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Diabetes exacerbates inflammatory bowel disease in mice with dietinduced obesity

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World Journal of Gastroenterology 2023年第33期29卷 4991-5004页

作者： Kendra L Francis kimberly m.alonge maria Cristina Pacheco Shannon J Hu Cody A Krutzsch Gregory J morton michael W Schwartz Jarrad m Scarlett Department of Pediatric Gastroenterology and Hepatology Seattle Children’s HospitalSeattleWA 98105United States 不详 Department of medicinal Chemistry University of WashingtonSeattleWA 98195United States Department of Laboratory medicine and Pathology Seattle Children's HospitalSeattleWA 98105United States

BACKGROUND The increased prevalence of inflammatory bowel disease(IBD)among patients with obesity and type 2 diabetes suggests a causal link between these diseases,potentially involving the effect of hyperglycemia to disrupt intestinal barrier *** To investigate whether the deleterious impact of diabetes on the intestinal barrier is associated with increased IBD severity in a murine model of colitis in mice with and without diet-induced *** mice were fed chow or a high-fat diet and subsequently received streptozotocin to induce diabetic-range *** weeks later,dextran sodium sulfate was given to induce *** select experiments,a subset of diabetic mice was treated with the antidiabetic drug dapagliflozin prior to colitis *** included both clinical and histological measures of colitis activity as well as histochemical markers of colonic epithelial barrier *** In mice given a high-fat diet,but not chow-fed animals,diabetes was associated with significantly increased clinical colitis activity and histopathologic markers of disease *** was also associated with a decrease in key components that regulate colonic epithelial barrier integrity(colonic mucin layer content and epithelial tight junction proteins)in diet-induced obese *** of these effects of diabetes in diet-induced obese mice was ameliorated by restoring *** In obese mice,diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of ***-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis *** findings suggest that effective diabetes management may decrease the clinical severity of IBD.

关键词： Inflammatory bowel disease Type 2 diabetes Obesity Intestinal barrier Hyperglycemia Colitis in mice Tight junction proteins

Budd-Chiari syndrome:A single-center experience

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World Journal of Gastroenterology 2014年第43期20卷 16236-16244页

作者： Tanya m Pavri Alan Herbst Rajender Reddy kimberly A Forde Division of Gastroenterology and Hepatology Perelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104United States Center for Clinical Epidemiology and Biostatistics Perelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104United States

AIm: To investigate challenges, risk factors, prognostic indicators, and treatment outcomes associated with Budd-Chiari syndrome (BCS) at a tertiary care center.

关键词： Budd-Chiari syndrome Transjugular intrahepatic portosystemic shunt Liver transplantation Anticoagulation Hepatic vein thrombosis

The Psb32 Protein Aids in Repairing Photodamaged Photosystem II in the Cyanobacterium Synechocystis 6803

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molecular Plant 2011年第6期4卷 1052-1061页

作者： kimberly m. Wegener Stefan Bennewitz Ralf Oelmuller Himadri B. Pakrasi Department of Biology Washington University St Louis MO 63130 USA Present address： Division of Biological Sciences University of Missouri Columbia MO 65211 USA Institute of Plant Physiology Friedrich-Schiller-University Jena Dornburger Str. 159 D-07743 Jena Germany

Photosystem II （PSII）, a membrane protein complex, catalyzes the photochemical oxidation of water to molecular oxygen. This enzyme complex consists of approximately 20 stoichiometric protein components. However, due to the highly energetic reactions it catalyzes as part of its normal activity, PSII is continuously damaged and repaired. With advances in protein detection technologies, an increasing number of sub-stoichiometric PSII proteins have been identified, many of which aid in the biogenesis and assembly of this protein complex. Psb32 （SII1390） has previously been identified as a protein associated with highly active purified PSII preparations from the cyanobacterium Synechocystis sp. PCC 6803. To investigate its function, the subcellular localization of Psb32 and the impact of deletion of the psb32 gene on PSII were analyzed. Here, we show that Psb32 is an integral membrane protein, primarily located in the thylakoid membranes. Al- though not required for cell viability, Psb32 protects cells from oxidative stress and additionally confers a selective fitness advantage in mixed culture experiments. Specifically, Psb32 protects PSII from photodamage and accelerates its repair. Thus, the data suggest that Psb32 plays an important role in minimizing the effect of photoinhibition on PSII.

关键词： Photosynthesis reactive oxygen species photoinhibition photodamage.

Perforated duodenal ulcer:An unusual manifestation of allergic eosinophilic gastroenteritis

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World Journal of Gastroenterology 2015年第44期21卷 12709-12712页

作者： Kevin m Riggle Ghassan Wahbeh Elizabeth m Williams kimberly J Riehle Department of General Surgery University of Washington Seattle Division of Gastroenterology Seattle Children’s Hospital Seattle Division of Pathology Seattle Children’s Hospital Seattle Division of Pediatric General and Thoracic Surgery Seattle Children’s Hospital

Spontaneous perforation of a duodenal ulcer secondary to allergic eosinophilic gastroenteritis(EGE) has not been previously reported. We present such a case in a teenager who presented with peritonitis. After exploration and operative repair of his ulcer, he continued to experience intermittent abdominal pain, and further evaluation revealed eosinophilic gastroenteritis in the setting of multiple food allergies. His EGE resolved after adhering to a restrictive diet. Both duodenal ulcers and EGE are very rarely seen in pediatric patients. EGE has a variable presentation depending on the layer(s) of bowel wall affected and the segment of the gastrointestinal tract that is involved. Once diagnosed, it may respond to dietary changes in patients with recognized food allergies, or to steroids in patients in whom an underlying cause is not identified. Our case highlights the need to keep EGE in the differential diagnosis when treating pediatric patients with duodenal ulcers. The epidemiology, pathophysiology, and treatment of EGE are also discussed, along with a review of the current literature.

关键词： Pediatric Duodenal ulcer Eosinophilic Gastroenteri

Application of reprogrammed patient cells to investigate the etiology of neurological and psychiatric disorders

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Frontiers in Biology 2012年第3期7卷 179-188页

作者： kimberly m. CHRISTIAN Hongjun SONG Guo-li mING Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA The Solomon Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA

Cellular reprogramming allows for the de novo generation of human neurons and glial cells from patients with neurological and psychiatric disorders. Crucially, this technology preserves the genome of the donor individual and thus provides a unique opportunity for systematic investigation of genetic influences on neuronal pathophysiology. Although direct reprogramming of adult somatic cells to neurons is now possible, the majority of recent studies have used induced pluripotent stem cells （iPSCs） derived from patient fibroblasts to generate neural progenitors that can be differentiated to specific neural cell types. Investigations of monogenic diseases have established proof-of-principle for many aspects of cellular disease modeling, including targeted differentiation of neuronal populations and rescue of phenotypes in patient iPSC lines. Refinement of protocols to allow for efficient generation of iPSC lines from large patient cohorts may reveal common functional pathology and genetic interactions in diseases with a polygenic basis. We review several recent studies that illustrate the utility of iPSC-based cellular models of neurodevelopmental and neurodegenerative disorders to identify novel phenotypes and therapeutic approaches.

关键词： reprogramming iPSCs neurodevelopment neurodegeneration

Increased Benthic Algal Primary Production in Response to the Invasive Zebra mussel (Dreissena polymorpha) in a Productive Ecosystem,Oneida Lake,New York

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Journal of Integrative Plant Biology 2008年第11期50卷 1452-1466页

作者： Rebecca K.Cecala Christine m.mayer kimberly L.Schulz Edward L.mills Biology Department Syracuse University Biology Deptartment Department of Environmental Sciences and Lake Erie Center University of Toledo State University of New York School of Environmental Science and Forestry Cornell Biological Field Station and Department of Natural Resources Cornell University

Increased water clarity associated with zebra mussel （Dreissena polymorpha） populations may favor benthic algal primary production in freshwater systems previously dominated by pelagic phytoplankton production. While zebra mussel-mediated water clarity effects on benthic primary production have been implicated in published reports, few production estimates are available. This study estimates benthic primary production in Oneida Lake, NY before and after zebra mussel invasion （1992）, using measured photosynthetic parameters （P^Bmax, α^β and β） from sampled benthic algal communities. In the summers of 2003 and 2004, primary production was measured as O2 evolution from algal communities on hard （cobble） and soft （sediment） substrate from several depths. We also backcast estimates of benthic primary production from measurements of light penetration since 1975. Estimates of whole-lake epipelic and epilithic algal primary production showed a significant （4%） increase and exhibited significantly less interannual variability subsequent to the establishment of zebra mussels. We applied our model to two lakes of differing trophic status; the model significantly overestimated benthic primary production in a hypereutrophic lake, but there was no significant difference between the actual and predicted primary production values in the oligotrophic lake. The hypereutrophic lake had higher zebra mussel densities than Oneida （224 vs. 41 per sample respectively）. Though total community respiration （measured in total darkness） was factored into our model predictions of production, our model may need modification when heterotrophic respiration is a large portion of total community metabolism.

关键词： Dreissena ecosystem engineering nonindigenous species Oneida Lake periphyton primary production.

INVERSE BORN SERIES FOR SCALAR WAVES

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Journal of Computational mathematics 2012年第6期30卷 601-614页

作者： kimberly Kilgore Shari moskow John C. Schotland Department of mathematics Drexel University Philadelphia PA 19104 USA Department of mathematics University of Michigan Ann Arbor MI 48109 USA

We consider the inverse scattering problem for scalar waves. We analyze the conver- gence of the inverse Born series and study its use in numerical simulations for the case of a spherically-symmetric medium in two and... 详细信息

关键词： Inverse scattering.

Another look at silent circulation of poliovirus in small populations

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Infectious Disease modelling 2018年第1期3卷 107-117页

作者： Dominika A.Kalkowska Radboud J.Duintjer Tebbens kimberly m.Thompson Kid Risk Inc.605 N.High St.#253ColumbusOH 43215USA

Background:Silent circulation of polioviruses complicates the polio endgame and motivates analyses that explore the probability of undetected circulation for different scenarios.A recent analysis suggested a relatively high probability of unusually long silent circulation of polioviruses in small populations(defined as 10,000 people or smaller).methods:We independently replicated the simple,hypothetical model by Vallejo et al.(2017)and repeated their analyses to explore the model behavior,interpretation of the results,and implications of simplifying ***:We found a similar trend of increasing times between detected cases with increasing basic reproduction number(R0)and population ***,we found substantially lower estimates of the probability of at least 3 years between successive polio cases than they reported,which appear more consistent with the prior *** small and isolated populations may sustain prolonged silent circulation,our reanalysis suggests that the existing rule of thumb of less than a 5%chance of 3 or more years of undetected circulation with perfect surveillance holds for most conditions of the model used by Vallejo et *** most realistic ***:Avoiding gaps in surveillance remains critical to declaring wild poliovirus elimination with high confidence as soon as possible after the last detected poliovirus,but concern about transmission in small populations with adequate surveillance should not significantly change the criteria for the certification of wild polioviruses.

关键词： Polio Small populations Silent circulation Stochastic modeling

Associations between extracurricular activity participation and health-related variables in underrepresented children

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Sports medicine and Health Science 2020年第2期2卷 102-108页

作者： Jeanette m.Ricci kimberly A.Clevenger Sandra Sellers Sharon Davenport Karin A.Pfeiffer michigan State University 308 W Circle DrEast LansingMI48823USA Crim Fitness Foundation 452 S.Saginaw StSuite 1FlintMI48502USA

Background:Children from underrepresented populations exhibit low levels of physical activity(PA),diet quality,and health-related quality of life(QoL),but participation in extracurricular activities may positively impact these health ***:To examine differences in PA,dietary behavior,and QoL in underrepresented children by extracurricular activity dose(0,1,≥2)and type(sports,dance/martial arts,art/music).methods:Children(N=754;Grades 4–6)completed the Physical Activity Questionnaire for Children,KidsScreen-27(QoL),and the School Physical Activity and Nutrition Survey and self-reported extracurricular activity ***-way mANOVA tests were used in this ***:Individuals participating in 1 and≥2 activities(pmartial arts(pmusic(p=0.029)had higher PA than *** participating in≥2 activities reported higher fruit intake compared to 1 activity and non-participants(p=0.009;pmpared to non-participants(p=0.001;p=0.025,respectively).Conclusions:Extracurricular activity participation was positively associated with health behaviors in underrepresented *** may be encouraged to allocate some of their resources to extracurricular activity programing.

关键词： Physical activity Dietary behavior Quality of life Youth Sport participation