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非溶血性输血反应实验室分析的最新进展

国际输血及血液学杂志 2011年第1期34卷 90-94,F0003页

作者： hirayama F 俞丽(节译) 徐伟娟(审校) 不详浙江省血液中心杭州310006

非溶血性输血反应（NHTRs）是最常见的输血反应,包括输血相关急性肺损伤（TRALI）、过敏与发热.血液成分中的抗人类白细胞抗原（HLA）和人中性粒细胞抗原（HNA）白细胞抗体（Abs）通常与NHTRs相关,尤其是TRALI.最近,我们建立一个5-细胞... 详细信息

非溶血性输血反应（NHTRs）是最常见的输血反应,包括输血相关急性肺损伤（TRALI）、过敏与发热.血液成分中的抗人类白细胞抗原（HLA）和人中性粒细胞抗原（HNA）白细胞抗体（Abs）通常与NHTRs相关,尤其是TRALI.最近,我们建立一个5-细胞-谱系的免疫荧光试验,一个改进的粒细胞免疫荧光试验,以及一个能稳定表达HNAs细胞谱系,以有效检测抗HNA-1至5和其他抗中性粒细胞抗原抗体.

关键词：非溶血性输血反应实验室分析中性粒细胞抗原输血相关急性肺损伤免疫荧光试验人类白细胞抗原白细胞抗体抗中性粒细胞

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采用复合汞齐电极电池的组合型低温度系数标准电池

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中国检验检测 1978年第2期 41-43页

作者： Hiroyuki hirayama 胡衍瑞袁杰

一、前言约瑟夫森电压标准的技术近来得到惊人的发展。1975年第十四次电学谘询委员会决定用约瑟夫森效应来保持电压单位。并报导,已经就两种实质上不相同的约瑟夫森电压保存系统作了相互比较,其一致性达到1×10-8数量级。在用约瑟夫森... 详细信息

一、前言约瑟夫森电压标准的技术近来得到惊人的发展。1975年第十四次电学谘询委员会决定用约瑟夫森效应来保持电压单位。并报导,已经就两种实质上不相同的约瑟夫森电压保存系统作了相互比较,其一致性达到1×10-8数量级。在用约瑟夫森电压标准检定的周期之间,通常

关键词：标准电池电压标准低温度系数汞齐电极组合型

Persimmon Leaf Flavonols Enhance the Anti-Cancer Effect of Heavy Ion Radiotherapy on Murine Xenograft Tumors

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Journal of Cancer Therapy 2013年第7期4卷 1150-1157页

作者： Kayoko Kawakami Hiroshi Nishida Naoto Tatewaki Kiyomi Eguchi-Kasai Kazunori Anzai Takahiro Eitsuka Tetsuya Konishi Masao hirayama Laboratory of Nutritional Biochemistry Niigata University of Pharmacy & Applied Life Sciences Niigata Japan National Institute of Radiological Sciences Chiba Japan

The cell cycle checkpoint system play a pivotal role in the cellular DNA damage response, and the discovery of checkpoint inhibitors is expected to sensitize current cancer therapies. Checkpoint signaling cascades are critically modulated by ATM (ataxia telangiectasia-mutated) and its related molecules. Generally, ATM primarily responds to ionizing irradiation-induced DNA double-strand breaks. Heavy ions from an accelerated carbon ion beam have been used to cure cancer because they are more effective than ionizing irradiation such as X-ray and γ-radiation in terms of biological damage. In a previous study, we demonstrated that a persimmon leaf flavonol (PLF) promoted the cytotoxic effect of chemotherapeutic agents on cancer cells through inhibition of checkpoint activities, especially in the ATM dependent pathway. The present study investigated whether PLF inhibits checkpoint activity during the DNA damage response induced by heavy ion irradiation. Treatment with PLF significantly increased the cytotoxicity of heavy ion irradiation in A549 adenocarcinoma cells. The phosphorylation of checkpoint proteins such as p53, SMC1, and Chk1 was increased by heavy ions. PLF reduced the phosphorylation of checkpoint proteins. Pre-treatment with PLF significantly prevented the decrease of mitotic cells in heavy ion-exposed cells. We further evaluated tumor volume in SCID mice inoculated with human lung adenocarcinoma A549 cells. The combination treatment of PLF and heavy ion resulted in a decrease of tumor volume compared with controls, although PLF itself did not exhibit any effect. These results indicate that PLF inhibits tumor growth through modulation of the DNA damage response. PLF may be useful for clinical application in combination with heavy ion radiotherapy.

关键词： DNA Damage Checkpoint Persimmon Leaf Flavonols Heavy Ion Irradiation Xenograft

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日本三菱UEC-LS系列发动机的发展

柴油机 1988年第4期 7-11页

作者： Tsuneya.hirayama 杜孟华

现在的LS系列发动机是由UEC-LA系列机发展而来的一种长冲程型发动机,这种新系列发动机设计成低速超长冲程,行程缸径比为3.6,它具有预料中的未来船舶推进主机所需要的合适特性。在此系列机的研制过程中,对气缸套与活塞环之间的摩擦学问... 详细信息

现在的LS系列发动机是由UEC-LA系列机发展而来的一种长冲程型发动机,这种新系列发动机设计成低速超长冲程,行程缸径比为3.6,它具有预料中的未来船舶推进主机所需要的合适特性。在此系列机的研制过程中,对气缸套与活塞环之间的摩擦学问题进行了系统的研究,并将所得结果引入到LS系列机的设计中去了。 LS系列机的设计直接继承了LA系列机的设计方案。本文还提供了LS系列机最初车间试验的结果。

关键词：缸套活塞环长冲程摩擦学进油孔气缸油 UEC-LS 系列机发动机

Combined Effects of Blood Pressure and Aldosterone on Cardiac Left Ventricular Mass Index—Ethnic Differences between Kazakh, Uygur and Han Subjects

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World Journal of Cardiovascular Diseases 2014年第3期4卷 99-105页

作者： Masakatsu Ohta Yuji Kasamaki Yukio Ozawa Atsushi hirayama Tomohiro Nakayama Hiroshi Kawamura Dilxat Himit Masayoshi Soma Yoichi Izumi Department of Cardiology Kanazawa Medical University Himi Municipal Hospital Himi Japan Department of Internal Medicine Nippon Dental University Tokyo Japan Department of Science and Research Xinjiang Medical University Urumqi China Division of Cardiology Department of Medicine Nihon University School of Medicine Tokyo Japan Division of General Medicine Department of Medicine Nihon University School of Medicine Tokyo Japan Division of Laboratory Medicine Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan

Previous Background: Hemodynamic factors, like blood pressure, have been established to be major determinants of cardiac left ventricular structure. However, several factors other than blood pressure to influence cardiac mass have been implicated. When we did medical survey, cardiac left ventricular mass index (LVMI) of one ethnic group that had higher blood pressure was found to be smaller than that of the other ethnic groups with a lower blood pressure. Such contradicted data from the present study were analyzed combining blood pressure, LVMI and chemical parameters obtained from blood and urine. Methods: In a medical survey conducted in Xinjiang, China, 279 people (65 - 70 years old) from three ethnic groups (Kazakh, Uygur and Han) from two separated regions provided blood and urine samples and underwent echocardiography and 24-h ambulatory blood pressure monitoring (ABPM). Results: Systolic and diastolic blood pressure obtained from ABPM and urinary sodium excretion values were significantly higher in Kazakh than that in Uygur and Han. However, LVMI in Kazakh was lower than that in other 2 groups. Plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were significantly lowest in Kazakh. The values of LVMI in all ethnic groups were positively related to both blood pressure and PAC. An inverse correlation was identified between PAC and urinary sodium excretion value. Conclusion: Although higher blood pressure in Kazakh subjects, their LVMI was lower than those of Uygur and Han, whose blood pressure was lower than that in Kazakh. These results suggest that blood pressure is not always a determinant for LVMI value. There is a possibility that relatively lower PAC resulted from higher sodium intake suppressed the rise in LVMI caused by higher blood pressure in Kazakh.

关键词： Left Ventricular Mass Aldosterone Blood Pressure Salt Intake

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三菱UEC LS新系列长行程船用柴油机

柴油机 1988年第2期 11-12页

作者： Yoshinori hirayama 蒋国鑫

三菱重工自1955年起就生产UE系列二冲程船用柴油机,这些年来对该系列不断开发,现又推出一种新的长行程LS系列机型(图1)。这种新的LS系列机的活塞行程加长15％,转速下降10％、功率提高15％。此外,LS系列机还保留着LA系列机的低油耗、装... 详细信息

三菱重工自1955年起就生产UE系列二冲程船用柴油机,这些年来对该系列不断开发,现又推出一种新的长行程LS系列机型(图1)。这种新的LS系列机的活塞行程加长15％,转速下降10％、功率提高15％。此外,LS系列机还保留着LA系列机的低油耗、装船简便和维护保养方便等传统特色。 LS系列有60LS和52LS两种型号,功率范围1134～14323kW,可广泛满足各种深水船舶的动力需求。这种柴油机持续运行状态时的平均有效压力为17bar,采用MET-SC型增压器。从试验台试验获得,在100％输出功率和扫气压力

关键词：船用柴油机长行程 UEC LS 船舶柴油机系列机扫气口 LS

Effects of Water Immersion in Different Water Depths on Respiratory Function and Respiratory Muscle Strength among Elderly People: An Observational Study

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Advances in Aging Research 2021年第4期10卷 71-77页

作者： Yoshihiro Yamashina Tomoko hirayama Hiroki Aoyama Hirofumi Hori Emiko Morita Nami Sakagami Wataru Nanikawa Shigeru Terada Masahiro Goto Kazuyuki Tabira Department of Physical Therapy Aino University Osaka Japan Department of Physical Therapy Biwako Professional University of Rehabilitation Shiga Japan Department of Physical Therapy Kio University Nara Japan

The aim was to investigate the effect of three water levels (umbilical, 4th rib, and clavicular) on the respiratory function and respiratory muscle strength among elderly. Spirometry and respiratory strength were measured on land as baseline data. Next, water depth conditions were determined randomly, and spirometry and respiratory muscle strength were measured at each water level. The Vital Capacity and Expiratory reserve volume in the clavicular level were significantly lower than those in the land and umbilical trials. No significant difference was observed in other respiratory functions. Chest circumference and respiratory muscle strength were not significantly different among all conditions.

关键词： Respiratory Functions Respiratory Muscle Strength Water Immersion Elderly People

High concentrations of human β-defensin 2 in gastric juice of patients with Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第31期11卷 4782-4787页

作者： Hajime Isomoto Hiroshi Mukae Hiroshi Ishimoto Yoshito Nishi Chun-Yang Wen Akihiro Wad Ken Ohnita Toshiya hirayama Masamitsu Nakazato Shigeru Kohno Second Department of Internal Medicine Nagasaki University School of Medicine Sakamoto 1-7-1Nagasaki Japan Department of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School of MedicineSakamoto 12-4 Nagasaki Japan Department of Bacteriology Institute of Tropical Medicine Nagasaki University School of Medicine Sakamoto 12-4 Nagasaki Japan Third Department of Internal Medicine Miyazaki Medical College Kiyotake Miyazaki Japan

AIM: Human β-defensin (HBD)-1 and HBD-2 are endogenous antimicrobial peptides. Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice duringH pylori ***: HBD-1 and HBD-2 concentrations were measured by radioimmunoassay in plasma and gastric juice of 49 H pylori-infected and 33 uninfected subjects and before and after anti-H pyloritreatment in 13 patients with H pylori-associated gastritis. Interleukin (IL)-1β and IL-8 concentrations in gastric juice were measured by enzyme-linked immunosorbent assay (ELISA). Histological grades of gastritis were determined using two biopsy specimens taken from the antrum and corpus. Reverse phase high performance liquid chromatography (RP-HPLC)was used to identify ***: HBD-2 concentrations in gastric juice, but not in plasma, were significantly higher in H pylori-positive than -negative subjects, albeit the post-treatment levels were unchanged. Immunoreactivity for HBD-2 was exclusively identified in H pylori-infected mucosa by RPHPLC. HBD-2 concentrations in gastric juice correlated with histological degree of neutrophil and mononuclear cell infiltration in the corpus. IL-1β levels correlated with those of IL-8, but not HBD-2. Plasma and gastric juice HBD-1concentrations were similar in H pylori-infected and uninfected ***: Our results place the β-defensins, especially HBD-2, in the front line of innate immune ***, HBD-2 may be involved in the pathogenesis of H pylori-associated gastritis, possibly through its function as immune and inflammatory mediator.

关键词： β-防御素2 胃液胃疾病幽门螺杆菌细菌感染

Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis

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World Journal of Gastroenterology 2013年第17期19卷 2718-2722页

作者： Hideo Suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki hirayama Ichinosuke Hyodo Department of Gastroenterology Institute of Clinical Medicine University of Tsukuba Graduate School Center of Integrative Medicine Tsukuba University of Technology

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation.

关键词： Qing Dai Herbal medicine Ulcerative colitis Hydroxyl radical Electron spin resonance