检索结果-南通市图书馆

Neuropsychological Assessment of Learning and Memory in Rats Following Ketamine Exposure during Late Adolescence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Behavioral and Brain Science 2020年第12期10卷 568-589页

作者： Julianna M. Davis David Compton Miranda Heit Ashley Fravel kimberly wood Department of Psychology Behavioral Neuroscience Program Palm Beach Atlantic University West Palm Beach USA

With the prevalent issue of drug abuse in society, research regarding the effects of ketamine, a drug frequently abused by youth in club settings, has increased. Despite its potential for misuse, ketamine has demonstrated potential as a fast-acting antidepressant and seems to work well for relieving treatment-resistant depression. However, previous research has shown ketamine use may cause impairments in frontal and medial temporal lobe functioning, leading to problems with memory. While under the influence of ketamine, individuals also display problems with spatial working memory when compared to individuals not dosed with ketamine. The majority of previous research has examined the short-term impact of ketamine use with studies on neurodevelopment largely confined to postnatal exposure. In the present study, the long-term effects on memory caused by repeated ketamine exposure during late adolescence were examined. Rats were used as nonhuman models in order to investigate the cognitive risks resulting from chronic use of ketamine. The results indicated that low-ketamine dosed rats demonstrated significantly better spatial memory recall compared to high-ketamine dosed rats. In addition, high-ketamine dosed rats appeared to struggle more with working memory than the rats in the low-ketamine and control groups. Similarly, both drug groups showed significantly more working memory and reference memory errors than the control group. This indicates that higher doses of ketamine during late adolescence may cause working and spatial memory impairments later in life.

关键词： Ketamine Memory Impairments Long-Term Effects Spatial Memory Working Memory

Unusually aggressive primary cloacogenic carcinoma of the vulva: A case report and literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2013年第5期2卷 302-305页

作者： Rajni Chibbar kimberly A. wood Christopher K. Giede Anita Agrawal College of Medicine University of Saskatchewan Saskatoon Canada Department of Obstetrics and Gynecology Royal University Hospital Saskatoon Canada Department of Obstetrics and Gynecology University of Saskatchewan Saskatoon Canada Department of Pathology University of Saskatchewan Saskatoon Canada

Vulvar cancer is an uncommon tumor and represents 3%-5% of all female genital tract malignancies. The overall incidence is 1.5/100,000 women. Histopathologically the vast majority (90%) are squamous cell carcinomas. Primary cloacogenic carcinoma of the vulva is extremely rare with less than 20 cases reported in English literature [1]. These tumors are thought to arise from embryonic or ectopic rests of cloacogenic tissue. The majority of these reported cases is relatively indolent cancer, only one case of cloacogenic carcinoma of the vulva reported metastatic spread to the inguinal lymph nodes and none that describe distant metastases. Here we present an aggressive and diagnostically challenging case of cloacogenic carcinoma of the vulva and a review of current literature to date.

关键词： Cloacogenic Vulvar Cancer Metastasis

A case of kidney metastasis in vulvar squamous cell carcinoma: A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2013年第5期2卷 306-309页

作者： Anita Agrawal kimberly A. wood Christopher K. Giede Rajni Chibbar College of Medicine University of Saskatchewan Saskatoon Canada Department of Obstetrics and Gynecology Royal University Hospital Saskatoon Canada Department of Obstetrics and Gynecology University of Saskatchewan Saskatoon Canada Department of Pathology Royal University Hospital Saskatoon Canada

Vulvar cancer is an uncommon tumor and represents 3%-5% of all female genital tract malignancies. Squamous cell carcinoma (SCC) is the most common carcinoma of the vulva. Distant metastasis of recurrent vulvar squamous cell carcinoma is rare and occurs late in the disease process. We report the first case of kidney metastasis from a vulvar squamous cell carcinoma in a 68-year-old Caucasian female. On initial presentation she was treated with radical vulvectomy, upper urethrectomy with bilateral inguinal and deep femoral lymph node dissection. She was staged as FIGO stage IVA and also received adjuvant chemo-radiation. She remained in remission for 24 months. Subsequently she was found to have a kidney tumor and underwent nephrectomy and was diagnosed with metastatic squamous cell carcinoma from the vulva to the kidney. In cases of recurrent vulvar carcinoma distant metastasis to the bones, breast, and brain is only rarely reported. Metastasis to kidneys from vulvar carcinoma is exceptionally rare with no reported cases in the literature. Renal metastasis should be considered in the differential diagnosis of kidney tumor in this group of women.

关键词： Vulva Squamous Cell Carcinoma Kidney Metastasis

Phase transitions between tropical,subtropical,and extratropical cyclones:A review from IWTC-10

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tropical Cyclone Research and Review 2023年第4期12卷 294-308页

作者： kimberly wood Wataru Yanase Jack Beven Suzana J.Camargo Joseph B.Courtney Chris Fogarty Junya Fukuda Naoko Kitabatake Matthew Kucas Ron McTaggart-Cowan Michelle Simoes Reboita Jacopo Riboldi The University of Arizona ArizonaUSA Meteorological Research Institute IbarakiJapan National Hurricane Center MiamiUSA Lamont-Doherty Earth Observatory Columbia UniversityPalisadesUSA Bureau of Meteorology MelbourneAustralia Canadian Hurricane Center Nova ScotiaCanada Japan Meteorological Agency TokyoJapan Meteorological College ChibaJapan Joint Typhoon Warning Center HonoluluUSA Environment and Climate Change Gatineau QuebecCanada Federal University of Itajuba ItajubaBrazil ETH Zurich ZurichSwitzerland

This review,which was adapted from a Tenth International Workshop on Tropical Cyclones(IWTC-10)report,discusses research findings and operational practices relevant to cyclone types and phase transitions(extratropical,subtropical,and tropical).The cyclone phase space(CPS)method is widely used in both historical investigations and real-time evaluation of cyclone type and transition;however,CPS parameter values depend on input data resolution,and universal thresholds do not currently exist to delineate when a cyclone transitions from one type to *** of phase transitions in a changing climate highlight potential latitude shifts in extratropical transition and increased potential for tropical transition,but realistic projections of future trends likely require high-resolution simulations that can capture the cyclone warm *** meteorological centers apply varied approaches to cyclone classification via CPS parameters and other criteria,some of which depend on the tropical basin,yet these approaches cannot fully address challenges in operational classification and subsequently in communicating risks associated with these phase *** recommend a multivariate historical assessment of tropical and subtropical cyclones across all basins in which they occur,including the South Atlantic Ocean and the Mediterranean Sea,to identify the potential for a more universal cyclone classification approach that meets operational needs.

关键词： Tropical cyclone Subtropical cyclone Extratropical transition Tropical transition

RECENT ADVANCES IN RESEARCH AND FORECASTING OF TROPICAL CYCLONE TRACK, INTENSITY, AND STRUCTURE AT LANDFALL

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tropical Cyclone Research and Review 2018年第2期7卷 85-105页

作者： MARIE-DOMINIQUE LEROUX kimberly wood RUSSELL L.ELSBERRY ESPERANZA O.CAYANAN ERIC HENDRICKS MATTHEW KUCAS PETER OTTO ROBERT ROGERS BUCK SAMPSON ZIFENG YU Météo-France DIROI/EC Mississippi State University University of Colorado-Colorado Springs Philippine Atmospheric Geophysical and Astronomical Services Administration Naval Postgraduate School Joint Typhoon Warning Center Bureau of Meteorology NOAA/AOML/Hurricane Research Division Naval Research Laboratory Shanghai Typhoon Institute and Laboratory of Typhoon Forecast Technique China Meteorological Administration

This review prepared for the fourth International Workshop on Tropical Cyclone Landfall Processes(IWTCLP-4) summarizes the most recent(2015-2017) theoretical and practical knowledge in the field of tropical cyclone(TC) track, intensity, and structure rapid changes at or near landfall. Although the focus of IWTCLPIV was on landfall, this summary necessarily embraces the characteristics of storms during their course over the ocean prior to and leading up to landfall. In the past few years, extremely valuable observational datasets have been collected for TC forecasting guidance and research studies using both aircraft reconnaissance and new geostationary or low-earth orbiting satellites at high temporal and spatial resolution. Track deflections for systems near complex topography such as that of Taiwan and La Réunion have been further investigated, and advanced numerical models with high spatial resolution necessary to predict the interaction of the TC circulation with steep island topography have been developed. An analog technique has been designed to meet the need for longer range landfall intensity forecast guidance that will provide more time for emergency preparedness. Probabilistic track and intensity forecasts have also been developed to better communicate on forecast uncertainty. Operational practices of several TC forecast centers are described herein and some challenges regarding forecasts and warnings for TCs making landfall are identified. This review concludes with insights from both researchers and forecasters regarding future directions to improve predictions of TC track, intensity, and structure at landfall.

关键词： tropical cyclone track intensity structure landfall rapid intensification rapid changes

Neurocircuit regeneration by extracellular matrix reprogramming

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian N.Levasseur kimberly M.Alonge Department of Medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Evolutionary responses to climate change and contaminants： Evidence and experimental approaches

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2015年第4期61卷 690-701页

作者： David A. kimberly Department of Biology Westminster College 442 Meldrum Science Center Salt Lake City UT 84105 USA Department of Environmental Toxicology The Institute of Environmental and Human Health Texas Tech University 1207 Gilbert Drive Lubbock Texas 79416 USA Environmental Science and Studies Program Towson University 8000 York Rd. Towson MD 21252 USA

A fundamental objective within ecotoxicology lies in understanding and predicting effects of contaminants. This ob- jective is made more challenging when global climate change is considered as an environmental stress that co-occurs with con- taminant exposure. In this multi-stressor context, evolutionary processes are particularly important. In this paper, we consider several non-＂omic＂ approaches wherein evolutionary responses to stress have been studied and discuss those amenable to a mul- tiple stressor context. Specifically, we discuss common-garden designs, artificial and quasi-natural selection, and the estimation of adaptive potential using quantitative genetics as methods for studying evolutionary responses to contaminants and climate change in the absence of expensive molecular tools. While all approaches shed light on potential evolutionary impacts of stressor exposure, they also have limitations. These include logistical constraints, difficulty extrapolating to real systems, and responses tied strongly to specific taxa, populations, and/or testing conditions. The most effective way to lessen these inherent limitations is likely through inclusion of complementary physiological and molecular tools, when available. We believe that an evolutionary context to the study of contaminants and global climate change is a high priority in ecotoxicology and we outline methods that can be implemented by almost any researcher but will also provide valuable insights [Current Zoology 61 （4）： 690-701, 2015].

关键词： Climate change Multiple stressors Adaptation Experimental evolution Quantitative genetics

Behavioral effects of social challenges and genomic mechanisms of social priming： What＇s testosterone got to do with it？

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2014年第6期60卷 791-803页

作者： kimberly A. ROSVALL Mark E PETERSON Indiana University Department of Biology and Center for the Integrative Study of Animal Behavior Bloomington IN 47405 USA Viterbo University Departments of Biology and Mathematics La Crosse WI 54601 USA

Social challenges from rival conspecifics are common in the lives of animals, and changes in an animal＇s social environment can influence physiology and behavior in ways that appear to be adaptive in the face of continued social instability （i.e. social priming）. Recently, it has become clear that testosterone, long thought to be the primary mediator of these effects, may not always change in response to social challenges, an observation that highlights gaps in our understanding of the proximate me- chanisms by which animals respond to their social environment. Here, our goal is to address the degree to which testosterone me- diates organismal responses to social cues. To this end, we review the behavioral and physiological consequences of social chal- lenges, as well as their underlying hormonal and gene regulatory mechanisms. We also present a new case study from a wild songbird, the dark-eyed junco Junco hyemalis, in which we find largely divergent genome-wide transcriptional changes induced by social challenges and testosterone, respectively, in muscle and liver tissue. Our review underscores the diversity of mechani- sms that link the dynamic social environment with an organisms＇ genomic, hormonal, and behavioral state. This diversity among species, and even among tissues within an organism, reveals new insights into the pattern and process by which evolution may alter proximate mechanisms of social priming.

关键词： Social priming Challenge hypothesis Aggression Hormonal mechanism Testosterone Genomics

Screening Helicobacter pylori genes induced during infection of mouse stomachs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第32期18卷 4323-4334页

作者： Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G wood Yisheng Ni kimberly Smith Sharon H Jackson William G Coleman Laboratory of Biochemistry and Genetics National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 20892 United States Laboratory of Host Defenses National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD 20892 United States

AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(***) as it relates to its survival in the ***:In vivo expression technology(IVET) systems are used to identify microbial virulence *** modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and *** novel IVET systems were developed by the fusion of random Sau3A DNA fragments of *** and a tandem-reporter system of chloramphenicol acetyltransferase and ***,each vector contains a kanamycin resistance *** used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that *** expresses in *** expression studies were conducted by infecting RAW 264.7 cells with *** was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced ***:In this study,we have identified 31 in vivo induced(ivi) genes in the initial *** 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse *** factors,vacA and cagA,were found in this screen and are known to play important roles in *** infection,colonization and *** detection validates the efficacy of these screening *** of the identified ivi genes have already been implicated to play an important role in the pathogenesis of *** and other bacterial pathogens such as Escherichia coli and Vibrio *** profiles of allivi genes were confirmed by real time PCR analysis of *** RNA isolated from *** infected RAW 264.7 *** compared the expression profile of *** and RAW 264.7 coculture with that of *** *** ge

关键词： Helicobacter pylori In vivo expression technology Virulence genes Mice Infection