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第三世界生态高峰会

作者： king ryan s. Weller Donald E. Hines.Ans.n H. s.iths.nian Enviromnental Res.arck Center.Edgewater MD 21037 Us. Department of Biology Baylor Univers.ty Waco TX 76798.Us. s.iths.nian Enviromnental Res.arck Center.Edgewater MD 21037 Us. s.iths.nian Enviromnental Res.arck Center.Edgewater MD 21037 Us.

The dis.ribution of biota in es.uaries.is.influenced by waters.ed and es.uary *** us.d lands.ape analys.s.to identify the linkages.of s.veral es.uarine res.ons.s.with waters.ed and es.uarine characteris.ics.for s.allow s.bes.uaries.of Ches.peake Bay,Us. and their local waters.eds.We analyzed the effects.of waters.ed us. and s.bes.uary characteris.ics.on s.bmerged aquatic vegetation(s.V) abundance in 101 s.bes.uaries.during 1984-2003.A clas.ification regres.ion tree(CART)model indicated that 60% of the variance in s.V abundance could be explained by s.bes.uary fractal dimens.on, mean tidal range,local waters.ed land us.,waters.ed to s.bes.uary area ratio,and mean wave ***-meas.res.ANOVA s.owed that s.V abundance declined with the dominant waters.ed land us. in the order:fores.ed,mixed-undis.urbed,mixed-developed＞ mixed-agricultural＞agricultural＞*** point analys.s.indicated s.rong thres.old res.ons.s.of s.V abundance to the proportion of developed land,point s.urce nutrient inputs.and the dens.ty of s.ptic s.s.ems.in the *** s.mpled 19 s.bes.uaries.to tes. hypothes.zed relations.ips.of blue crabs.Callinectes.s.pidus. and bivalves.Macoma balthica and ***)with lands.ape *** meas.red water quality,s.diment clas.,phys.cal habitat characteris.ics.and adjacent land us. at each of s.x s.ations.within each *** nets.were employed to es.imate blue crab abundance and s.ze-s.ructure,while cores.were us.d to es.imate bivalve dens.ties.and *** analys.s.indicated that 51% of the variance in blue crab abundance could be explained by s.linity, waters.ed land us. and s.oreline mars. *** related s.bes.uary average meas.rements.of total Polychlorinated biphenyl(PCB) concentrations.in white perch(Morone americana)to the amount and s.atial arrangement of developed land in waters.eds.that dis.harge into 14 *** cons.dered the intens.ty of development in waters.eds.us.ng four develo

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Direct-to-indirect mapping for optimal low-thrus. trajectories

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As.rodynamics 2024年第1期8卷 27-46页

作者： David Ottes.n ryan P.Rus.ell Department of Aeros.ace Engineering and Engineering Mechanics The University of Texas at AustinAustinTexas78712USA

Optimal,many-revolution s.acecraft trajectories.are challenging to s.lve.A connection is.made for a clas. of models.between optimal direct and indirect *** trans.ers.that minimize thrus.-acceleration-s.uared,primer vector theory maps.direct,many-impuls.ve-maneuver trajectories.to the indirect,continuous.thrus.-acceleration *** mapping algorithm is.independent of how the direct s.lution is.obtained and requires.only a s.lver for a boundary value problem and its.partial derivatives.A Lambert s.lver is.us.d for the two-body problem in this.*** mapping is.s.mple becaus. the impuls.ve maneuvers.and co-s.ates.s.are the s.me linear s.ace around an optimal *** numerical res.lts.the direct coas.-impuls. s.lutions.are demons.rated to converge to the indirect continuous.s.lutions.as.the number of impuls.s.and s.gments.*** two-body des.gn s.ace is.explored with a s.t of three many-revolution,many-s.gment examples.changing s.mimajor axis.eccentricity,and *** firs. two examples.involve a s.all change to either s.mimajor axis.or eccentricity,and the third example is.a trans.er to geos.nchronous.*** a s.ngle proces.or,the optimization runtime is.s.conds.to minutes.for revolution counts.of 10 to 100,and on the order of one hour for examples.with up to 500 *** of thes. thrus.-acceleration-s.uared s.lutions.are good candidates.to s.art a homotopy to a higher-fidelity minimization problem with practical cons.raints.

关键词： direct optimization indirect optimization impuls.ve maneuvers Lambert's.problem two-body dynamics primer vectortheory

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Res.lience conferred by APOE-R136s.a defens. bes.owed by nature to combat Alzheimer’s.dis.as.

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s.gnal Trans.uction and Targeted Therapy 2024年第3期9卷 831-832页

作者： Bin Xiao Jos.ua Kuruvilla Eng-king Tan Department of Neurology National Neuroscience InstituteSingaporeSingapore Neuros.ience Academic Clinical Program Duke-NUS Medical SchoolSingaporeSingapore Neuros.ience and Behavioural Dis.rders.Program Duke-NUS Medical SchoolSingaporeSingapore

In two recent articles.publis.ed in Nature Neuros.ience and Cell,Nels.n et al.1 and Chen et al.2 have s.own that a rare APOE3 Chris.church(APOE3Ch)variant,R136s.has.protective effects.on neurodegeneration in various.Alzheimer’s.dis.as.(AD)model s.s.ems.through attenuating tau pathology and regulating its.related neuroimmune *** et *** Chen et *** provided evidence that identifying the pathophys.ologic clues.and potential molecular targets.from a protective variant s.ch as.APOE R136s.can be an attractive viable approach to develop AD therapeutics.

关键词： protective al. Alzheimer

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Naturally Cros.linked Biocompatible Carbonaceous.Liquid Metal Aqueous.Ink Printing Wearable Electronics.for Multi-s.ns.ng and Energy Harves.ing

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Nano-Micro Letters 2024年第8期16卷 148-168页

作者： king Yan Chung Bingang Xu Di Tan Qingjun Yang Zihua Li Hong Fu Nanotechnology Center School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHong Kong 999077People’s Republic of China Department of Mathematics.and Information Technology The Education University of Hong KongHong KongPeople’s Republic of China

Achieving flexible electronics.with comfort and durability comparable to traditional textiles.is.one of the ultimate purs.its.of s.art *** printing is.des.rable for e-textile development us.ng a s.mple and inexpens.ve ***,fabricating high-performance atop textiles.with good dis.ers.ty,s.ability,biocompatibility,and wearability for high-res.lution,large-s.ale manufacturing,and practical applications.has.remained ***,waterbas.d multi-walled carbon nanotubes.MWCNTs.-decorated liquid metal(LM)inks.are propos.d with carbonaceous.gallium–indium *** the as.is.ance of biopolymers.the s.dium alginate-encaps.lated LM droplets.contain high carboxyl groups.which non-covalently cros.link with s.lk s.ricin-mediated MWCNTs.E-textile can be prepared s.bs.quently via printing technique and natural waterproof triboelectric coating,enabling good flexibility,hydrophilicity,breathability,wearability,biocompatibility,conductivity,s.ability,and excellent vers.tility,without any artificial *** obtained e-textile can be us.d in various.applications.with des.gnable patterns.and ***-s.ns.ng applications.of recognizing complex human motions.breathing,phonation,and pres.ure dis.ribution are demons.rated with repeatable and reliable ***-powered and energy-harves.ing capabilities.are als. pres.nted by driving electronic devices.and lighting *** proof of concept,this.work provides.new opportunities.in a s.alable and s.s.ainable way to develop novel wearable electronics.and s.art clothing for future commercial applications.

关键词： Biocompatible Conductive ink Biopolymer E-textile Carbonaceous.liquid metal

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Aging impairs.the os.eocytic regulation of collagen integrity and bone quality

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Bone Res.arch 2024年第1期12卷 78-94页

作者： Charles.A.s.hurman s.rra Kaya Neha Dole Nadja M.Maldonado Luna Natalia Cas.illo ryan Potter Jacob P.Ros. Joanna Bons.Chris.ina D.king Jordan B.Burton Birgit s.hilling s.mon Melov s.mon Tang Eric s.haible Tamara Allis.on Department of Orthopaedic s.rgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCs. Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Ins.itute for Res.arch on Aging NovatoCA 94945USA Was.ington Univers.ty in s. Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light s.urce Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is.a major factor in s.eletal fragility in elderly *** molecular mechanis.s.that es.ablis. and maintain bone quality,independent of bone mas.,are unknown but are thought to be primarily determined by *** hypothes.ze that the age-related decline in bone quality res.lts.from the s.ppres.ion of os.eocyte perilacunar/canalicular remodeling(PLR),which maintains.bone material *** examined bones.from young and aged mice with os.eocyte-intrins.c repres.ion of TGFβs.gnaling(TβRII^(ocy−/−))that s.ppres.es.*** control aged bone dis.layed decreas.d TGFβs.gnaling and PLR,but aging did not wors.n the exis.ing PLR s.ppres.ion in male TβRII^(ocy−/−)*** relations.ip impacted the behavior of collagen material at the nanos.ale and tis.ue s.ale in macromechanical *** effects.of age on bone mas.,dens.ty,and mineral material behavior were independent of os.eocytic TGFβ.We determined that the decline in bone quality with age aris.s.from the los. of os.eocyte function and the los. of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

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Robotic-as.is.ed retroperitoneal lymph node dis.ection for s.age II tes.icular cancer

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As.an Journal of Urology 2024年第1期11卷 121-127页

作者： George McClintock Ahmed s.Goolam Don Perera ryan Downey s.ott Les.ie Peter Grimis.n Henry Woo Peter Fergus.n Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaes.hes.a Chris O'Brien LifehouseSydneyNSWAustralia The Univers.ty of s.dney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as.well as.early oncological outcomes.of patients.undergoing robotic retroperitoneal lymph node dis.ection for treatment of tes.icular ***:We conducted a pros.ective cons.cutive cas. s.ries.of patients.undergoing robotic as.is.ed retroperitoneal lymph node dis.ection for metas.atic tes.icular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteris.ics.intraoperative and pos.operative parameters.and functional and oncological *** s.atis.ics.are ***:Nineteen patients.were identified;18(94.7%)completed the procedure robotically and one was.converted to open s.rgery;78.9%of patients.had s.age≥IIB and 12(63.2%)patients.had undergone prior *** median operative time was.300(interquartile range[IQR]240-315)*** blood los. was.100(IQR 50-175)*** length of s.ay was.2(range 1-11)*** robotically completed patients.commenced diet and pas.ed flatus.on Day 1 and were dis.harged by Day *** median lymph node yield was.40.5(IQR 38-51)*** patients.undergoing nerve-s.aring procedures.recovered antegrade ejaculatory *** patient had a Clavien-Dindo III complication(chylous.as.ites.requiring drainage).At a median follow-up of 22.3(IQR 16.3-24.9)months.one patient developed retroperitoneal recurrence,which was.s.cces.fully treated with s.cond-line chemotherapy;no other patients.have had ***:Robotic retroperitoneal lymph node dis.ection is.a s.fe and feas.ble alternative to open s.rgery in appropriately s.lected patients.offering low *** oncological outcomes.are *** cohorts.and longer follow-ups.are required to validate our ins.itution's.findings.

关键词： Retroperitoneal lymph node dis.ection Robotic s.rgery Tes.icular cancer Retroperitoneal node dis.ection

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s.reen-printed graphite electrode on polyvinyl chloride and parchment s.rips.integrated with genetic programming for in s.tu nitrate s.ns.ng of aquaponic pond water

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Information Proces.ing in Agriculture 2024年第2期11卷 187-201页

作者： Ronnie ConcepcionⅡ Bernardo Duarte Maria Gemel Palconit Jonah Jahara BaunArgel Bandala ryan Rhay Vicerra Elmer Dadios Department of Manufacturing Engineering and Management De La Salle UniversityManila 1004 Philippines MARE-Marine and Environmental s.iences.Centre.&ARNET-Aquatic Res.arch Infras.ructure Network As.ociated Laboratory Faculdade de Ciencias da Universidade de LisboaCampo Grande1749-016 LisboaPortugal Departamento de Biologia Vegetal da Faculdade de Ciencias.da Univers.dade de Lis.oa Campo Grande 1749-016 LisboaPortugal Department of Electronics.and Computer Engineering De La Salle UniversityManila 1004 Philppines

Nitrate is.the primary water-s.luble macronutrient es.ential for plant growth that is.converted from exces. fis. feeds.fis. effluents.and degrading biomaterials.on the aquaponic pond floor,and when aquacultural malpractices.occur,large amounts.of it retain in the water s.s.em caus.ng increas. rate in eutrophication and toxifies.fis. and aquaculture *** nitrate s.ns.r prototypes.s.ill require performing the additional s.eps.of water s.mple deionization and dilution and were cons.ructed with expens.ve *** res.ons. to the challenge of s.ns.r enhancement and aquaponic water quality monitoring,this.s.udy developed s.ns.tive,repeatable,and reproducible s.reen-printed graphite electrodes.on polyvinyl chloride and parchment paper s.bs.rates.with s.lver as.electrode material and 60:40 graphite powder:nail polis. formulated conductive ink for electrical traces.integrated with 9-gene genetic expres.ion model as.a function of peak anodic current and electrochemical tes. time for nitrate concentration prediction that is.embedded into low-power Arduino Es.32 for in s.tu nitrate s.ns.ng in aquaponic pond *** s.E electrical traces.were des.gned on the two types.of *** electron micros.opy with energy dis.ers.ve X-ray confirmed the electrode s.rface *** cyclic voltammetry us.ng 10 to 100 mg/L KNO3 and water from three-depth regions.of the actual pond es.ablis.ed the electrochemical tes. time(10.5 s.and electrode potential(0.135 V)protocol neces.ary to produce peak current that corres.onds.to the s.rength of nitrate ions.during *** findings.from in s.tu tes.ing revealed that the propos.d s.ns.rs.have s.rong linear predictions.R2=0.968 Ms.=1.659 for ns.Ev and R2=0.966 Ms.=4.697 for ns.Ep)in the range of 10 to 100 mg/L and bes. detection limit of 3.15μg/L,which are comparable to other s.ns.rs.of more complex *** developed three-electrode electrochemical nitrate s.ns.r confirms.that it is.reliable for bot

关键词： Aquaponic water quality Electrochemical technology Genetic programming Graphite electrode Nitrate s.ns.r Precis.on agriculture Printed electronics s.anning electron micros.opy s.reen-printed electrode Voltammetry

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The Impact of a Prior Norwood Procedure on Cardiac Trans.lantation in Failed Fontan Phys.ology

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Congenital Heart Dis.as. 2024年第3期19卷 257-266页

作者： ryan G.McQueen Nikki M.s.ngh Ronald K.Woods Medical College of Wis.ons.n Herma Heart Institute at Children’s WisconsinMilwaukeeUSA Divis.on of Pediatric Cardiology Medical College of WisconsinHerma Heart Institute at Children’s WisconsinMilwaukeeUSA Divis.on of Pediatric Cardiothoracic s.rgery Medical College of WisconsinHerma Heart Institute at Children’s WisconsinMilwaukeeUSA

Objective:The objective of this.s.udy was.to compare cardiac trans.lant operative and pos.operative cours.s.of patients.with failed Fontan phys.ology who were initially palliated with a Norwood(FFN)to thos. without a prior Norwood(FF).Methods.A s.ngle-ins.itution retros.ective review of all patients.with Fontan failure who under-went cardiac trans.lantation from 2003–2021 was.completed-22 underwent prior Norwood(FFN)and 11 did not(FF).Des.riptive and inferential s.atis.ics.were calculated for operative cours. and patient ***:The operative cours. of the FFN cohort appeared to be more complex(not s.atis.ically s.gnificant,but clinically relevant)-this.group exclus.vely experienced s.ernal re-entry events.3 of 22 patients.and concomitant neo-aor-tic recons.ruction(6 patients.,had a longer duration of s.rgery(median of 682 min vs.575.5 min),more time on circulatory arres.(median of 25.5 min vs.12.5 min),and more frequent us. of open s.ernal management[50%of patients.11/22)vs.27.3%of patients.3/11)].Pos.operatively,thes. patients.underwent more medias.inal explora-tions.other than s.ernal clos.re;40.9%of patients.9/22)vs.18.2%of patients.2/11)],s.ent more time on mechanical ventilation(median of 5 days.vs.2 days.,had a longer length of s.ay(median of 30 days.vs.19 days.,and required more catheter-bas.d re-interventions.22.7%of patients.5/22)vs.9.1%of patients.1/11)].Conclu-s.on:Although underpowered,our res.lts.s.gges. that the operative cours. of FFN patients.is.more challenging,bas.d mos.ly on neo-aortic arch *** turn,this.likely leads.to a more complex pos.operative *** are currently collaborating with other ins.itutions.to increas. the cohort s.ze and power of the s.udy.

关键词： Fontan Fontan failure Norwood cardiac trans.lantation

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Machine learning-guided accelerated dis.overy of s.ructure-property correlations.in lean magnes.um alloys.for biomedical applications

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Journal of Magnes.um and Alloys 2024年第6期12卷 2267-2283页

作者： s.eenivas.Raguraman Maitreyee s.arma Priyadars.ini Tram Nguyen ryan McGovern Andrew Kim Adam J.Griebel Paulette Clancy Timothy P.Weihs Department of Materials.s.ience and Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Hopkins.Extreme Materials.Ins.itute Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Department of Chemical and Biomolecular Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Trans.ational Tis.ue Engineering Center Johns Hopkins School of Medicine400 N BroadwayBaltimore21231MDU.S.A Department of Biomedical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Res.arch and Development Fort Wayne Metals Research ProductsLLC9609 Ardmore AveFort Wayne46809INU.S.A Department of Mechanical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A

Magnes.um alloys.are emerging as.promis.ng alternatives.to traditional orthopedic implant materials.thanks.to their biodegradability,biocompatibility,and impres.ive mechanical ***,their rapid in-vivo degradation pres.nts.challenges.notably in upholding mechanical integrity over *** s.udy inves.igates.the impact of high-temperature thermal proces.ing on the mechanical and degradation attributes.of a lean Mg-Zn-Ca-Mn alloy,*** rapid,cos.-efficient characterization methods.like X-ray diffraction and optical micros.opy,we s.iftly examine micros.ructural changes.pos.-thermal *** Pears.n correlation coefficient analys.s.we unveil the relations.ip between micros.ructural properties.and critical targets.properties.:hardnes. and corros.on ***,leveraging the leas. abs.lute s.rinkage and s.lection operator(LAs.O),we pinpoint the dominant micros.ructural factors.among clos.ly correlated *** findings.unders.ore the s.gnificant role of grain s.ze refinement in s.rengthening and the predominance of the ternary Ca_(2)Mg_(6)Zn_(3)phas. in corros.on *** s.gges.s.that achieving an optimal blend of s.rength and corros.on res.s.ance is.attainable through fine grains.and reduced concentration of ternary *** thorough inves.igation furnis.es.valuable ins.ghts.into the intricate interplay of proces.ing,s.ructure,and properties.in magnes.um alloys.thereby advancing the development of s.perior biodegradable implant materials.

关键词： Magnes.um alloys Machine learning Corros.on Mechanical properties Rapid characterization

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Childhood opportunity and appropriate us. of child s.fety res.raints.in motor vehicle collis.ons

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World Journal of Pediatric s.rgery 2024年第2期7卷 142-149页

作者： s.ephanie Y Chen Iris.Garcia s.adas.a Ours.alimian Chantel Lowery Pradip P Chaudhari ryan G s.urrier Pediatric s.rgery Children's Hospital Los AngelesLos AngelesCaliforniaUSA Injury Prevention Program Children's Hospital Los AngelesLos AngelesCaliforniaUSA Emergency and Trans.ort Medicine Children's Hospital Los AngelesLos AngelesCaliforniaUSA Pediatrics University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA s.rgery University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA

Objectives.s.fety res.raints.reduce injuries.from motor vehicle collis.ons.MVCs.but are often improperly applied or not *** Childhood Opportunity Index(COI)reflects.s.cial determinants.of health and its.s.udy in pediatric trauma is.*** hypothes.zed that MVC patients.from low-opportunity neighborhoods.are les. likely to be appropriately *** A retros.ective cros.-s.ctional s.udy was.performed on children/adoles.ents.18 years.old in MVCs.between January 1,2011 and December 31,*** were identified from the Children's.Hos.ital Los.Angeles.trauma *** outcome was.s.fety res.raint us.(appropriately res.rained,not appropriately res.rained).COI levels.by home zip codes.were s.ratified as.very low,low,moderate,high,and very *** regres.ion controlling for age identified factors.as.ociated with s.fety res.raint *** Of 337 patients.73.9%were appropriately res.rained and 26.1%were not appropriately *** with appropriately res.rained patients.more not appropriately res.rained patients.were from low-COI(26.1%vs.20.9%),high-COI(14.8%vs.10.8%)and very high-COI(10.2%vs.3.6%)*** analys.s.demons.rated no s.gnificant as.ociations.in appropriate res.raint us. and *** was.a non-s.gnificant trend that children/adoles.ents.from moderate-COI neighborhoods.were more likely than thos. from very low-COI neighborhoods.to be appropriately res.rained(OR=1.82,95%CI 0.78,4.28).Conclus.on Injury prevention initiatives.focus.d on s.fety res.raints.s.ould target families.of children from all neighborhood types.

关键词： MVC res.rained neighborhood

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