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Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam

Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 795-800页

作者： Thu Dang kim Hai nguyen Thanh Duong nguyen Thuy Loi Vu Duc Thu Vu Thi Hung Vu Manh Patcharee Boonsiri Tung Bui Thanh Department of Pharmacology and Clinical Pharmacy School of Medicine and PharmacyVietnam National University Department of Pharmaceutics and Pharmaceutical Technology School of Medicine and PharmacyVietnam National University Department of Pharmacology Hanoi University of Pharmacy Department of Pharmacognosy and Traditional Pharmacy School of Medicine and PharmacyVietnam National University Faculty of Biology VNU University of Science Key Laboratory of Enzyme and Protein Technology VNU University of Science Department of Pharmacology School of PharmacyLac Hong University Department of Biochemistry Faculty of MedicineKhon Kaen University

Objective:To evaluate the antitumor activity both in vitro and in vivo of saponin–phospholipid complex of Panax ***:The in vitro cytotoxic effect of saponins extract and saponin–phospholipid complex against human lung cancer NCI-H460 and breast cancer cell lines BT474 was examined using MTS *** in vivo evaluation of antitumor potential,saponin and saponin–phospholipid complex were administered orally in rats induced mammary carcinogenesis by 7,12-dimethylbenz(a)anthracene,for 30 ***:Our data showed that saponin–phospholipid complex had stronger anticancer effect compared to saponin *** IC50 values of saponin–phospholipid complex and saponin extract for NCI-H460 cell lines were 28.47 mg/m L and 47.97 mg/mL,respectively and these values for BT474 cells were 53.18 mg/mL and 86.24 mg/mL,*** vivo experiments,administration of saponin,saponin–phospholipid complex and paclitaxel(positive control) effectively suppressed 7,12-dimethylbenz(a) anthracene-induced breast cancer evidenced by a decrease in tumor volume,the reduction of lipid peroxidation level and increase in the body weight,and elevated the enzymatic antioxidant activities of superoxide dismutase,catalase,glutathione peroxidase in rat breast ***:Our study suggests that saponin extract from Panax notoginseng and saponin–phospholipid complex have potential to prevent cancer,especially breast cancer.

关键词： Panax notoginseng Saponin Saponin–phospholipid complex Breast cancer Antitumor

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The Obstacles and Potential Solution Clues of Prime Editing Applications in Tomato

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BioDesign Research 2022年第1期2022卷 11-18页

作者： Tien Van Vu Ngan Thi nguyen Jihae kim Swati Das Jinsu Lee Jae-Yean kim Division of Applied Life Science(BK21 FOUR Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 660-701Republic of Korea National Key Laboratory for Plant Cell Biotechnology Agricultural Genetics InstituteKm 02Pham Van Dong RoadCo Nhue 1Bac Tu LiemHanoi 11917Vietnam Division of Life Science Gyeongsang National University501 Jinju-daeroJinju 52828Republic of Korea Nulla Bio Inc. 501 Jinju-daeroJinju 660-701Republic of Korea.

Precision genome editing is highly desired for crop *** recently emerged CRISPR/Cas technology offers great potential applications in precision plant genome engineering.A prime editing(PE)approach combining a reverse transcriptase(RT)with a Cas9 nickase and a“priming”extended guide RNA(gRNA)has shown a high frequency for precise genome modification in mammalian cells and several plant ***,the applications of the PE approach in dicot plants are still limited and *** designed and tested prime editors for precision editing of a synthetic sequence in a transient assay and for desirable alleles of 10 loci in tomato by stable *** data obtained by targeted deep sequencing also revealed only low PE efficiencies in both the tobacco and tomato *** assessment of the activities of the PE components uncovered that the fusion of RT to Cas9 and the structure of PE gRNAs(pegRNAs)negatively affected the cleaving activity of the Cas9 *** self-complementarity between the primer binding sequences(PBSs)and spacer sequence might pose risks to the activity of the Cas9 ***,modifying the pegRNA sequences by shortening or introducing mismatches to the PBSs to reduce their melting temperatures did not enhance the PE efficiency at the MADS-box protein(SlMBP21),alcobaca(SlALC),and acetolactate synthase 1(SlALS1)*** data show challenges of the PE approach in tomato,indicating that a further improvement of the PE system for successful applications is demanded,such as the use of improved expression systems for enriching active PE complexes.

关键词： CRISPR/Cas precise editing

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Hydrodeoxygenation of Bio-Oil on Bimetallic Catalysts: From Model Compound to Real Feed

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Journal of Sustainable Bioenergy Systems 2015年第4期5卷 151-160页

作者： Thuan Minh Huynh Udo Armbruster Luong Huu nguyen Duc anh nguyen Andreas Martin Leibniz Institute for Catalysis at University of Rostock Rostock Germany Vietnam Petroleum Institute Hanoi Vietnam

Two series of bimetallic Ni-Co catalysts and corresponding monometallic catalysts with ca. 20 wt% metal loading were evaluated in hydrodeoxygenation (HDO) of phenol as a model compound for bio-oil. The bimetallic catalysts outperformed the corresponding monometallic catalyst in terms of conversion and cyclohexane selectivity. This could be attributed to the formation of Ni-Co alloy, which caused a decrease in metal particle size and stabilized Ni active sites in the near surface region. The balanced combination of formed Ni-Co alloy with acidity from supports allowed performing all individual steps in the reaction network toward desired products at high rate. Consequently, the two best-performing catalysts were tested in HDO of wood based bio-oil, showing that the bimetallic catalyst 10Ni10Co/HZSM-5 was more effective than 20Ni/HZSM-5 in terms of degree of deoxygenation and upgraded bio-oil yield. These findings might open an opportunity for development of a novel cheap but effective catalyst for a key step in the process chain from biomass to renewable liquid fuels.

关键词： Bimetallic Catalysts Hydrodeoxygenation Phenol Bio-Oil Ni-Co Alloy

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Compensation of Zn substitution and secondary phase controls effective mass and weighted mobility in In and Ga co-doped ZnO material

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Journal of Materiomics 2021年第4期7卷 742-755页

作者： Oanh Kieu Truong Le anh Tuan Thanh Pham Ngoc kim Pham Trang Huyen Cao Pham Truong Huu nguyen Dung Van Hoang Hanh Kieu Thi Ta Dai Cao Truong Hoa Thi Lai Thuy Dieu Thi Ung Vinh Cao Tran Thang Bach Phan aboratory of Advanced Materials University of ScienceHoChiMinh City700000Viet Nam Vietnam National University HoChiMinh City700000Viet Nam Faculty of Physics and Engineering Physics University of ScienceHoChiMinh City700000Viet Nam Faculty of Materials Science and Technology University of ScienceHoChiMinh City700000Viet Nam Center for Innovative Materials and Architectures(INOMAR) HoChiMinh CityViet Nam Institute of Materials Science Vietnam Academy of Science and TechnologyHanoi100000Viet Nam

Conductivity s and thermal conductivity k are directly related to carrier concentration while Seebeck coefficient S is inversely proportional to carrier ***,improving thermoelectric(TE)performance is ***,the first-time analysis of secondary phase-controlled TE performance in terms of density-of-state effective mass m*d,weighted mobility mw and quality factor B is discussed in ZnO *** results show that the secondary spinel phase Ga2O_(3)(ZnO)9 not only impacts on k but also on s and S at high temperature,while the effect of carrier concentration seem to be dominant at low *** the high-spinel-segregation sample,a compensation of dopant atoms from the spinel to substitutional sites in the ZnO matrix at high temperature leads to a low decreased rate of temperaturedependent m**** compensation process also induces a band sharpening,a small mw reduction,and a large B *** a result,In and Ga co-doped ZnO bulk with the highest spinel segregation achieves the greatest PF improvement by 112.8%,owing to enhanced Seebeck coefficient by 110%as compared to the good Zn-substitution sample.

关键词： Thermoelectrics In and Ga co-Doped ZnO Secondary phase Zn substitution DOS effective Mass Weighted mobility

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An electrochemical and microstructural characterization of steel-mortar admixed with corrosion inhibitors

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中国科学:技术科学 2010年第4期40卷 436-436页

作者： Tuan anh nguyen Recep AVCI Corrosion and Sustainable Infrastructure Laboratory Western Transportation Institute College of Engineering Montana State University Imaging and Chemical Analysis Laboratory Department of PhysicsMontana State University

The present research brings new insights on the role of admixed corrosion inhibitors in the processes of cement hydration and rebar *** admixing of NaCl and the corrosion inhibitors in fresh mortar was found to alter the morphology and microstructure of the hardened mortar at the steel-mortar interfacial *** admixing of the inhibitors increased the risk of carbonation of cement hydrates at the steel-mortar interfacial region,but partially displaced chloride ions. Chloride and the admixed inhibitors facilitated the formation of different cement hydrates and affected chloride binding at the steel-mortar interfacial *** admixing of all three inhibitors was found to increase the polarization resistance of steel,indicating reduced corrosion rate of the steel over 48-day exposures to salt ponding.

关键词： corrosion inhibitor rebar corrosion steel-mortar interface FESEM EDX XPS EIS

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Impacts of the Financial Factors on Schedule Delays Risk of the International Contracting Projects: Evidence from Highway BOT Pro-jects in Vietnam

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World Journal of Engineering and Technology 2015年第4期3卷 311-319页

作者： Hong-anh Vu Jianqiong Wang Lianxing Min Thihong-Nhung nguyen School of Economics and Management Southwest Jiaotong University Chengdu China School of Management Chengdu University of Traditional Chinese Medicine Chengdu China

Vietnam has become a major market for construction enterprises from East Asian countries, especially from China, to participate in international project contracting, but serious schedule delays have important adverse effects on local government and foreign investment companies. Based on international engineering contracting mode of Vietnam highway BOT construction projects, we discussed the drive financial factors of schedule delays, using the methods of exploratory factor analysis and questionnaire survey, and evaluated the effects of various factors which are through regression analysis. The empirical results show that the five categories of financial factors, including the policy change, slow payment, financial mismanagement, financial market changes and lack of fiscal, have significant effects on schedule delay. Furtherly, we suggested that strengthening policy research and improving financial management ability should be used to reduce the influence of relevant financial factors on schedule delay, to improve the profitability of international businesses and the motivation of foreign enterprises to participate in Vietnam highway project.

关键词： Scheduling Risk Management Exploratory Analysis Project Delay Fiscal Factors Risk Evaluation

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A Comparison of Control Methods for Z-Source Inverter

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Energy and Power Engineering 2012年第4期4卷 187-195页

作者： Cong-Thanh Pham Anwen Shen Phan Quoc Dzung nguyen Bao anh nguyen Xuan Phu Dept of Control Science and Engineering Huazhong University of Science and Technology Wuhan China HCMC University of Technology Ho Chi Minh City Vietnam

In recent years, Z-source inverters (ZSI) have been proposed as an replacement power conversion concept which it has both voltage buck and boost abilities. In addition, ZSI doesn’t require dead-time to protection short circuit at two switches any of the same phase leg in the inverter bridge and to achieve optimal harmonic of current, voltage. This paper presents two different control methods (CM) for ZSI. The aim of this study to compare between two modulation methods, there are modi?ed space vector pulse width modulation method (MSVM) and the simple boost control (SBC) about the unique harmonic performance features, the total average and peak switching device power of the inverter system. In addition, this paper also analyzes about the ability exceed modulation index in linear region of two CM using MATLAB/Simulink.

关键词： Buck-Boost Current Source Inverters (CSIs) Pulse-Width Modulation (PWM) Voltage Source Inverters (VSIs) Z-Source Inverters (ZSI)

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Biodegradable Quaternary Ammonium Salts for Processing Iron Ores

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American Journal of Analytical Chemistry 2014年第10期5卷 646-654页

作者： Xiaoqing Weng anh V. nguyen Guangjun Mei Yongfu Yu School of Chemical Engineering The University of Queensland Brisbane Australia School of Resources and Environmental Engineering Wuhan University of Technology Wuhan China

Two biodegradable quaternary ammonium salts were synthesized and used as cationic collectors in processing iron ores by froth flotation. The flotation behaviors of iron minerals with the new biodegradable quaternary ammonium collectors were investigated by micro-flotation tests of quartz (SiO2) and magnetite (Fe3O4). It was observed that the new biodegradable collectors were effective in separating quartz from magnetite by flotation. At the collector concentration of 1 × 10﹣4 mol/L, the recovery of quartz using the M301 and M302 collectors can reach its maximum of 67.97% and 91.18%, respectively. For a wide pH range, they also show good selectivity. By the measuring zeta potentials of the new quaternary ammonium salts, the results show that quaternary ammonium salt is preferred to adsorb on the surface of quartz. The two quaternary ammonium collectors are also determined as readily biodegradable collectors, according to the OECD301B evaluation standard.

关键词： Quaternary Ammonium Salt Micro-Flotation Zeta Potential Biodegradation

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Soil Gas Radon Measurement for Identifying Active Faults in Thua Thien Hue (Vietnam)

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Journal of Geoscience and Environment Protection 2020年第7期8卷 44-64页

作者： Pham Tich Xuan nguyen anh Duong Vu Van Chinh Pham Thanh Dang nguyen Xuan Qua nguyen Van Pho Institute of Geological Sciences Vietnam Academy of Science and Technology Hanoi Vietnam Institute of Geophysics Vietnam Academy of Science and Technology Hanoi Vietnam

The solid-state nuclear track detectors have long been applied to assess the activity of tectonic faults. We measured the Radon (Rn) concentration in soil gas on 09 profiles with a total of 245 measurement points in Thua Thien Hue area (Vietnam). Measurement results show that the Rn concentration in soil gas ranges from ~10 Bq/m3 to 144,570 Bq/m3. There is a clear difference in the Rn concentration on the granite rock of Dai Loc complex compared to the remaining rocks. The calculated background value and anomaly threshold of Rn concentration on the granite rock of Dai Loc complex and on the remaining rocks are 33,488 Bq/m3, 82,839 Bq/m3 and 5313 Bq/m3, 24,850 Bq/m3 respectively. Spatial distribution of Rn concentration in soil gas reflects the existence of faults since Rn concentration increases at the points above or near fault lines. The level of expression of fault activity is assessed by radon activity index (KRn), which is calculated by the ratio of anomaly value to background value of Rn concentration. According to KRn, in Thua Thien Hue area, only the Dakrong-Hue fault shows a strong expression of activity with high and very high KRn (the maximum KRn = 27.21). The Truong Son, Huu Trach River, Ta Trach River and Bo River fault zones do not show clear activity with low and medium KRn. There is no Rn anomaly value recorded on the Rao Trang fault, demonstrating that it is likely to be inactive at present. The study results indicate that the Rn concentration in soil gas is a strong evidence of the existence of faults or tectonic fracture zones as the Rn concentration always increases at the points above or near the fault line.

关键词： Radon Active Fault Radon Activity Index Thua Thien Hue Vietnam

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Optimum Determination of Partial Transmission Ratios of Mechanical Driven Systems Using a V-belt and a Three-Step Helical Gearbox

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Journal of Environmental Science and Engineering(B) 2017年第6期6卷 328-331页

作者： Dang anh Tuan nguyen Khac Tuan Vu Ngoc Pi Mechanical Engineering Faculty Thai Nguyen University of Technology Thai Nguyen 23000 Vietnam Automotive and Power Machinery Faculty Thai Nguyen University of Technology Thai Nguyen 23000 Vietnam

This paper introduces a new study on the optimum calculation of partial transmission ratios of a mechanical drive system using a V-belt and a three-step helical gearbox in order to get the minimum size of the system. The chosen objective function was the cross section dimension of the system. In solving the optimization problem, the design equation for pitting resistance of a gear set was investigated and equations on moment equilibrium condition of a mechanic system including a V-belt and three helical gear units and their regular resistance condition were analysed. From the results of the study, effective formulas for determination of the partial ratios of the V-belt and three-step helical gearboxes were introduced. As using explicit models, the partial ratios can be determined accurately and simply.

关键词： Transmission ratio gearbox design optimum design V-belt drive helical gearbox.

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