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Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1031-1042页

作者： Ka-On Lam Man-Chi Fu kin-sang lau Kam-Mo Lam Cheuk-Wai Choi Wan-Hang Chiu Cheng-Man Yuen Lai-Han Kwok Fong-Kit Tam Wing-Lok Chan Sum-Yin Chan Pui-Ying Ho To-Wai Leung Ho-Fun Lee Department of Clinical Oncology LKS Faculty of MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology Queen Mary HospitalHong KongChina Clinical Oncology Centre The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Pharmacy Queen Mary HospitalHong KongChina Department of Diagnostic Radiology LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Cetuximab in combination with oral fluoropyrimidine(FP)remains controversial in metastatic colorectal cancer(mCRC).In view of the regional variation in the tolerability of FP,we conducted a retrospective analysis to compare oral FP with infusional FP in combination with cetuximab in Chinese *** To compare the efficacy and safety profile of cetuximab in combination with oral FP and infusional FP in Chinese population in the real-world *** A retrospective cohort study was done to analyse consecutive patients with Kras wild-type mCRC who received first-line treatment with cetuximab and FP-based chemotherapy in our unit from January 2010 to December ***-five eligible patients were *** median follow-up of our cohort was 65.0 *** The median progression-free survival(mPFS)and median overall survival(mOS)of the entire cohort were 9.66 mo(95%CI:7.72–12.5)and 25.8 mo(95%CI:18.7–35.6),*** oral FP and infusional FP,there was no statistical significant difference in the mPFS[9.79 mo(95%CI:7.49–12.7)vs 9.63 mo(95%CI:6.34–13.4);P=0.72]and mOS[25.8 mo(95%CI:15.2–35.6)vs 26.3 mo(95%CI:18.7–41.2);P=0.63].Grade 3 or above adverse events were reported in 28.4%of patients,being similar with oral and infusional FP,and included 10.5%of neutropenia and 2.1%of diarrhoea *** The current analysis demonstrates comparable efficacy and safety profiles of cetuximab in combination with oral and infusional FP in Chinese *** results expand treatment options for Chinese patients and invite revision of existing treatment guidelines to incorporate oral FP-based chemotherapy plus cetuximab.

关键词： Capecitabine 5-Fluorouracil Cetuximab Metastatic colorectal cancer Chinese

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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui kin Lam Zonglin Dai Eric Ho Yin lau Carrie Yuen Ting Ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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Precise mode control of laser-written waveguides for broadband,low-dispersion 3D integrated optics

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Light(Science & Applications) 2024年第6期13卷 1186-1195页

作者： Yuying Wang Lijing Zhong Kuen Yao lau Xuhu Han Yi Yang Jiacheng Hu Sergei Firstov Zhi Chen Zhijun Ma Limin Tong kin Seng Chiang Dezhi Tan Jianrong Qiu College of Optical Science and Engineering Zhejiang University310027HangzhouChina Institute of Light+X Science and Technology College of Information Science and EngineeringNingbo University315211NingboChina School of Optoelectronic Science and Engineering&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University215006SuzhouChina Prokhorov General Physics Institute of the Russian Academy of Sciences Dianov Fiber Optics Research Center38 Vavilov str.Moscow119333Russia Zhejiang Lab 311121HangzhouChina College of Materials Science and Engineering Key Laboratory of Advanced Materials of Yunnan ProvinceKunming University of Science and Technology650093KunmingYunnanChina Department of Electrical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARChina School of Materials Science and Engineering Zhejiang University310027HangzhouChina

Three-dimensional(3D)glass chips are promising waveguide platforms for building hybrid 3D photonic circuits due to their 3D topological capabilities,large transparent windows,and low coupling *** present,the key challenge in scaling down a benchtop optical system to a glass chip is the lack of precise methods for controlling the mode field and optical coupling of 3D waveguide ***,we propose an overlap-controlled multi-scan(OCMS)method based on laser-direct lithography that allows customizing the refractive index profile of 3D waveguides with high spatial precision in a variety of *** the basis of this method,we achieve variable mode-field distribution,robust and broadband coupling,and thereby demonstrate dispersionless LP21-mode conversion of supercontinuum pulses with the largest deviation of<0.1 dB in coupling ratios on 210 nm *** approach provides a route to achieve ultra-broadband and low-dispersion coupling in 3D photonic circuits,with overwhelming advantages over conventional planar waveguide-optic platforms for on-chip transmission and manipulation of ultrashort laser pulses and broadband supercontinuum.

关键词： waveguide mode dispersion

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Specializing liquid electrolytes and carbon-based materials in EDLCs for low-temperature applications

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Journal of Energy Chemistry 2022年第5期31卷 580-602页

作者： Pui-yan Hung Huihui Zhang Han Lin Qiaoshi Guo kin-tak lau Baohua Jia Centre for Translational Atomaterials Faculty of ScienceEngineering and TechnologySwinburne University of TechnologyMelbourne VIC 3122Australia SEMITRI Pty Ltd. Watson NorthMelbourne VIC 3122Australia

Electric double-layer capacitors(EDLCs) are emerging technologies to meet the ever-increasing demand for sustainable energy storage devices and systems in the 21 st Century owing to their advantages such as long lifetime, fast charging speed and environmentally-friendly nature, which play a critical part in satisfying the demand of electronic devices and systems. Although it is generally accepted that EDLCs are suitable for working at low temperatures down to-40℃, there is a lack of comprehensive review to summarize the quantified performance of EDLCs when they are subjected to low-temperature environments. The rapid and growing demand for high-performance EDLCs for auxiliary power systems in the aeronautic and aerospace industries has triggered the urge to extend their operating temperature range,especially at temperatures below-40℃. This article presents an overview of EDLC’s performance and their challenges at extremely low temperatures including the capability of storing a considerable amount of electrical energy and maintaining long-term stability. The selection of electrolytes and electrode materials is crucial to the performance of EDLCs operating at a desired low-temperature range. Strategies to improve EDLC’s performance at extremely low temperatures are discussed, followed by the future perspectives to motivate more future studies to be conducted in this area.

关键词： Electric double-layer capacitors(EDLCs) Liquid electrolytes Carbon-based materials Low-temperature applications

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Tailoring specific properties of polymer-based composites by using graphene and its associated compounds

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International Journal of Smart and Nano Materials 2020年第2期11卷 173-189页

作者： Pui-yan Hung kin Tak lau Qiaoshi Guo Baohua Jia Bronwyn Fox Faculty of Science Engineering and TechnologySwinburne University of TechnologyMelbourneVICAustralia SEMITRI Pty Ltd Watsonia NorthMelbourneVICAustralia

Graphene and its associated compounds have been identified as extraordinary structural nano-fillers that can tailor the properties of new polymer-based composites with specific *** possesses perfect 2D atomic architecture and has a large surface area that enhances the bonding,with tailored functional groups on its surface with polymer chains to form high strength ***,a lot of research has focused on developing composites with high specific strength,high electrical and thermal conductivities,high impact resistance,excellent energy storage capability and ability to maintain their strength at low-temperature environments by using graphene,graphene oxide(GO),reduced graphene oxide(rGO)or carbon nanotube/*** goals are to design composites that can meet specific requirements for different engineering *** this paper,the discussion on all aspects in relation to the use of graphene and its associated compounds for advanced composites will be given in *** potentiality of using these materials for high-tech applications will be *** to date,it has been proved that the use of graphene-based nanofillers does improve the mechanical,interfacial bonding,electrical,thermal and electromagnetic interference shield properties of polymer-based *** adding a small amount of these nanofillers do make a big difference to the properties of host materials.

关键词： Graphene mechanical Properties energy low Temperature

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Biocomposites:Their multifunctionality

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International Journal of Smart and Nano Materials 2010年第1期1卷 13-27页

作者： kin-tak lau Mei-po Ho Chi-ting Au-Yeung Hoi-yan Cheung Centre of Excellence in Engineered Fibre Composites Faculty of Engineering and SurveyingUniversity of Southern QueenslandQueenslandAustralia Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

During the last decade,tissue engineering has shown a considerable promise in providing more viable alternatives to surgical procedures for harvested tissues,implants and *** to the fast development on nano-and biomaterial technologies,it is now possible for doctors to use patients’cells to repair orthopaedic defects such as focal articular cartilage *** order to support the three-dimensional tissue formation,scaffolds made by biocompatible and bioresorbable polymers and composite materials,for providing temporary support of damaged body and cell structures,have been developed *** ceramic and metallic materials have been widely accepted for the development of implants,their non-resorbability and necessity of second surgical operation(like for bone repair),which induce extra pain for the patients,limit their wide *** development of different types of biocomposites for biomedical engineering applications is *** biocomposites include(i)basic biomaterials;(ii)natural fiber-reinforced biocomposites and(iii)nanoparticle-reinforced *** multifunctionality is discussed in terms of the control of mechanical properties,biodegradability and bioresorbability.

关键词： multifunctional materials biocomposite

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Determinants of Competitiveness: Observations in China's Textile and Apparel Industries

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China & World Economy 2009年第2期17卷 45-64页

作者： Chi-Keung lau, kin-Man To Zhiming Zhang Jing Chen PhD candidate Institute of Textile and Clothing （ITC） Hong Kong Polytechnic University Hong Kong. Assistant Professor ITC Hong Kong Polytechnic University Hong Kong. Associate Professor ITC Hong Kong Polytechnic University Hong Kong. Research Assistant ITC Hong Kong Polytechnic University Hong Kong.

This paper attempts to explore key determinants of competitiveness in the textile and apparel industries, with special reference to Chinese Mainland. The authors conduct a survey that is designed to use productivity, supply-side and demand-side determinants to measure enterprises＇ competitiveness. The collected survey data is then analyzed using factor analysis to capture the related determining factors indicative of competitiveness at the enterprise level. The findings demonstrate that government policies and related industry infrastructure are the most important determinants of competitiveness in the textile and apparel industries, followed by domestic demand. This suggests that the improvement of industry infrastructure can foster industry performance, and that more resources should be endowed to enhance the domestic business competitiveness of local enterprises. The development of domestic demand will foster the competitiveness of the textile and apparel industries on a more sustainable basis.

关键词： China competitiveness textile and clothing industries

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Liquid-phase exfoliation of violet phosphorus for electronic applications

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SmartMat 2021年第2期2卷 226-233页

作者： Shenghuang Lin Wai kin Lai Yanyong Li Wei Lu Gongxun Bai Shu Ping lau Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomHong KongChina Songshan Lake Materials Laboratory Songshan Lake International Innovation Entrepreneurship CommunityDongguan CityGuangdongChina Institute of Optoelectronic Materials and Devices China Jiliang UniversityHangzhouChina

Large-scale production of two-dimensional(2D)materials still is a crucial point toward its practical *** phosphorus(VP)with a wide bandgap accelerates and broadens the potential applications of elemental phosphorus in ***,we demonstrate the scalable production of solution-processable violet phosphorus flakes stably dispersed in several *** exfoliated VP flakes exhibit thickness-dependent visible photoluminescence characteristics,which covers the shortcoming of black ***,the VP-based field-effect transistor reveals relatively competitive electrical properties to other liquid-phase exfoliated 2D *** study paves the way for a wide range of applications of optical devices,energy storage,catalysis,and sodium batteries based on large-scale VP flakes.

关键词： field effect transistor liquid-phase exfoliation photoluminescence violet phosphorus

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Traditional Chinese medicine poisoning in the emergency departments in Hong Kong: Trend, clinical presentation and predictors for poor outcome

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World Journal of Emergency Medicine 2021年第2期12卷 143-150页

作者： Rex Pui kin Lam Eric Ho Yin lau Wai Lam Yip Joe Kai Shing Leung Matthew Sik Hon Tsui Emergency Medicine Unit Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina Accident and Emergency Department Pamela Youde Nethersole Eastern HospitalHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Dear editor,Traditional Chinese medicine (TCM) is popular in many countries,especially in the Chinese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed Chinese medicine products/herbs in the preceding *** reasons for consumption include regulating bodily functions,curing disease,and building up health.

关键词： has editor curing

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An unusual case of hypereosinophilic syndrome and disseminated intravascular coagulation

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Chinese Medical Journal 2005年第18期118卷 1582-1584页

作者： YEUNG Tok-fai lau Siu-wah WONG kin Department of Medicine and Geriatrics Our Lady of Maryknoll Hospital Hong Kong ChinaDepartment of Medicine and Geriatrics Our Lady of Maryknoll Hospital Hong Kong China Department of Medicine and Geriatrics Our Lady of Maryknoll Hospital Hong Kong China

Idiopathic hypereosinophilic syndrome （HES） is a heterogeneous disorder characterized by hypereosinophilia and organ damage which affects men more commonly than women （9：1）. The disease can be detected incidentally, but more often presents either insidiously or acutely with cardiac, neurological, cutaneous, pulmonary or gastro- intestinal manifestations, with cardiac involvement being a major cause of morbidity and morality in patients. 1.2 Although a major mechanism of tissue damage in HES is due to thromboembolism,3 fullblown disseminated intravascular coagulation （DIC） is apparently rare. This paper describes a man who presented acutely with life-threatening DIC complicating HES and its management, the first Chinese case reported in the literature.

关键词： hypereosinophilic syndrome·disseminated intravascular syndrome·low molecular weight heparin

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