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Long-Term Trends in Pre-Summer Daytime and Nocturnal Extreme Hourly Rainfall in a Coastal City of South China

Journal of Tropical Meteorology 2023年第1期29卷 39-54页

作者：苏琳李俊鲁黄伟健冯志雄 School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)ZhuhaiGuangdong 519082 China Key Laboratory of Tropical Atmospheric-Ocean System Ministry of EducationZhuhaiGuangdong 519082 China Earth OceanAtmosphere Sciences ThrustThe Hong Kong University of Science and Technology(Guangzhou):Guangzhou 511453 China Hong Kong Observatory Hong Kong Special Administrative Region(SAR)China Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong Kong SARChina Department of Mathematics The Hong Kong University of Science and TechnologyHong Kong SARChina

The long-term trends in the occurrence frequency of pre-summer daytime and nocturnal extreme hourly rainfall(EXHR) during 1988-2018 in Hong Kong and their spatial distributions are examined and analyzed. Despite a significant increasing trend observed in the occurrence frequency of pre-summer EXHRs during the investigated period,the increase in daytime and nocturnal EXHRs show distinct spatial patterns. Nocturnal EXHRs show uniform increasing trends over the entire Hong Kong. However, the increase in daytime EXHRs is concentrated over the northern or eastern areas of Hong Kong, indicating a downstream shift of pre-summer EXHRs in Hong Kong with regard to the prevailing southwesterly monsoonal flows in south China. The clustering of weather types associated with daytime and nocturnal EXHRs further reveals that the increase in EXHRs over Hong Kong are mainly contributed by the increase of the events associated with southwesterly monsoonal flows with relatively high speeds. During the past few decades, the southwesterly monsoonal flows at coastal south China have undergone a substantial weakening due to the increased surface roughness induced by the urbanization over the Guangdong-Hong Kong-Macao Greater Bay Area since 1990s,leading to enhanced low-level convergence and thus significant increase in EXHRs at coastal south China. Meanwhile,daytime sea-wind circulation at coastal south China is markedly enhanced during the investigated period, which is the main reason for the northward shift of daytime EXHRs in Hong Kong. In addition, the blocked southwesterly monsoonal flows at coastal south China are detoured eastward, leading to stronger convergence and increase in EXHRs at eastern coast of Hong Kong, especially during daytime, when the easterly sea winds prevail at the region.

关键词： extreme hourly rainfall diurnal rainfall cycle linear trend coastal Pearl River Delta

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Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer’s disease

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Translational Neurodegeneration 2013年第1期2卷 174-182页

作者： Shuk wai Ho Yuk Tung chanel Tsui Ting Ting Wong Stanley Kwok-Kuen Cheung William B Goggins Lau Ming Yi Kwok kin Cheng Larry Baum Department of Surgery The University of Hong KongPokfulamHong KongChina School of Biomedical Sciences(Pharmacology) The University of NottinghamNottinghamUK Department of Microbiology The University of Hong KongPokfulamHong KongChina School of Public Health and Primary Care The Chinese University of Hong KongShatinHong KongChina School of Pharmacy The Chinese University of Hong KongShatinHong KongChina

Alzheimer’s disease(AD),the most common dementia,is characterized by potentially neurotoxic aggregation of Aβ peptide and tau protein,and their deposition as amyloid plaques and neurofibrillary tangles(NFTs).Tau aggregation also occurs in other common neurodegenerative *** dementia(FTD)can be caused by tau mutations that increase the susceptibility of tau to hyperphosphorylation and aggregation,which may cause neuronal dysfunction and deposition of NFTs.17-allylamino-17-demethoxygeldanamycin(17-AAG)is a potent inhibitor of heat shock protein 90(Hsp90),a cytosolic chaperone implicated in the proper folding and functions of a repertoire of client proteins.17-AAG binds to Hsp90 and enhances degradation of Hsp90 client *** sought to determine whether 17-AAG can reduce Aβ and tau pathology in the brains of AD and FTD model mice expressing Aβ or P301L mutant tau,*** were randomized to receive 25,5,or 0 mg/kg 17-AAG thrice weekly from age eight to 11 *** was performed by rotarod test on motor function,on the area occupied by plaques in hippocampus or NFTs in medulla tissue sections,and on mortality.A high dose of 17-AAG tended to decrease NFTs in male mice(p=0.08).Further studies are required to confirm the effect of 17-AAG in diseases of tau aggregation.

关键词： Dementia Mouse Tangles Plaques

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Early-onset primary torsional dystonia in a 4-generation Chinese family with a mutation in the DYT1 gene

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Chinese Medical Journal 2005年第10期118卷 873-876页

作者： YEUNG wai Lan LAM Ching Wan CHENG wai Tsoi SIN Ngai Chuen WONG Wing kin WONG Chun Nei TSE Ka Ming FOK Tai Fai Departments of Paediatrics Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Chemical Patholog Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Paediatrics and Adolescent Medicine Queen Mary HospitalUniversity of Hong Kong Nuclear Medicine&PET Division Scanning DepartmentSt.Teresa’s HospitalHong KongChina

Primary torsion dystonia(PTD)is a clinically and genetically heterogeneous movement *** least thirteen different types of dystonia can be distinguished on a genetic basis.~1 The DYT1 gene was first mapped by Ozelius et al in 1989.~2(Kramer et)al^3 linked the same locus to PTD in 12 Ashkenazi Jewish families in *** patients with early-onset generalized PTD were caused by the same three base pair(GAG)deletion in the DYT1 gene on chromosome 9q34.^(1,4,5)The product of the gene is a protein called torsinA.~5(Although the)function of this protein is as yet uncertain,it is widely distributed throughout the brain with high levels in the substantia nigra compacta dopamine neurones.

关键词： DYT1 gene dystonia positron emission tomography

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A REVIEW OF THE STORM CHARACTERISTICS OF TYPHOON KALMAEGI (1415) AND RELATED FORECASTING CONSIDER ATIONS IN HONG KONG

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Tropical Cyclone Research and Review 2014年第4期3卷 243-255页

作者： Chun-wing Choy Yee-ting Junella Tam Dick-shum Lau wai-kin Wong Hong Kong Observatory Hong KongChina

Kalmaegi(1415)required the issuance of Gale or Storm Wind Signal No.8 in Hong Kong in 2014,even though it passed by at a distance of 370 km from Hong Kong during its closest *** surges triggered by Kalmaegi caused backflow of sea water in some low lying areas in both Hong Kong and *** paper reviews the use of observational data in monitoring the cyclone characteristics and studies the synoptic factors leading to its fast movement and extensive *** combined analysis of multi-platform satellite wind retrieval,in-situ surface observations and aircraft reconnaissance data over the northern part of the South China Sea is found to be useful in depicting the cyclone *** analysis suggests that the relatively large size of Kalmaegi may be attributed to monsoon shear pattern during its formation stage and the subsequent strengthening of southwesterlies over the northern part of the South China Sea.A strong subtropical ridge north of Kalmaegi not only provides strong steering and thus its high translational speed,but also leads to extensive gale force wind distribution over its northern *** performance of various numerical prediction models in forecasting the movement,intensity change and wind structure of Kalmaegi,as well as the storm surge triggered,is assessed and presented.

关键词： Kalmaegi Hong Kong tropical cyclone forecasting track wind structure

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Designing a Shared Single Display Education Application through Interactive Patterns

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Journal of Software Engineering and Applications 2014年第13期7卷 1074-1086页

作者： wai Shiang Cheah edwin Mit Marlene Valeri AiSiok Marlene Valeri AiSiok Lu Department of Computing Universiti Malaysia Sarawak Kota Samarahan Malaysia Faculty of Engineering Computing and Science Swinburne University Sarawak Malaysia

Interactive patterns are able to promote the notion of reusability in groupware application development. Hence, these patterns support the comprehensiveness of both the interaction design and implementation while easing code modification for groupware application. Groupware is used to describe a broad range of technologies that support person-to-person collaboration. How to design and develop a groupware in an effective manner remains a research question worth exploring. This paper introduces a reusable method, patterns, to develop a single shared display application. Nine different interactive patterns that allow participants to interact collaboratively or non-collaboratively in a single shared display application are introduced in this paper. This is followed by the presentation of our quantitative results on the usability of the interactive patterns and the reusability of the patterns in designing and maintaining a single shared display application. From the results, not only are the patterns useful and easy to understand, the patterns actually ease the process of designing and maintenance during the application development under a single shared display.

关键词： Collaborative Learning Interaction Design Shared Single Display

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Efficacy of enteric-coated mycophenolate sodium （myfortic） in patients with severe lupus nephritis

Efficacy of enteric-coated mycophenolate sodium （myfortic）...

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The 8th International Congress on SLE

作者： Siu-ka Mak kin-yee Lo Man-wai Lo Shuk-fan chan Gensy MW Tong Ping-nam Wong Andrew KM Wong Renal Unit Department of Medicine ＆ GeriatricsKwong Wah HospitalKowloonHong Kong SARChina Renal Unit Department of Medicine ＆ GeriatricsKwong Wah HospitalKowloonHong Kong SARChina Renal Unit Department of Medicine ＆ GeriatricsKwong Wah HospitalKowloonHong Kong SARChina Renal Unit Department of Medicine ＆ GeriatricsKwong Wah HospitalKowloonHong Kong SARChina Renal Unit Department of Medicine ＆ GeriatricsKwong Wah HospitalKowloonHong Kong SARChina Renal Unit Department of Medicine ＆ GeriatricsKwong Wah HospitalKowloonHong Kong SARChina Renal Unit Department of Medicine ＆ GeriatricsKwong Wah HospitalKowloonHong Kong SARChina

＜正＞Purpose:The ideal treatment of lupus nephritis has yet to be *** use of both cyclophosphamide and mycophe- nolate mofetil have been associated with encouraging results, but the incidence of side-effects is *** is no data on the use of another formulation of mycophenolic acid, enteric-coated mycophenolate sodium.

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A Potential Anti-metastatic Chinese Herb Andrographis paniculata—Its In Vitro Activities in Esophageal Cancer Cells and Endothelial Cells

A Potential Anti-metastatic Chinese Herb Andrographis panicu...

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第十四届全国中药和天然药物学术研讨会

作者： Grace Gar-Lee Yue Julia kin-Ming Lee Kar-Man chan Kwok-Pui Fung Philip wai-Yan Chiu Clara Bik-San Lau The Chinese University of Hong Kong

＜正＞Esophageal cancer is associated with high postoperative recurrence and systemic *** adjuvant chemotherapy and concurrent radiation have shown favourable efficacies,searching for alternative treatments for metast...

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Molecular basis of von Hippel-Lindau syndrome in Chinese patients

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Chinese Medical Journal 2011年第2期124卷 237-241页

作者： SIU wai-kwan MA Ronald Ching-wan LAM Ching-wan MAK Chloe Miu YUEN Yuet-ping LO Fai-man Ivan chan kin-wan LAM Siu-fung LING Siu-cheung TONG Sui-fan SO Wing-yee CHOW Chun-chung TANG Mary Hoi-yin TAM wing-hung chan Albert Yan-wo Department of Pathology Princess Margaret Hospital Hong Kong China Department of Medicine & Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong China Clinical Genetic Service Department of Health Hong Kong China Department of Medicine and Geriatrics Princess Margaret Hospital Hong Kong China Department of Paediatrics and Adolescent Medicine Princess Margaret Hospital Hong Kong China Department of Obstetrics & Gynaecology Tsan Yuk Hospital Hong Kong China Department of Obstetrics & Gynaecology The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China

Background Von Hippel-Lindau （VHL） syndrome is an autosomal dominant familial cancer syndrome predisposing the affected individuals to multiple tumours in various *** genetic basis of VHL in Southern Chinese is largely *** this study,we characterized the mutation spectrum of VHL in nine unrelated Southern Chinese *** Nine probands with clinical features of VHL,two symptomatic and eight asymptomatic family members were included in this *** diagnosis was performed twice for one *** probands had only isolated bilateral *** VHL gene was screened for mutations by polymerase chain reaction,direct sequencing and multiplex ligation-dependent probe amplification （MLPA）.Results The nine probands and the two symptomatic family members carried heterozygous germline *** different VHL mutations were identified in the nine *** splicing mutation,NM_000551.2：c.463＋1G〉T,was *** other seven VHL mutations,c.233A〉G [***78Ser],c.239G〉T [***80lle],c.319C〉G [***107Gly],c.481C〉T [***161X],c.482G〉A [***161GIn],c.499C〉T [***167Trp] and an exon 2 deletion,had been previously *** asymptomatic family members were positive for the mutation and the other five tested *** prenatal diagnosis,the fetuses were positive for the *** Genetic analysis could accurately confirm VHL syndrome in patients with isolated tumours such as sporadic phaeochromocytoma or epididymal papillary *** detection in asymptomatic family members allows regular tumour surveillance and early intervention to improve their ***-based diagnosis can have an important impact on clinical management for VHL families.

关键词： von Hippel-Lindau syndrome VHL gene Chinese VHL mutations

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私有公共空间与空间正义之博弈——以香港地区为例

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国际城市规划 2023年第3期38卷 73-82,98页

作者：简祎罗洁梅王安琪陈汉云陈蔚镇邵健伟香港理工大学设计学院中国香港香港理工大学中国香港同济大学浙江工业大学设计与建筑学院城乡规划系香港理工大学建筑及房地产学系中国香港同济大学建筑与城市规划学院景观学系香港理工大学公共设计研究室中国香港

私有公共空间作为增加城市公共空间存量、提升空间品质、激发城市活力的策略已日渐普遍。然而,私有公共空间被质疑是迎合了当下绅士化审美趋势的产物,是商业资本用以实现社会控制的排他性空间,引发了业界对空间不公的讨论。本研究通过... 详细信息

私有公共空间作为增加城市公共空间存量、提升空间品质、激发城市活力的策略已日渐普遍。然而,私有公共空间被质疑是迎合了当下绅士化审美趋势的产物,是商业资本用以实现社会控制的排他性空间,引发了业界对空间不公的讨论。本研究通过梳理空间正义的相关理论,以香港地区商业公共空间为实证研究对象,探讨私有公共空间中空间正义的表达。从活动多样性、安全性与管理、邻近与可步行性、公共性和公众参与五个方面剖析其中公私权力的界限,理解私人所有权与空间正义间的冲突性生产关系和微妙的阈限性。挖掘私有公共空间在空间正义语境下作为缓解城市不公的中介效益,有助于实现公共空间的优化配置,缓解社会不公平现象。

关键词：私有公共空间空间正义可达性社会包容公共性多样性

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论特别行政区实施基本法的宪制责任——以澳门特别行政区基本法实践为视角

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港澳研究 2019年第1期 29-36,94页

作者：骆伟建澳门大学法学院

全面准确理解、坚定不移执行"一国两制"和基本法,有赖于特别行政区行政、立法和司法机关切实履行宪制责任。因而,有必要首先厘清宪制责任的内涵,宪制责任的主体、职责和职权,宪制责任的履行以及宪制责任意识等要素,再进一步建立起宪制... 详细信息

全面准确理解、坚定不移执行"一国两制"和基本法,有赖于特别行政区行政、立法和司法机关切实履行宪制责任。因而,有必要首先厘清宪制责任的内涵,宪制责任的主体、职责和职权,宪制责任的履行以及宪制责任意识等要素,再进一步建立起宪制责任制度,为"一国两制"和基本法的实施提供制度保障。

关键词：宪法基本法宪制责任澳门

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