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Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： Chao Sun George Boon-Bee Goh Wan-Cheng Chow Wah-Kheong Chan Grace Lai-Hung Wong Wai-Kay Seto Yi-Hsiang huang Han-Chieh Lin I-Cheng Lee Hye Won Lee Seung Up kim Vincent Wai-Sun Wong Jian-Gao Fan Center for Fatty Liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of Clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFLD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(CKD)were defined by an estimated glomerular filtration rate(eGFR)with value of<90 mL/min/1.73 m^(2) and<60 mL/min/1.73 m^(2),respectively,as estimated by the CKD-Epidemiology Collaboration(CKD-EPI)***:Among 529 included NAFLD patients,the prevalence rates of impaired renal function and CKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for CKD(P<0.05).Furthermore,increased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(P<0.05).Compared with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/L or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(P<0.05).Conclusions:Agile 3+and Agile 4 are reliable for identifying NAFLD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

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A comprehensive review of dwell time optimization methods in computer-controlled optical surfacing

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Light(Advanced Manufacturing) 2024年第3期5卷 142-171页

作者： Tianyi Wang Xiaolong Ke Lei huang Qingqing Cui Zili Zhang Chunjin Wang Hyukmo Kang Weslin Pullen Heejoo Choi Daewook kim Vipender Negi Qian Kemao Yi Zhu Stefano Giorgio Philip Boccabella Nathalie Bouet Corey Austin Mourad Idir National Synchrotron Light Source II(NSLS-II) Brookhaven National LaboratoryP.O.Box 5000UptonNY 11973USA School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen 361024China State Key Laboratory of Ultra-precision Machining Technology Department of Industrial Systems and EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina James C.Wyant College of Optical Sciences University of Arizona1630 E.University Blvd.P.O.Box 210094TucsonAZ 85721-0094USA Large Binocular Telescope Observatory University of ArizonaTucsonAZ 85721USA Department of Astronomy and Steward Observatory University of Arizona933 N.Cherry Ave.TucsonAZ85721USA Indian Institute of Technology Delhi Hauz KhasNew Delhi 110016India School of Computer Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798

Dwell time plays a vital role in determining the accuracy and convergence of the computer-controlled optical surfacing ***,optimizing dwell time presents a challenge due to its ill-posed nature,resulting in non-unique *** address this issue,several well-known methods have emerged,including the iterative,Bayesian,Fourier transform,and matrix-form *** their independent development,these methods share common objectives,such as minimizing residual errors,ensuring dwell time's positivity and smoothness,minimizing total processing time,and enabling flexible dwell *** paper aims to comprehensively review the existing dwell time optimization methods,explore their interrelationships,provide insights for their effective implementations,evaluate their performances,and ultimately propose a unified dwell time optimization methodology.

关键词： Dwell time optimization Computer-controlled optical surfacing Finishing Polishing Optical fabrication

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Hydrodynamic optimization of a triswach

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Journal of Hydrodynamics 2014年第6期26卷 856-864页

作者： YANG Chi huang Fuxin kim Hyunyul School of Physics Astronomy and Computational Sciences George Mason University NAVATEK South KingstownRI 02879USA

A new methodology for hydrodynamic optimization of a Tri SWACH is developed, which considers not only the positions of the side hulls but also the shape of the side hulls. In order to account for the strong near-field interference effects between closely-spaced multihulls, an integrated hydrodynamic computational tool that consists of a potential-flow based simple CFD tool and an Euler/RANS/Navier-Stokes based advanced CFD tool has been further developed and integrated into a practical multiobjective hydrodynamic optimization tool. The other components of this hydrodynamic optimization tool consist of a hull shape representation and modification module and an optimization module. This enhanced multi-objective hydrodynamic optimization tool has been applied to the hydrodynamic design optimization of the Tri SWACH for reduced drag by optimizing the side hulls only. A new methodology is developed to optimize side hull forms so that the Tri SWACH has a minimal drag for a wide speed range and for various side hull positions. Two sets of the side hulls are developed and used for the design of two optimal Tri SWACH models. Model tests are carried out for two optimal Tri SWACH models at Webb Institute for validations. Substantial drag reductions have been obtained for a wide range of speed.

关键词： hydrodynamics optimization drag reduction CFD trimaran surface modification

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A NUMERICAL ANALYSIS OF THE VENTILATION PERFORMANCE FOR DIFFERENT VENTILATION STRATEGIES IN A SUBWAY TUNNEL

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Journal of Hydrodynamics 2012年第2期24卷 193-201页

作者： huang Yuan-dong LI Chan kim Chang Nyung School of Environment and Architecture University of Shanghai for Science and Technology China College of Engineering Kyung Hee University Yongin 449-701 Korea Graduate School Kyung Hee University Yongin 449-701 Korea Industrial Liaison Research Institute Kyung Hee University Yongin 449-701 Korea

An unsteady three-dimensional analysis of the ventilation performance is carried out for different ventilation strategies to find out a ventilation method with a high performance in a subway *** natural ventilation performance associated with a train-induced air flow in a subway tunnel is *** dynamic layering method is used to consider the moving boundary of a train in the current CFD *** geometries of the modeled tunnel and the subway train are partially based on those of the Seoul *** effects of the structure of the ventilation duct and the geometry of the partitions on the ventilation performance are *** results show that the combined ventilation ducts （to be designed）,and the partitioning blocks installed along the middle of tunnel （already in existences） are helpful for air *** study can provide some guidance for the design of ventilation ducts in a subway system.

关键词： ventilation performance subway tunnel train-induced air flow natural ventilation duct numerical analysis

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Determining node duty cycle using Q-learning and linear regression for WSN

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Frontiers of Computer Science 2021年第1期15卷 17-23页

作者： Han Yao huang Kyung Tae kim Hee Yong YOUN College of Software Sungkyunkwan UniversitySuwon 440-746Korea

Wireless sensor network(WSN)is effective for monitoring the target environment,which consists of a large number of sensor nodes of limited *** efficient medium access control(MAC)protocol is thus imperative to maximize the energy efficiency and performance of *** most existing MAC protocols are based on the scheduling of sleep and active period of the nodes,and do not consider the relationship between the load condition and *** this paper a novel scheme is proposed to properly determine the duty cycle of the WSN nodes according to the load,which employs the Q-leaming technique and function approximation with linear *** allows low-latency energy-efficient scheduling for a wide range of traffic conditions,and effectively overcomes the limitation of Q-learning with the problem of continuous state-action ***3 simulation reveals that the proposed scheme significantly improves the throughput,latency,and energy efficiency compared to the existing fully active scheme and S-MAC.

关键词： wireless sensor network media access control duty-cycle scheduling Q-leaming linear regression

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Local pixel patterns

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Computational Visual Media 2015年第2期1卷 157-170页

作者： Fangjun huang Xiaochao Qu Hyoung Joong kim Jiwu huang School of Information Science and Technology Sun Yat-sen University Graduate School of Information Security Korea University College of Information Engineering Shenzhen University

In this paper, a new class of image texture operators is proposed. We firstly determine that the number of gray levels in each B × B subblock is a fundamental property of the local image texture. Thus, an occurrence histogram for each B × B sub-block can be utilized to describe the texture of the image. Moreover, using a new multi-bit plane strategy, i.e., representing the image texture with the occurrence histogram of the first one or more significant bit-planes of the input image, more powerful operators for describing the image texture can be obtained. The proposed approach is invariant to gray scale variations since the operators are, by definition,invariant under any monotonic transformation of the gray scale, and robust to rotation. They can also be used as supplementary operators to local binary patterns(LBP) to improve their capability to resist illuminance variation, surface transformations, etc.

关键词： texture multi-bit gray scale rotation

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Virtual screening of inorganic materials synthesis parameters with deep learning

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npj Computational Materials 2017年第1期3卷 14-22页

作者： Edward kim Kevin huang Stefanie Jegelka Elsa Olivetti Department of Materials Science and Engineering MITCambridgeMAUSA Department of EECS and CSAIL MITCambridgeMAUSA

Virtual materials screening approaches have proliferated in the past decade,driven by rapid advances in first-principles computational techniques,and machine-learning *** comparison,computationally driven materials synthesis screening is still in its infancy,and is mired by the challenges of data sparsity and data scarcity:Synthesis routes exist in a sparse,highdimensional parameter space that is difficult to optimize over directly,and,for some materials of interest,only scarce volumes of literature-reported syntheses are *** this article,we present a framework for suggesting quantitative synthesis parameters and potential driving factors for synthesis *** use a variational autoencoder to compress sparse synthesis representations into a lower dimensional space,which is found to improve the performance of machine-learning *** realize this screening framework even in cases where there are few literature data,we devise a novel data augmentation methodology that incorporates literature synthesis data from related materials *** apply this variational autoencoder framework to generate potential SrTiO_(3) synthesis parameter sets,propose driving factors for brookite TiO_(2) formation,and identify correlations between alkali-ion intercalation and MnO_(2) polymorph selection.

关键词： synthesis variational inorganic

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Surface-floating gold nanorod super-aggregates with macroscopic uniformity

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Nano Research 2018年第5期11卷 2379-2391页

作者： Abdul R. Ferhan Youju huang Anirban Dandapat Dong-Hwan kim School of Chemical and Biomedical Engineering Nanyang Technological University 62 Nonyang Drive 6374S7 Singapore School of Chemical Engineering Sungkyunkwan University Gyeonggi-do 16419 Republic of Korea

We present a simple method for obtaining high-density two- and three- dimensional assemblies of gold nanorods （AuNRs） on polymer brush, referred to as ＂surface-floating super-aggregates＂, with uniform distribution spanning macroscopic distances. This was achieved via the single-step immersion of a poly（oligo ethylene glycol methacrylate） brush-containing substrate in a AuNR solution without any form of functionalization. Owing to extensive macroscale plasmonic coupling, we observed for the first time the gradual evolution of a unique sharp peak in addition to the transverse and longitudinal peaks, in this case, in the near-infrared （NIR） region. We also highlight the dynamic nature of these surface-floating super-aggregates, in which the AuNRs spread out when immersed in solution and collapse when dried to facilitate the access of probe molecules for biosensing applications. As a proof of concept, the surface-floating super-aggregates were used for surface-enhanced Raman spectroscopy, with which we detected rhodamine 6G at as low as sub-femtomolar concentrations. Owing to the excellent large-area uniform coverage and extreme simplicity of the fabrication method, such AuNR assemblies can easily be mass-produced and incorporated into cheap biosensors suitable for consumer use in the near future.

关键词： nanoparticle polymer brush nanocomposites surface-enhanced Raman spectroscopy (SERS)

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Fabrication of SiCw/Ti3SiC2 composites with improved thermal conductivity and mechanical properties using spark plasma sintering

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Journal of Advanced Ceramics 2020年第4期9卷 462-470页

作者： Xiaobing Zhou Lei Jing Yong Duk Kwon Jin-Young kim Zhengren huang Dang-Hyok Yoon Jaehyung Lee Qing huang Engineering Laboratory of Advanced Energy Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China School of Materials Science and Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Union Materials Corporation Daegu42710Republic of Korea

High strength SiC whisker-reinforced Ti3SiC2 composites(SiCw/Ti3SiC2)with an improved thermal conductivity and mechanical properties were fabricated by spark plasma *** bending strength of 10 wt%SiCw/Ti3SiC2 was 635 MPa,which was approximately 50%higher than that of the monolithic Ti3SiC2(428 MPa).The Vickers hardness and thermal conductivity(k)also increased by 36%and 25%,respectively,from the monolithic Ti3SiC2 by the incorporation of 10 wt%*** remarkable improvement both in mechanical and thermal properties was attributed to the fine-grained uniform composite microstructure along with the effects of incorporated *** SiCw/Ti3SiC2 can be a feasible candidate for the in-core structural application in nuclear reactors due to the excellent mechanical and thermal properties.

关键词： SiC whisker Ti3SiC2 mechanical property thermal conductivity spark plasma sintering

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The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers

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Genomics, Proteomics & Bioinformatics 2023年第3期21卷 619-631页

作者： Sijia Wu Zhiwei Fan Pora kim Liyu huang Xiaobo Zhou School of Life Science and Technology Xidian UniversityXi’an 710071China West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610040China Center for Computational Systems Medicine School of Biomedical InformaticsThe University of Texas Health Science Center at HoustonHoustonTX 77030USA

Adenosine-to-inosine(A-to-I)RNA editing,constituting nearly 90%of all RNA editing events in humans,has been reported to contribute to the tumorigenesis in diverse ***,the comprehensive map for functional A-to-I RNA editing events in cancers is still *** fill this gap,we systematically and intensively analyzed multiple tumorigenic mechanisms of A-to-I RNA editing events in samples across 33 cancer types from The Cancer Genome *** individual candidate among1,500,000 quantified RNA editing events,we performed diverse types of downstream functional ***,we identified 24,236 potentially functional A-to-I RNA editing events,including the cases in APOL1,IGFBP3,GRIA2,BLCAP,and *** events might play crucial roles in the scenarios of tumorigenesis,due to their tumor-related editing frequencies or probable effects on altered expression profiles,protein functions,splicing patterns,and microRNA regulations of tumor *** functional A-to-I RNA editing events(https://***/CAeditome/)will help better understand the cancer pathology from the A-to-I RNA editing aspect.

关键词： A-to-I RNA editing Cancer Protein recoding Alternative splicing MicroRNA regulation

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