）, very low mass ratio （q - 0.096） binary system, indicating that it is now in the late evolution stage of a contact binary; while for Case B, it is a red system with extraordinarily long orbital period with respect to the period-color relation for normal contact binaries, which suggests that this binary has evolved off the main sequence. The well known O＇Connell effect （e.g., AB 0.03 mag） was found in the dataset obtained in November 2008, which could be due to the existence of starspots on the components, therefore the corresponding spot properties （for Case A： hot spot; for Case B： dark spot） were determined using the Wilson-Devinney code. With the purpose of analyzing the dark spot activity for Case B, we compared the light curves derived in different observing runs, and found that a slight change appeared from November to December, 2008, which indicates the evolution of spot activity on at least one component over a time scale of about one month.

关键词： stars: binaries: close -- stars: binaries: eclipsing -- stars: spots

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1D-2D nanohybrid-based textile strain sensor to boost multiscale deformative motion sensing performance

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Nano Research 2022年第9期15卷 8398-8409页

作者： Xiaoting Li Keng Huat Koh Jiaqi Xue Chun ho So Na Xiao Chung Tin king Wai Chiu Lai Department of Biomedical Engineering City University of Hong KongKowloon TongHong KongChina

The development of strain sensors with both superior sensitivity(gauge factor(GF)>100)and broad strain-sensing range(>50%strain)is still a grand ***,which demonstrate significant structural deformation under microscale motion,are required to offer high *** connection of materials upon large-scale motion is demanded to widen strainsensing ***,it is hard to achieve both features ***,we design a crepe roll structure-inspired textile yarn-based strain sensor with one-dimensional(1D)-two-dimensional(2D)nanohybrid strain-sensing sheath,which possesses superior *** ultrastretchable strain sensor exhibits a wide and stable strain-sensing range from microscale to large-scale(0.01%–125%),and superior sensitivity(GF of 139.6 and 198.8 at 0.01%and 125%,respectively)*** strain sensor is structurally constructed by a superelastic 1D-structured core elastomer polyurethane yarn(PUY),a novel high conductive crepe roll-structured(CRS)1D-2D nanohybrid multilayer sheath which assembled by 1D nanomaterials silver nanowires(AgNWs)working as bridges to connect adjacent layers and 2D nanomaterials graphene nanoplates(GNPs)offering brittle lamellar structure,and a thin polydopamine(PDA)wrapping layer providing protection in exterior *** the stretching/deformation process,microcracks originate and propagate in the GNPs lamellar structure enable resistance to change significantly,while AgNWs bridge adjacent GNPs to accommodate applied stress partially and boost *** 1D crepe roll structure-inspired strain sensor demonstrates multifunctionality in multiscale deformative motion detection,such as respiratory motions of Sprague–Dawleyw rat,flexible digital display,and proprioception of multi-joint finger bending and antagonistic flexion/extension motions of its flexible continuum body.

关键词： crepe roll-inspired multifunctional yarn strain sensor one-dimensional silver nanowires/two-dimensional graphene nanoplates(1D AgNWs/2D GNPs)nanohybrid multi-scale motion detection e-textiles tactile sensing proprioception of the endoscopic robot

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Mothers’ health-related quality of life: Its relationship with children’s health-related quality of life and behavior in low-income families

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Family Medicine and Community Health 2016年第4期4卷 4-12页

作者： Rosa Sze Man Wong Vivian Yawei Guo Patrick Ip Carlos king ho Wong Esther Yee Tak Yu Colman Siu cheung Fung Cindy Lo Kuen Lam Department of Family Medicine and Primary Care The University of Hong KongAp Lei Chau ClinicAp Lei ChauHong KongChina Department ofPaediatrics and Adolescent Medicine TheUniversity of Hong KongQueen Mary HospitalHong KongChina

Objective:To examine the association between mothers’health-related quality of life(HRQOL)and their children’s HRQOL and behavior in low-income ***:Mothers of 278 children aged 6-12 years from low-income families were invited to complete the Child Health Questionnaire Parent Form 50(CHQ-PF50)and the Strength and Dif-ficulties Questionnaire(SDQ)for their children as well as the 12-item Short-Form Health Survey version 2(SF-12v2)and the Patient Health Questionnaire-2(PHQ-2).Multiple linear regressions with mother-child pairs as the unit of analysis were performed to examine the associations between maternal and child variables with adjustment of mother-and child-level ***:Compared with the general population,low-income mothers had a lower mean SF-12v2 mental component summary score and their children also had lower mean CHQ-PF50 physi-cal and psychosocial summary scores and SDQ total difficulties *** of mothers with SF-12v2 scores below the population mean of 50 had significantly worse CHQ-PF50 scores and higher SDQ total difficulties *** mother’s PHQ-2 depression status had no association with the child’s CHQ-PF50 ***:Our findings suggest that more attention should be paid to reducing the negative impact of health problems on mothers’daily roles in childcare in low-income families.

关键词： Health-related quality of life child health child behavior low income

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Interactions Between Arbuscular Mycorrhizae and Plants in Phytoremediation of Metal-Contaminated Soils: A Review

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Pedosphere 2013年第5期23卷 549-563页

作者： LEUNG ho-Man WANG Zhen-Wen YE Zhi-hong YUNG Kin-Lam PENG Xiao-Ling cheung Kwai-Chung Department of Biology Hong Kong Baptist University School of Biological Science and Technology Yangzhou University State Key Laboratory for Bio-control and School of Life Sciences Sun Yat-sen University Division of Science and Technology BNU-HKBU United International College Department of Applied Sciences Hong Kong Institute of Vocational Education (Chai Wan)

Metal contamination in the environment is a global concern due to its high toxicity to living organisms and its worldwide distribution. The principal goal of this review is to examine the current strategies and technologies for the remediation of metal- contaminated soils by metal-accumulating plants and assess the roles of arbnscular mycorrhizal （AM） fungi in remediation of soils under hyperaccumulator or non-accumulator plants. The use of plants to remove metals from the environment or reduce the toxicity, known as phytoremediation, is an environmentally sustainable and low cost remediation technology. The mechanisms of the use of hyperaccumulator plants for phytoremediation included solubilization of the metal in the soil matrix, the plant uptake of the metal, detoxification/chelation and sequestration, and volatilization. Recently, some ecologists have found that phytoremediation with the aids of mycorrhizae can enhance efficiency in the removal of toxic metals. AM fungi can facilitate the survival of their host plants growing on metal-contaminated land by enhancing their nutrient acquisition, protecting them from the metal toxicity, absorbing metals, and also enhancing phytostabilization and phytoextraction. Such information may be useful for developing phytoremediation program at metal-contaminated sites.

关键词： AM fungi heavy metals hyperaccumulator plant phytoextraction phytostabilization

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Prey decline leads to diet shift in the largest population of Indo-Pacific humpback dolphins?

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Integrative Zoology 2021年第4期16卷 548-574页

作者： Wenzhi LIN Leszek KARCZMARSKI Ruilian ZhoU Yaqian MO Lang GUO Sam king Fung YIU Xi NING Tak-cheung WAI Yuping WU School of Marine Sciences Zhuhai Key Laboratory of Marine Bioresources and EnvironmentGuangdong Provincial Key Laboratory of Marine Resources and Coastal EngineeringSouthern Marine Science and Engineering Guangdong LaboratorySun Yat-Sen UniversityZhuhaiChina Division of Cetacean Ecology Cetacea Research InstituteLantauHong Kong SARChina Marine Mammal and Marine Bioacoustics Laboratory Institute of Deep-sea Science and EngineeringChinese Academy of SciencesSanyaChina School of Biological Sciences University of Hong KongPokfulamHong Kong SARChina State Key Laboratory of Marine Pollution City University of Hong KongHong Kong SARChina

The Pearl River Delta(PRD)region on the southeast coast of China has long been known as a highly productive fishing *** the late 1980s,fishing pressure in the PRD has been intense,which warrants concerns of potential fishery-related impacts on the food resources and foraging ecology of apex marine predators in this region,such as the Indo-Pacific humpback dolphin(Sousa chinensis).In this study,we examined 54 stomachs with food remains,collected from beached carcasses of humpback dolphins recovered during fifteen years between 2003 and *** 6043 identified prey items represent 62 teleost taxa,primarily small estuarine fish,but also larger reef *** dolphins appear to be opportunistic foragers,hunting across the water-column,with preference for shoaling and meaty fishes(*** lucidus IRI%=38.6%,Johnius belangerii IRI%=23.1%,Mugil cephalus IRI%=14.0%).Our findings suggest a dietary shift in recent years,from primarily demersal(as previously reported)to greater intake of neritic and pelagic *** foraging group size has decreased in recent years,which corresponds with declining size and numbers of prey items retrieved from dolphin *** suggest that these are indicators of declining food *** with a shortage of preferred prey,humpback dolphins may have broadened their dietary spectrum to maintain their daily energy intake,while their foraging group size decreased in response to the altered tradeoff between the costs and benefits of group foraging.

关键词： feeding ecology Pearl River Delta prey decline Sousa chinensis stomach content analysis

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Intravenous fluid selection rationales in acute clinical management

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World Journal of Emergency Medicine 2018年第1期9卷 13-19页

作者： Wing Yan Shirley cheung Wai Kwan cheung Chun ho Lam Yeuk Wai Chan Hau Ching Chow Ka Lok Cheng Yau Hang Wong Chak Wah Kam Accident and Emergency Department Tuen Mun Hospital

BACKGROUND: Intravenous fluid(IVF) is commonly used in acute clinical management. This study aimed to review the choice and primary considerations in IVF prescriptions and to evaluate the adequacy of guidelines and trainings on it in the New Territories West Cluster(NTWC) of hong ***: This is a descriptive study based on data collected from an online survey. Data were processed by SPSS for statistical analysis. This study focused on a general description and doctor-nurse between group comparison. Participants were asked the choice of IVF for nine acute clinical scenarios and provide reason. A 1–10 scale was used to assess the sufficiency of guideline, training and information, and time for revision on IVF ***: 0.9% sodium chloride was the most familiar IVF(36%), followed by 5% Dextrose solution(26%). In the nine scenarios, the most chosen IVF was 0.9% sodium chloride(37%–61%). There was significant difference in the choice of IVF between doctors and nurses in 7 cases. The second most chosen IVF for doctors was Plasma-Lyte A while that for nurses was Gelofusine. Departmental practice was the most chosen reason to account for the prescription. The adequacy of guideline, information and training, and time for revision was rated 5. Doctors had significantly more time at work than nurses to update knowledge in IVF prescription(5.41 versus 4.57).CONCLUSION: 0.9% sodium chloride was mostly chosen. The choice of IVF was mainly based on departmental practice. Adequacy of guideline, information and training, and time for revision on IVF prescription were average, indicating significant training deficit.

关键词： Intravenous fluid Acute care Resuscitation

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The RNA Pol Ⅱ sub-complex hsRpb4/7 is required for viability of multiple human cell lines

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Protein & Cell 2012年第11期3卷 846-854页

作者： Yang Zhao Kim K.C.Li king Pan Ng Chi ho Ng Kevin A.W.Lee Division of Life Science The Hong Kong University of Science and TechnologySai KungHong Kong S.A.R.China

The evolutionarily conserved RNA Polymerase Ⅱ Rpb4/7 sub-complex has been thoroughly studied in yeast and impacts gene expression at multiple levels including transcription,mRNA processing and *** addition Rpb4/7 exerts differential effects on gene expression in yeast and Rpb4 is not obligatory for yeast(***)*** roles for human(hs)Rpb4/7 have not been extensively described and we have probed this question by depleting hsRpb4/7 in established human cell lines using RNA *** find that Rpb4/7 protein levels are inter-dependent and accordingly,the functional effects of depleting either protein are ***4/7 exhibits gene-specific effects and cells initially remain viable upon hsRpb4/7 *** prolonged hsRpb4/7 depletion is cytotoxic in the range of cell lines *** cell death occurs by an unknown mechanism and in some cases is accompanied by a pronounced elongated cell *** conclusion we provide evidence for a gene-specific role of hsRpb4/7 in human cell viability.

关键词： RNA PolymeraseⅡ hsRpb4/7 sub-complex gene expression cell viability cell shape

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Gastrointestinal and hepatic side effects of potential treatment for COVID-19 and vaccination in patients with chronic liver diseases

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World Journal of Hepatology 2021年第12期13卷 1850-1874页

作者： Man Fai Law Rita ho Kimmy Wan Tung Law Carmen Ka Man cheung Department of Medicine and Therapeutics Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Medicine North District HospitalHong KongChina West Island School Hong KongChina

The outbreak of coronavirus disease 2019(COVID-19)is a global *** clinical trials have been performed to investigate potential treatments or vaccines for this disease to reduce the high morbidity and *** drugs of higher interest include umifenovir,bromhexine,remdesivir,lopinavir/ritonavir,steroid,tocilizumab,interferon alpha or beta,ribavirin,fivapiravir,nitazoxanide,ivermectin,molnupiravir,hydroxychloroquine/chloroquine alone or in combination with azithromycin,and ***(GI)symptoms and liver dysfunction are frequently seen in patients with COVID-19,which can make it difficult to differentiate disease manifestations from treatment adverse *** symptoms of COVID-19 include anorexia,dyspepsia,nausea,vomiting,diarrhea and abdominal *** injury can be a result of systemic inflammation or cytokine storm,or due to the adverse drug effects in patients who have been receiving different *** monitoring of liver function should be ***-19 vaccines have been rapidly developed with different technologies including mRNA,viral vectors,inactivated viruses,recombinant DNA,protein subunits and live attenuated *** with chronic liver disease or inflammatory bowel disease and liver transplant recipients are encouraged to receive vaccination as the benefits outweigh the *** against COVID-19 is also recommended to family members and healthcare professionals caring for these patients to reduce exposure to the severe acute respiratory syndrome coronavirus 2 virus.

关键词： COVID-19 treatment Gastrointestinal side effects Hepatic side effects COVID-19 vaccine Chronic liver disease Liver transplantation

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