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Medial tibial plateau morphology and stress fracture location:A magnetic resonance imaging study

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World Journal of Orthopedics 2017年第6期8卷 484-490页

作者： kiminori Yukata Issei Yamanaka Yuzuru Ueda Sho Nakai Hiroyoshi Ogasa Yosuke Oishi Jun-ichi Hamawaki Department of Orthopedic Surgery Yamaguchi University Graduate School of Medicine

AIM To determine the location of medial tibial plateau stress fractures and its relationship with tibial plateau morphology using magnetic resonance imaging(MRI).METHODS A retrospective review of patients with a diagnosis of stress fracture of the medial tibial plateau was performed for a 5-year period. Fourteen patients [three female and 11 male, with an average age of 36.4 years(range, 15-50 years)], who underwent knee MRI, were included. The appearance of the tibial plateau stress fracture and the geometry of the tibial plateau were reviewed and measured on MRI.RESULTS Thirteen of 14 stress fractures were linear, and one of them stellated on MRI images. The location of fractures was classified into three types. Three fractures were located anteromedially(AM type), six posteromedially(PM type), and five posteriorly(P type) at the medial tibial plateau. In addition, tibial posterior slope at the medial tibial plateau tended to be larger when the fracture was located more posteriorly on MRI.CONCLUSION We found that MRI showed three different localizations of medial tibial plateau stress fractures, which were associated with tibial posterior slope at the medial tibial plateau.

关键词： Magnetic resonance imaging Runner Stress fracture Tibial plateau Tibial posterior slope

Effects of sclerostin antibody on bone healing

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World Journal of Orthopedics 2021年第9期12卷 651-659页

作者： Atsushi Mihara kiminori Yukata Toshihiro Seki Ryuta Iwanaga Norihiro Nishida Kenzo Fujii Yuji Nagao Takashi Sakai Department of Orthopedic Surgery Yamaguchi University Graduate School of MedicineUbe 755-8505Japan

Promoting bone healing after a fracture has been a frequent subject of research.Recently,sclerostin antibody(Scl-Ab)has been introduced as a new anabolic agent for the treatment of osteoporosis.Scl-Ab activates the canonical Wnt(cWnt)-β-catenin pathway,leading to an increase in bone formation and decrease in bone resorption.Because of its rich osteogenic effects,preclinically,Scl-Ab has shown positive effects on bone healing in rodent models;researchers have reported an increase in bone mass,mechanical strength,histological bone formation,total mineralized callus volume,bone mineral density,neovascularization,proliferating cell nuclear antigen score,and bone morphogenic protein expression at the fracture site after Scl-Ab administration.In addition,in a rat critical-size femoral-defect model,the Scl-Ab-treated group demonstrated a higher bone healing rate.On the other hand,two clinical reports have researched Scl-Ab in bone healing and failed to show positive effects in the femur and tibia.This review discusses why Scl-Ab appears to be effective in animal models of fracture healing and not in clinical cases.

关键词： Canonical Wnt-β-catenin pathway Fracture healing Osteoporosis Romosozumab Sclerostin antibody

听音室立体声重放系统中IACC的分布(英文)

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华南理工大学学报（自然科学版） 2007年第B10期35卷 84-87页

作者： kiminori Mouri Hiroshi Otani Yoshinobu Hazama Willstage Co.Ltd.1-6-9WakakusaKusatsu-CityShigaJapan

在日本家庭中,听音室非常受欢迎.人们在自己的起居室中安装了优质的音响系统,用以欣赏音乐.最近,许多公司推出了很多有架子的音响系统设备,以方便人们放置喇叭和音响系统.但是大多数日本人都不知道如何将起居室改造成听音室.双耳互相关... 详细信息

在日本家庭中,听音室非常受欢迎.人们在自己的起居室中安装了优质的音响系统,用以欣赏音乐.最近,许多公司推出了很多有架子的音响系统设备,以方便人们放置喇叭和音响系统.但是大多数日本人都不知道如何将起居室改造成听音室.双耳互相关系数(IACC)是评价声场的重要参量,低的IACC值会带给人更好的音乐享受.文中探讨了现有房间中立体声重放系统的IACC分布.

关键词：双耳互相关系数听音室设备

Cystic lesion around the hip joint

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World Journal of Orthopedics 2015年第9期6卷 688-704页

作者： kiminori Yukata Sho Nakai Tomohiro Goto Yuichi Ikeda Yasunori Shimaoka Issei Yamanaka Koichi Sairyo Jun-ichi Hamawaki Department of Orthopedic Surgery Hamawaki Orthopaedic Hospital Department of Orthopaedics Tokushima University Hospital

This article presents a narrative review of cystic lesions around the hip and primarily consists of 5 sections:Radiological examination, prevalence, pathogenesis, symptoms, and treatment. Cystic lesions around the hip are usually asymptomatic but may be observed incidentally on imaging examinations, such as computed tomography and magnetic resonance imaging. Some cysts may enlarge because of various pathological factors, such as trauma, osteoarthritis, rheumatoid arthritis, or total hip arthroplasty(THA), and may become symptomatic because of compression of surrounding structures, including the femoral, obturator, or sciatic nerves, external iliac or common femoral artery, femoral or external iliac vein, sigmoid colon, cecum, small bowel, ureters, and bladder. Treatment for symptomatic cystic lesions around the hip joint includes rest, nonsteroidal anti-inflammatory drug administration, needle aspiration, and surgical excision. Furthermore, when these cysts are associated with osteoarthritis, rheumatoid arthritis, and THA, primary or revision THA surgery will be necessary concurrent with cyst excision. Knowledge of the characteristic clinical appearance of cystic masses around the hip will be useful for determining specific diagnoses and treatments.

关键词： Bursa Cystic lesion Ganglion cyst Hip Synovial cyst

Indirect inguinal hernia containing portosystemic shunt vessel: A case report

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World Journal of Clinical Cases 2021年第2期9卷 509-515页

作者： Masahiro Yura Kikuo Yo Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Hiroto Fujisaki AkiraHirata kiminori Takano Kumiko Hongo Kimiyasu Yoneyama Motohito Nakagawa Department of Surgery Hiratsuka City HospitalHiratsuka 2540065KanagawaJapan

BACKGROUND Inguinal hernia repair is one of the most common general surgical operations worldwide.We present a case of indirect inguinal hernia containing an expanded portosystemic shunt vessel.CASE SUMMARY We report a 72-year-old man who had a 4 cm×4 cm swelling in the right inguinal region,which disappeared with light manual pressure.Abdominal-pelvic computed tomography(CT)revealed a right inguinal hernia containing an expanded portosystemic shunt vessel,which had been noted for 7 years due to liver cirrhosis.We performed Lichtenstein’s herniorrhaphy and identified the hernia sac as being indirect and the shunt vessel existing in the extraperitoneal cavity through the internal inguinal ring.Then,we found two short branches between the expanded shunt vessel and testicular vein in the middle part of the inguinal canal and cut these branches to allow the shunt vessel to return to the extraperitoneal cavity of the abdomen.The hernia sac was returned as well.We encountered no intraoperative complications.After discharge,groin seroma requiring puncture at the outpatient clinic was observed.CONCLUSION If an inguinal hernia patient has portal hypertension,ultrasound should be used to determine the contents of the hernia.When atypical vessels are visualized,they may be shunt vessels and additional CT is recommended to ensure the selection of an adequate approach for safe hernia repair.

关键词： Inguinal hernia Lichtenstein’s herniorrhaphy Portosystemic shunt Portal hypertension Shunt vessel Case report

Change in Aggregate Shape of Heat Treated Carbon Nanoparticles

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Journal of Chemistry and Chemical Engineering 2013年第4期7卷 326-333页

作者： kiminori Ono Mlkl Yanaka Aki watanabe Yoshiya Matsukawa Yasuhiro Saito Hideyuki Aoki OkiteruFukuda Takayuki Aoki Togo Yamaguchi Department of Chemical Engineering Graduate School of Engineering Tohoku University Sendai 980-8579 Japan ASAHI CARBON Co. Ltd. Niigata 950-0883 Japan

To better understand the fusion mechanism of heated carbon black, heat treatment is conducted for carbon black produced by benzene pyrolysis. The effects of (a) heating time, (b) heating temperature and (c) heating rate on the aggregate shape and mean primary particle diameter of the carbon black are investigated using TEM (transmission electron microscopy). The mean primary particle diameter does not change significantly when carbon black is heat treated. For short heating times and low heating temperatures, the aggregate shapes become simple when compared with those of non-heated carbon black, and shapes become complex with an increase in the heating time. Also, for low heating rates, the aggregate shapes become significantly simple when compared with those of non-heated carbon black. The results of this study suggest that sintering between primary particles is promoted under relatively low heating temperatures, and Ostwald ripening among aggregates is promoted under relatively high heating temperatures.

关键词：碳纳米颗粒集料形状 Ostwald熟化透射电子显微镜加热时间加热温度一次粒径加热速度

Pharmacological Modulation by Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang) and the Ingredients in Rat Intestinal Smooth Muscle

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Chinese Medicine 2011年第2期2卷 62-70页

作者： Hiroyasu Satoh kiminori Tsuro 不详

Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang), a formulation of Japanese herbal (Kampo) medicines, is composed of Paeoniae Radix and Glycyrrhizae Radix. Effects of Shakuyakukanzoto and the ingredients on rat intestinal tract were examined. Shakuyakukanzoto (0.01 - 0.3 mg/ml) relaxed a carbachol (CCh, 0.3 μM) - induced contraction in a concentration-dependent manner. Both components (Paeoniae radix and Glycyrrhizae radix) also relaxed the CCh-induced contraction. At 0.1 to 1 mM, their constituents (paeoniflorin and glycyrrhetic acid) and the metabolic products (18-α- and 18-β-glycyrrhetinic acids) exerted almost the same actions. The relaxations induced by Shakuyakukanzoto were not modified by 1 μM nicardipine, 10 μM suramin (ATP receptor inhibitor) and several K+ channel inhibitors, but was attenuated by 20 μM IBMX (a phosphodiesterase inhibitor). Also, IBMX inhibited the relaxations induced by paeoniflorin and glycyrrhetic acid, but not by other ingredients. Nicardipine decreased the relaxation of just 18-α-glycyrrhetinic acid. Even in non-treatment with CCh, Shakuyakukanzoto relaxed the intestinal tract. CCh (0.3 μM) elicited spontaneous contractions in 23% specimens, depressed by application of Shakuyakukanzoto. These results indicate that Shakuyakukanzoto causes a remarkable relaxation by the anti-cholinergic and the PDE inhibitory actions, but by minor contribution of Ca2+ channel inhibition. Thus, Shakuyakukanzoto exerts an anti-spasmodic action due to the interaction with pharmacological effects of its ingredients.

关键词： Shakuyakukanzoto Paeoniae Radix Paeoniflorin Glycyrrhetic Acid PDE Inhibition Anti-Cholinergic Action Ca2+ Channel Inhibition Intestinal Tract

Studies of Montmorillonite Mechanochemically Decomposed at Different Water Contents

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Geomaterials 2017年第2期7卷 41-50页

作者： Koichiro Fujimoto kiminori Sato Department of Environmental Sciences Tokyo Gakugei University Tokyo Japan

Clay minerals, as e.g. montmorillonite, abundantly exist in the slip zones such as earthquake faults and landslides. Water contents are an important factor for controlling slip behavior, since montmorillonite contains a considerable amount of water molecules compared with other clay minerals. Here, a series of mechanochemical milling experiments were conducted for montmorillonite at the water contents ranging from 0% to 800%. Decomposition occurs at the water contents below 25% and above 600%, which are well correlated with the consistency limits of montmorillonite reported so far, i.e. shrinkage/plastic and liquid limits, respectively. Montmorillonite is found to be effectively decomposed into amorphous materials at the water contents below the shrinkage/plastic limit. In the region of water content between shrinkage/plastic and liquid limits, decomposition cannot be achieved solely by the mechanochemical treatment. At the water contents higher than the liquid limit, decomposition is again started. The present work demonstrates that the degree of decomposition can be of usefulness for speculating how the water molecules behave in the slip zones in nature.

关键词： Montmorillonite-Water System Slip Zone Fault Milling Amorphous Material Consistency Limits

Glycolytic Synchronization in Yeast Cells via ATP and Other Metabolites: Mathematical Analyses by Two-Dimensional Reaction-Diffusion Models

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Natural Science 2014年第10期6卷 719-732页

作者： Hiroshi Serizawa Takashi Amemiya kiminori Itoh Graduate School of Environment and Information Sciences Yokohama National University Yokohama Japan

Possibilities of synchronized oscillations in glycolysis mediated by various extracellular metabolites are investigated theoretically using two-dimensional reaction-diffusion systems, which originate from the existing seven-variable model. Our simulation results indicate the existence of alternative mediators such as ATP and 1,3-bisphosphoglycerate, in addition to already known acetaldehyde or pyruvate. Further, it is also suggested that the alternative intercellular communicator plays a more important role in the respect that these can synchronize oscillations instantaneously not only with difference phases but also with different periods. Relations between intercellular coupling and synchronization mechanisms are also analyzed and discussed by changing the values of parameters such as the diffusion coefficient and the cell density that can reflect in tercellular coupling strength.

关键词： Acetaldehyde ATP Glycolytic Oscillation Intercellular Coupling Reaction-Diffusion Model Synchronization