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The virtual peripheral nerve academy:education for the identification and treatment of peripheral nerve disorders

Plastic and Aesthetic Research 2022年第1期9卷 707-715页

作者： Erica B.Lee Allison Podsednik kimberly khoo Amal Cheema Raysa Cabrejo Chen Shen Joseph Rosen A.Lee Dellon Department of Plastic and Reconstructive Surgery Johns Hopkins School of MedicineMD 89011USA Department of Plastic and Reconstructive Surgery The University of Texas Rio Grande ValleyEdinburgTX 78539USA Department of Plastic and Reconstructive Surgery Geisel School of Medicine at DartmouthHanoverNH 03755USA

Millions of people around the globe suffer peripheral nerve injuries caused by trauma and medical ***,medical school curricula are profoundly deficient in peripheral nerve *** lack of knowledge within the healthcare profession may cause inadequate patient *** developed the Virtual Peripheral Nerve Academy(VPNA)as a reusable virtual learning environment to provide medical students with detailed education on the peripheral nervous system(PNS).Students are introduced to the PNS through virtual 3D rendering of the human body,wherein they visualize individual nerves through dissection and observe normal motor and sensory function associated with each *** structures that are absent from traditional texts are included in this visualization,ranging from the innervation of joints to the normal anatomic variation required for differential diagnosis of pain after an *** modules on peripheral nerve disorders allow students to observe pathophysiological mechanisms,associated symptomatology,and appropriate *** are briefed on a patient clinical case,then interact with a patient avatar to learn the appropriate diagnostics,including physical exam maneuvers and electrodiagnostic *** modules on peripheral nerve surgeries detail surgical *** VPNA data and analytics dashboards allow medical students and course instructors to assess skill improvement and identify specific learning *** built-in learner management system and availability on both computer-based and virtual reality platforms facilitate integration into any existing medical school ***,this immersive technology enables every medical student to learn about the peripheral nervous system and gain competency in treating real-life nerve pathologies.

关键词： Virtual reality peripheral nervous system nerve surgical education medical education simulation plastic surgery

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Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian N.Levasseur kimberly M.Alonge Department of Medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

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Evolutionary responses to climate change and contaminants： Evidence and experimental approaches

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Current Zoology 2015年第4期61卷 690-701页

作者： David A. kimberly Department of Biology Westminster College 442 Meldrum Science Center Salt Lake City UT 84105 USA Department of Environmental Toxicology The Institute of Environmental and Human Health Texas Tech University 1207 Gilbert Drive Lubbock Texas 79416 USA Environmental Science and Studies Program Towson University 8000 York Rd. Towson MD 21252 USA

A fundamental objective within ecotoxicology lies in understanding and predicting effects of contaminants. This ob- jective is made more challenging when global climate change is considered as an environmental stress that co-occurs with con- taminant exposure. In this multi-stressor context, evolutionary processes are particularly important. In this paper, we consider several non-＂omic＂ approaches wherein evolutionary responses to stress have been studied and discuss those amenable to a mul- tiple stressor context. Specifically, we discuss common-garden designs, artificial and quasi-natural selection, and the estimation of adaptive potential using quantitative genetics as methods for studying evolutionary responses to contaminants and climate change in the absence of expensive molecular tools. While all approaches shed light on potential evolutionary impacts of stressor exposure, they also have limitations. These include logistical constraints, difficulty extrapolating to real systems, and responses tied strongly to specific taxa, populations, and/or testing conditions. The most effective way to lessen these inherent limitations is likely through inclusion of complementary physiological and molecular tools, when available. We believe that an evolutionary context to the study of contaminants and global climate change is a high priority in ecotoxicology and we outline methods that can be implemented by almost any researcher but will also provide valuable insights [Current Zoology 61 （4）： 690-701, 2015].

关键词： Climate change Multiple stressors Adaptation Experimental evolution Quantitative genetics

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Behavioral effects of social challenges and genomic mechanisms of social priming： What＇s testosterone got to do with it？

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Current Zoology 2014年第6期60卷 791-803页

作者： kimberly A. ROSVALL Mark E PETERSON Indiana University Department of Biology and Center for the Integrative Study of Animal Behavior Bloomington IN 47405 USA Viterbo University Departments of Biology and Mathematics La Crosse WI 54601 USA

Social challenges from rival conspecifics are common in the lives of animals, and changes in an animal＇s social environment can influence physiology and behavior in ways that appear to be adaptive in the face of continued social instability （i.e. social priming）. Recently, it has become clear that testosterone, long thought to be the primary mediator of these effects, may not always change in response to social challenges, an observation that highlights gaps in our understanding of the proximate me- chanisms by which animals respond to their social environment. Here, our goal is to address the degree to which testosterone me- diates organismal responses to social cues. To this end, we review the behavioral and physiological consequences of social chal- lenges, as well as their underlying hormonal and gene regulatory mechanisms. We also present a new case study from a wild songbird, the dark-eyed junco Junco hyemalis, in which we find largely divergent genome-wide transcriptional changes induced by social challenges and testosterone, respectively, in muscle and liver tissue. Our review underscores the diversity of mechani- sms that link the dynamic social environment with an organisms＇ genomic, hormonal, and behavioral state. This diversity among species, and even among tissues within an organism, reveals new insights into the pattern and process by which evolution may alter proximate mechanisms of social priming.

关键词： Social priming Challenge hypothesis Aggression Hormonal mechanism Testosterone Genomics

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THE CAYUGA MEDICAL CENTER A Case Study in Landscape Master Planning and Sustainability

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Journal of Green Building 2011年第2期6卷 17-28页

作者： kimberly Michaels RLA LEED APand Catherine Callahan Trowbridge&Wolf LLP

INTRODUCTION Long-term planning is essential for larger institutions to achieve sustainable goals and *** be truly sustainable,individual projects must fit within a larger scope of campus *** and site systems such as parking,transportation,pedestrian connectivity,storm water treatment,and human health and well-being must be considered and coordinated.

关键词： restorative gardens sustainable landscape planning master planning health care design LEED

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Venous thromboembolism in inflammatory bowel disease

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World Journal of Gastroenterology 2020年第12期26卷 1231-1241页

作者： kimberly Cheng Adam S Faye Department of Medicine NewYork-Presbyterian Columbia University Medical CenterNew YorkNY 10032United States Department of Medicine Columbia University Medical CenterNewYork-Presbyterian HospitalNew YorkNY 10032United States

Patients with inflammatory bowel disease(IBD)are at an increased risk for venous thromboembolism(VTE).VTE events carry significant morbidity and mortality,and have been associated with worse outcomes in patients with *** have suggested that the hypercoagulable nature of the disease stems from a complex interplay of systems that include the coagulation cascade,natural coagulation inhibitors,fibrinolytic system,endothelium,immune system,and ***,clinical factors that increase the likelihood of a VTE event among IBD patients include older age(though some studies suggest younger patients have a higher relative risk of VTE,the incidence in this population is much lower as compared to the older IBD patient population),pregnancy,active disease,more extensive disease,hospitalization,the use of certain medications such as corticosteroids or tofacitinb,and IBD-related *** the increased risk of VTE among IBD patients and the safety of pharmacologic prophylaxis,adherence rates among hospitalized IBD patients appear to be ***,recent data suggests that there is a population of high risk IBD patients who may benefit from post-discharge *** review will provide an overview of patient specific factors that affect VTE risk,elucidate reasons for lack of VTE prophylaxis among hospitalized IBD patients,and focus on recent data describing those at highest risk for recurrent VTE post-hospital discharge.

关键词： Inflammatory bowel disease Venous thromboembolism Prophylaxis Deep venous thrombosis Pulmonary embolism Ulcerative colitis

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Emerging wearable technology applications in gastroenterology:A review of the literature

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World Journal of Gastroenterology 2021年第12期27卷 1149-1160页

作者： kimberly PL Chong Benjamin KP Woo College of Osteopathic Medicine Western University of Health SciencesPomonaCA 91766United States Department of Psychiatry and Biobehavioral Sciences Olive View-University of California Los Angeles Medical CenterSylmarCA 91342United States

The field of gastroenterology has recently seen a surge in wearable technology to monitor physical activity,sleep quality,pain,and even gut *** past decade has seen the emergence of wearable devices including Fitbit,Apple Watch,AbStats,and ingestible *** this review,we discuss current and future devices designed to measure sweat biomarkers,steps taken,sleep efficiency,gastric electrical activity,stomach pH,and intestinal *** also summarize several clinical studies to better understand wearable devices so that we may assess their potential benefit in improving healthcare while also weighing the challenges that must be addressed.

关键词： Wearable technology Wearables Ingestibles Smartphone Remote patient monitoring Gastroenterology

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5-Fluorouracil dose escalation generated desensitized colorectal cancer cells with reduced expression of protein methyltransferases and no epithelial-to-mesenchymal transition potential

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Oncology Research 2024年第6期32卷 1047-1061页

作者： kimberly FENECH ISAAC MICALLEF BYRON BARON Centre for Molecular Medicine and Biobanking University of MaltaMsidaMSD 2080Malta Department of Tumor Genetics and Biology Graduate School of Medical SciencesFaculty of Life SciencesKumamoto UniversityKumamoto860-8556Japan

Background:Colorectal cancer(CRC)is one of the most frequently diagnosed *** many cases,the poor prognosis of advanced CRC is associated with resistance to treatment with chemotherapeutic drugs such as 5-Fluorouracil(5-FU).The epithelial-to-mesenchymal transition(EMT)and dysregulation in protein methylation are two mechanisms associated with chemoresistance in many *** study looked into the effect of 5-FU dose escalation on EMT and protein methylation in *** and Methods:HCT-116,Caco-2,and DLD-1 CRC cell lines were exposed to dose escalation treatment of *** motility and invasive potentials of the cells before and after treatment with 5-FU were investigated through wound healing and invasion *** was followed by aWestern blot which analyzed the protein expressions of the epithelial marker E-cadherin,mesenchymal marker vimentin,and the EMT transcription factor(EMTTF),the snail family transcriptional repressor 1(Snail)in the parental and desensitized *** blotting was also conducted to study the protein expressions of the protein methyltransferases(PMTs),Euchromatic histone lysine methyltransferase 2(EHMT2/G9A),protein arginine methyltransferase(PRMT5),and SET domain containing 7/9(SETD7/9)along with the global lysine and arginine methylation ***:The dose escalation method generated 5-FU desensitized CRC cells with distinct morphological features and increased tolerance to high doses of *** 5-FU desensitized cells experienced a decrease in migration and invasion when compared to the parental *** was reflected in the observed reduction in E-cadherin,vimentin,and Snail in the desensitized cell ***,the protein expressions of EHMT2/G9A,PRMT5,and SETD7/9 also decreased in the desensitized cells and global protein lysine and arginine methylation became dysregulated with 5-FU ***:This study showed that continuous,dose-escalation treatment of 5-FU in CRC cells generated 5-FU

关键词： Chemoresistance Epithelial-to-mesenchymal transition Protein methylation Protein methyltransferases

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Methods for engineering therapeutic peptides

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Chinese Chemical Letters 2018年第7期29卷 1074-1078页

作者： Yaohao Li kimberly A.Clark Zhongping Tan Department of Chemistry and Biochemistry and BioFrontiers Institute University of Colorado

Peptides are a class of drugs that have become increasingly important and influential for the treatment of many human diseases. Compared to traditional small molecule drugs, peptides have the potential for higher target specificity and potency, along with better safety profiles. On the other hand, the complex and fragile nature of peptides poses significant challenges for their administration. Of particular concern is that they are often unstable and can be rapidly degraded by various proteases after dosing. To address these inherent problems of peptides, many different methods have been attempted. Here, we briefly review these methods, with an emphasis on the effect of each method.

关键词： Therapeutic peptides Engineering Half-life Stability Solubility Aggregation Permeability

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INVERSE BORN SERIES FOR SCALAR WAVES

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Journal of Computational Mathematics 2012年第6期30卷 601-614页

作者： kimberly Kilgore Shari Moskow John C. Schotland Department of Mathematics Drexel University Philadelphia PA 19104 USA Department of Mathematics University of Michigan Ann Arbor MI 48109 USA

We consider the inverse scattering problem for scalar waves. We analyze the conver- gence of the inverse Born series and study its use in numerical simulations for the case of a spherically-symmetric medium in two and... 详细信息

关键词： Inverse scattering.

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