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ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia

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Cellular & Molecular Immunology 2024年第2期21卷 203-204页

作者： Sujin Lee Tae Jin kim Department of Immunology Sungkyunkwan University School of MedicineSuwon16419Republic of Korea

B cells have an essential immunoregulatory function,which is mediated by the secretion of IL-10 and TGFβand interaction with activated CD4^(+)T *** antibody-independent function of B cells contributes to ameliorating autoimmune diseases or infection-induced tissue *** this Cellular and Molecular Immunology issue,Fu et *** that regulatory B(Breg)cells play a critical role in resolving Pseudomonas aeruginosa-induced pneumonia[1].

关键词： metabolism pneumonia Immunology

Comparative study between Embosphere®and Marine gel®as embolic agents for chemoembolization of hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 102-109页

作者： Hyo-Cheol kim Jin Woo Choi Department of Radiology Seoul National University HospitalSeoul 03080South Korea

BACKGROUND While gelatin sponge particles and calibrated microspheres are commonly used as embolic materials in conventional transarterial chemoembolization(cTACE),direct comparisons between these embolic agents are *** To compare the efficacy and safety of superselective cTACE using Embosphere®or Marine gel®in patients with early-stage hepatocellular carcinoma(HCC).METHODS This retrospective study included 70 patients with small(<4 cm)HCC who underwent cTACE with Embosphere®(n=33)or Marine gel®(n=37)as the embolic agent at a single center between March 2021 and July *** radiologic images and clinical data were retrospectively reviewed,with an emphasis on tumor response,procedure-related complications,and local tumor *** primary index tumor was assessed on a 1-mo follow-up image,and local progression-free survival was obtained using the Kaplan-Meier method and was compared by the log-rank *** The median tumor size of both groups was 1.5 cm,and 69 patients achieved a complete response one month after *** cumulative local recurrence rate at 12 mo was 15.5%in the Embosphere®group and 14.4%in the Marine gel®*** local progression-free survival was not significantly different between the two groups(P=0.83).In the multivariate analysis,high serum alphafetoprotein was the only significant poor prognostic factor for local tumor progression(P=0.01).Postembolization syndrome occurred in 36.4%of the Embosphere®group and 35.1%of the Marine gel®group,and there were no cases of biloma,biliary duct dilation,or liver abscess in either *** Calibrated gelatin sponge particles(Marine gel®)and calibrated microspheres(Embosphere®)have similar outcomes in terms of tumor response for superselective cTACE of small HCC.

关键词： Hepatocellular carcinoma Chemoembolization Temporary embolic material Permanent embolic material Tumor response

A Novel Framework to Construct S-Box Quantum Circuits Using System Modeling: Application to 4-Bit S-Boxes

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 545-561页

作者： Yongjin Jeon Seungjun Baek Jongsung kim Department of Financial Information Security Kookmin UniversitySeoul02707Republic of Korea

Quantum computers accelerate many algorithms based on the superposition principle of quantum *** Grover algorithm provides significant performance to malicious users attacking symmetric key *** the performance of attacks using quantum computers depends on the efficiency of the quantum circuit of the encryption algorithms,research research on the implementation of quantum circuits is *** paper presents a new framework to construct quantum circuits of substitution boxes(S-boxes)using system *** model the quantum circuits of S-boxes using two layers:Toffoli and linear *** generate vector spaces based on the values of qubits used in the linear layers and apply them to find quantum *** framework finds the circuit bymatching elements of vector spaces generated fromthe input and output of a given S-box,using the forward search or themeet-in-the-middle *** developed a tool to apply this framework to 4-bit *** the 4-bit S-box quantum circuit construction tool LIGHTER-R only finds circuits that can be implemented with four qubits,the proposed tool achieves the circuits with five *** proposed tool can find quantum circuits of 4-bit odd permutations based on the controlled NOT,NOT,and Toffoli gates,whereas LIGHTER-R is unable to perform this task in the same *** expect this technique to become a critical step toward optimizing S-box quantum circuits.

关键词： System modeling quantum circuit S-box circuit quantum computer

Ionizing terahertz waves with 260 MV/cm from scalable optical rectification

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Light(Science & Applications) 2024年第6期13卷 1075-1087页

作者： Hyeongmun kim Chul Kang Dogeun Jang Yulan Roh Sang Hwa Lee Joong Wook Lee Jae Hee Sung Seong Ku Lee Ki-Yong kim Advanced Photonics Research Institute GISTGwangju61005Korea Department of Physics and Optoelectronics Convergence Research Center Chonnam National UniversityGwangju61186Korea Pohang Accelerator Laboratory POSTECHPohang37673Korea Center for Relativistic Laser Science Institute for Basic ScienceGwangju61005Korea Institute for Research in Electronics and Applied Physics Department of PhysicsUniversity of MarylandCollege ParkMaryland20742USA

Terahertz(THz)waves,known as non-ionizing radiation owing to their low photon energies,can actually ionize atoms and molecules when a sufficiently large number of THz photons are concentrated in time and ***,we demonstrate the generation of ionizing,multicycle,15-THz waves emitted from large-area lithium niobate crystals via phase-matched optical rectification of 150-terawatt laser pulses.A complete characterization of the generated THz waves in energy,pulse duration,and focal spot size shows that the field strength can reach up to 260 megavolts per *** particular,a single-shot THz interferometer is employed to measure the THz pulse duration and spectrum with complementary numerical *** intense THz pulses are irradiated onto various solid targets to demonstrate THz-induced tunneling ionization and plasma *** study also discusses the potential of nonperturbative THz-driven ionization in gases,which will open up new opportunities,including nonlinear and relativistic THz physics in plasma.

关键词： optical interferometer matched

A Comprehensive Survey on Federated Learning in the Healthcare Area: Concept and Applications

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2239-2274页

作者： Deepak Upreti Eunmok Yang Hyunil kim Changho Seo Department of Convergence Science Kongju National UniversityChungcheongnam-doGongju-si32588South Korea Department of Information Security Cryptologyand MathematicsKookmin UniversitySeoul02707South Korea Department of Information and Communication Engineering Chosun UniversityGwangju61452South Korea Basic Science Research Institution Kongju National UniversityChungcheongnam-doGongju-si32588South Korea

Federated learning is an innovative machine learning technique that deals with centralized data storage issues while maintaining privacy and *** involves constructing machine learning models using datasets spread across several data centers,including medical facilities,clinical research facilities,Internet of Things devices,and even mobile *** main goal of federated learning is to improve robust models that benefit from the collective knowledge of these disparate datasets without centralizing sensitive information,reducing the risk of data loss,privacy breaches,or data *** application of federated learning in the healthcare industry holds significant promise due to the wealth of data generated from various sources,such as patient records,medical imaging,wearable devices,and clinical research *** research conducts a systematic evaluation and highlights essential issues for the selection and implementation of federated learning approaches in *** evaluates the effectiveness of federated learning strategies in the field of *** offers a systematic analysis of federated learning in the healthcare domain,encompassing the evaluation metrics *** addition,this study highlights the increasing interest in federated learning applications in healthcare among scholars and provides foundations for further studies.

关键词： Federated learning artificial intelligence machine learning privacy healthcare

Caching Strategies in NDN Based Wireless Ad Hoc Network:A Survey

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Computers, Materials & Continua 2024年第7期80卷 61-103页

作者： Ahmed Khalid Rana Asif Rehman Byung-Seo kim Department of Computer Science FAST School of ComputingNational University of Computer and Emerging SciencesLahore54000Pakistan Department of Software and Communications Engineering Hongik UniversitySejong City30016Republic of Korea

Wireless Ad Hoc Networks consist of devices that are wirelessly *** Ad Hoc Networks(MANETs),Internet of Things(IoT),and Vehicular Ad Hoc Networks(VANETs)are the main domains of wireless ad hoc *** is used in wireless ad hoc *** is based on Transmission Control Protocol(TCP)/Internet Protocol(IP)network where clients and servers interact with each other with the help of IP in a pre-defined *** fetches data from a fixed *** redundancy,mobility,and location dependency are the main issues of the IP network *** these factors result in poor performance of wireless ad hoc *** main disadvantage of IP is that,it does not provide in-network ***,there is a need to move towards a new network that overcomes these *** Data Network(NDN)is a network that overcomes these *** is a project of Information-centric Network(ICN).NDN provides in-network caching which helps in fast response to user *** NDN in wireless ad hoc network provides many benefits such as caching,mobility,scalability,security,and *** considering the certainty,in this survey paper,we present a comprehensive survey on Caching Strategies in NDN-based Wireless *** cachingmechanism-based results are also *** the last,we also shed light on the challenges and future directions of this promising field to provide a clear understanding of what caching-related problems exist in NDN-based wireless ad hoc networks.

关键词： Content centric network Internet of Things mobile ad hoc network named data network vehicular ad hoc network

Comparison of commercial silicon-based anode materials for the design of a high-energy lithium-ion battery

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Nano Research 2024年第6期17卷 5270-5277页

作者： Minhong Choi Eunhan Lee Jaekyung Sung Namhyung kim Minseong Ko Division of Convergence Materials Engineering Pukyong National UniversityBusan 48547Republic of Korea Department of Materials Engineering and Convergence Technology Gyeongsang National University501 Jinju-daeroJinju 52828Republic of Korea Department of Materials System Engineering Pukyong National UniversityBusan 48547Republic of Korea

Silicon(Si)is considered a potential alternative anode for next-generation Li-ion batteries owing to its high theoretical capacity and ***,the commercial use of Si anodes is hindered by their large volume expansion(~300%).Numerous efforts have been made to address this *** these efforts,Si-graphite co-utilization has attracted attention as a reasonable alternative for high-energy anodes.A comparative study of representative commercial Si-based materials,such as Si nanoparticles,Si suboxides,and Si−Graphite composites(SiGC),was conducted to characterize their overall performance in high-energy lithium-ion battery(LIB)design by incorporating conventional ***-Si was found to exhibit poor electrochemical performance,with severe volume expansion during *** suboxide provided excellent cycling stability in a full-cell evaluation with stable volume variation after 50 cycles,but had a large irreversible capacity and remarkable volume expansion during the first *** displayed a good initial Coulombic efficiency and the lowest volume change in the first cycle owing to the uniformly distributed nano-Si layer on graphite;however,its long-term cycling stability was relatively *** complement each disadvantage of Si suboxide and SiGC,a new combination of these Si-based anodes was suggested and a reasonable improvement in overall battery performance was successfully achieved.

关键词： silicon-based anode high-energy comparison lithium ion battery blended electrode

Lipid phosphorylation by a diacylglycerol kinase suppresses ABA biosynthesis to regulate plant stress responses

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Molecular Plant 2024年第2期17卷 342-358页

作者： Jianwu Li Shuaibing Yao Sang-Chul kim Xuemin Wang Department of Biology University of Missouri-St.LouisSt.LouisMO 63121USA Donald Danforth Plant Science Center St.LouisMO 63132USA

Lipid phosphorylation by diacylglycerol kinase(DGK)that produces phosphatidic acid(PA)plays important roles in various biological processes,including stress responses,but the underlying mechanisms remain ***,we show that DGK5 and its lipid product PA suppress ABA biosynthesis by interacting withABA-DEFICIENT2(ABA2),a key ABA biosynthesis enzyme,to negatively modulate plant responseto abiotic stress tested in Arabidopsis *** of DGK5 function rendered plants less damaged,whereas overexpression(OE)of DGK5 enhanced plant damage to water and salt *** dgk5 mutant plants exhibited decreased total cellular and nuclear levels of PA with increased levels of diacylglycerol,whereas DGK5-OE plants displayed the opposite ***,we found that both DGK5 and PA bind to the ABA-synthesizing enzyme ABA2 and suppress its enzymatic ***,the dgk5 mutant plants exhibited increased levels of ABA,while DGK5-OE plants showed reduced ABA *** addition,we showed that both DGK5 and ABA2 are detected in and outside the nuclei,and loss of DGK5 function decreased the nuclear association of *** found that both DGK5 activity and PA promote nuclear association of *** together,these results indicate that both DGK5 and PA interact with ABA2 to inhibit its enzymatic activity and promote its nuclear sequestration,thereby sup-pressing ABA production in response to abiotic *** study reveals a sophisticated mechanism by which DGK5 and PA regulate plant stress responses.

关键词： diacylglycerol kinase phosphatidic acid diacylglycerol lipid signaling stress responses lipid-protein binding protein-protein interaction Arabidopsis

Performance of the EDACS-ADP incorporating high-sensitivity troponin assay:Do components of major adverse cardiac events matter?

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World Journal of Emergency Medicine 2024年第3期15卷 175-180页

作者： Yedalm Yoo Shin Ahn Bora Chae Won Young kim Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea

BACKGROUND:The accelerated diagnostic protocol(ADP)using the Emergency Department Assessment of Chest pain Score(EDACS-ADP),a tool to identify patients at low risk of a major adverse cardiac event(MACE)among patients presenting with chest pain to the emergency department,was developed using a contemporary troponin *** study was performed to validate and compare the performance of the EDACS-ADP incorporating high-sensitivity cardiac troponin I between patients who had a 30-day MACE with and without unstable angina(MACE I and II,respectively).METHODS:A single-center prospective observational study of adult patients presenting with chest pain suggestive of acute coronary syndrome was *** performance of EDACS-ADP in predicting MACE was assessed by calculating the sensitivity and negative predictive ***:Of the 1,304 patients prospectively enrolled,399(30.6%;95%confidence interval[95%CI]:27.7%–33.8%)were considered low-risk using the *** them,the rates of MACE I and II were 1.3%(5/399)and 1.0%(4/399),*** EDACS-ADP showed sensitivities and negative predictive values of 98.8%(95%CI:97.2%–99.6%)and 98.7%(95%CI:97.0%–99.5%)for MACE I and 98.7%(95%CI:96.8%–99.7%)and 99.0%(95%CI:97.4%–99.6%)for MACE II,***:EDACS-ADP could help identify patients as safe for early ***,when unstable angina was added to the outcome,the 30-day MACE rate among the designated lowrisk patients remained above the level acceptable for early discharge without further evaluation.

关键词： Chest pain Major adverse cardiac event Acute coronary syndrome Emergency department