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Family Medicine and Community Health 2017年第3期5卷 215-222页

作者： Lap-kin Chiang Cheuk-wai Kam Lorna V.Ng Family Medicine and General Outpatient Department Kwong Wah HospitalHong Kong

Objective:To estimate prevalence of OSA among at risk adult patients in primary care *** test the correlation and agreement between overnight pulse oximetry and polysomnography(PSG).To test the OSA screening performance of overnight pulse *** and Setting:Prospective case series involving adult Chinese patients with risk fac-tors for OSA at a primary care clinic of Hong ***:The prevalence and severity of OSA were established based on overnight pulse oximetry derived oxygen desaturation index(ODI).Screening performance of overnight pulse oxi-metry was compared directly with gold standard diagnostic test ***:Three hundred and five male and 229 female patients were ***(48.3%)was the top presenting *** hundred and twenty five patients(60.9%)were screened positive to have *** hundred and nine patients had performed PSG,the ODI_4 and apnoea-hypopnea index(AHI)had Pearson correlation coefficient 0.71(P<0.001).Bland and Alt-man plot showed good *** designation criteria of ODI_4≥5 events/hr,the sensitivity and specificity for OSA diagnosis are 94.4%and 78.9%***:The prevalence of OSA is 60.9% among adult primary care population who are at risk for *** pulse oximetry shows good performance as a screening tool for the screening of OSA.

关键词： Obstructive sleep apnea overnight pulse oximetry primary care

Early-onset primary torsional dystonia in a 4-generation Chinese family with a mutation in the DYT1 gene

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Chinese Medical Journal 2005年第10期118卷 873-876页

作者： YEUNG wai Lan LAM Ching Wan CHENG wai Tsoi SIN Ngai Chuen WONG Wing kin WONG Chun Nei TSE Ka Ming FOK Tai Fai Departments of Paediatrics Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Chemical Patholog Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Paediatrics and Adolescent Medicine Queen Mary HospitalUniversity of Hong Kong Nuclear Medicine&PET Division Scanning DepartmentSt.Teresa’s HospitalHong KongChina

Primary torsion dystonia(PTD)is a clinically and genetically heterogeneous movement *** least thirteen different types of dystonia can be distinguished on a genetic basis.~1 The DYT1 gene was first mapped by Ozelius et al in 1989.~2(Kramer et)al^3 linked the same locus to PTD in 12 Ashkenazi Jewish families in *** patients with early-onset generalized PTD were caused by the same three base pair(GAG)deletion in the DYT1 gene on chromosome 9q34.^(1,4,5)The product of the gene is a protein called torsinA.~5(Although the)function of this protein is as yet uncertain,it is widely distributed throughout the brain with high levels in the substantia nigra compacta dopamine neurones.

关键词： DYT1 gene dystonia positron emission tomography

Extracorporeal shock wave therapy for chronic pelvic pain syndrome

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Extracorporeal shock wave therapy for chronic pelvic pain sy...

Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)

第十七届全国泌尿外科学术会议

作者： Tsz kin TSANG Lung wai chan Satish Shrestha Urology care of Hong Kong University hospital of Macau

Introduction and Objectives Prostatitis is one of the most frequent urological diseases diagnosed in *** pelvic pain syndrome(CPPS) is considered to show an incidence between 1.5-10%among the male population all over ...

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Genomics, Proteomics & Bioinformatics 2003年第4期1卷 247-262页

作者： Raymond kin Hi Hui Raymond Tsz Yeung Wong Chi wai Yip Frederick Chi Ching Leung Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.

The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identifi-

关键词： severe acute respiratory syndrome SARS-CoV genome phylogenetics human leukocyte antigen (HLA) system molecular epidemiology

Traditional Chinese medicine poisoning in the emergency departments in Hong Kong: Trend, clinical presentation and predictors for poor outcome

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World Journal of Emergency Medicine 2021年第2期12卷 143-150页

作者： Rex Pui kin Lam Eric Ho Yin Lau wai Lam Yip Joe Kai Shing Leung Matthew Sik Hon Tsui Emergency Medicine Unit Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina Accident and Emergency Department Pamela Youde Nethersole Eastern HospitalHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Dear editor,Traditional Chinese medicine (TCM) is popular in many countries,especially in the Chinese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed Chinese medicine products/herbs in the preceding *** reasons for consumption include regulating bodily functions,curing disease,and building up health.

关键词： has editor curing

私有公共空间与空间正义之博弈——以香港地区为例

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国际城市规划 2023年第3期38卷 73-82,98页

作者：简祎罗洁梅王安琪陈汉云陈蔚镇邵健伟香港理工大学设计学院中国香港香港理工大学中国香港同济大学浙江工业大学设计与建筑学院城乡规划系香港理工大学建筑及房地产学系中国香港同济大学建筑与城市规划学院景观学系香港理工大学公共设计研究室中国香港

私有公共空间作为增加城市公共空间存量、提升空间品质、激发城市活力的策略已日渐普遍。然而,私有公共空间被质疑是迎合了当下绅士化审美趋势的产物,是商业资本用以实现社会控制的排他性空间,引发了业界对空间不公的讨论。本研究通过... 详细信息

私有公共空间作为增加城市公共空间存量、提升空间品质、激发城市活力的策略已日渐普遍。然而,私有公共空间被质疑是迎合了当下绅士化审美趋势的产物,是商业资本用以实现社会控制的排他性空间,引发了业界对空间不公的讨论。本研究通过梳理空间正义的相关理论,以香港地区商业公共空间为实证研究对象,探讨私有公共空间中空间正义的表达。从活动多样性、安全性与管理、邻近与可步行性、公共性和公众参与五个方面剖析其中公私权力的界限,理解私人所有权与空间正义间的冲突性生产关系和微妙的阈限性。挖掘私有公共空间在空间正义语境下作为缓解城市不公的中介效益,有助于实现公共空间的优化配置,缓解社会不公平现象。

关键词：私有公共空间空间正义可达性社会包容公共性多样性

Liquid-phase exfoliation of violet phosphorus for electronic applications

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SmartMat 2021年第2期2卷 226-233页

作者： Shenghuang Lin wai kin Lai Yanyong Li Wei Lu Gongxun Bai Shu Ping Lau Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomHong KongChina Songshan Lake Materials Laboratory Songshan Lake International Innovation Entrepreneurship CommunityDongguan CityGuangdongChina Institute of Optoelectronic Materials and Devices China Jiliang UniversityHangzhouChina

Large-scale production of two-dimensional(2D)materials still is a crucial point toward its practical *** phosphorus(VP)with a wide bandgap accelerates and broadens the potential applications of elemental phosphorus in ***,we demonstrate the scalable production of solution-processable violet phosphorus flakes stably dispersed in several *** exfoliated VP flakes exhibit thickness-dependent visible photoluminescence characteristics,which covers the shortcoming of black ***,the VP-based field-effect transistor reveals relatively competitive electrical properties to other liquid-phase exfoliated 2D *** study paves the way for a wide range of applications of optical devices,energy storage,catalysis,and sodium batteries based on large-scale VP flakes.

关键词： field effect transistor liquid-phase exfoliation photoluminescence violet phosphorus

Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma

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Neural Regeneration Research 2012年第9期7卷 645-651页

作者： Xue-Song Mi kin Chiu Geoffrey Van Justin wai Chung Leung Amy Cheuk Yin Lo SookjaKim Chung Raymond Chuen-Chung chang Kwok-Fai So Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Eye Institute Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Research Centre of Heart BrainHormone and Healthy AgingLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina The Joint Laboratory for Brain Function and Health （BFAH） Jinan University and The University of Hong Kong Guangzhou 510632Guangdong Province China

Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells （RGCs） in a rat chronic ocular hypertension （COH） model. Here, we investigated the expression of endothelin-1 （ET-1）, a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure （IOP） was induced in the right eye of SD rats using argon laser photocoagulation. （1） The expression of ET-1, ETA and ETB in normal and COH retinas was studied. （2） Some COH rats were fed daily with Lycium barbarum Polysaccharides （LBP） using 1 mg/kg or phosphate-buffered saline （PBS） for 3 weeks （started 1 week before photocoagulation）. The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that （1） Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. （2） After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. （3） By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature.

关键词： retinal ganglion cell Lycium barbarum Polysaccharides glaucoma endothelin-1

PROGRESS IN HONG KONG'S TROPICAL CYCLONE FORECASTING AND WARNING SERVICES IN RECENT DECADES

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Tropical Cyclone Research and Review 2018年第1期7卷 37-50页

作者： wai-kin WONG CHUN-WING CHOY Hong Kong Observatory

With modern infrastructures and effective warning systems,casualties,damages and losses due to tropicalcyclones(TCs)have been significantly reduced over the years in Hong ***,densely populated coastal cities like Hong Kong will need to continuously enhance its resilience to high winds,heavy rain and storm surges brought by TCs,especially with the growing concern of the challenges induced by climate change and sea level *** embracing the advance of remote sensing,communication and numerical modelling technology,the Hong Kong Observatory(HKO)continues to improve its TC monitoring and forecasting techniques as well as forecasting and warning services to meet the needs of the *** paper concisely reviews the major development and achievement of TC-related operation and services of HKO in recent decades,in aspects such as Numerical Weather Prediction(NWP)models,nowcasting techniques,warning communication and public *** thrusts on TC forecasting and warning services of HKO will also be discussed.

关键词： Hong Kong Observatory tropical cyclones forecasting and warning services

Molecular basis of von Hippel-Lindau syndrome in Chinese patients

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Chinese Medical Journal 2011年第2期124卷 237-241页

作者： SIU wai-kwan MA Ronald Ching-wan LAM Ching-wan MAK Chloe Miu YUEN Yuet-ping LO Fai-man Ivan chan kin-wan LAM Siu-fung LING Siu-cheung TONG Sui-fan SO Wing-yee CHOW Chun-chung TANG Mary Hoi-yin TAM wing-hung chan Albert Yan-wo Department of Pathology Princess Margaret Hospital Hong Kong China Department of Medicine & Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong China Clinical Genetic Service Department of Health Hong Kong China Department of Medicine and Geriatrics Princess Margaret Hospital Hong Kong China Department of Paediatrics and Adolescent Medicine Princess Margaret Hospital Hong Kong China Department of Obstetrics & Gynaecology Tsan Yuk Hospital Hong Kong China Department of Obstetrics & Gynaecology The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China

Background Von Hippel-Lindau （VHL） syndrome is an autosomal dominant familial cancer syndrome predisposing the affected individuals to multiple tumours in various *** genetic basis of VHL in Southern Chinese is largely *** this study,we characterized the mutation spectrum of VHL in nine unrelated Southern Chinese *** Nine probands with clinical features of VHL,two symptomatic and eight asymptomatic family members were included in this *** diagnosis was performed twice for one *** probands had only isolated bilateral *** VHL gene was screened for mutations by polymerase chain reaction,direct sequencing and multiplex ligation-dependent probe amplification （MLPA）.Results The nine probands and the two symptomatic family members carried heterozygous germline *** different VHL mutations were identified in the nine *** splicing mutation,NM_000551.2：c.463＋1G〉T,was *** other seven VHL mutations,c.233A〉G [***78Ser],c.239G〉T [***80lle],c.319C〉G [***107Gly],c.481C〉T [***161X],c.482G〉A [***161GIn],c.499C〉T [***167Trp] and an exon 2 deletion,had been previously *** asymptomatic family members were positive for the mutation and the other five tested *** prenatal diagnosis,the fetuses were positive for the *** Genetic analysis could accurately confirm VHL syndrome in patients with isolated tumours such as sporadic phaeochromocytoma or epididymal papillary *** detection in asymptomatic family members allows regular tumour surveillance and early intervention to improve their ***-based diagnosis can have an important impact on clinical management for VHL families.

关键词： von Hippel-Lindau syndrome VHL gene Chinese VHL mutations