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Change in Aggregate Shape of Heat Treated Carbon Nanoparticles

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Journal of Chemistry and Chemical Engineering 2013年第4期7卷 326-333页

作者： kiminori ono Mlkl Yanaka Aki Watanabe Yoshiya Matsukawa Yasuhiro Saito Hideyuki Aoki OkiteruFukuda Takayuki Aoki Togo Yamaguchi Department of Chemical Engineering Graduate School of Engineering Tohoku University Sendai 980-8579 Japan ASAHI CARBON Co. Ltd. Niigata 950-0883 Japan

To better understand the fusion mechanism of heated carbon black, heat treatment is conducted for carbon black produced by benzene pyrolysis. The effects of （a） heating time, （b） heating temperature and （c） heating rate on the aggregate shape and mean primary particle diameter of the carbon black are investigated using TEM （transmission electron microscopy）. The mean primary particle diameter does not change significantly when carbon black is heat treated. For short heating times and low heating temperatures, the aggregate shapes become simple when compared with those of non-heated carbon black, and shapes become complex with an increase in the heating time. Also, for low heating rates, the aggregate shapes become significantly simple when compared with those of non-heated carbon black. The results of this study suggest that sintering between primary particles is promoted under relatively low heating temperatures, and Ostwald ripening among aggregates is promoted under relatively high heating temperatures.

关键词： Carbon black soot heat treatment.

听音室立体声重放系统中IACC的分布(英文)

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华南理工大学学报（自然科学版） 2007年第B10期35卷 84-87页

作者： kiminori Mouri Hiroshi Otani Yoshinobu Hazama Willstage Co.Ltd.1-6-9WakakusaKusatsu-CityShigaJapan

在日本家庭中,听音室非常受欢迎.人们在自己的起居室中安装了优质的音响系统,用以欣赏音乐.最近,许多公司推出了很多有架子的音响系统设备,以方便人们放置喇叭和音响系统.但是大多数日本人都不知道如何将起居室改造成听音室.双耳互相关... 详细信息

在日本家庭中,听音室非常受欢迎.人们在自己的起居室中安装了优质的音响系统,用以欣赏音乐.最近,许多公司推出了很多有架子的音响系统设备,以方便人们放置喇叭和音响系统.但是大多数日本人都不知道如何将起居室改造成听音室.双耳互相关系数(IACC)是评价声场的重要参量,低的IACC值会带给人更好的音乐享受.文中探讨了现有房间中立体声重放系统的IACC分布.

关键词：双耳互相关系数听音室设备

Pharmacological Modulation by Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang) and the Ingredients in Rat Intestinal Smooth Muscle

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Chinese Medicine 2011年第2期2卷 62-70页

作者： Hiroyasu Satoh kiminori Tsuro 不详

Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang), a formulation of Japanese herbal (Kampo) medicines, is composed of Paeoniae Radix and Glycyrrhizae Radix. Effects of Shakuyakukanzoto and the ingredients on rat intestinal tract were examined. Shakuyakukanzoto (0.01 - 0.3 mg/ml) relaxed a carbachol (CCh, 0.3 μM) - induced contraction in a concentration-dependent manner. Both components (Paeoniae radix and Glycyrrhizae radix) also relaxed the CCh-induced contraction. At 0.1 to 1 mM, their constituents (paeoniflorin and glycyrrhetic acid) and the metabolic products (18-α- and 18-β-glycyrrhetinic acids) exerted almost the same actions. The relaxations induced by Shakuyakukanzoto were not modified by 1 μM nicardipine, 10 μM suramin (ATP receptor inhibitor) and several K+ channel inhibitors, but was attenuated by 20 μM IBMX (a phosphodiesterase inhibitor). Also, IBMX inhibited the relaxations induced by paeoniflorin and glycyrrhetic acid, but not by other ingredients. Nicardipine decreased the relaxation of just 18-α-glycyrrhetinic acid. Even in non-treatment with CCh, Shakuyakukanzoto relaxed the intestinal tract. CCh (0.3 μM) elicited spontaneous contractions in 23% specimens, depressed by application of Shakuyakukanzoto. These results indicate that Shakuyakukanzoto causes a remarkable relaxation by the anti-cholinergic and the PDE inhibitory actions, but by minor contribution of Ca2+ channel inhibition. Thus, Shakuyakukanzoto exerts an anti-spasmodic action due to the interaction with pharmacological effects of its ingredients.

关键词： Shakuyakukanzoto Paeoniae Radix Paeoniflorin Glycyrrhetic Acid PDE Inhibition Anti-Cholinergic Action Ca2+ Channel Inhibition Intestinal Tract

Systemic gemcitabine combined with intra-arterial low-dose cisplatin and 5-fluorouracil for advanced hepatocellular carcinoma: Seven cases

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World Journal of Gastroenterology 2008年第16期14卷 2602-2608页

作者： kiminori Uka Hiroshi Aikata Shintaro Takaki Tomokazu Kawaoka Hiromi Saneto Daiki Miki Shoichi Takahashi Naoyuki Toyota Katsuhide Ito Kazuaki Chayama Department of Medicine and Molecular Science Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Sciences Hiroshima University Department of Radiology Hiroshima University Hospital

The combination of intra-arterial low-dose cisplatin and 5-fluorouracil (5-FU) is effective against advanced hepatocellular carcinoma (HCC). Systemic gemcitabine chemotherapy seems effective in many cancers. We report the results of combination therapy with systemic gemcitabine, intra-arterial low-dose cisplatin and 5-FU (GEMFP). Seven patients with non-resectable advanced HCC were treated with GEMFP. One course of chemotherapy consisted of daily intra-arterial cisplatin (20 mg/body weight/hour on d 1, 10 mg/body weight per 0.5 h on d 2-5 and 8-12), followed by 5-FU (250 mg/body weight per 5 h on d 1-5 and 8-12) via an injection port. Gemcitabine at 1000 mg/m2 was administered intravenously at 0.5 h on d 1 and 8. The objective response was 57%. The response to GEMFP was as follows: complete response (no patients), partial response (four patients), stable disease (three patients), and progressive disease (no patients). The median survival period was 8 mo (range, 5-55). With regard to the National Cancer Institute Common Toxicity Criteria (NCI-CTC) grade 3 or 4 adverse reactions, seven (100%), seven, six (86%) and one (14%) patients developed leukopenia, neutropenia, thrombocytopenia and anemia, respectively. GEMFP may potentially be effective for non- resectable advanced HCC, but it has severe hematologic toxicity.

关键词： 5-fluorouracil Cisplatin Gemcitabine Hepatocellular carcinoma

Studies of Montmorillonite Mechanochemically Decomposed at Different Water Contents

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Geomaterials 2017年第2期7卷 41-50页

作者： Koichiro Fujimoto kiminori Sato Department of Environmental Sciences Tokyo Gakugei University Tokyo Japan

Clay minerals, as e.g. montmorillonite, abundantly exist in the slip zones such as earthquake faults and landslides. Water contents are an important factor for controlling slip behavior, since montmorillonite contains a considerable amount of water molecules compared with other clay minerals. Here, a series of mechanochemical milling experiments were conducted for montmorillonite at the water contents ranging from 0% to 800%. Decomposition occurs at the water contents below 25% and above 600%, which are well correlated with the consistency limits of montmorillonite reported so far, i.e. shrinkage/plastic and liquid limits, respectively. Montmorillonite is found to be effectively decomposed into amorphous materials at the water contents below the shrinkage/plastic limit. In the region of water content between shrinkage/plastic and liquid limits, decomposition cannot be achieved solely by the mechanochemical treatment. At the water contents higher than the liquid limit, decomposition is again started. The present work demonstrates that the degree of decomposition can be of usefulness for speculating how the water molecules behave in the slip zones in nature.

关键词： Montmorillonite-Water System Slip Zone Fault Milling Amorphous Material Consistency Limits

Benefit of laparoscopic liver resection in high body mass index patients

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World Journal of Gastroenterology 2016年第10期22卷 3015-3022页

作者： Hiroki Uchida Yukio Iwashita Kunihiro Saga Hiroomi Takayama kiminori Watanabe Yuichi Endo Kazuhiro Yada Masayuki Ohta Masafumi Inomata Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine

AIM: To explore the impact of body mass index(BMI) on surgical outcomes in patients undergoing laparoscopic liver resection(LLR).METHODS: From January 2010 to February 2015, sixty-eight patients who underwent primary partial liver resection in our institute were retrospectively reviewed. Surgical outcomes of LLR were compared with those of open liver resection(OLR). In addition, we analyzed associations with BMI and surgical ***: Among 68 patients, thirty-nine patients underwent LLR and 29 were performed OLR. Significant difference in operation time, blood loss, and postoperative hospital stay was observed. There were no signi ficant di fferences in mortali ty and morbidity in two groups. Twenty-two patients(32.4%) were classified as obese(BMI ≥ 25). A statistically significant correlation was observed between BMI and operation time, between BMI and blood loss in OLR, but not in LLR. The operation time and blood loss of OLR were significantly higher than that of LLR in obese patients. Open liver resection and BMI were independent predictors for prolonged operation time and increased blood loss in multivariate ***: The present study demonstrated that BMI had influenced to surgical outcomes of OLR. LLR was less influenced by BMI and had great benefit in obese patients.

关键词： Laparoscopic liver resection Obesity Body mass index Prolonged operation time Increased blood loss

Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第3期13卷 414-420页

作者： kiminori Uka Hiroshi Aikata Shintaro Takaki Hiroo Shirakawa Soo Cheol Jeong Keitaro Yamashina Akira Hiramatsu Hideaki Kodama Shoichi Takahashi Kazuaki Chayama Department of Medicine and Molecular Science Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Sciences Hiroshima University Hiroshima Japan

AIM: To assess the clinical features and prognosis of 151 patients with extrahepatic metastases from primary hepatocellular carcinoma (HCC), and describe the treatment strategy for such patients. METHODS: After the diagnosis of HCC, all 995 consecutive HCC patients were followed up at regular intervals and 151 (15.2%) patients were found to have extrahepatic metastases at the initial diagnosis of primary HCC or developed such tumors during the follow-up period. We assessed their clinical features, prognosis, and treatment strategies. RESULTS: The most frequent site of extrahepatic metastases was the lungs (47%), followed by lymph nodes (45%), bones (37%), and adrenal glands (12%). The cumulative survival rates after the initial diagnosis of extrahepatic metastases at 6, 12, 24, and 36 mo were 44.1%, 21.7%, 14.2%, 7.1%, respectively. The median survival time was 4.9 mo (range, 0-37 mo). Fourteen patients (11%) died of extrahepatic HCC, others died of primary HCC or liver failure. CONCLUSION: The prognosis of HCC patients with extrahepatic metastases is poor. With regard to the cause of death, many patients would die of intrahepatic HCC and few of extrahepatic metastases. Although most of HCC patients with extrahepatic metastases should undergo treatment for the primary HCC mainly, treatment of extrahepatic metastases in selected HCC patients who have good hepatic reserve, intrahepatictumor stage (T0-T2), and are free of portal venous invasion may improve survival.

关键词： Hepatocellular carcinoma Extrahepatic metastases Prognosis Causes of death

Glycolytic Synchronization in Yeast Cells via ATP and Other Metabolites: Mathematical Analyses by Two-Dimensional Reaction-Diffusion Models

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Natural Science 2014年第10期6卷 719-732页

作者： Hiroshi Serizawa Takashi Amemiya kiminori Itoh Graduate School of Environment and Information Sciences Yokohama National University Yokohama Japan

Possibilities of synchronized oscillations in glycolysis mediated by various extracellular metabolites are investigated theoretically using two-dimensional reaction-diffusion systems, which originate from the existing seven-variable model. Our simulation results indicate the existence of alternative mediators such as ATP and 1,3-bisphosphoglycerate, in addition to already known acetaldehyde or pyruvate. Further, it is also suggested that the alternative intercellular communicator plays a more important role in the respect that these can synchronize oscillations instantaneously not only with difference phases but also with different periods. Relations between intercellular coupling and synchronization mechanisms are also analyzed and discussed by changing the values of parameters such as the diffusion coefficient and the cell density that can reflect in tercellular coupling strength.

关键词： Acetaldehyde ATP Glycolytic Oscillation Intercellular Coupling Reaction-Diffusion Model Synchronization

CT/^(99m)Tc-GSA SPECT fusion images demonstrate functional differences between the liver lobes

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World Journal of Gastroenterology 2013年第21期19卷 3217-3225页

作者： Tatsuaki Sumiyoshi Yasuo Shima Ryoutarou Tokorodani Takehiro Okabayashi Akihito Kozuki Yasuhiro Hata Yoshihiro Noda Yoriko Murata Toshio Nakamura kiminori Uka Department of Gastroenterological Surgery Kochi Health Sciences CenterIke 2125KochiJapan Department of Radiology Kochi Health Sciences CenterIke 2125KochiJapan Department of Gastroenterology Kochi Health Sciences CenterIke 2125KochiJapan

AIM: To evaluate the functional differences between the 2 liver lobes in non-cirrhotic patients by using computed tomography/99mTc-galactosyl human serum albumin (CT/99mTc-GSA) single-photon emission computed tomography (SPECT) fusion images. METHODS: Between December 2008 and March 2012, 264 non-cirrhotic patients underwent preoperative liver function assessment using CT/99mTc-GSA SPECT fusion images. Of these, 30 patients, in whom the influence of a tumor on the liver parenchyma was estimated to be negligible, were selected. Specifically, the selected patients were required to meet either of the following criteria: (1) the presence of an extrahepatic tumor; or (2) presence of a single small intrahepatic tumor. These 30 patients were retrospectively analyzed to calculate the percentage volume (%Volume) and the percentage function (%Function) of each lobe. The ratio between the %Function and %Volume (function-to-volume ratio) of each lobe was also calculated, and the ratios were compared between the 2 lobes. Furthermore, the correlations between the function-to-volume ratio and each of 2 liver parameters [lobe volume and diameter ratio of the left portal vein to the right portal vein (LPV-to-RPV diameter ratio)] were investigated. RESULTS: The median values of %Volume and %Function were 62.6% and 67.1% in the right lobe, with %Function being significantly higher than %Volume (P < 0.01). The median values of %Volume and %Function were 31.0% and 28.7% in the left lobe, with %Function being significantly lower than %Volume (P < 0.01). The function-to-volume ratios of the right lobe (1.04-1.14) were significantly higher than those of the left lobe (0.74-0.99) (P < 0.01). The function-to-volume ratio showed no significant correlation between the lobe volume in either lobe. In contrast, the function-to-volume ratio showed significant correlations with the LPV-to-RPV diameter ratio in both lobes (right lobe: negative correlation, rs = -0.37, P = 0.048; left lobe: positive

关键词： Computed tomography 99mTc neogalactoalbumin Single-photon emission computed tomography Fusion image Liver Portal system