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Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders

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Signal Transduction and Targeted Therapy 2019年第1期4卷 320-322页

作者： Zhihua Yang Shuang Zhang Fuquan Zhang Yao Yao Kwangwoo kim David Meyre Hongmei Zhang Hai Liao Shuquan Rao Xinhe huang School of Life Science and Engineering Southwest Jiaotong UniversityChengdu 610031China Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072China Wuxi Mental Health Center Nanjing Medical UniversityWuxi 214151China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 10005China Department of Biology Kyung Hee UniversitySeoul 02447Korea Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonON L8S 4K1Canada Department of Pathology and Molecular Medicine McMaster UniversityHamiltonON L8S 4K1Canada Department of Biology Georgia State UniversityAtlantaGA 30303USA

Dear Editor,Major mood disorders,which primarily include bipolar disorder(BD)and major depressive disorder(MDD),are among the most common psychiatric disorders and are recognized as leading causes of morbidity ***,twin and adoption studies have consistently indicated moderate-to-strong genetic contribu-tions to the risk of major mood disorders.1 Genetic association and genome-wide association studies(GWAS)suggest that there is some degree of overlap for some specific disorders but also specific genetic diversity.2 DAOA(D-amino acid oxidase activator),a gene located on human chromosome 13q33.2,plays a crucial role in the central nervous system through binding with DAO(encoding D-amino acid oxidase).Convergent lines of biological evidence suggest that DAOA is an attractive candidate gene for major mood disorders.

关键词： DAO attractive disorders

Identifying quasi-2D and 1D electrides in yttrium and scandium chlorides via geometrical identification

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npj Computational Materials 2018年第1期4卷 17-25页

作者： Biao Wan Yangfan Lu Zewen Xiao Yoshinori Muraba Junghwan kim Dajian huang Lailei Wu Huiyang Gou Jingwu Zhang Faming Gao Ho-kwang Mao Hideo Hosono Key Laboratory of Metastable Materials Science and Technology College of Material Science and EngineeringYanshan University066004 QinhuangdaoChina Center for High Pressure Science and Technology Advanced Research 100094 BeijingChina Materials Research Center for Element Strategy Tokyo Institute of Technology4259 NagatsutachoMidori-ku Yokohama226-8503 KanagawaJapan Laboratory for Materials and Structures Institute of Innovative ResearchTokyo Institute of TechnologyMailbox R3-44259 Nagatsuta-choMidori-ku226-8503 YokohamaJapan Key Laboratory of Applied Chemistry College of Environmental and Chemical EngineeringYanshan University066004 QinhuangdaoChina Geophysical Laboratory Carnegie Institution of Washington5251 Broad Branch Road NWWashingtonDC 20015USA

Developing and understanding electron-rich electrides offers a promising opportunity for a variety of electronic and catalytic *** a geometrical identification strategy,here we identify a new class of electride material,yttrium/scandium chlorides Y(Sc)_(x)Cl_(y)(yx<2).Anionic electrons are found in the metal octahedral framework *** diverse electronic dimensionality of these electrides is quantified explicitly by quasi-two-dimensional(2D)electrides for[YCl]^(+)∙e−and[ScCl]^(+∙)e−and one-dimensional(1D)electrides for[Y_(2)Cl_(3)]^(+)∙e−,[Sc_(7)Cl_(10)]^(+)∙e−,and[Sc5Cl8]2+∙2e−with divalent metal elements(Sc^(2+):3d^(1) and Y^(2+):4d^(1)).The localized anionic electrons were confined within the inner-layer spaces,rather than inter-layer spaces that are observed in A_(2)B-type 2D electrides,***_(2)***,when hydrogen atoms are introduced into the host structures to form YClH and Y2Cl3H,the generated phases transform to conventional ionic compounds but exhibited a surprising reduction of work function,arising from the increased Fermi level energy,contrary to the conventional electrides reported so far.Y_(2C)l_(3) was experimentally confirmed to be a semiconductor with a band gap of 1.14 *** results may help to promote the rational design and discovery of new electride materials for further technological applications.

关键词： yttrium quasi rational

Li-ion battery material under high pressure:amorphization and enhanced conductivity of Li4Ti5O12

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National Science Review 2019年第2期6卷 239-246页

作者： Yanwei huang Yu He Howard Sheng Xia Lu Haini Dong Sudeshna Samanta Hongliang Dong Xifeng Li Duck Young kim Ho-kwang Mao Yuzi Liu Heping Li Hong Li Lin Wang Center for High Pressure Science and Technology Advanced Research College of Materials and Environmental Engineering Hangzhou Dianzi University Key Laboratory of High-temperature and High-pressure Study of the Earth's Interior Institute of Geochemistry Chinese Academy of Sciences Department of Physics and Astronomy George Mason University State Key Laboratory of Organic-Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Energy Beijing University of Chemical Engineering School of Mechatronic Engineering and Automation Shanghai University Geophysical Laboratory Carnegie Institution Center for Nanoscale Materials Argonne National Laboratory Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

Lithium titanium oxide(Li4Ti5O12,LTO),a‘zero-strain’anode material for lithium-ion batteries,exhibits excellent cycling ***,its poor conductivity highly limits its ***,the structural stability and conductivity of LTO were studied using in situ high-pressure measurements and first-principles *** underwent a pressure-induced amorphization(PIA)at 26.9 *** impedance spectroscopy revealed that the conductivity of LTO improved significantly after amorphization and that the conductivity of decompressed amorphous LTO increased by an order of magnitude compared with its starting ***,our calculations demonstrated that the different compressibility of the Li O6and Ti O6octahedra in the structure was crucial for the *** amorphous phase promotes Li+diffusion and enhances its ionic conductivity by providing defects for ion *** results not only provide an insight into the pressure depended structural properties of a spinel-like material,but also facilitate exploration of the interplay between PIA and conductivity.

关键词： high pressure pressure-induced amorphization lithium-ion battery materials ionic conductivity

Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana

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Synthetic and Systems Biotechnology 2020年第3期5卷 236-243页

作者： Fengwei Li Li Ma Xingwang Zhang Jingfei Chen Feifei Qi Yinyue huang Zepeng Qu Lishan Yao Wei Zhang Eung-Soo kim Shengying Li State Key Laboratory of Microbial Technology Shandong UniversityQingdaoShandong266237China Shandong Provincial Key Laboratory of Synthetic Biology CAS Key Laboratory of BiofuelsQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdaoShandong266101China Department of Biological Engineering Inha UniversityIncheon22212South Korea Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong266237China

The cytochrome P450 enzyme CYP-sb21 from the rare actinomycete Sebekia benihana is capable of hydroxylating the immunosuppressive drug molecule cyclosporine A(CsA)primarily at the 4th N-methyl leucine(MeLeu4),giving rise toγ-hydroxy-N-methyl-L-Leu4-CsA(CsA-4-OH).This oxidative modification of CsA leads to dramatically reduced immunosuppressive activity while retaining the hair growth-promoting side-effect,thus demonstrating great application potential in both pharmaceutical and cosmetic ***,this P450 enzyme also hydroxylates CsA at the unwanted position of the 9th N-methyl leucine(MeLeu9),indicating that the regioselectivity needs to be improved for the development of CsA-4-OH into a commercial hair growth ***,we report the crystal structure of CYP-sb21 in its substrate-free form at 1.85Å.Together with sequence and 3D structure comparisons,Autodock-based substrate docking,molecular dynamics(MD)simulation,and site-directed mutagenesis,we identified a number of key residues including R294,E264,and M179 that can improve catalytic efficiency or change the regioselectivity of CYP-sb21 towards CsA,setting the stage for better enzymatic preparation of *** study also provides new insights into the substrate recognition and binding mechanism of P450 enzymes that accommodate bulky substrates.

关键词： Cytochrome P450 monooxygenase Crystal structure Cyclosporine A Regioselectivity Hair growth stimulator

Meeting report: a close look at oral biofilms and microbiomes

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International Journal of Oral Science 2018年第3期10卷 147-151页

作者： Xin Xu Feng Chen Zhengwei huang Lvyan Ma Li Chen Yaping Pan Jian Xu Syngcuk kim Denis Kinane Hyun Koo Xuedong Zhou State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics West China Hospital of StomatologySichuan University Central Laboratory Peking University School and Hospital of Stomatology Department of Endodontics Ninth People’sHospital Shanghai Jiao Tong University School of Medicine State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Key Laboratory of Medical Molecular Virology Ministry of Education and Health Fudan University Department of Periodontics School of Stomatology Chinese Medical UniversityShenyang China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Department of Endodontics School of Dental Medicine University of Pennsylvania Department of Periodontics School of Dental Medicine University of Pennsylvania Divisions of Pediatric Dentistry and Community Oral Health Department of Orthodontics School of Dental Medicine University of Pennsylvania

The "Biofilms, Microbiomes and Oral Diseases: Challenges and Future Perspectives" symposium jointly organized by Penn Dental Medicine and West China School of Stomatology was held on 30 September 2017 at Penn Wharton China Center(PWCC) in Beijing,China. The topics included the pathogenicity of oral biofilms, novel strategies for the control of biofilm-related diseases, oral microbiome and single-cell approaches, and the link between oral diseases and overall health. Researchers from a number of disciplines, representing institutions from China and Penn Dental Medicine, gathered to discuss advances in our understanding of biofilms, as well as future directions for the control of biofilm-related oral and systemic diseases.

关键词： Meeting report a close look at oral biofilms and microbiomes

超声联合酶处理下TG酶交联大豆分离蛋白凝胶特性研究

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农业机械学报 2022年第4期53卷 394-402页

作者：李杨马召蕾郑丽黄雨洋金技峰滕飞东北农业大学食品学院哈尔滨150030 哈尔滨商业大学食品工程学院哈尔滨150030 张哲九平壤商业大学给养系平壤950003

为研究超声联合酶处理对大豆分离蛋白(SPI)结构和对谷氨酰胺转氨酶(TG)交联的SPI凝胶性能的影响,采用内源性荧光光谱、傅里叶红外变换光谱解析超声联合酶处理对SPI结构的影响,并以粒径、游离巯基含量、表面疏水性、凝胶强度、持水性及... 详细信息

为研究超声联合酶处理对大豆分离蛋白(SPI)结构和对谷氨酰胺转氨酶(TG)交联的SPI凝胶性能的影响,采用内源性荧光光谱、傅里叶红外变换光谱解析超声联合酶处理对SPI结构的影响,并以粒径、游离巯基含量、表面疏水性、凝胶强度、持水性及微观结构为指标,探究SPI结构改变与功能特性之间的关系。红外及荧光光谱表明,与未经处理SPI和经单一改性处理的SPI相比,超声联合酶处理使蛋白α-螺旋和β-转角相对含量降低,β-折叠和无规则卷曲相对含量上升,蛋白结构伸展,促使游离巯基和疏水基团暴露,提高了SPI游离巯基含量和表面疏水性。与未处理SPI相比,经超声联合酶处理的SPI凝胶效果最佳,形成了均匀致密的凝胶网络,其凝胶强度和持水率分别提升了(278.04±18.81)%和(89.51±2.78)%,超声联合酶处理可以改善SPI结构以及TG交联的SPI凝胶特性。

关键词：大豆分离蛋白超声木瓜蛋白酶结构凝胶性

Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 78-93,I0009-I0013页

作者： Jin Hean Koh Darren Jun Hao Tan Yuki Ong Wen Hui Lim Cheng Han Ng Phoebe Wen Lin Tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning Qi Pang Beom Kyung kim Nicholas Syn Alfred Kow Brian K.P.Goh Daniel Q.huang Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore Division of Hepatobiliary&Pancreatic Surgery Department of SurgeryNational University HospitalSingaporeSingapore Department of Internal Medicine Yonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalYonsei University Health SystemSeoulRepublic of Korea Biostatistics and Modelling Domain Saw Swee Hock School of Public HealthNational University of Singapore and National University Health SystemSingaporeSingapore Department of Hepato-Pancreato-Biliary and Transplant Surgery Division of SurgerySingapore General HospitalSingaporeSingapore Liver Transplant Service SingHealth Duke-NUS Transplant CentreSingaporeSingapore

Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease *** aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan ***:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan ***-analyses and meta-regression were conducted using random-effects ***:We screened 2,278 studies and included 35 studies with 18,421 *** was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;P<0.01]and DFS(HR=2.71;95%CI:2.23-3.28;P<0.01)compared to LT,with similar findings among intention-to-treat(ITT)*** uninodular disease,OS in LR was comparable to LT(P=0.13)but DFS remained poorer(HR=2.95;95%CI:2.30-3.79;P<0.01).By region,LR had poorer OS versus LT in North America and Europe(P≤0.01),but not Asia(P=0.25).LR had inferior survival versus LT in studies completed before 2010(P=0.01),but not after 2010(P=0.12).Cohorts that underwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to *** between LR and LT were similar in uninodular *** risk of recurrence after LR is threefold that of LT.

关键词： Hepatocellular carcinoma(HCC) liver resection(LR) liver transplant survival recurrence

A TVD SCHEME FOR INCOMPRESSIBLE FLOW COUPLED WITH DIFFERENT TURBULENCE MODLES ON A GROUND-MOUNTED SQUARE-RIB FLOW

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Journal of Hydrodynamics 2007年第6期19卷 743-750页

作者： WANG Jia-song huang Zhen School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200240 China

A finite-difference Total Variation Diminishing （TVD） numerical simulation model for coupling the Reynolds Averaged Navier-Stokes （RANS） equations, pressure-relative continuity equation and various k-εturbulence models was developed to solve the incompressible flow based on the pseudo-compressibility method. The hyperbolicity of all these equations was studied and the discretization of the fully coupling equations with all the primal variables and source terms were made in this article. Numerical simulation for modeling the flow around a ground-mounted square rib was implemented and validated by comparing with the published wind tunnel experimental data. It is shown that such a numerical simulation method with a proper turbulence model has a very good accuracy to simulate the flow around a surface-mounted rib. It is concluded that the Renormalization Group （RNG） and Chen-kim k-εturbulence models have much better ability to predict the characteristics of the vortex structure and flow separation than the standard k-εmodel.

关键词： Total Variation Diminishing (TVD) scheme Reynolds Averaged Navier-Stokes (RANS) turbulence models,square rib pseudo-compressibility method

Joint Power Control and Scheduling for Two-Cell Energy Efficient Broadcasting with Network Coding

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Communications and Network 2013年第3期5卷 312-318页

作者： Linyu huang Chi Wan Sung Seong-Lyun kim Dept. of Electronic Engineering City University of Hong Kong Hong Kong SAR School of Electrical and Electronic Engineering Yonsei University Seoul Korea

We consider the energy minimization problem for a two-cell broadcasting system, where the focus is devising energy efficient joint power control and scheduling algorithms. To improve the retransmission efficiency, linear network coding is applied to broadcast packets. Combined with network coding, an optimal algorithm is proposed, which is based on dynamic programming. To reduce computational complexity, two sub-optimal algorithms are also proposed for large networks. Simulation results show that the proposed schemes can reduce energy consumption up to 57% compared with the traditional Automatic Repeat-reQuest (ARQ).

关键词： Power Control Network Coding Broadcast Scheduling Energy Minimization