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The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes:A randomized cross-over design

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Journal of Sport and Health Science 2021年第4期10卷 499-506页

作者： kimberley l.way Angela S.lee Stephen M.Twigg Nathan A.Johnson Faculty of Medicine and Health Discipline of Exercise and Sports ScienceUniversity of SydneyLidcombeNSW 2141Australia Charles Perkins Centre University of SydneyCamperdownNSW 2006Australia Boden Collaboration for Obesity NutritionExercise and Eating DisordersUniversity of SydneyCamperdownNSW 2006Australia Faculty of Medicine and Health Central Clinical SchoolUniversity of SydneyCamperdownNSW 2006Australia Department of Endocrinology Diabetes CentreRoyal Prince Alfred HospitalSydneyNSW 2050Australia

Background:Individuals with diabetes have greater central arterial stiffness,wave reflections,and hemodynamics,all of which promote the accelerated cardiovascular pathology seen in this *** aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness,wave reflections,and hemodynamics in healthy individuals;however,the effects of acute aerobic exercise in reducing these outcomes is not well established in people with ***,implementation of high-intensity interval exercise(HIIE)has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic ***,the effect of HIIE on the aforementioned outcomes in people with diabetes is not *** purpose of this study was to(i)describe the central arterial stiffness,wave reflections,and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise(MICE)in adults with diabetes;and(ii)compare the effects of HIIE and MICE on the aforementioned ***:A total of 24 adult men and women(aged 29-59 years old)with type 1(n=12)and type 2(n=12)diabetes participated in a randomized cross-over *** participants completed the following protocols:(i)HIIE:cycling for 4×4 min at 85%-95%of heart rate peak(HR_(peak)),interspersed with 3 min of active recovery at 60%-70%HR_(peak);(ii)MICE:33 min of continuous cycling at 60%-70%HR_(peak);and(iii)control(CON):lying quietly in a supine position for 30 ***:A significant group￡time effect was found for changes in central systolic blood pressure(F=3.20,p=0.01)with a transient reduction for the HIIE group but not for the MICE or CON *** was a significant group￡time effect for changes in augmentation index at a heart rate of 75 beats/min(F=2.32,p=0.04)with a decrease following for HIIE and MICE but not for *** all other measures of central arterial stiffness and hemodynamics,no significant changes were observed(p>0.05).Conclusion:A bout of

关键词： Augmentation index Central systolic blood pressure Diabetes High-intensity interval exercise

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Managing arterial health in adults with metabolic diseases: Is high-intensity interval exercise the answer? Response to the commentary by lopes et al.

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Journal of Sport and Health Science 2021年第4期10卷 510-512页

作者： kimberley l.way Angelo Sabag Angela S.lee Stephen M.Twigg Nathan A.Johnson School of Exercise and Nutrition Sciences Faculty of HealthDeakin UniversityBurwoodVIC 3125Australia Exercise Physiology and Cardiovascular Health lab University of Ottawa Heart InstituteOttawaON K1Y 4W7Canada NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia Central Clinical School Faculty of Medicine and HealthUniversity of SydneyCamperdownNSW 2050Australia Department of Endocrinology Diabetes CentreRoyal Prince Alfred HospitalSydneyNSW 2050Australia Discipline of Exercise and Sports Science Faculty of Medicine and HealthUniversity of SydneyLidcombeNSW 2141Australia Boden Collaboration for Obesity NutritionExercise and Eating DisordersUniversity of SydneyCamperdownNSW 2006Australia

Dear editor,We thank lopes et al.^(1) for their interest in our study and for writing an insightful commentary based on our findings,which were recently published in the Journal of Sport and Health Science,^(2) and for their work.^(3) As noted by the authors,there is consistency in several key findings between our laboratories,and this should serve as a basis for future investigation in this *** agree that there has been little work examining the effect of high-intensity interval exercise(HIIE)on central arterial stiffness.

关键词： al. finding thank

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Isolation of Picocyanobacteria (Order Synechococcales) and Occurrence of the Cyanotoxin Anatoxin-A in a Shallow Mesotrophic Pond

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Journal of Water Resource and Protection 2023年第9期15卷 299-314页

作者： Nancy J. leland kimberley Crocker Pearson Marty K. Burke Jeffrey T. Miller Alison Watts James F. Haney Department of Biological Sciences University of New Hampshire Center for Freshwater Biology and Ecotoxicology Durham New Hampshire USA lim-Tex North Andover Massachusetts USA Brewster Natural Resources Advisory Commission Brewster Massachusetts USA Brewster Ponds Coalition Brewster Massachusetts USA Department of Civil and Environmental Engineering University of New Hampshire College of Engineering and Physical Sciences Durham New Hampshire USA

We have verified the use of a serial filtration method to isolate picocyanobacteria for analysis. We used eDNA metabarcoding to confirm the picocyanobacteria as members of the Order Synechococcales, Genus Cyanobium, specifically Cyanobium 6307. Fluorometric analysis using accessory pigments phycocyanin and phycoerythrin described periods of excess biomass, where the net growth rate model confirmed these conditions. The total anatoxin-a concentrations in the picocyanobacterial sample ranged from 0.0074 - 6.41 μg·l-1 representing a 40-fold difference over the entire sampling season. Sampling frequency of every three days appeared to be an important factor in capturing these changes in anatoxin-a concentration. During a period of excess biomass, we were able to establish a linear correlation between cyanobacterial biomass and Anatoxin-a concentrations.

关键词： Picocyanobacteria Anatoxin-a eDNA Phycocyanin Phycoerythrin

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Is tumor cell specificity distinct from tumor selectivity in vivo?A quantitative NIR molecular imaging analysis of nanoliposome targeting

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Nano Research 2021年第5期14卷 1344-1354页

作者： Girgis Obaid kimberley Samkoe Kenneth Tichauer Shazia Bano Yeonjae Park Zachary Silber Sassan Hodge Susan Callaghan Mina Guirguis Srivalleesha Mallidi Brian Pogue Tayyaba Hasan Wellman Center for Photomedicine Massachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Bioengineering University of Texas at DallasRichardsonTX75080USA Thayer School of Engineering Dartmouth CollegeHanoverNH037551USA Armour College of Engineering Illinois Institute of TechnologyChicagoIL60616USA Division of Health Sciences and Technology Harvard University and Massachusetts Institute of TechnologyCambridgeMA02139USA

The significance and ability for receptor targeted nanoliposomes(tNls)to bind to their molecular targets in solid tumors in vivo has been questioned,particularly as the efficiency of their tumor accumulation and selectivity is not always predictive of their efficacy or molecular *** study presents,for the first time,in situ near-infrared(NIR)molecular imaging-based quantitation of the in vivo specificity of tNls for their target receptors,as opposed to tumor selectivity,which includes influences of enhanced tumor permeability and *** show that neither tumor delivery nor selectivity(tumor-to-normal ratio)of cetuximab and IRDye conjugated tNls correlate with epidermal growth factor receptor(EGFR)expression in U251,U87,and 9l tumors,and in fact underrepresent their imaging-derived molecular specificity by up to 94.2%.Conversely,their in vivo specificity,which we quantify as the concentration of tNl-reported tumor EGFR provided by NIR molecular imaging,correlates positively with EGFR expression levels in vitro and ex vivo(Pearson’s r=0.92 and 0.96,respectively).This study provides a unique opportunity to address the problematic disconnect between tNl synthesis and in vivo *** findings encourage their continued adoption as platforms for precision medicine,and facilitates intelligent synthesis and patient customization in order to improve safety profiles and therapeutic outcomes.

关键词： molecular recognition receptors nanoparticles specificity cancer

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Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors

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Journal of Molecular Cell Biology 2020年第3期12卷 202-215页

作者： Augustin le Naour Melissa Prat Benolt Thibault Renaud Mével léa lemaitre Helene leray Marie-Veronique Joubert kimberley Coulson Muriel Golzio lise lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc Institut Claudius Regaud-IUCT Oncopole Universite de ToulouseToulouseFrance INSERM UMR 1037 Cancer Research Center of Toulouse(CRCT)ToulouseFrance UMR 152 Pharma Dev Universite de ToulouseIRDUPSToulouseFrance UMR CNRS 5089 Institut de Pharmacologie et de Biologie Structurale(IPBS)ToulouseFrance

Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and *** this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs *** tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCl1),CXCl2,and interleukin 8(Il-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor ***,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor *** CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral *** ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of *** high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance.

关键词： chemoresistance macrophages mesenchymal stromal cells ovarian adenocarcinoma chemokines

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Effect of dietary fiber and threonine content on intestinal barrier function in pigs challenged with either systemic *** lipopolysaccharide or enteric Salmonella Typhimurium

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Journal of Animal Science and Biotechnology 2020年第3期11卷 724-735页

作者： Michael O.Wellington kimberley Hamonic Jack E.C.Krone John K.Htoo Andrew G.Van Kessel Daniel A.Columbus Prairie Swine Centre Inc.SaskatoonSK S7H 5N9Canada Department of Animal and Poultry Science University of SaskatchewanSaskatoonSK S7N 5A8Canada Evonik Nutrition&Care GmbH Hanau-WolfgangGermany

Background:The independent and interactive effects of dietary fiber(DF)and threonine(Thr)were investigated in growing pigs challenged with either systemic *** lipopolysaccharide(lPS)or enteric Salmonella Typhimurium(ST)to characterise their effect on intestinal barrier ***:In experiment 1,intestinal barrier function was assessed via oral lactulose and mannitol(l:M)gavage and fecal mucin analysis in pigs challenged with *** lPS and fed low fiber(lF)or high fiber(HF)diets with graded dietary *** lactulose recovery and l:M ratio increased(PlPS inoculation period in lF fed pigs but not in HF fed *** mucin output was increased(PlF fed *** experiment 2,RT-qPCR,ileal morphology,digesta volatile fatty acid(VFA)content,and fecal mucin output were measured in Salmonella Typhimurium challenged pigs,fed lF or HF diets with standard or supplemented dietary *** inoculation increased(Pl mucin output compared to the unchallenged *** Thr increased fecal mucin output in the HF-fed pigs(Fib×Thr;Plet cell numbers(Plusion:Dietary fiber appears to improve barrier function through increased mucin production capacity(i.e.,goblet cell numbers,MUC2 gene expression)and secretion(i.e.,fecal mucin output).The lack of effect of dietary Thr in Salmonella-challenged pigs provides further evidence that mucin secretion in the gut is conserved and,therefore,Thr may be limiting for growth under conditions of increased mucin production.

关键词： Barrier function E.coli lipopolysaccharide Fiber Goblet cells Mucin Salmonella Swine Threonine

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In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

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Journal of Molecular Cell Biology 2020年第8期12卷 644-653页

作者： Tijmen H.Booij Wouter N.leonhard Hester Bange Kuan Yan Michiel Fokkelman Anna J.Plugge kimberley A.M.Veraar Johannes G.Dauwerse Gerard J.P.van Westen Bob van de Water leo S.Price Dorien j.M.Peters Division of Toxicology Leiden Academic Centre for Drug Research(LACDR)Leiden UniversityLeidenThe Netherlands Present address:NEXUS Personalized Health Technologies ETH ZurichSwitzerland Department of Human Genetics Leiden University Medical Center(LUMC)LeidenThe Netherlands OcellO B.V. LeidenThe Netherlands Division of Medicinal Chemistry Leiden Academic Centre for Drug Research(LACDR)LeidenThe Netherlands

Polycystic kidney disease(PKD)is a prevalent genetic disorder,characterized by the formation of kidney cysts that progressively lead to kidney *** currently available drug tolvaptan is not well tolerated by all patients and there remains a strong need for alternative *** signalling rewiring in PKD that drives cyst formation is highly complex and not fully *** a consequence,the effects of drugs are sometimes difficult to *** previously established a high-throughput microscopy phenotypic screening method for quantitative assessment of renal cyst ***,we applied this 3D cyst growth phenotypic assay and screened 2320 small drug-like molecules,including approved *** identified 81 active molecules that inhibit cyst ***-parametric phenotypic profiling of the effects on 3D cultured cysts discriminated molecules that showed preferred pharmacological effects above genuine toxicological ***,a triterpenoid from Tripterygium wilfordii,was identified as a potent inhibitor of cyst growth in *** an in vivo iKspCre-Pkd1^lox,lox mouse model for PKD,celastrol inhibited the growth of renal cysts and maintained kidney function.

关键词： PKD celastrol pyrvinium pamoate high-content screening 3D

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Pilot study文献案例分享——迷走神经刺激联合康复治疗缺血性卒中恢复期上肢运动功能障碍

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中国卒中杂志 2019年第9期14卷 939-941页

作者：张晨 kimberley TJ PIERCE D PRUDENTE CN 国家神经系统疾病临床医学研究中心 100070 首都医科大学附属北京天坛医院神经病学中心美国田纳西大学健康科学中心神经病学科不详

2018年12月,Stroke杂志发表了一项关于卒中后运动障碍应用迷走神经刺激康复治疗的随机、国际多中心、双盲、假治疗对照的预试验,题目是“Vagus nerve stimulation paired with upp er l imb rehabi l it ation af ter chronic stroke:ab... 详细信息

2018年12月,Stroke杂志发表了一项关于卒中后运动障碍应用迷走神经刺激康复治疗的随机、国际多中心、双盲、假治疗对照的预试验,题目是“Vagus nerve stimulation paired with upp er l imb rehabi l it ation af ter chronic stroke:ablinded randomized pilot study”。

关键词：迷走神经刺激上肢运动功能障碍运动障碍卒中后预试验康复治疗案例分享

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The effects of indigenous prescribed fire on riparian vegetation in central California

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Ecological Processes 2013年第1期2卷 245-253页

作者： Don l Hankins Department of Geography and Planning California State University-ChicoChicoCAUSA

Introduction:Fire has a long history,but little documented role,as a process in riparian *** millennia California Indians have applied fire to riparian ecosystems for a variety of purposes,but the effects of such fires on riparian vegetation are poorly known outside of traditional knowledge structures of indigenous ***:This study involved the seasonal application of fire based on traditional ecological knowledge versus alternate burn methods to assess fire effects on riparian vegetation in central ***:While the annual variation amongst treatments was not significant,the results of this study suggest that fall burns support higher overall richness and native species richness;spring burns yield a decrease in overall richness,but an increase in native species richness;and summer burns contribute to an initial decline in overall and native species *** evenness indices of treatments increase most with spring and summer ***:These findings are key to understanding the seasonal role of fire in managing native species in areas prone to non-native or other invasive *** research demonstrates the application of traditional ecological knowledge to facilitate an understanding of how prescribed fire could aid in the management and conservation of riparian ecosystems.

关键词： Riparian California Indian Fire Indigenous Traditional ecological knowledge

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World Journal of Critical Care Medicine 2022年第4期11卷 236-245页

作者： Vincent Issac lau Jeffrey A Johnson Sean M Bagshaw Oleksa G Rewa John Basmaji kimberley A lewis M Elizabeth Wilcox Kali Barrett Francois lamontagne Francois lauzier Niall D Ferguson Simon J W Oczkowski Kirsten M Fiest Daniel J Niven Henry T Stelfox Waleed Alhazzani Margaret Herridge Robert Fowler Deborah J Cook Bram Rochwerg Feng Xie Department of Critical Care Medicine University of AlbertaEdmonton T6G 2B7ABCanada School of Public Health Inst Hlth EconUniversity of AlbertaEdmonton T6G 2B7ABCanada Department of Medicine Division of Critical CareWestern UniversityLondon N6A 5W9Canada Division of Critical Care McMaster UniversityHamilton L8N 4A6Canada Interdepartmental Division of Critical Care University of TorontoToronto M5T 2S8Canada Department of Medicine University SherbrookeSherbrooke J1H 5N4Canada Departments of Medicine and Anesthesiology University LavalLaval G1V 4G2Canada Department Critical Care Medicine University of TorontoToronto M5G 2C4Canada Department of Medicine McMaster ClinHamilton Gen HospMcMaster UniversityHamilton L8N 4A6Canada Department of Community Health Sciences&Institute for Public Health University of CalgaryCalgary T2N 2T9Canada Department of Critical Care Medicine University CalgaryCalgary T2N 2T9Canada Department of Community Health Sciences University of CalgaryCalgary T2N 2T9Canada Department of Medicine McMaster UniversityHamilton L8N 4A6Canada Indepartmental Division of Critical Care University Health NetworkToronto M5G 2C4Canada Departments of Medicine and Critical Care Medicine Sunnybrook Health Sciences CenterInstitute of Health Policy Management and EvaluationUniversity of TorontoToronto M4N 3M5Canada Health Research Methods Evidence and ImpactMcMaster UniversityHamilton L8N 3Z5Canada

Mortality is a well-established patient-important outcome in critical care *** contrast,morbidity is less uniformly reported(given the myriad of critical care illnesses and complications of each)but may have a common end-impact on a patient’s functional capacity and health-related quality-of-life(HRQol).Survival with a poor quality-of-life may not be acceptable depending on individual patient values and ***,as mortality decreases within critical care,it becomes increasingly important to measure intensive care unit(ICU)survivor *** measurements with a preference-based scoring algorithm can be converted into health utilities on a scale anchored at 0(representing death)and 1(representing full health).They can be combined with survival to calculate quality-adjusted life-years(QAlY),which are one of the most widely used methods of combining morbidity and mortality into a composite *** QAlYs have been use for health-technology assessment decision-making,an emerging and novel role would be to inform clinical decision-making for patients,families and healthcare providers about what expected HRQol may be during and after ICU *** care randomized control trials(RCTs)have not routinely measured or reported HRQol(until more recently),likely due to incapacity of some patients to participate in patient-reported outcome *** differences in HRQol measurement tools can lead to non-comparable *** this end,we propose the validation of a gold-standard HRQol tool in critical care,specifically the *** combined health-utility and mortality(disaggregated)and QAlYs(aggregated)can be reported,with disaggregation allowing for determination of which components are the main drivers of the QAlY *** use of HRQol,health-utility,and QAlYs in critical care RCTs has the potential to:(1)Increase the likelihood of finding important effects if they exist;(2)improve research efficiency;and(3)help inform optimal m

关键词： Critical care health-related quality of life Quality-adjusted life-years Health-utility Mortality Morbidity Kaplan-Meier curves

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