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Molecular Mechanisms Contributing to Resistance to Tyrosine Kinase-Targeted Therapy for Non-Small Cell Lung Cancer

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Clinical oncology and cancer researeh 2012年第1期9卷 18-22页

作者： Fariz Nurwidya Akiko murakami Fumiyuki Takahashi Kazuhisa Takahashi Department of Respiratory Medicine Juntendo University School of Medicine

One of the most important pathways in non-small cell lung cancer(NSCLC) is the epidermal growth factor receptor(EGFR) pathway. This pathway affects several crucial processes in tumor development and progression,including tumor cell proliferation,apoptosis regulation,angiogenesis,and metastatic *** EGFR is currently being intensely *** are witnessing the development of a number of potential molecular-inhibiting treatments for application in clinical *** the last decade,the tyrosine kinase(TK) domain of the EGFR was identified in NSCLC patients,and it has responded very well with a dramatic clinical improvement to TK inhibitors such are gefitinib and ***,there were primary and/or secondary resistance to these treatments,as shown by clinical *** molecular biology studies provided some explanations for the drug resistance *** molecular mechanisms of resistance need to be *** in-depth understanding of these targeted-therapy resistance may help us explore new strategies for overcoming or reversing the resistance to these inhibitors for the future of NSCLC treatment.

关键词： carcinoma non-small-cell lung mutation drug resistance

Seasonal Changes in the Circadian Rhythm of Gas Released from Harvested Cucumbers

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Natural Science 2022年第11期14卷 503-516页

作者： Osamu Takagi Masamichi Sakamoto kimiko Kawano Mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Vegetables and fruits are known to have long-lasting biological reactions even after harvesting. Volatile components may be released as a biological response to stimulation or injury. We measured the concentrations of volatiles released from the cut surfaces of cucumbers after their harvest and analyzed the relationship between the time the cucumbers were cut and gas concentrations. The results showed that gas concentrations indicate a circadian rhythm. We previously reported that the circadian rhythm of gas concentrations was 6 hours per cycle in the summer, i.e., from the vernal equinox to the autumnal equinox, and 24 hours per cycle in the winter, i.e., from the autumn equinox to the vernal equinox. We analyzed the gas concentrations emitted from cucumber sections in more detail in this paper and found that the circadian rhythms differ among winter, spring, summer, and autumn seasons. We found that one cycle of the circadian rhythm was 8 hours in winter, 6 hours in spring, 24 hours in summer, and a mixed cycle of 24 and 12 hours in autumn.

关键词： Cucumis sativus Biosensor Circadian Rhythm Season Gas Pyramid

Potential Power of the Pyramidal Structure IV: Discovery of Entanglement Due to Pyramid Effects

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Natural Science 2021年第7期13卷 258-272页

作者： Osamu Takagi Masamichi Sakamoto kimiko Kawano Mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

Since October 2007, we have been conducting rigorous scientific research on the unexplained “power” of a pyramidal structure (PS). From our research results so far, we could classify pyramid effects by the PS into the following two types: (i) the pyramid effects due to the potential power of the PS and (ii) the pyramid effects due to the influence of the test subject meditating inside the PS. We have been using edible cucumber sections as the biosensors. The pyramid effect existence was clarified by measuring and analyzing the concentration of volatile components released from the biosensors. The biosensors were arranged as a pair: one member of the pair was placed at the PS apex and the other was placed at the calibration control point 8.0 m away from the PS. In this paper, we report a new discovery regarding the type (i) pyramid effects. We discovered a phenomenon considered to be entanglement between the biosensor pairs detecting the pyramid effects. In other words, the biosensors at the PS apex, which were affected by the potential power of the PS, affected the biosensors at the calibration control point. We also confirmed that the effects on the biosensors placed at the calibration control point were not due to the potential power of the PS. Furthermore, we showed that the magnitude of the effect of entanglement changed with the seasons. We expect that our research results will be widely accepted in the future and will become the foundation for a new research field in science, with a wide range of applications.

关键词： Pyramid Potential Power Entanglement Meditation Non-Contact Effect Biosensor Cucumis sativus Gas Psi Index

Potential Power of the Pyramidal Structure VIII: Exploration of Periodic Diurnal Oscillation of Pyramid Power and Bio-Entanglement

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Natural Science 2023年第4期15卷 179-189页

作者： Osamu Takagi Masamichi Sakamoto kimiko Kawano Mikio Yamamoto International Research Institute (IRI) Chiba Japan Aquavision Academy Chiba Japan

To date, numerous books have been published on so-called “pyramid power” but there have been few academic papers on this subject other than our own. Since 2007, to demonstrate the pyramid power, we have undertaken strictly scientific experiments using a pyramidal structure (PS) that we have carefully constructed. In previous reports, we used the edible cucumber, Cucumis sativus as an effective and practical biosensor. Through measurement and analysis of volatile components (gas concentrations) emitted from the biosensor, we were able to demonstrate the existence of the pyramid power and revealed some of its characteristics. In a paper published in 2022, we showed that gas concentration release from this biosensor displayed a circadian rhythm and that this rhythm changed with the season. Based on the result that the biosensor had a periodic diurnal oscillation called a circadian rhythm, we questioned whether or not pyramid power and Bio-Entanglement also had periodic diurnal oscillations. In this paper, we investigated that possibility. Our results have shown that pyramid power and Bio-Entanglement do not exhibit significant periodic diurnal oscillations. Thus we have revealed for the first time that the field associated with pyramid power is a type of static field that always exerts a constant influence. We expect that our research results will be widely accepted in the future and will become the foundation for a new research field in science, with a wide range of applications.

关键词： Pyramid Potential Power Bio-Entanglement Diurnal Oscillation Biosensor Cucumis sativus Gas Psi Index

Retro-labyrinthine Lesion Site Detected by Galvanic Vestibular Stimulation Elicited Vestibular-evoked Myogenic Potentials in Patients with Auditory Neuropathy

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Current Medical Science 2021年第4期41卷 695-704页

作者： Zi-chen CHEN Yu-zhong ZHANG Huan-di ZHAO Xinyu WEI Toshihisa murofushi Juan HU Ying CHENG Fei-yun CHEN Xin-da XU Min XU Qing ZHANG Department of Otorhinolaryngology Headand Neck SurgerySecond Affiliated Hospital of Xi’an Jiaotong University School of MedicineXi’an710000China Department of Otorhinolaryngology-Head and Neck Surgery Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai200082China Shanghai Jiaotong University School of Medicine Ear Institute Shanghai200082China Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Shanghai200082China Department of Otolaryngology Teikyo University School of Medicine Mizonokuchi HospitalKawasaki213-0001Japan Department of Otorhinolaryngology Affiliated Ophthalmology and Otolaryngology Hospital of Fudan UniversityShanghai200082China

Objective Auditory neuropathy(AN)is a unique pattern of hearing loss with preservation of hair cell *** condition is characterized by the presence of otoacoustic emissions(OAE)or cochlear microphonic(CM)responses with severe abnormalities of the auditory brainstem response(ABR).The vestibular branches of the VIII cranial nerve and the structures innervated by it can also be ***,the precise lesion sites in the vestibular system are not well characterized in patients with *** The air-conducted sound(ACS)vestibular-evoked myogenic potentials(VEMPs)and galvanic vestibular stimuli(GVS)-VEMPs were examined in 14 patients with *** On examination of VEMPs(n=14,28 ears),the absent rates of ACS-cervical VEMP(cVEMP),ACS-ocular VEMP(oVEMP),GVS-cVEMP,GVS-oVEMP and caloric test were 92.9%(26/28),85.7%(24/28),67.9%(19/28),53.6%(15/28),and 61.5%(8/13),*** functions of the saccule,inferior vestibular nerve,utricle,superior vestibular nerve,and horizontal semicircular canal were found in 25.0%(7/28),67.9%(19/28),32.1%(9/28),53.6%(15/28)and 61.5%(8/13)patients,*** comparing the elicited VEMPs parameters of AN patients with those of normal controls,both ACS-VEMPs and GVS-VEMPs showed abnormal results in AN patients(such as,lower presence rates,elevated thresholds,prolonged latencies,and decreased amplitudes).Conclusion The study suggested that patients with AN often have concomitant vestibular ***-labyrinthine lesions were more frequently observed in this ***-VEMPs combined with ACS-VEMPs may help identify the lesion sites and facilitate detection of areas of vestibular dysfunction in these patients.

关键词： auditory neuropathy vestibular-evoked myogenic potentials galvanic vestibular stimulation air-conducted sound

Forecasting of Asian dust storm that occurred on May 10-13, 2011, using an ensemble-based data assimilation system

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Particuology 2016年第5期14卷 121-130页

作者： Keiya Yumimoto Hiroshi murakami Taichu Y. Tanaka Tsuyoshi T. Sekiyama Akinori Ogi Takashi Maki Meteorological Research Institute 1-1 Nagamine Tsukuba Ibaraki 305-0052 Japan Earth Observation Research Center Japan Aerospace Exploration Agency 2-1-1 Sengen Tsukuba Ibaraki 305-8505Japan Japan MeteorologicalAgency 1-3-40temachi Chiyoda-ku Tokyo lO0-8122Japan

An ensemble-based assimilation system that used the MASINGAR ink-2 （Model of Aerosol Species IN the Global AtmospheRe Mark 2） dust forecasting model and satellite-derived aerosol optical thickness （AOT） data. processed in the JAXA （Japan Aerospace Exploration Agency） Satellite Monitoring for Environmental Studies （JASMES） system with MODIS （Moderate Resolution Imaging Spectroradiometer） observations. was used to quantify the impact of assimilation on forecasts of a severe Asian dust storm during May 10-13. 2011. The modeled bidirectional reflectance function and observed vegetation index employed in JASMES enable AOT retrievals in areas of high surface reflectance, making JASMES effective for dust forecasting and early warning by enabling assimilations in dust storm source regions. Forecasts both with and without assimilation were validated using PM^0 observations from China, Korea, and Japan in the TEMM WG1 dataset. Only the forecast with assimilation successfully captured the contrast between the core and tail of the dust storm by increasing the AOT around the core by 70-150% and decreasing it around the tail by 20-30% in the 18-h forecast. The forecast with assimilation improved the agreement with observed PMlo concentrations, but the effect was limited at downwind sites in Korea and Japan because of the lack of observational constraints for a mis-forecasted dust storm due to cloud.

关键词： Data assimilation Aerosol transport model Ensemble Kalman filter Satellite observation Aerosol optical thickness Asian dust

Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment

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Bone Research 2017年第4期5卷 384-390页

作者： Yukio Nakamura Takako Suzuki Mikio Kamimura Kohei murakami Shota Ikegami Shigeharu Uchiyama Hiroyuki Kato Department of Orthopedic Surgery Shinshu University School of MedicineMatsumotoJapan Department of Orthopedic Surgery Showa-lnan General HospitalKornaganeJapan Center of Osteoporosis and Spinal Disorders Kamimura Orthopaedic ClinicMatsumotoJapan

To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group （18 cases） or a denosumab plus vitamin D supplementation group （combination group; 23 cases）. We measured serum bone alkaline phosphatase （BAP）, tartrate-resistant acid phosphatase （TRACP）-5b and urinary N-terminal telopeptide of type-I collagen （NTX） at baseline, 1 week, as well as at I month and 2, 4, 8 and 12 months. We also measured bone mineral density （BMD） of L1-4 lumbar vertebrae （L）-BMD and bilateral hips （H）-BMD at baseline and at 4, 8 and 12 months. There was no significant difference in patient background. TRACP-5b and urinary NTX were significantly suppressed in both groups from I week to 12 months （except at 12 months for NTX）. In the combination group, TRACP-5b was significantly decreased compared with the denosumab monotherapy group at 2 and 4 months （P 〈 0.05）. BAP was significantly suppressed in both groups at 2-12 months. L-BMD significantly increased at 8 and 12 months （8.9%） in the combination group and at 4, 8 and 12 months （6.0%） in the denosumab monotherapy group, compared with those before treatment. H-BMD was significantly increased in the combination group （3.6%） compared with the denosumab group （1.2%） at 12 months （P 〈 0.05）. Compared with denosumab monotherapy, combination therapy of denosumab with vitamin D and calcium stopped the decrease in calcium caused by denosumab, inhibited bone metabolism to a greater extent, and increased BMD （especially at the hips）.

关键词： BMD TRACP Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment NTX

Effect of process parameters on electrical,optical properties of IZO films produced by inclination opposite target type DC magnetron sputtering

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中国有色金属学会会刊：英文版 2009年第4期19卷 997-1000页

作者： Do-Hoon SHIN Yun-Hae KIM Joong-Won HAN Kyung-Man MOON Ri-Ichi murakami Korean Air Aerospace Division Department of Mechanical and Material Engineering Korea Maritime University Department of Mechanical Engineering The University of Tokushima

IZO films were deposited onto PET substrate at room temperature with the inclined opposite target type DC magnetron sputtering equipment,in which a sintered oxide IZO target(doped with 10% ZnO,packing density of 99.99%) was *** effects of total sputtering pressure and film thickness on IZO films properties were *** the films produced at room temperature have a amorphous structure,irrespective of the total sputtering pressure and film thickness.A resistivity of the order of 10-4 Ωcm was obtained for IZO films deposited at lower pressure(film thickness of 190 nm).The resistivity of IZO films deposited at room temperature depends on film thickness and shows a minimum at a thickness of 530 nm.

关键词：溅射薄膜工艺参数光学性能磁控直流类型薄膜厚度电力

Optimization of laser illumination configuration for directly driven inertial confinement fusion

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Matter and Radiation at Extremes 2017年第2期2卷 55-68页

作者： Masakatsu murakami Daiki Nishi Institute of Laser Engineering Osaka UniversityOsaka 565-0871Japan

Optimum laser configurations are presented to achieve high illumination uniformity with directly driven inertial confinement fusion *** axisymmetric absorption pattern of individual laser beams,theoretical models are reviewed in terms of the number of laser beams,system imperfection,and laser beam *** a self-organizing system of charged particles on a sphere,a simple numerical model is provided to give an optimal configuration for an arbitrary number of laser *** a result,such new configurations as“M48”and“M60”are found to show substantially higher illumination uniformity than any other existing direct drive systems.A new polar direct-drive scheme is proposed with the laser axes keeping off the target center,which can be applied to laser configurations designed for indirectly driven inertial fusion.

关键词： Analytical model Laser illumination design Polar direct drive Inertial confinement fusion