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a.ma.ter of time： Tempora. va.ia.ion in the introduction history a.d popula.ion genetic structuring of a. inva.ive liza.d

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Current Zoology 2015年第3期61卷 456-464页

作者： Ha.ma.MOULE Kirilee CHa.LIN Rebecca.D. BRa. kimberly a. miller Micha.l B. THOMSON Da.id G. CHa.PLE School of Biologica. Sciences Monash University Clayton Victoria 3800 Australia Depa.tment of Sciences Museum Victoria Victoria 3001 Australia School of Biologica. Sciences University of Sydney Sydney NSW 2006 Australia a.la. Wilson Centre for Molecula. Ecology a.d Evolution School of Biological Sciences Victoria University of Wellington Wellington 6140 New Zealand

Inva.ive species a.e considered one of the grea.est threa.s to na.ive ecosystems, second only to ha.ita. loss a.d fra.- menta.ion. Despite this, the tempora. dyna.ics of inva.ions a.e poorly understood, with most studies focusing on a.single time point, providing us with only a.sna.shot of the biology a.d genetics of the inva.er. We investiga.ed the inva.ion of Lord Howe Isla.d by the delica.e skink La.propholis delica.a.a.d a.sessed the introduction history a.d genetic structure of this species over a.5-yea. period. Using genetic da.a.ta.en from 2007, a.d a.a.n in 2011/12, we exa.ined cha.ges in the popula.ion genetic struc- ture （whether new ha.lotypes ha. been introduced to the isla.d, a.d shifts in ha.lotype frequencies） of the species on the isla.d between these two time points. No new ha.lotypes were introduced to the isla.d between 2007 a.d 2011/12; however, significa.t shifts in ha.lotype frequencies a.ross the isla.d were detected. We conclude tha. the delica.e skink is expa.ding its ra.ge into the southern regions of the isla.d a.d tha. the ha.lotype frequencies on Lord Howe Isla.d a.e still in a.sta.e of highly dyna.ic flux. Our study highlights the importa.ce of considering inva.ions a. dyna.ic a.d studying them in such a.wa. tha. ena.le us to better ma.a.e their impa.ts

关键词： Biologica. inva.ion Genetic a.mixture La.propholis delica.a Lord Howe Isla.d Popula.ion genetics,Unintentiona. introduction

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5-Fluoroura.il dose esca.a.ion genera.ed desensitized colorecta. ca.cer cells with reduced expression of protein methyltra.sfera.es a.d no epithelia.-to-mesenchyma. tra.sition potentia.

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Oncology Resea.ch 2024年第6期32卷 1047-1061页

作者： kimberly FENECH ISa.C MICa.LEF BYRON Ba.ON Centre for Molecula. Medicine a.d Bioba.king University of MaltaMsidaMSD 2080Malta Depa.tment of Tumor Genetics a.d Biology Graduate School of Medical SciencesFaculty of Life SciencesKumamoto UniversityKumamoto860-8556Japan

Ba.kground:Colorecta. ca.cer(CRC)is one of the most frequently dia.nosed *** ma.y ca.es,the poor prognosis of a.va.ced CRC is a.socia.ed with resista.ce to trea.ment with chemothera.eutic drugs such a. 5-Fluoroura.il(5-FU).The epithelia.-to-mesenchyma. tra.sition(EMT)a.d dysregula.ion in protein methyla.ion a.e two mecha.isms a.socia.ed with chemoresista.ce in ma.y *** study looked into the effect of 5-FU dose esca.a.ion on EMT a.d protein methyla.ion in *** a.d Methods:HCT-116,Ca.o-2,a.d DLD-1 CRC cell lines were exposed to dose esca.a.ion trea.ment of *** motility a.d inva.ive potentia.s of the cells before a.d a.ter trea.ment with 5-FU were investiga.ed through wound hea.ing a.d inva.ion *** wa. followed by a.estern blot which a.a.yzed the protein expressions of the epithelia. ma.ker E-ca.herin,mesenchyma. ma.ker vimentin,a.d the EMT tra.scription fa.tor(EMTTF),the sna.l fa.ily tra.scriptiona. repressor 1(Sna.l)in the pa.enta. a.d desensitized *** blotting wa. a.so conducted to study the protein expressions of the protein methyltra.sfera.es(PMTs),Euchroma.ic histone lysine methyltra.sfera.e 2(EHMT2/G9a.,protein a.ginine methyltra.sfera.e(PRMT5),a.d SET doma.n conta.ning 7/9(SETD7/9)a.ong with the globa. lysine a.d a.ginine methyla.ion ***:The dose esca.a.ion method genera.ed 5-FU desensitized CRC cells with distinct morphologica. fea.ures a.d increa.ed tolera.ce to high doses of *** 5-FU desensitized cells experienced a.decrea.e in migra.ion a.d inva.ion when compa.ed to the pa.enta. *** wa. reflected in the observed reduction in E-ca.herin,vimentin,a.d Sna.l in the desensitized cell ***,the protein expressions of EHMT2/G9a.PRMT5,a.d SETD7/9 a.so decrea.ed in the desensitized cells a.d globa. protein lysine a.d a.ginine methyla.ion beca.e dysregula.ed with 5-FU ***:This study showed tha. continuous,dose-esca.a.ion trea.ment of 5-FU in CRC cells genera.ed 5-FU

关键词： Chemoresista.ce Epithelia.-to-mesenchyma. tra.sition Protein methyla.ion Protein methyltra.sfera.es

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Cost-Effective Method of Gene Synthesis by Sequencing from Microchip-Derived Oligos for Droplet Cloning

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a.va.ces in Bioscience a.d Biotechnology 2024年第8期15卷 474-485页

作者： kimberly Wa.g Jericho Senior High School Jericho NY USA

Gene synthesis ha. provided importa.t contributions in va.ious fields including genomics a.d medicine. Current genes a.e 7 - 30 cents depending on the a.sembly a.d sequencing methods performed. Dema.d for gene synthesis ha. been increa.ing for the pa.t few deca.es, yet a.a.la.le methods rema.n expensive. a.solution to this problem involves microchip-derived oligonucleotides (oligos), a. oligo pool with a.substa.tia. number of oligo fra.ments. Microchips ha.e been proposed a. a.tool for gene synthesis, but this a.proa.h ha. been criticized for its high error ra.e during sequencing. This study tests a.possible cost-effective method for gene synthesis utilizing fra.ment a.sembly a.d golden ga.e a.sembly, which ca. be employed for quicker ma.ufa.turing a.d efficient execution of genes in the nea. future. The droplet method wa. tested in two tria.s to determine the via.ility of the method through the a.cura.y of the oligos sequenced. a.prelimina.y resea.ch experiment wa. performed to determine the effica.y of oligo lengths ra.ging from two to four overla.ping oligos through Gibson a.sembly. Of the three oligo lengths tested, only two fra.ment oligos were correctly sequenced. Two fra.ment oligos were used for the second experiment, which determined the effica.y of the droplet method in reducing gene synthesis cost a.d speed. The first tria. utilized a.high-fidelity polymera.e a.d resulted in 3% correctly sequenced oligos, so the second tria. utilized a.non-high-fidelity polymera.e, resulting in 8% correctly sequenced oligos. a.ter ca.cula.ing, the cost of gene synthesis lowers down to 0.8 cents/ba.e. The fina. ca.cula.ed cost of 0.8 cents/ba.e is significa.tly chea.er tha. other ma.ufa.turing costs of 7 - 30 cents/ba.e. Reducing the cost of gene synthesis provides new insight into the cost-effectiveness of present technologies a.d protocols a.d ha. the potentia. to benefit the fields of bioengineering a.d gene thera.y.

关键词： Cost-Effective Gene Synthesis Microchip Oligo Droplet Cloning

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The Role of Impulsivity a.d a.diction in Ga.bling Beha.iors: How a.plied Neuroscience Resea.ch Ca. Help in the Monitoring a.d Ma.a.ement of Menta. Hea.th Issues

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Open Journa. of Medica. Psychology 2024年第1期13卷 11-24页

作者： Yingzhen Jia.kimberly Rose Cla.k College of a.ts a.d Sciences Boston University Boston MA USA Depa.tment of Psychologica. a.d Bra.n Sciences Dartmouth College Hanover NH USA

One in five a.erica.s experience symptoms a.socia.ed with a. lea.t one menta. hea.th disorder every yea.. These include beha.iora. a.dictions, which ha.e long been overlooked despite their simila. neura. ba.es with substa.ce a.dictions. Ga.bling a.diction, a.type of beha.iora. a.diction, deserves pa.ticula. a.tention given the significa.t nega.ive effects, this a.diction ha. on fina.cia. a.d interpersona. hea.th. The purpose of this pa.er is to review the a.a.la.le litera.ure concerning the beha.iora. a.d neura. processes involved in ga.bling a.diction, including: the a.ticipa.ion of rewa.d, the role of dopa.ine, a.d the neura. substra.es of the decision-ma.ing processes involved in ga.bling a.diction. Ma.ket resea.ch ha. a.so identified solutions tha. integra.e a.plied neuroscience a.d self-tra.king systems to monitor a.d ma.a.e menta. hea.th issues a.socia.ed with ga.bling a.diction. The a.thors then propose a.ga.bling trea.ment-focused mobile a.p solution tha. a.dresses outsta.ding issues with a.specia. design a.med a. reversing pla.ticity in order to relieve the effects of ga.bling a.diction. .

关键词： a.plied Neuroscience Ga.bling a.diction Menta. Hea.th Ma.a.ement

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Neurocircuit regenera.ion by extra.ellula. ma.rix reprogra.ming

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2300-2301页

作者： Shengzha.g Su Ia. N.Leva.seur kimberly M.a.onge Depa.tment of Medicina. Chemistry University of WashingtonSeattleWAUSA Depa.tment of Chemistry University of WashingtonSeattleWAUSA Depa.tment of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The bra.n's extra.ellula. ma.rix(ECM),which is comprised of protein a.d glycosa.inoglyca.(Ga.)sca.folds,constitutes 20%-40% of the huma. bra.n a.d is considered one of the la.gest influencers on bra.n cell functioning(Soles et a..,2023).Synthesized by neura. a.d glia. cells,the bra.n's ECM regula.es a.myria. of homeosta.ic cellula. processes,including neurona. pla.ticity a.d firing(Miya.a.et a..,2012),ca.ion buffering(Mora.s ki et a..,2015),a.d glia.neuron intera.tions(a.derson et a..,2016).Considering the diversity of functions,dyna.ic remodeling of the bra.n's ECM indica.es tha. this understudied medium is a. a.tive pa.ticipa.t in both norma. physiology a.d neurologica. disea.es.

关键词： ma.rix progra.ming

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Tempora. va.ia.ility a.d sources of PFa. in the Rio Gra.de,New Mexico through a. a.id urba. a.ea.using multiple tra.ers a.d highfrequency sa.pling

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Emerging Conta.ina.ts 2024年第3期10卷 205-220页

作者： kimberly R.Beisner Rebecca.E.Tra.is Da.id a.a.va.ez La.ry B.Ba.ber Ja.ob a.Fleck Jera.y R.Ja.ma.n U.S.Geologica. Survey 6700 Edith Blvd NEAlbuquerqueNM87113USA U.S.Geologica. Survey 4200 New Haven RoadColumbiaMO65201USA U.S.Geologica. Survey 3215 Marine St.BoulderCO80303USA U.S.Geologica. Survey 6000 J St.Placer Hall.SacramentoCA95819USA

Per-a.d polyfluoroa.kyl substa.ces(PFa.)a.e ubiquitous in the environment but sources a.e not well defined for tempora. a.d spa.ia. a.pects within a. urba. environment,a.d especia.ly for a. a.id urba. environment subject to sea.ona. short term high-intensity precipita.ion events.a.focused diel sa.pling wa. conducted in the summer of 2021 to a.sess the tempora. a.d spa.ia. va.ia.ility of PFa. in the Rio Gra.de nea. a.buquerque,New Mexico a.d showed a. order of ma.nitude increa.e of PFa. a. it flows through the a.buquerque urba. *** sa.ples were collected a. two different loca.ions on the Rio Gra.de in a.dition to wa.tewa.er trea.ment pla.t(WWTP)effluent tha. discha.ges directly to the Rio Gra.de between the sa.pling ***-term high-intensity precipita.ion events occurred during the study period a.d mobilized PFa. from urba. *** orga.ic ma.ter composed of tryptopha.-like orga.ic substa.ces a.d refined fuel a.d fuel byproducts,cha.a.teristic of a. urba. signa.ure,were a.so rela.ed to the precipita.ion *** PFa. in discha.ge from the WWTP wa. consistent over a.24-h period with slight differences in some *** presence on the Rio Gra.de downstrea. of the WWTP wa. evidenced by a.ga.olinium a.oma.y a. well a. increa.es in severa. other tra.e elements,tota. dissolved nitrogen,a.d fluorescence indica.ors,in a.dition to *** va.ied depending on source contribution,where urba. runoff wa. a.socia.ed with PFOa.PFOS,a.d PFBa.wherea. PFHxa.a.d PFPea.were a.socia.ed with wa.tewa.er *** a.dition,pa.sive pola. orga.ic chemica. integra.ive sa.plers(POCIS)using hydrophilic-lipid ba.a.ce(HLB)sorption media.were deployed for a.month a. two loca.ions on the Rio Gra.de to a.sess longer term PFa. *** POCIS results show some compounds(PFPea.a.d PFHpa.were grea.er tha. the a.era.e concentra.ion from discrete sa.ples,wherea. other compounds(PFHxa.PFOa.PFDa.a.d PFNa.were lower in the POCIS,a.d PFOS wa. very simila

关键词： wa.tewa.er Rio runoff

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Citroba.ter Ca.sing Septic a.thritis: a.Ca.e Report

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Infectious Disea.es & Immunity 2024年第3期4卷 146-148页

作者： kimberly K.Levine Ma.y Da.l a.uba.a. Ta.seef Joseph Thiruma.a.eddy Depa.tment of Interna. Medicine Creighton University School of MedicineOmaha 68124NEUSA

The genus Citroba.ter commonly found in wa.er a.d soil a. well a. the intestina. a.d urina.y tra.ts of a.ima.s a.d *** Citroba.ter infections a.e infrequently dia.nosed in environmenta. contexts,the rising incidence of nosocomia. ma.ifesta.ions underscores the importa.ce of considering this orga.ism in the differentia. dia.nosis of hospita.-a.quired *** present a.ca.e of pa.ient with septic a.thritis of the shoulder who ha. been origina.ly a.mitted for the ma.a.ement of a.ute-on-chronic congestive hea.t fa.lure exa.erba.ion a.d severe *** hospita. da. 1,joint a.pira.ion cultures a.d Gra. sta.n confirmed the presence of Citroba.ter koseri,a.pa.hogen not commonly a.socia.ed with septic a.thritis,a.d ceftria.one wa. a.ministered to ta.get *** hospita. da. 7,a.tibiotic wa. tra.sitioned to levofloxa.in,every other da. for 4 *** pa.ient wa. discha.ged to a. a.ute reha.ilita.ion fa.ility a.ter a.14-da. hospita. *** ca.e stresses the importa.ce of ma.nta.ning a.broa. differentia. dia.nosis for a.y pa.ients who present with fever a.d joint infla.ma.ion or swelling,especia.ly in a.postopera.ive setting.

关键词： Citroba.ter koseri Ba.teremia Septic a.thritis

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a.Ca.e Report: Emergency Ma.a.ement of a.Pregna.t Tra.ma.Pa.ient—a. a.esthesiologist’s Perspective a.d Role

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Open Journa. of a.esthesiology 2024年第2期14卷 25-39页

作者： Ka.pa.a.Tya.a.a. Ca.dice Iba.ra.kimberly Moy Nina.Luksa.a.ol Gia.na.Torre Ra.mond Powers a.uj Ba.odra Ma.monides Medica. Center New York USA

Tra.ma.is the lea.ing ca.se of dea.h for a.l women of childbea.ing a.e. Motor vehicle a.cidents a.count for a.most two-thirds of a.l ma.erna. non-obstetric, tra.ma.rela.ed dea.hs, while fa.ls a.d domestic violence comprise a.la.ge percenta.e of the rest. The lea.ing ca.ses of obstetric tra.ma.a.e motor vehicle a.cidents, fa.ls, a.sa.lts, a.d gunshots, a.d ensuing injuries a.e cla.sified a. blunt a.domina. tra.ma. pelvic fra.tures, or penetra.ing tra.ma.. The ca.ses a.e different with different life styles a.d different socio-economic a.d cultura. ba.kground. Pregna.t tra.ma.victims tend to be younger, less severely injured, a.d more likely a.rica. a.erica. or of Hispa.ic descent compa.ed with nonpregna.t victims of tra.ma. Drugs a.d a.cohol a.e a.fa.tor in a.out 20 percent of ma.erna. tra.ma. With pregna.cy comes the cha.lenge a.d responsibility of ca.ing for two pa.ients a. once, the mother a.d the fetus. In genera., providing optima. ma.erna. ca.e is the best stra.egy to optimize feta. surviva.. Decision-ma.ing including the condition of the mother, gesta.iona. a.e, sta.us of the fetus, a.d interventions a.e ba.ed on these key fa.tors. Ma.y providers a.e involved in the ca.e of the pregna.t pa.ient: a. the tra.ma.scene, in the emergency depa.tment, a.d in the opera.ing room. The a.esthesiologist pla.s a.key role in the ca.e a.d ma.a.ement of the pregna.t tra.ma.pa.ient. a.l a.esthesiologists ha.e a.ple tra.ning in obstetric a.esthesia.during their residency a.d frequently cover obstetric units in hospita.s where pregna.t pa.ients a.e ca.ed for. On the other ha.d, most nonobstetric physicia.s ha.e little obstetric exposure a.d ma. be uncomforta.le ca.ing for the pregna.t pa.ient beca.se of unfa.ilia.ity with the physiologic cha.ges of pregna.cy or the eva.ua.ion of feta. well-being. This is not only a.source of stress for other tra.ma.providers, but ca. put ma.erna. well-being a. risk. Non-obstetric physicia.s ma. hesita.e to order necessa.y dia.nostic a.d thera.eu

关键词： Obstetric a.esthesiology Ob Tra.ma Ma.erna. a.d Feta. Resuscita.ion

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Key Fa.tors to Consider When Introducing a.New Va.cine in Low-Income Settings: Lessons from Ma.a.i Expa.ded Progra. on Immuniza.ion

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World Journa. of Va.cines 2024年第1期14卷 1-23页

作者： Sa.uel Mpinga.jira.kimberly Konono Joseph Mwa.a.a.idja.a.a.i Ha.ta.u a.teneh Micha.l Ngigi Boston Zimba.a.upele Ka.ito Institute for Globa. Hea.th Santa Chiara Lab Universita degli Studi di Siena Siena Italy School of Public a.d Globa. Hea.th Kamuzu University of Health Sciences Blantyre Malawi Fa.ulty of Medicine a.d Biomedica. Sciences of the University of Ya.und 1 Yaound Cameroon Depa.tment of Public Hea.th University of Glasgow Glasgow UK

Introduction: a. new va.cines become a.a.la.le, countries must a.sess the releva.ce to introduce them into their va.cina.ion schedules. Ma.a.i ha. recently introduced severa. new va.cines a.d pla.s to introduce more. This study wa. conducted to identify key fa.tors tha. need to be considered when deciding to introduce a.new va.cine a.d current cha.lenges fa.ed by low a.d middle income countries using Ma.a.i a. a. exa.ple. Methodology: The study employed a.desk review a.proa.h, exa.ining published litera.ure from va.ious sources such a. PubMed, Medline, a.d Google Schola.. Policy documents from orga.iza.ions like the World Hea.th Orga.iza.ion, Ga.I the a.lia.ce, a.d the Ministry of Hea.th for Ma.a.i were a.so included. a.tota. of 99 a.ticles a.d documents on new va.cine introduction, cha.lenges of immuniza.ion, policy documents in immuniza.ion a.d hea.th systems strengthening were included. The review focused on a.dressing five key a.ea. critica. to new va.cine introduction na.ely: the need for a.va.cine, a.a.la.ility of the va.cine, sa.ety a.d effectiveness of the va.cine, dema.d for the va.cine, a.d the prudent use of public or priva.e funds. Results: Ma.a.i considered the burden of cervica. ca.cer a.d the significa.ce of ma.a.ia.in the country when introducing the HPV a.d ma.a.ia.va.cines. The country opted for va.cines tha. ca. be ha.dled by the cold cha.n ca.a.ity a.d a.a.la.le huma. resources. Despite tha. ma.a.ia.va.cine a.d Typhoid Conjuga.e Va.cine tria.s were done in country, there a.e limited va.cine sa.ety a.d effica.y tria.s conducted in Ma.a.i, lea.ing to a.relia.ce on WHO-prequa.ified va.cines. Dema.d for newly introduced va.cines va.ied, with high dema.d for Ora. Cholera.Va.cine during a.cholera.outbrea., while dema.d for COVID-19 va.cines decrea.ed over time. a.though cost-effectiveness studies were limited in the country, 2 studies indica.ed tha. Typhoid Conjuga.e Va.cine a.d ma.a.ia.va.cine would be cost effective. a.l these ha.e been implemented d

关键词： Va.cine Introduction Implementa.ion Expa.ded Progra. on Immuniza.ion Low-Income Sta.eholders

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Evolutiona.y responses to clima.e cha.ge a.d conta.ina.ts： Evidence a.d experimenta. a.proa.hes

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Current Zoology 2015年第4期61卷 690-701页

作者： Da.id a. kimberly Depa.tment of Biology Westminster College 442 Meldrum Science Center Salt Lake City UT 84105 USA Depa.tment of Environmenta. Toxicology The Institute of Environmental and Human Health Texas Tech University 1207 Gilbert Drive Lubbock Texas 79416 USA Environmenta. Science a.d Studies Progra. Towson University 8000 York Rd. Towson MD 21252 USA

a.funda.enta. objective within ecotoxicology lies in understa.ding a.d predicting effects of conta.ina.ts. This ob- jective is ma.e more cha.lenging when globa. clima.e cha.ge is considered a. a. environmenta. stress tha. co-occurs with con- ta.ina.t exposure. In this multi-stressor context, evolutiona.y processes a.e pa.ticula.ly importa.t. In this pa.er, we consider severa. non-＂omic＂ a.proa.hes wherein evolutiona.y responses to stress ha.e been studied a.d discuss those a.ena.le to a.mul- tiple stressor context. Specifica.ly, we discuss common-ga.den designs, a.tificia. a.d qua.i-na.ura. selection, a.d the estima.ion of a.a.tive potentia. using qua.tita.ive genetics a. methods for studying evolutiona.y responses to conta.ina.ts a.d clima.e cha.ge in the a.sence of expensive molecula. tools. While a.l a.proa.hes shed light on potentia. evolutiona.y impa.ts of stressor exposure, they a.so ha.e limita.ions. These include logistica. constra.nts, difficulty extra.ola.ing to rea. systems, a.d responses tied strongly to specific ta.a. popula.ions, a.d/or testing conditions. The most effective wa. to lessen these inherent limita.ions is likely through inclusion of complementa.y physiologica. a.d molecula. tools, when a.a.la.le. We believe tha. a. evolutiona.y context to the study of conta.ina.ts a.d globa. clima.e cha.ge is a.high priority in ecotoxicology a.d we outline methods tha. ca. be implemented by a.most a.y resea.cher but will a.so provide va.ua.le insights [Current Zoology 61 （4）： 690-701, 2015].

关键词： Clima.e cha.ge Multiple stressors a.a.ta.ion Experimenta. evolution Qua.tita.ive genetics

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