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Two-stage dynamic recrystallization and texture evolution in Al-7Mg alloy during hot torsion

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1900-1911页

作者： Kwang Tae son Chang Hee Cho Myoung Gyun kim Ji Woon Lee school of Mechanical Industrialand Manufacturing EngineeringOregon State UniversityCorvallis OR 97331USA Department of Materials.s.ience Engineering Northwestern UniversityEvanston IL 60208USA Research Institute of Industrial science and Technology(RIsT) Pohang 37673Rep.of Korea Division of Advanced Materials Engineering Kongju National UniversityCheonan 31080Rep.of Korea Center for Advanced Materials and Parts of Powders Kongju National UniversityCheonan 31080Rep.of Korea

Hot torsion tes.s.were performed on the Al-7Mg alloy at the temperature ranging from 300 to 500℃ and strain rates between 0.05 and 5 s^(-1) to explore the progressive dynamic recrystallization(DRX)and texture *** DRX behavior of the alloy manifested two distinct stages.s.age 1 at strain of≤2 and stage 2 at strains of≥*** stage 1,there was a slight increase in the DRXed grain fraction(X_(DRX))with predominance of discontinuous DRX(DDRX),followed by a modest change in X_(DRX) until the transition to stage *** 2 was marked by an accelerated rate of DRX,culminating in a substantial final X_(DRX) of~*** backscattered diffraction(EBsD)analys.s.on a sample in stage 2 revealed that continuous DRX(CDRX)predominantly occurred within the(121)[001]grains,whereas the(111)[110]grains underwent a geometric DRX(GDRX)evolution without a noticeable sub-grain ***,a modified Avrami’s DRX kinetics model was utilized to predict the microstructural refinement in the Al-7Mg alloy during the DRX *** this kinetics model did not accurately capture the DDRX behavior in stage 1,it effectively simulated the DRX rate in stage *** texture index was employed to ass.s. the evolution of the texture isotropy during hot-torsion test,demonstrating significant improvement(>75%)in texture randomness before the commencement of stage *** initial texture evolution is attributed to the rotation of parent grains and the substructure evolution,rather than to an increase in X_(DRX).

关键词： Al-7Mg alloys hot deformation hot torsion tests dynamic recrystazlliation microstructure texture

Alloy design for laser powder bed fusion additive manufacturing:a critical review

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International Journal of Extreme Manufacturing 2024年第2期6卷 29-63页

作者： Zhuangzhuang Liu Qihang Zhou Xiaokang Liang Xiebin Wang Guichuan Li kim Vanmeensel Jianxin Xie Key Laboratory for Advanced Materials Processing(MOE) Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Capital Aerospace Machinery Corporation Limited Beijing 100076People’s Republic of China Key Laboratory for Liquid-solid structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJingshi Road 17923Jinan 250061People’s Republic of China Department of Materials Engineering KU LeuvenLeuven 3001Belgium

Metal additive manufacturing(AM)has been extensively studied in recent *** the significant progress achieved in manufacturing complex shapes and structures,challenges.s.ch as.s.vere cracking when using existing alloys for laser powder bed fusion(L-PBF)AM have *** challenges arise because commercial alloys are primarily designed for conventional casting or forging process.s.overlooking the fast cooling rates.s.eep temperature gradients and multiple thermal cycles of *** address this,there is an urgent need to develop novel alloys.s.ecifically tailored for L-PBF *** review provides a comprehensive summary of the strategies employed in alloy design for *** aims to guide future research on designing novel alloys dedicated to L-PBF instead of adapting existing *** review begins by discussing the features of the L-PBF process.s.focusing on rapid solidification and intrinsic heat ***,the printability of the four main existing alloys(Fe-,Ni-,Al-and Ti-based alloys)is critically ass.s.ed,with a comparison of their conventional *** was found that the weldability criteria are not always applicable in estimating ***,the review presents recent advances in alloy development and associated strategies,categorizing them into crack mitigation-oriented,microstructure manipulation-oriented and machine learning-ass.s.ed ***,an outlook and suggestions are given to highlight the issues that need to be addressed in future work.

关键词： laser powder bed fusion alloy design printability crack mitigation

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脾静脉异常:病例报道及文献回顾

世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 50-50页

作者： Lau s.T. kim s.s. Lee s.L. Ledbetter D.J. 平智广 Children' s Hospital Regional Medical Center 4800 Sand Point Way NE G-0035 SeattleWA 98105 United States

The spleen aris.s.from a mesenchymal bulge at the 6-mm stage of development. There are a wide variety of splenic anomalies and variations that range from benign to clinically significant, and this article presents a brief review of splenic embryology and a case report of an anomalous.s.lenic vein that precluded the formation of a Nissen fundoplication.

关键词：病例报道静脉异常脾异常文献回顾 Nissen胃底折叠术间充质细胞发育过程临床意义胚胎发育

High mobility group box 1 in the central nervous.s.stem:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi Department of Brain science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous.s.stem disorders.s.ch as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple scleros.s.epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous.s.stem *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous.s.stem *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous.s.stem,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous.s.stem may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous.s.stem damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

ATP-binding cassette transporters as possible targets for the intervention of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 721-722页

作者： Hiu Chuen Lok Glenda M.Halliday Woojin scott kim Brain and Mind Centre&school of Medical sciences The University of SydneySydneyNSWAustralia

ATP-binding cassette(ABC)transporters are ubiquitous membrane-bound proteins that are responsible for the translocation of a broad spectrum of substrates across cellular membranes,including lipids,amino acids,nucleosides.s.gars,and ***,ABC transporters are highly expressed in the *** their functions in the brain still need to be elucidated,several members are implicated in the pathogenes.s.of neurodegenerative diseas.s.including Alzheimer’s disease(AD),Parkinson’s disease(PD),and frontotemporal *** this perspective,we will review current knowledge of ABC transporters in the central nervous.s.stem in terms of physiological functions and pathology in ***,we will explore the possibilities of ABC transporters as potential targets in the development of therapeutics for neurodegenerative diseas.s.

关键词： sugar degenerative diseases

Absence of enhancement in a lesion does not preclude primary central nervous.s.stem T-cell lymphoma:A case report

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World Journal of Clinical Cases 2024年第2期12卷 374-382页

作者： Chan-seop kim Chi-Hoon Choi Kyung sik Yi Yook kim Jisun Lee Chang Gok Woo Young Hun Jeon Department of Radiology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Radiology Seoul National University HosptialSeoul 03080South Korea

BACKGROUND Primary central nervous.s.stem lymphoma(PCNsL)is a non-Hodgkin lymphoma that originates in the central nervous.s.stem(CNs)and is exclusively limited to the *** most PCNs.s.are diffuse large B-cell lymphomas,primary CNs T-cell lymphomas(PCNsTLs)are *** typically demonstrate some degree of enhancement on contrast-enhanced magnetic resonance imaging(MRI).To the best of our knowledge,non-enhancing PCNsTL has not been reported *** sUMMARY A 69-year-old male presented to the neurology department with complaints of mild cognitive impairment and gradual onset of left lower leg weakness over a span of two *** MRI showed asymmetric T2-hyperintense lesions within the *** enhancement was observed on the contrast-enhanced T1 *** initial diagnos.s.was neuro-Behçet’s *** high-dose steroid therapy,no alterations in the lesions were identified on initial *** patient’s.s.mptoms deteriorated *** MRI performed one month after the initial scan revealed an increased lesion ***,brain biopsy confirmed the diagnos.s.of *** patient underwent definitive combined ***,the patient developed bacteremia and died of septic shock approximately three months after *** The absence of enhancement in the lesion did not rule out PCNsTL.A biopsy approach is advisable for pathological confirmation.

关键词： Central nervous.s.stem neoplasms Non-Hodgkin Lymphoma T-cell Lymphoma Primary central nervous.s.stem lymphoma Primary central nervous.s.stem T-cell lymphoma Case report

Production of chitosan-based composite film reinforced with lignin-rich lignocellulose nanofibers from rice husk

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Journal of Bioresources and Bioproducts 2024年第2期9卷 174-184页

作者： Hye Jee Kang Yeon Ju Lee Jin Kyoung Lee Irnia Nurika sri suhartini Deokyeong Choe Dong Hyun kim Hoon Choi Natasha P.Murphy Ho Yong kim Young Hoon Jung school of Food science and Biotechnology Kyungpook National UniversityDaegu 41566Republic of Korea CPR s&T Co. Ltd.Gunpo 15880Republic of Korea Department of Agroindustrial Technology Faculty of Agricultural TechnologyUniversitas BrawijayaMalang 65145Indonesia Renewable Resources and Enabling sciences Center National Renewable Energy LaboratoryGoldenCO 80401United States Center for Bio-based Chemistry Korea Research Institute of Chemical TechnologyUlsan 44429Republic of Korea

Lignocellulosic nanofibers(LCNFs),implying lignin-containing cellulose fibers,maintain the prop-erties of both lignin and cellulose,which are hydrophobic and hydrophilic,*** pres-ence of hydrophobic lignin in LCNFs is expected to be an economical and attractive option that can improve the thermal and mechanical properties of ***,this.s.udy was conducted to produce lignin-rich LCNFs from sugar-rich waste obtained from rice hus.s.after acidic *** LCNFs were produced from the lignin-rich solid fractions obtained after pretreatment and enzymatic hydrolys.s.which were then incorporated as an additive into a chitosan-based *** variations in lignin content in the range of approximately 50.6%-66.8%in differently obtained LCNFs gave significantly different optical strengths and mechanical *** controllable process.s.may allow for customized film ***,the glucose-rich liquid fractions obtained after pretreatment and enzymatic hydrolys.s.were used as a substrate for ethanol fermentation to achieve total utilization of rice husk biomass *** conclusion,the lignin-rich biomass fraction holds promise as a suitable material for chitosan-LCNF film and has the potential to increase the economic feasibility of the biomaterial industry.

关键词： Rice husk Lignocellulose nanofiber Lignin-based material Chitosan film Upcycling

Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a s.s.ematic review and meta-analysis

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Neural Regeneration Research 2024年第7期19卷 1584-1592页

作者： Jong Mi Park Masoud Rahmati sang Chul Lee Jae Il shin Yong Wook kim Department and Research Institute of Rehabilitation Medicine Yonsei University College of MedicineSeoulSouth Korea Department of Physical Education and sport sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran Department of Pediatrics Yonsei University College of MedicineSeoulSouth Korea

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease *** cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s *** stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of *** performed a meta-analys.s.to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal *** searched bibliographic databas.s.PubMed/MEDLINE,Embase,CENTRAL,scopus,and Web of science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,*** study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences.s.D)between the treatment and control *** use the s.s.ematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analys.s.and review of animal studies checklist for study quality ass.s.ment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the *** with mesenchymal stem cells.s.gnificantly improved motor function as ass.s.ed by the amphetamine-induced rotational *** the stem cell types,the bone marrow Ms.s.with neurotrophic factor group showed la rgest effect size(sMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(sMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a

关键词： animal animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation

Roles of host proteas.s.in the entry of sARs-CoV-2

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Animal Diseases 2024年第1期4卷 27-39页

作者： Alexandria Zabiegalal Yunjeong kim Kyeong-Ok Chang Department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State University1800 Denison Avenue ManhattanKS 66506USA

The spike protein(s)of sARs-CoV-2 is responsible for viral attachment and entry,thus a major factor for host s.s.ep-tibility,tissue tropism,virulence and *** s is divided with s1 and s2 region,and the s1 contains the receptor-binding domain(RBD),while the s2 contains the hydrophobic fusion domain for the entry into the host *** host proteas.s.have been implicated in the activation of sARs-CoV-2 s through various c leavage *** this article,we review host proteas.s.including furin,trypsin,transmembrane protease serine 2(TMPRss2)and cathepsins in the activation of sARs-CoV-2 *** betacoronavirus.s.including sARs-CoV-2 have polybasic residues at the s1/s2 site which is.s.bjected to the cleavage by *** s1/s2 cleavage facilitates more ass.s.able RBD to the receptor ACE2,and the binding triggers further conformational changes and exposure of the s2'site to proteas.s.such as type Il transmembrane serine proteas.s.TTPRs)including *** the presence of TMPRss2 on the target cells.s.Rs-CoV-2 can utilize a direct entry route by fusion of the viral envelope to the cellular *** the absence of TMPRss2,sARs-CoV-2 enter target cells via endosomes where multiple cathepsins cleave the s for the successful *** host proteas.s.involved in the cleavage of the s were *** article also includes roles of 3C-like protease inhibitors which have inhibitory activity against cathepsin L in the entry of sARs-CoV-2,and discussed the dual roles of such inhibitors in virus replication.

关键词： sARs-CoV-2 spike protein(s) Host proteases Cleavage site Virus entry