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Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation

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Neural Regeneration Research 2024年第5期19卷 1112-1118页

作者： Meng Wang Shi-Qi Yao Yao Huang Jia-Jian Liang Yanxuan Xu Shaowan Chen Yuhang Wang Tsz kin Ng wai Kit Chu Qi Cui Ling-Ping Cen Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Intraocular pressure elevation can induce retinal ganglion cell death and is a clinically reversible risk factor for glaucoma,the leading cause of irreversible *** previously demonstrated that casein kinase-2 inhibition can promote retinal ganglion cell survival and axonal regeneration in rats after optic nerve *** investigate the underlying mechanism,in the current study we increased the intraocular pressure of adult rats to 75 mmHg for 2 hours and then administered a casein kinase-2 inhibitor(4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole)by intravitreal *** found that intravitreal injection of 4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole promoted retinal ganglion cell survival and reduced the number of infiltrating *** analysis showed that the mitogen activated protein kinase signaling pathway was involved in the response to intraocular pressure elevation but was not modulated by the casein kinase-2 ***,casein kinase-2 inhibition downregulated the expression of genes(Cck,Htrsa,Nef1,Htrlb,Prph,Chat,Slc18a3,Slc5a7,Scn1b,Crybb2,Tsga10ip,and Vstm21)involved in intraocular pressure *** data indicate that inhibition of casein kinase-2 can enhance retinal ganglion cell survival in rats after acute intraocular pressure elevation via macrophage inactivation.

关键词： casein kinase-2 glaucoma intraocular pressure elevation macrophages retinal ganglion cells

Laparoscopic excision of Meckel's diverticulum in children:What is the current evidence?

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World Journal of Gastroenterology 2014年第41期20卷 15158-15163页

作者： kin wai edwin chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer wai Cheung Mou Yuk Him Tam Division of Paediatric Surgery and Paediatric Urology Department of SurgeryThe Prince of Wales HospitalThe Chinese University of Hong Kong

Complications aroused from Meckel's diverticulum tend to developed in *** presented with abdominal pain,intestinal obstruction,intussusception or gastrointestinal bleeding may actually suffered from complicated Meckel's *** the advancement of minimally invasive surgery(MIS) in children,the use of laparoscopy in the diagnosis and subsequent laparoscopic excision of Meckel's diverticulum has gained ***,single incision laparoscopic surgery(SILS) has emerged as a new technique in minimally invasive *** review offers the overview in the development of MIS in the management of children suffered from Meckel's *** current evidence in different laparoscopic techniques,including conventional laparoscopy,SILS,the use of special laparoscopic instruments,intracorporeal diverticulectomy and extracorporeal diverticulectomy in the management of Meckel's diverticulum in children were revealed.

关键词： Laparoscopy Meckel’s diverticulum Children

Cystic meconium peritonitis with jejunoileal atresia:Is it associated with unfavorable outcome?

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World Journal of Clinical Pediatrics 2017年第1期6卷 40-44页

作者： kin wai edwin chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer wai Cheung Mou Yuk Him Tam Division of Paediatric Surgery and Paediatric Urology Department of Surgerythe Prince of Wales Hospitalthe Chinese University of Hong Kong

AIM To compare the outcome between patients with jejunoileal atresia(JIA) associated with cystic meconium peritonitis(CMP) and patients with isolated JIA(JIA without CMP).METHODS A retrospective study was conducted for all neonates with JIA operated in our institute from January 2005 to January *** including the gestation age,sex,birth weight,age at operation,the presence of associated syndrome was *** outcome including the type of operation performed,operative time,the need for reoperation and mortality were *** demographics and the outcome between the 2 groups were *** During the study period,53 neonates had JIA underwent operation in our *** neonates(32%) were associated with *** was no statistical difference on the demographics in the two *** with CMP had earlier operation than patients with isolated JIA(mean 1.4 d vs 3 d,P = 0.038).Primaryanastomosis was performed in 16 patients(94%) with CMP and 30 patients(83%) with isolated JIA(P = 0.269).Patients with CMP had longer operation(mean 190 min vs 154 min,P = 0.004).There were no statistical difference the need for reoperation(3 vs 6,P = 0.606) and mortality(2 vs 1,P = 0.269) between the two *** Primary intestinal anastomosis can be performed in94% of patients with JIA associated with *** patients with CMP had longer operative time,the mortality and reoperation rates were low and were comparable to patients with isolated JIA.

关键词： Meconium Peritonitis Atresia Jejunoileal

On Effective Campus Attack Response:Insights from Agent-Based Simulation for Improving Emergency Information Sharing System Design and Response Strategy

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International Journal of Disaster Risk Science 2022年第3期13卷 435-447页

作者： Steven Beattie Jing Yang Sunny Xi wai kin Victor chan Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen518055China

Information sharing systems are a critical component of emergency response—especially in campus attack situations that unfold very *** design of effective information sharing systems is often difficult,however,due to a lack of data on these assault *** work takes an agent-based approach to simulate three campus emergency information sharing system design alternatives in the context of a college campus knife attack,and incorporates data from on-campus student surveys and parameter tuning *** are evaluated according to:(1)improved student attack response outcomes;and(2)effective institutional response to the *** results confirm that increased awareness supports rapid emergency reporting,but an important gap exists between students'awareness and their ability to respond effectively,which depends on a number of campus-specific factors.A strong positive impact is seen from safe and efficient information sharing with *** impact depends largely on reporting system implementation qualities,as opposed to campus-specific *** a campus in China,WeChat was used as a basis for messaging *** simulation results show a 9%drop in casualties and a 22%faster police response time from a text-based reporting system using‘‘base''WeChat features instead of traditional phone *** results also project a 30%drop in casualties and 52%faster police response time using a system designed around a WeChat Mini Program or standalone campus emergency reporting *** outcomes suggest a number of recommendations for improving outdated campus emergency information-sharing systems and response strategies.

关键词： Agent-based impact analysis Agent-based modeling Campus security Emergency response Information sharing

Use of laparoscopy as the initial surgical approach of impalpable testes:10-year experience

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World Journal of Clinical Pediatrics 2015年第4期4卷 155-159页

作者： kin wai edwin chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer wai Cheung Mou Yuk Him Tam Division of Paediatric Surgery and Paediatric Urology Department of Surgerythe Prince of Wales Hospitalthe Chinese University of Hong Kong

AIM: To review the experience in the management of impalpable testes using laparoscopy as the initial approach and the need for inguinal ***: From January 2004 to June 2014, 339 patients with undescended testes underwent operation in our institute. Fifty patients(15%) had impalpable testes. All children with impalpable testes underwent initial laparoscopy. A retrospective review was conducted on this group of patients and the outcome was ***: Forty children had unilateral impalpable testis. Ten children had bilateral impalpable testes. Thirty-one children(78%) in the unilateral group underwent subsequent inguinal exploration while 4 children(40%) in the bilateral group underwent inguinal exploration(P < 0.05). Orchidopexy was performed in 16 children(40%) in the unilateral group and 9 children(90%) in the bilateral group(P < 0.05). Regarding the 24 children with unilateral impalpable testis and underwent orchidectomy for testicular nubbin(n = 19) or atrophic testes(n = 2) or has vanishing testes(n = 3); contralateral testicular hypertrophy was noticed in 10(41%). No intra-operative complication was encountered. Two children after staged Fowler-Stephensprocedure and 1 child after inguinal orchidopexy had atrophic ***: The use of laparoscopy in children with impalpable testes is a safe procedure and can guide the need for subsequent inguinal exploration. Children with unilateral impalpable testis were associated with an increased need for inguinal exploration after laparoscopy. Orchidopexies could be performed successfully in 90% of children with bilateral impalpable testes.

关键词： Laparoscopy Impalpable Testis Inguinal

Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection

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Neural Regeneration Research 2022年第12期17卷 2643-2648页

作者： Ling-Ping Cen Tsz kin Ng wai Kit Chu Chi Pui Pang Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Both inflammation and anti-inflammation are involved in the protection of retinal *** of the hypothalamic growth hormone-releasing hormone receptor(GHRHR)have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs,some with systemic *** effects are also found in ocular inflammatory and neurologic injury *** experimental models of mice and rats,both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental *** review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.

关键词： neuroprotection ocular inflammation optic nerve injury retinal ganglion cells uveitis

Radar-based Characteristics and Formation Environment of Supercells in the Landfalling Typhoon Mujigae in 2015

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Advances in Atmospheric Sciences 2022年第5期39卷 802-818页

作者： Lanqiang BAI Zhiyong MENG Ruilin ZHOU Guixing CHEN Naigeng WU wai-kin WONG School of Atmospheric Sciences Sun Yat-sen Universityand Key Laboratory of Tropical Atmosphere-Ocean SystemMinistry of Educationand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Institute of Tropical and Marine Meteorology China Meteorological AdministrationGuangzhou 510640China Hong Kong Observatory Hong Kong 999077China

This study presents the radar-based characteristics and formation environment of supercells spawned by the tornadic landfalling Typhoon Mujigae(2015)in October *** than 100 supercells were identified within a 24-hour period around the time of the typhoon’s landfall,of which three were tornadic with a rotational intensity clearly stronger than those of non-tornadic *** identified supercells were concentrated within a relatively small area in the northeast quadrant beyond 140 km from the typhoon *** supercells were found more likely to form over flat topography and were difficult to maintain in mountainous *** the study period,more supercells formed offshore than *** mesocyclones of the identified supercells were characterized by a small diameter generally less than 5 km and a shallow depth generally less than 4 km above ground *** environmental analysis revealed that the northeast quadrant had the most favorable conditions for the genesis of supercell in this typhoon *** nondimensional supercell composite parameter(SCP)and entraining-SCP(E-SCP)were effective in separating supercell from non-supercell *** though the atmosphere in the typhoon’s northeast quadrant was characterized by an E-SCP/SCP value supportive of supercell organization,orography was an impeditive factor for the supercell *** findings support the use of traditional parameters obtained from midlatitude supercells to assess the supercell potential in a tropical cyclone envelope.

关键词： supercell tropical cyclone atmospheric environment radar meteorology

Successful capture of red thrombus in acute inferior ST-elevation myocardial infarction

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Journal of Geriatric Cardiology 2018年第10期15卷 647-648页

作者： wai-kin CHI Chi-Yuen chan Division of Cardiology Department of Medicine and TherapeuticsPrince of Wales Hospitalthe Chinese University of Hong KongHong KongChina

A 50-year-old gentleman with past medical history of hypertension presented with acute inferior ST-segment elevation myocardial infarction (STEMI).He complained severe chest pain despite onset time was more than *** p... 详细信息

关键词： Embolic protection device Successful capture Thrombus

Clinicopathological survey of 23 patients with lacrimal fossa lesions in Hong Kong

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 311-313页

作者： Danny Siu-Chun Ng edwin chan kin Yau Clement wai-Nang chan Department of Ophthalmology Tung Wah Eastern Hospital

AIM: To survey the clinicopathological correlations of lacrimal fossa lesions in the Hong Kong population. METHODS: A total of 23 patients with lacrimal fossa lesions were identified radiologically. The mean age at the time of diagnosis was 52 year-old. The medical records of patients diagnosed with lacrimal fossa lesions and subsequently underwent radiological investigations were collected and reviewed retrospectively throughout a six years period from 2000 to 2006 from three regional hospitals (Tung Wah Eastern Hospital, Pamela Youde Nethersole Eastern Hospital and Queen Mary Hospital) belonging to the Hong Kong Mega Cluster. Patient demographics, presenting signs and symptoms, imaging modalities, pathological reports and subsequent management were recorded. RESULTS: The most common initial presenting symptom was upper lid swelling (83%) followed by proptosis (13%). 19 patients (83%) had benign lacrimal fossa lesion and 4 patients (17%) had malignancy. Three of the malignancies were lymphomas and one was adenoid cystic carcinoma. CONCLUSION: Age is an important factor in considering the differential diagnosis of lacrimal fossa lesion. Lymphoproliferative diseases have the highest incidence in patients over 60 years of age while inflammatory lesions are more common in younger patients in Hong Kong.

关键词： lacrimal gland tumor lymphoma