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Surgical outcomes for unilateral superior oblique palsy in Chinese population: a retrospective study

International Journal of Ophthalmology(English edition) 2015年第1期8卷 107-112页

作者： Gordon shing kin Yau Victor Tak Yau Tam Jacky Wai Yip Lee Theo Tak Kwong chan Can Yin Fun Yuen Department of Ophthalmology Caritas Medical Centre Department of Anatomy Faculty of MedicineUniversity of Hong Kong

AIM: To evaluate the outcome after surgery for unilateral superior oblique(SO) palsy in ***: The medical records of 39 patients that underwent surgery for unilateral SO palsy between January 2003 and December 2012 at Caritas Medical Centre, Hong Kong, were retrospectively reviewed. All surgeries were performed by a single surgeon. Pre-operative assessments for vertical deviation, cyclo-deviation, and Knapp’s classification were obtained to determine the nature and degree of surgical *** deviation was measured at 1wk; 1, 6mo and on last follow-up day post-operatively. Cyclo-deviation was measured on last follow-up day ***: During the 10 y period, 39 subjects were recruited. The most common etiology was congenital(94.9%). Knapp’s Type III(66.7%) and Type I(12.8%)classifications were the most common subtypes. To treat SO palsy, the most common surgical procedures were:isolated inferior oblique(IO) anteriorization(41.0%),isolated IO myectomy(10.3%), and isolated IO recession(10.3%). At 3.5 ±2.1y post-operatively, the vertical deviation was significantly reduced(15.1 ±6.2 PD versus0.5±1.4 PD, P <0.0001) without significant improvement in cyclo-deviation(P =0.5). Initial vertical deviation was correlated with cyclo-torsion(r =0.4, P =0.007). Those with over-correction had greater initial vertical deviation(19.4±7.2 PD versus 13.2±4.3 PD, P =0.003). After a single operation, 84.6% of subjects achieved a vertical deviation within ±3 PD.· CONCLUSION: The majority of subjects achieved corrected vertical deviation after a single surgery although there was no improvement in *** with over-correction of primary position deviation had greater preoperative vertical deviation and it may be related to simultaneous multiple muscle surgery.

关键词： superior oblique palsy vertical deviation surgery diplopia

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Inferior vena cava reconstruction in extended right hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 533-534页

作者： Karin KY Ho Sui Ling Sin kin Pan Au Henry HY Lee Daniel TL chan Albert chan Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Surgery Yan Chai Hospital7 Yan Chai StreetHong KongChina State Key Laboratory of Liver Research(Li Ka shing Faculty of Medicine The University of Hong Kong)102 Pok Fu Lam RoadHong KongChina

To the Editor : Barcelona Clinic Liver Cancer(BCLC) Stage C hepatocellular carcinoma(HCC) with vascular invasion has been considered unresectable. However, the curative rate from systemic treatment is rather dismal. Even with the use of immunotherapy, complete remission is less than 10% [ 1 ]. On the contrary, recent advances in transplant oncology, especially in the application of liver transplant-related surgical techniques in complex liver resections, make the operation possible for patients with locally advanced HCC who were previously considered to be unresectable [ 2 ]. We hereby present the surgical management of a patient with giant HCC in right liver lobe with inferior vena cava(IVC) invasion.

关键词： invasion vena Liver

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Traditional Chinese medicine poisoning in the emergency departments in Hong Kong: Trend, clinical presentation and predictors for poor outcome

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World Journal of Emergency Medicine 2021年第2期12卷 143-150页

作者： Rex Pui kin Lam Eric Ho Yin Lau Wai Lam Yip Joe Kai shing Leung Matthew Sik Hon Tsui Emergency Medicine Unit Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina Accident and Emergency Department Pamela Youde Nethersole Eastern HospitalHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Dear editor,Traditional Chinese medicine (TCM) is popular in many countries,especially in the Chinese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed Chinese medicine products/herbs in the preceding *** reasons for consumption include regulating bodily functions,curing disease,and building up health.

关键词： has editor curing

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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui kin Lam Zonglin Dai Eric Ho Yin Lau Carrie Yuen Ting Ip Ho Ching chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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铱(Ⅲ)卟啉β-羟乙与基醛的碳氢键活化(英文)

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无机化学学报 2014年第1期30卷 75-84页

作者：陈松森陈建成香港中文大学化学系

铱(Ⅲ)卟啉β-羟乙基,IrⅢ(ttp)CH2CH2OH(ttp=5,10,15,20-二价阴离子tetratolylporphyrinato),发现选择性裂解芳醛的醛的碳-氢键和给铱酰基配合物。酰基铱配合物对羰基化和脱羰反应以及潜在的功能化研究的很好的候选材料。这碳-氢键的... 详细信息

铱(Ⅲ)卟啉β-羟乙基,IrⅢ(ttp)CH2CH2OH(ttp=5,10,15,20-二价阴离子tetratolylporphyrinato),发现选择性裂解芳醛的醛的碳-氢键和给铱酰基配合物。酰基铱配合物对羰基化和脱羰反应以及潜在的功能化研究的很好的候选材料。这碳-氢键的建议活化机理:通过初始的β-羟基消除IrⅢ(ttp)CH2CH2OH生成IrⅢ(ttp)OH,然后进行与醛的CH键的σ-键复分解发生。

关键词：配合物铱羰基化和脱羰反应

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Confounders in developing a machine learning model for colorectal liver metastasis post-hepatectomy prognostications

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Hepatobiliary Surgery and Nutrition 2024年第2期13卷 389-390页

作者： kin Pan Au Tan To Cheung Department of Surgery School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

We extend our gratitude to *** and colleagues for their valuable feedback and comments on our article(1).We developed a machine learning model which predicted the outcomes of surgical treatment for colorectal liver metastasis(CRLM)with good discriminative *** analyzing the data,we found that patients who underwent neoadjuvant chemotherapy before resection had lower rates of overall survival and disease-free *** agree that the negative impact of neoadjuvant chemotherapy on survival is probably a confounding factor due to a more advanced disease status at the time of *** is supported by our data,which show that patients who received neoadjuvant therapy were more likely to have had bilobar liver metastasis(45.2%vs.23.3%,P<0.001)and multiple liver lesions(64.9%vs.42.3%,P<0.001)when compared to those who underwent upfront hepatectomy.

关键词： metastasis chemotherapy colorectal

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Successful conservative management of Class III iatrogenic aortic dissection

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Journal of Geriatric Cardiology 2018年第3期15卷 235-237页

作者： Wai kin Chi Gary Tse Bryan PY Yan Department of Medicine and Therapeutics Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Division of Cardiology Prince of Wales Hospital Shatin Hong Kong China Li Ka shing Institute of Health Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

Iatrogenic aortic dissection （IAD） is a rare complication of percutaneous coronary intervention （PCI） with an estimated incidence of 0.02%--0.04%. lAD occurs more frequently in the setting of urgent PCI for acute myocardial infarction （AMI）（0.19%） than for elective procedures （0.01%）.[11 The mortality risk associated with IAD is high （16%） and is comparable to that for spontaneous aortic dissection （16%）.Urgent surgery is the treatment of choice for extensive dissection or hemodynamic instability. In this report, we present a case of severe IAD that was managed conservatively with good clinical outcome.

关键词： Conservative management Iatrogenic aortic dissection Percutaneous coronary intervention

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Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats

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Neuroscience Bulletin 2013年第4期29卷 509-516页

作者： Qiuju Yuan Huanxing Su kin Chiu Wutian Wu Zhi-Xiu Lin Department of Anatomy The University of Hong Kong School of Chinese Medicine Faculty of Science The Chinese University of Hong Kong State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences University of Macao State Key Laboratory of Brain and Cognitive Sciences Development and Growth Li Ka Shing Faculty of Medicine The University of Hong Kong Research Center of Reproduction Development and Growth Li Ka Shing Faculty of Medicine The University of Hong Kong GHM Institute of CNS Regeneration Jinan University

Conflicting findings exist regarding the link between functional recovery and the regrowth of spinal tracts across the lesion leading to the restoration of functional contacts. In the present study, we investigated whether functional locomotor recovery was attributable to anatomical regeneration at postnatal day 1 （PN1）, PN7, PN14 and in adult rats two months after transection injury at the tenth thoracic segment of the spinal cord. The Basso, Beattie, and Bresnahan scores showed that transection led to a failure of hindlimb locomotor function in PN14 and adult rats. However, PN1 and PN7 rats showed a significant level of stepping function after complete spinal cord transection. Unexpectedly, unlike the transected PN14 and adult rats in which the spinal cord underwent limited secondary degeneration and showed a scar at the lesion site, the rats transected at PN1 and PN7 showed massive secondary degeneration both anterograde and retrograde, leaving a 〉5-mm gap between the two stumps. Furthermore, retrograde tracing with fluorogold （FG） also showed that FG did not cross the transection site in PN1 and PN7rats as in PN14 and adult rats, and re-transection of the cord caused no apparent loss in locomotor performance in the rats transected at PN1. Thus, these three lines of evidence strongly indicated that the functional recovery after transection in neonatal rats is independent of regrowth of spinal tracts across the lesion site. Our results support the notion that the recovery of locomotor function in developing rats may be due to intrinsic adaptations in the spinal circuitry below the lesion that control hindlimb locomotor activity rather than the regrowth of spinal tracts across the lesion. The difference in secondary degeneration between neonatal and adult rats remains to be explored.

关键词： neonatal spinal cord injury regeneration functional recovery rat

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Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma

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Cellular & Molecular Immunology 2010年第1期7卷 61-68页

作者： kin Chiu Sze-Chun Yeung Kwok-Fai So Raymond Chuen-Chung chang Laboratory of Neurodegenerative Diseases Department of AnatomyUniversity of Hong KongPokfulamHong KongChina State Key Laboratory of Brain and Cognitive Sciences University of HongKongPokfulamHongKongChina Research Centre of Heart BrainHormone and Healthy AgingLiKa Shing Faculty of MedicineUniversity of Hong KongPokfulamHong KongChina

Monocyte chemoattractant protein-1(MCP-1)/CCL2 is a C–C chemokine involved in the activation and recruitment of monocytic cells to injury ***-1/CCL2 can induce either neuroprotection or neurodestruction in vitro,depending on the experimental *** aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells(RGCs)is exacerbated or attenuated in an experimental glaucoma *** a high concentration(1000 ng)of MCP-1/CCL2 and lipopolysaccharide(LPS)-exacerbated RGC loss,100 ng MCP-1/CCL2 provided neuroprotection towards *** MCP-1/CCL2(100 ng)also upregulated insulin-like growth factor-1(IGF-1)immunoreactivity in the *** neuroprotective effect of MCP-1/CCL2 was not due to the massiveinfiltration of microglia/*** together,this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma.

关键词： glaucoma IGF-1 MCP-1/CCL2 microglia neuroprotection

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Catalytic Phosphination and Arsination

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合成化学 2004年第Z1期12卷 116-116页

作者： Kwong Fuk Yee chan kin shing Department of Chemistry Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis? The Chinese University of Hong Kong Shatin New Territories Hong Kong China A University Grants Committee Area of Excellence Scheme (Hong Kong).Department of Chemistry Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis? The Chinese University of Hong Kong Shatin New Territories Hong Kong China A University Grants Committee Area of Excellence Scheme (Hong Kong).

The catalytic, user-friendly phosphination and arsination of aryl halides and triflates by triphenylphosphine and triphenylarsine using palladium catalysts have provided a facile synthesis of functionalized aryl phosphines and arsines in neutral media. Modification of the cynaoarisne yielded optically active N, As ligands which will be screened in various asymmetric catalysis.

关键词： Catalytic Phosphination and Arsination

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