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Discovering peptides a.d computa.iona. investiga.ions of a.multiepitope va.cine ta.get Mycoba.terium tuberculosis

Synthetic a.d Systems Biotechnology 2024年第3期9卷 391-405页

作者： Truc ly Nguyen Heeba. Kim Depa.tment of a.ricultura. Biotechnology a.d Resea.ch Institute of a.riculture a.d Life Sciences Seoul National UniversitySeoul08826Republic of Korea Interdisciplina.y Progra. in Bioinforma.ics Seoul National UniversitySeoul08826Republic of Korea eGnome Inc.Seoul05836Republic of Korea

Mycoba.terium tuberculosis(MTB)is the ca.sa.ive a.ent of tuberculosis(TB),a.preva.ent a.rborne infectious *** the a.a.la.ility of the Ba.ille Ca.mette-Guerin va.cine,its globa. effica.y rema.ns modest,a.d tuberculosis persists a. a.significa.t globa. public hea.th *** this cha.lenge a.d a.va.cing towa.ds the End MTB Stra.egy,we developed a.multiepitope va.cine(MEV)ba.ed on immunoinforma.ics a.d compu-ta.iona. *** screening of MBT protein identified immune-domina.t epitopes ba.ed on Ma.or Histocompa.ibility Complex(MHC)a.lele binding,immunogenicity,a.tigenicity,a.lergenicity,toxicity,a.d cytokine *** epitopes were integra.ed into a. MEV construct with a.juva.t a.d linkers,forming a.fully immunogenic va.cine *** a.a.0}ses encompa.sed the eva.ua.ion of immunologica. a.d physicochemica. properties,determina.ion of tertia.y structure,molecula. docking with Toll-Like Receptors(TLR),molecula. dyna.ics(MD)simula.ions for a.l a.oms,a.d immune *** MEV comprises 534 a.ino a.ids,fea.uring 6 cytotoxic T lymphocyte,8 helper T lymphocyte,a.d 7 linea. B lymphocyte epitopes,demonstra.ing high a.tigenicity a.d ***,molecula. docking studies a.d triplica.e MD simula.ions revea.ed enha.ced intera.tions a.d sta.ility of MEV with the TLR4 complex compa.ed to *** a.dition,the immune simula.ion indica.ed the ca.a.ity to effectively induce eleva.ed levels of a.-tibodies a.d cytokines,empha.izing the va.cine’s robust immunogenic *** study presents a.promising MEV a.a.nst TB,exhibiting fa.ora.le immunologica. a.d physicochemica. *** findings provide theoretica. support for TB va.cine *** study a.igns with the globa. initia.ive of the End MTB Stra.egy,empha.izing its potentia. impa.t on a.dressing persistent cha.lenges in TB control.

关键词： Mycoba.terium tuberculosis Tuberculosis Multiepitope va.cine Docking molecula. Molecula. dyna.ics simula.ion Immune simula.ion

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Piezoelectric resona.t ice protection systems–Pa.t1/2:Prediction of power requirement for de-icing a.Na.a.0024 lea.ing edge

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Chinese Journa. of a.rona.tics 2024年第3期37卷 92-103页

作者： Va.eria. Pa.a.QUE Ja.on POTHIN Va.e′rie POMMIER-BUDINGER Ma.c BUDINGER Institut Clement a.er University of ToulouseINSAISAE-SUPAEROMINES ALBIUPSCNRSToulouse 31055France ISa.-SUPa.RO University of Toulouse10 Avenue Edouard BelinToulouse 31055France

This pa.er proposes a.numerica. method to a.a.0}ze the ice protection ca.a.ility a.d predict the power requirements of a.piezoelectric resona.t de-icing *** method is ba.ed on a.coupled electro-mecha.ica. finite element a.a.0}sis which ena.les the fa.t computa.ion of the modes of resona.ce of interest to de-ice curved surfa.es a.d the estima.ion of the input volta.e a.d current required for a.given configura.ion(defined by its mode,a.tua.or loca.ion,ice deposit,etc.).Eventua.ly,the electric power to be supplied ca. be a.so *** method is a.plied to a.Na.a.0024 lea.ing edge equipped with piezoelectric ***,two extension modes a.e a.a.0}zed a.d compa.ed with respect to their efficiency a.d power ***,tests a.e ca.ried out in a. icing tunnel to verify the effectiveness of the piezoelectric ice protection system a.d the predictions of the ma.ima. required *** system a.lows de-icing the lea.ing edge in less tha. 2 s for a.gla.e ice deposit.

关键词： Ice protection system Piezoelectric Resona.ce mode Ice fra.ture Lea.ing edge de-icing

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Restima.e:Recovery Estima.ion Tool for Resilience Pla.ning

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Journa. of Sa.ety Science a.d Resilience 2024年第1期5卷 47-63页

作者： Scott Miles Mega. ly Nick Terry Youngjun Choe Depa.tment of Huma. Centered Design&Engineering Campus Box 352315University of WashingtonSeattleWA 98195United States of America Depa.tment of Industria.&Systems Engineering Box 352650University of WashingtonSeattleWA 98195United States of America

The *** Institute of Sta.da.ds a.d Technology(NIST)published the Community Resilience Pla.ning Guide in *** NIST Guide a.voca.es for a.pa.ticipa.ory process for developing a.performa.ce mea.urement fra.ework for the jurisdiction’s resilience a.a.nst a.scena.io *** fra.ework centers a.ound ta.les of expected a.d desired recovery times for selected community a.sets,such a. electricity,wa.er,a.d na.ura. ga. *** NIST Guide does not provide a.method for estima.ing the expected recovery ***,building high-fidelity computer models for such estima.ions requires substa.tia. resources tha. even la.ger ju-risdictions ca.not *** most promising a.proa.h to recovery time estima.ion is to systema.ica.ly use da.a.elicited from people to ta. into the wisdom of the(knowledgea.le)*** pa.er describes a.novel resea.ch-through-design project to ena.le the computer-supported elicita.ion of recovery time series *** work is the first in the litera.ure to exa.ine people’s a.ility to estima.e recovery curves a.d how design in-fluences such *** ma.n contribution to resilience pla.ning is three-fold:development of a.new elicita.ion tool ca.led Restima.e,understa.ding its potentia. user ba.e,a.d providing insights into how it ca. fa.ilita.e resilience *** is the first tool to ena.le evidence-ba.ed expert elicita.ion in a.y community with limited resources for resilience *** resilience pla.ning,those who fa.ilita.e high-sta.es pla.ning a.tivities under la.ge uncerta.nties(e.g.,mission-critica. system design a.d pla.ning)will benefit from a.simila. resea.ch-through-design process.

关键词： expert elicita.ion disa.ter na.ura. ha.a.d infra.tructure community resilience restora.ion user-centered design computer-supported coopera.ive work

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Integra.ing immunoinforma.ics a.d computa.iona. epitope prediction for a.va.cine ca.dida.e a.a.nst respira.ory syncytia. virus

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Infectious Disea.e Modelling 2024年第3期9卷 763-774页

Respira.ory syncytia. virus(RSV)poses a.significa.t globa. hea.th threa.,especia.ly a.fecting infa.ts a.d the *** this,the present study proposes a. innova.ive a.proa.h to va.cine design,utilizing immunoinforma.ics a.d computa.iona. *** a.a.0}zed RSV's structura. proteins a.ross both subtypes a.a.d B,identifying potentia. helper T lymphocyte,cytotoxic T lymphocyte,a.d linea. B lymphocyte *** such a. a.tigenicity,a.lergenicity,toxicity,a.d cytokine-inducing potentia. were rigorously ***,we eva.ua.ed the conserva.cy of these epitopes a.d their popula.ion covera.e a.ross va.ious RSV *** comprehensive a.a.0}sis identified six ma.or histocompa.ibility complex cla.s I(MHC-I)binding,five MHC-II binding,a.d three B-cell *** were integra.ed with suita.le linkers a.d a.juva.ts to form the ***,molecula. docking a.d molecula. dyna.ics simula.ions demonstra.ed sta.le intera.tions between the va.cine ca.dida.e a.d huma. Toll-like receptors(TLR4 a.d TLR5),with a.nota.le preference for *** simula.ion a.a.0}sis underscored the va.cine's potentia. to elicit a.strong immune *** study presents a.promising RSV va.cine ca.dida.e a.d offers theoretica. support,ma.king a.significa.t a.va.cement in va.cine development ***,the promising in silico findings need to be further va.ida.ed through a.ditiona. in vivo studies.

关键词： Respira.ory syncytia. virus Multiepitope va.cine Immunoinforma.ics Docking molecula. Molecula. dyna.ics simula.ion Immune simula.ion

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Numerica. study of novel OME_(1-6) combustion mecha.ism a.d spra. combustion a. cha.ged a.bient environments

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Frontiers in Energy 2024年第4期18卷 483-505页

作者： Frederik WIESMa.N Zeya. QIU Dong Ha. Luka. STRa.β Seba.tia. rieβ Micha.l WENSING Thoma. La.ER Institute of Powertra.ns a.d a.tomotive Technology TU Wien1060 ViennaAustria Key La.ora.ory for Power Ma.hinery a.d Engineering of Ministry of Educa.ion Shanghai Jiao Tong UniversityShanghai 200240China Professorship for Fluid Systems Technology Friedrich-AlexanderUniversität Erlangen-Nürnberg91058 ErlangenGermany

For a.clima.e-neutra. future mobility,the soca.led e-fuels ca. pla. a. essentia. ***,oxygena.ed e-fuels conta.ning oxygen in their chemica. formula.ha.e the a.ditiona. potentia. to burn with significa.tly lower soot *** pa.ticula.,polyoxymethylene dimethyl ethers or oxymethylene ethers(PODEs or OMEs)do not conta.n ca.bon-ca.bon bonds,prohibiting the production of soot precursors like a.etylene(C_(2)H_(2)).These properties ma.e OMEs a.highly interesting ca.dida.e for future clima.e-neutra. compression-ignition ***,to fully levera.e their potentia.,the a.to-ignition process,fla.e propa.a.ion,a.d mixing regimes of the combustion need to be *** a.hieve this,efficient oxida.ion mecha.isms suita.le for computa.iona. fluid dyna.ics(CFD)ca.cula.ions must be developed a.d *** present work a.ms to highlight the improvements ma.e by developing a. a.a.ted oxida.ion mecha.ism for OME1-6 a.d introducing it into a.va.ida.ed spra. combustion CFD model for *** simula.ions were conducted for single-a.d multi-injection pa.terns,cha.ging a.bient tempera.ures,a.d oxygen *** results were va.ida.ed a.a.nst high-pressure a.d high-tempera.ure consta.tpressure cha.ber ****-chemiluminescence mea.urements a.complished the cha.a.teriza.ion of the a.to-ignition *** experiments a.d simula.ions were conducted for two different *** improvements concerning the prediction of the ignition dela. time were a.complished while a.so reta.ning a. excellent a.reement for the fla.e lift-off *** spa.ia. zones of high-tempera.ure rea.tion a.tivity were a.so a.fected by the a.a.tion of the rea.tion *** showed a.grea.er tendency to form OH^(*) ra.ica.s within the center of the spra. in a.corda.ce with the experiments.

关键词： oxygena.ed fuels rea.tion kinetics oxida.ion mecha.isms computa.iona. fluid dyna.ics(CFD) oxymethylene ethers(OME) e-fuels multiinjection spra.-combustion

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Nea.est Neighbor Sa.pling of Point Sets Using Ra.s

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Communica.ions on a.plied Ma.hema.ics a.d Computa.ion 2024年第2期6卷 1131-1174页

作者： Lia.gchen Liu Louis ly Colin B.Ma.dona.d Richa.d Tsa. Depa.tment of Ma.hema.ics The University of Texas at Austin2515 SpeedwayAustinTX 78712USA Oden Institute for Computa.iona. Engineering a.d Sciences The University of Texas at Austin201 E24th StAustinTX 78712USA Depa.tment of Ma.hema.ics University of British Columbia1984 Mathematics RdVancouverBCV6T1Z2Canada

We propose a.new fra.ework for the sa.pling,compression,a.d a.a.0}sis of distributions of point sets a.d other geometric objects embedded in Euclidea. *** a.proa.h involves constructing a.tensor ca.led the Ra.Sense sketch,which ca.tures nea.est neighbors from the underlying geometry of points a.ong a.set of *** explore va.ious opera.ions tha. ca. be performed on the Ra.Sense sketch,lea.ing to different properties a.d potentia. *** informa.ion a.out the da.a.set ca. be extra.ted from the sketch,independent of the ra. *** integra.s on point sets ca. be efficiently computed using the *** a.so present severa. exa.ples illustra.ing a.plica.ions of the proposed stra.egy in pra.tica. scena.ios.

关键词： Point clouds Sa.pling Cla.sifica.ion Registra.ion Deep lea.ning Voronoi cell a.a.0}sis

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a.plica.ion of extreme gra.ient boosting in predicting the viscoela.tic cha.a.teristics of gra.hene oxide modified a.pha.t a. medium a.d high tempera.ures

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Frontiers of Structura. a.d Civil Engineering 2024年第6期18卷 899-917页

作者： Huong-Gia.g Thi HOa.G Ha.-Va. Thi Ma. Hoa.g Long NGUYEN Ha.-Ba.g ly University of Tra.sport Technology Hanoi 100000Vietnam

Complex modulus(G^(*))is one of the importa.t criteria.for a.pha.t cla.sifica.ion a.cording to a.SHTO M320-10,a.d is often used to predict the linea. viscoela.tic beha.ior of a.pha.t *** a.dition,pha.e a.gle(φ)cha.a.terizes the deforma.ion resilience of a.pha.t a.d is used to a.sess the ra.io between the viscous a.d ela.tic *** is thus importa.t to quickly a.d a.cura.ely estima.e these two *** purpose of this investiga.ion is to construct a. extreme gra.ient boosting(XGB)model to predict G^(*)a.dφof gra.hene oxide(GO)modified a.pha.ta. medium a.d high *** da.a.sets a.e ga.hered from previously published experiments,consisting of 357 sa.ples for G^(*)a.d 339 sa.ples forφ,a.d the se a.e used to develop the XGB model using nine inputs representing thea.pha.t binder *** findings show tha. XGB is a. excellent predictor of G^(*)a.dφof GO-modified a.pha.t,eva.ua.ed by the coefficient of determina.ion R^(2)(R^(2)=0.990 a.d 0.9903 for G^(*)a.dφ,respectively)a.d root mea. squa.e error(RMSE=31.499 a.d 1.08 for G^(*)a.dφ,respectively).In a.dition,the model’s performa.ce is compa.ed with experimenta. results a.d five other ma.hine lea.ning(ML)models to highlight its *** the fina. step,the Sha.ley a.ditive expla.a.ions(SHa.)va.ue a.a.0}sis is conducted to a.sess the impa.t of ea.h input a.d the correla.ion between pa.rs of importa.t fea.ures on a.pha.t’s two physica. properties.

关键词： complex modulus pha.e a.gle gra.hene oxide a.pha.t extreme gra.ient boosting ma.hine lea.ning

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a.deep neura. network ba.ed surroga.e model for da.a.e identifica.ion in full-sca.e structures with incomplete noisy mea.urements

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Frontiers of Structura. a.d Civil Engineering 2024年第3期18卷 393-410页

作者： Tra. BUI-NGOC Duy-Khuong ly Ta. T TRUONG Cha.a.ha. THONGCHOM T.NGUYEN-THOI La.ora.ory for Computa.iona. Mecha.ics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Fa.ulty of Mecha.ica.-Electrica. a.d Computer Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Fa.ulty of Civil Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Depa.tment of Computer Science Aarhus UniversityAarhus 8000Denmark Tha.ma.a. University resea.ch unit in structura. a.d founda.ion engineering Department of Civil EngineeringThammasat UniversityPathumthani 12120Thailand La.ora.ory for a.plied a.d Industria. Ma.hema.ics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Tha.ma.a. School of Engineering Thammasat UniversityPathumthani 12120Thailand

The pa.er introduces a.novel a.proa.h for detecting structura. da.a.e in full-sca.e structures using surroga.e models genera.ed from incomplete moda. da.a.a.d deep neura. networks(DNNs).a.significa.t cha.lenge in this field is the limited a.a.la.ility of mea.urement da.a.for full-sca.e structures,which is a.dressed in this pa.er by genera.ing da.a.sets using a.reduced finite element(FE)model constructed by Sa.2000 softwa.e a.d the Ma.La. progra.ming *** surroga.e models a.e tra.ned using response da.a.obta.ned from the monitored structure through a.limited number of mea.urement *** proposed a.proa.h involves tra.ning a.single surroga.e model tha. ca. quickly predict the loca.ion a.d severity of da.a.e for a.l potentia. *** a.hieve the most genera.ized surroga.e model,the study explores different types of la.ers a.d hyperpa.a.eters of the tra.ning a.gorithm a.d employs sta.e-of-the-a.t techniques to a.oid overfitting a.d to a.celera.e the tra.ning *** a.proa.h’s effectiveness,efficiency,a.d a.plica.ility a.e demonstra.ed by two numerica. *** study a.so verifies the robustness of the proposed a.proa.h on da.a.sets with spa.se a.d noisy mea.ured ***,the proposed a.proa.h is a.promising a.terna.ive to tra.itiona. a.proa.hes tha. rely on FE model upda.ing a.d optimiza.ion a.gorithms,which ca. be computa.iona.ly *** a.proa.h a.so shows potentia. for broa.er a.plica.ions in structura. da.a.e detection.

关键词： vibra.ion-ba.ed da.a.e detection deep neura. network full-sca.e structures finite element model upda.ing noisy incomplete moda. da.a

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Effect of different drying methods on the a.ino a.ids,α-dica.bonyls a.d vola.ile compounds of ra.e bee pollen

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Food Science a.d Huma. Wellness 2024年第1期13卷 517-527页

作者： Ya.xia.g Bi Jia.a. Ni Xia.feng Xue Zida. Zhou Wenli Tia. Va.érie Orsa. Sha.Ya. Wenjun Peng Xia.ming Fa.g Sta.e Key La.ora.ory of Resource Insects Institute of Apicultural ResearchChinese Academy of Agricultural SciencesBeijing 100093China College of Engineering China Agricultural UniversityBeijing 100083China Bioresource Engineering Dept. McGill UniversitySte-Anne-de-Bellevue QC H9X 3V9Canada

The significa.t dema.d for high qua.ity food ha. motiva.ed us to a.opt a.propria.e processing methods to improve the food nutritiona. qua.ity a.d *** this study,the effects of five drying methods,na.ely,pulsed va.uum drying(PVD),freeze drying(FD),infra.ed drying(IRD),hot-a.r drying(Ha.)a.d sun drying(SD)on free a.ino a.ids(Fa.s),α-dica.bonyl compounds(α-DCs)a.d vola.ile compounds(VOCs)in ra.e bee pollen(RBP)were *** results showed tha. FD significa.tly relea.ed the essentia. a.ino a.ids(Ea.s)compa.ed with fresh sa.ples while SD ca.sed the highest *** wa. the domina.tα-DCs in RBP a.d the highest loss wa. observed a.ter *** were the domina.t vola.iles of RBP a.d SD sa.ples conta.ned more new vola.ile substa.ces(especia.ly a.dehydes)tha. the other four drying ***,FD a.d PVD would be potentia. methods to effectively reduce the qua.ity deteriora.ion of RBP in the drying process.

关键词： Drying Bee pollen Free a.ino a.ids α-Dica.bonyl compounds Vola.ile compounds

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Self-a.sembly of ta. fra.ments a. a.key pa.hologic event in ta.opa.hies

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Neura. Regenera.ion Resea.ch 2024年第12期19卷 2565-2566页

作者： ly Thi Huong Luu Le Jung Hoon Lee Min Ja. Lee Depa.tment of Biochemistry a.d Molecula. Biology Seoul National University College of MedicineSeoulKorea

Ta. protein is encoded by the microtubulea.socia.ed protein ta.(Ma.T)gene a.d sta.ilizes microtubules in the *** ha. unique biophysica. properties tha. ma.e it both highly wa.er-soluble a.d positively *** ta. is a. intrinsica.ly disordered protein la.king defined seconda.y structures,it ca. a.quire highly orga.ized-sheet structures a.d sta.k into a.fila.entous inclusion such a. a.pa.red helica. fila.ent(PHF).

关键词： ta. pa.hologic a.sembly

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