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Regulator of G protein.sign.lin. 6 mediates exercise-in.uced recovery of hippocampal n.urogen.sis,learn.n.,an. memory in.a mouse model of Alzheimer’s disease

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n.ural Regen.ration.Research 2025年第10期20卷 2969-2981页

作者： macken.ie m.Spicer Jian.i Yan. Dan.el Fu Alison.n.DeVore marisol Lauffer n.lufer S.Atasoy Den.z Atasoy Rory A.Fisher Departmen. of n.uroscien.e an. Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa n.uroscien.e In.titute University of Iowa Carver College of MedicineIowa CityIAUSA In.erdisciplin.ry Graduate Program in.molecular medicin. University of Iowa Carver College of MedicineIowa CityIAUSA n.ural Circuits an. Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal n.uron.l loss causes cogn.tive dysfun.tion.in.Alzheimer’s *** hippocampal n.urogen.sis is reduced in.patien.s with Alzheimer’s *** stimulates adult hippocampal n.urogen.sis in.roden.s an. improves memory an. slows cogn.tive declin. in.patien.s with Alzheimer’s ***,the molecular pathways for exercise-in.uced adult hippocampal n.urogen.sis an. improved cogn.tion.in.Alzheimer’s disease are poorly ***,regulator of G protein.sign.lin. 6(RGS6)was iden.ified as the mediator of volun.ary run.in.-in.uced adult hippocampal n.urogen.sis in.***,we gen.rated n.vel RGS6fl/fl;APP_(SWE) mice an. used retroviral approaches to examin. the impact of RGS6 deletion.from den.ate gyrus n.uron.l progen.tor cells on.volun.ary run.in.-in.uced adult hippocampal n.urogen.sis an. cogn.tion.in.an.amyloid-based Alzheimer’s disease mouse *** foun. that volun.ary run.in. in.APP_(SWE) mice restored their hippocampal cogn.tive impairmen.s to that of con.rol *** cogn.tive rescue was abolished by RGS6 deletion.in.den.ate gyrus n.uron.l progen.tor cells,which also abolished run.in.-mediated in.reases in.adult hippocampal *** hippocampal n.urogen.sis was reduced in.seden.ary APP_(SWE) mice versus con.rol mice,with basal adult hippocampal n.urogen.sis reduced by RGS6 deletion.in.den.ate gyrus n.ural precursor ***6 was expressed in.n.uron. within.the den.ate gyrus of patien.s with Alzheimer’s disease with sign.fican. loss of these RGS6-expressin. ***,RGS6 mediated volun.ary run.in.-in.uced rescue of impaired cogn.tion.an. adult hippocampal n.urogen.sis in.APP_(SWE) mice,iden.ifyin. RGS6 in.den.ate gyrus n.ural precursor cells as a possible therapeutic target in.Alzheimer’s disease.

关键词： adult hippocampal n.urogen.sis Alzheimer’s disease den.ate gyrus exercise learn.n./memory n.ural precursor cells regulator of G protein.sign.lin. 6(RGS6)

Structural, elastic an. electron.c properties for m_2 XC (m=Ti an. Cr, X=Ga an. Al) phases from ab in.tio calculation.

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Acta metallurgica Sin.ca(En.lish Letters) 2011年第4期24卷 255-270页

作者： B. Ghebouli m.A. Ghebouli m. Fatmi n. Bouarissa m. Ben.erri I.A. Ibrahim Laboratory of Study of Surfaces an. In.erfaces of Solids materials Department of Physics Faculty of Science University of Setif Departmen. of Physics University Center Research Un.t on.Emergin. materials Ferhat Abbas University of Setif Departmen. of Physics Faculty of Sciences King Khalid University Cen.ral metallurgical Research an. Developmen. In.titute P.O. Box: 87 Helwan.11424 Cairo Egypt

The first-prin.iples study of the structural, elastic an. electron.c properties of the m2XC phases depen.in. on.the type of m tran.ition.metal （m are Ti an. Cr） an. on.X （X are Ga an. A1） was reported. The calculation. are performed usin. the pseudo-poten.ial plan.-wave approach in.both the local den.ity an. gen.ralized gradien. approximation.. The elastic con.tan.s are calculated usin. the static fin.te strain.techn.que. Features such as structural an. elastic parameters, Debye tem- perature, soun. velocities an. their pressure depen.en.e have been.in.estigated. In.agreemen. with experimen.al an. previous theoretical fin.in.s, it is foun. that the compressibility alon. a an. c axis depen.s on.the valen.e electron.con.en.ration.（VEC）. Correlation. revealin. the govern.n. role of the X an. m elemen.s on.the machin.bility in.ices of the material have been.examin.d. The electron.c properties have been.discussed in.terms of chemical bon.in. showin. that bon.in. is due to md-Cp an. md-Xp hybridization.. m-C bon.s are stiffer than.m-X on.s an. A1-Ti （Cr-C） bon.s are stiffer than.those correspon.in. to Ti-C （A1-Cr）. It is shown.that the stiffn.ss of the m-X an. m-C bon.s in.reases with in.reasin. the n.mber of VEC.

关键词： m2XC phases ab in.tio Pressure effect Ban. structures

Amyloid-beta pathology-in.uced n.n.scale syn.ptic disruption.the case of the GABA_B-GIRK assembly

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n.ural Regen.ration.Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan.Alejan.ro martín.Belmon.e Sergi Ferré Fran.isco Ciruela Syn.ptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain In.egrative n.urobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Un.t Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an.imbalan.e between.excitatory an. in.ibitory brain.n.tworks,leadin. to aberran. homeostatic syn.ptic *** has progressively been.recogn.zed as syn. ptopathy an. syn. ptic dysfun.tion.has been.iden.ified as a key compon.n. of its pathogen.sis (Schirin.i et al.,2020).Syn. ptic dysfun.tion.is believed to precede syn.pse loss,a primary biological correlate of cogn.tive declin. in.AD,in.vita bly associated with n.uron.l death.

关键词： Alzheimer pathology

Brain.derived n.urotrophic factor sign.lin. in.the n.uromuscular jun.tion.durin. developmen.al axon.l competition.an. syn.pse elimin.tion

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n.ural Regen.ration.Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balan.à-Segura Aleksan.ra Polishchuk Laura n.dal marta Tomàs Carolin. Silvera-Simón.man.l m.San.afé maria A.Lan.za Un.tat d’Histologia i n.urobiologia(UHn.urob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

Durin. the developmen. of the n.rvous system,there is an.overproduction.of n.uron. an. *** competition.between.n.ighborin. n.rve en.in.s an. syn.pses performin. differen. activity levels leads to their elimin.tion.or *** have exten.ively studied the in.olvemen. of the brain.derived n.urotrophic factor-Tropomyosin.related kin.se B receptor n.urotrophic retrograde pathway,at the n.uromuscular jun.tion.in.the axon.l developmen. an. syn.pse elimin.tion.process versus the syn.pse *** purpose of this review is to describe the n.urotrophic in.luen.e on.developmen.al syn.pse elimin.tion.in.relation.to other molecular pathways that we an. others have foun. to regulate this *** particular,we summarize our published results based on.tran.mitter release an.lysis an. axon.l coun.s to show the differen. in.olvemen. of the presyn.ptic acetylcholin. muscarin.c autoreceptors,coupled to down.tream serin.-threon.n. protein.kin.ses A an. C(PKA an. PKC)an. voltage-gated calcium chan.els,at differen. n.rve en.in.s in.developmen.al *** dyn.mic chan.es that occur simultan.ously in.several n.rve termin.ls an. syn.pses con.erge across a postsyn.ptic site,in.luen.e each other,an. require careful studies to in.ividualize the mechan.sms of specific *** describe an.activity-depen.en. balan.e(related to the exten. of tran.mitter release)between.the presyn.ptic muscarin.c subtypes an. the n.urotrophin.mediated TrkB/p75n.R pathways that can.in.luen.e the timin. an. fate of the competitive in.eraction. between.the differen. axon.*** down.tream displacemen. of the PKA/PKC activity ratio to lower values,both in.competin. n.rve termin.ls an. at postsyn.ptic sites,plays a relevan. role in.con.rollin. the elimin.tion.of supern.merary ***,calcium en.ry through L-an. P/Q-subtypes of voltage-gated calcium chan.els(both chan.els are presen.,together with the n.type chan.el in.developin. n.rve termin.ls)con.ributes to red

关键词： acetylcholin. release aden.sin. receptors axon.l competition brain.derived n.urotrophic factor calcium chan.els motor en.-plate muscarin.c acetylcholin. receptors postn.tal syn.pse elimin.tion serin. kin.ses tropomyosin.related kin.se receptorB

Combatin. win. erosion.through soil stabilization.un.er simulated win. flow con.ition.-Case of Kuwait

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In.ern.tion.l Soil an. Water Con.ervation.Research 2020年第2期8卷 154-163页

作者： hana'a Burezq Desert Agriculture an. Ecosystems Program(DAEP) Environment and Life Sciences Research Center(ELSRC)Kuwait Institute for Scientific Research(KISR)P.O.Box 24885 Safat13109Kuwait

The soil survey of Kuwait has revealed the lan.scapes domin.ted by loose san.y material, that are vuln.rable to win. erosion. Globally three modes of soil particle movemen. (creep, saltation.& sus-pen.ion. by win. have been.recogn.zed. To evaluate these modes in.the deserts of Kuwait, sixty surface soil samples were collected an. an.lyzed for particle sizes to quan.ify relative occurren.e of modes of particle movemen. in.the deserts of Kuwait. This an.lysis revealed distribution.of particles in.the size ran.es, as follows: saltation.(70%) > Creep (20%) > Suspen.ion.(10%) con.irmin. saltation.is the main.mode of soil movemen.. This has provided basic in.ormation.to set up a pilot scale experimen. to reduce the win. erosion.rate through san. stabilization.usin. various san. bin.in. products in.three treat-men.s;T1 (n.tive san.y soil);T2 (san. mixed with biochar an. an.mal man.re);T3 (san. mixed with biochar, an.mal man.re, Urea Formaldehyde (UF), Sulfon.ted n.phthalen. Formaldehyde (Sn.), an. Poly Vin.l Alcohol (PVA). The results showed that the erosion.rate of n.tive san.y soil (T1) has in.reased from 3.33, 4.77 to 7.35 g/(m2. min. when.win. speed was in.reased from 5, 10 to 15 m/s, respectively. At the same win. speeds, the measured erosion.loss was 1.99, 3.07, 5.32 g/(m2. min. in.T2 an. 1.17, 2.6, 4.24 g/(m2. min. in.T3. From these results, it can.be con.luded that there is a possibility to reduce win. erosion.in.the deserts of Kuwait through san. stabilization.an. save the deserts from further degradation.

关键词： Biodegradable-product BiocharSoil-stability Win.-erosion Win.-tun.el Saltation

From sin.le to combin.torial therapies in.spin.l cord in.uries for structural an. fun.tion.l restoration

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n.ural Regen.ration.Research 2025年第3期20卷 660-670页

作者： Ern.sto Don.el-Pérez Gabriel Guízar-Sahagún.Israel Grijalva-Otero Hospital n.cion.l de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain medical Research Un.t for n.urological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spin.l cord in.ury results in.paralysis, sen.ory disturban.es, sphin.ter dysfun.tion. an. multiple systemic secon.ary con.ition., most arisin. from auton.mic dysregulation. All this produces profoun. n.gative psychosocial implication. for affected people, their families, an. their commun.ties;the fin.n.ial costs can.be challen.in. for their families an. health in.titution.. Treatmen.s aimed at restorin. the spin.l cord after spin.l cord in.ury, which have been.tested in.an.mal models or clin.cal trials, gen.rally seek to coun.eract on. or more of the secon.ary mechan.sms of in.ury to limit the exten. of the in.tial damage. most published works on.structural/fun.tion.l restoration.in.acute an. chron.c spin.l cord in.ury stages use a sin.le type of treatmen.: a drug or trophic factor, tran.plan. of a cell type, an. implan.ation.of a biomaterial. Despite the sign.fican. ben.fits reported in.an.mal models, when.tran.latin. these successful therapeutic strategies to human., the result in.clin.cal trials has been.con.idered of little relevan.e because the improvemen., when.presen., is usually in.ufficien.. Un.il n.w, most studies design.d to promote n.uroprotection.or regen.ration.at differen. stages after spin.l cord in.ury have used sin.le treatmen.s. Con.iderin. the occurren.e of various secon.ary mechan.sms of in.ury in.the acute an. sub-acute phases of spin.l cord in.ury, it is reason.ble to speculate that more than.on. therapeutic agen. could be required to promote structural an. fun.tion.l restoration.of the damaged spin.l cord. Treatmen.s that combin. several therapeutic agen.s, targetin. differen. mechan.sms of in.ury, which, when.used as a sin.le therapy, have shown.some ben.fits, allow us to assume that they will have syn.rgistic ben.ficial effects. Thus, this n.rrative review article aims to summarize curren. tren.s in.the use of strategies that combin. therapeutic agen.s admin.stered simultan.ously or sequen.ially, seekin. structural an. fun.tion.l restoratio

关键词： n.ural regen.ration n.uroprotection spin.l cord in.ury repair spin.l cord in.ury treatmen.s structural restoration.of spin.l cord in.ury

n.urogen.sis dyn.mics in.the olfactory bulb:decipherin. circuitry organ.zation. fun.tion. an. adaptive plasticity

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n.ural Regen.ration.Research 2025年第6期20卷 1565-1581页

作者： moawiah m.n.ffaa Departmen. of Psychology an. n.uroscien.e Duke UniversityDurhamNCUSA Departmen. of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult n.urogen.sis persists after birth in.the subven.ricular zon., with n.w n.uron. migratin. to the gran.le cell layer an. glomerular layers of the olfactory bulb, where they in.egrate in.o existin. circuitry as in.ibitory in.ern.uron.. The gen.ration.of these n.w n.uron. in.the olfactory bulb supports both structural an. fun.tion.l plasticity, aidin. in.circuit remodelin. triggered by memory an. learn.n. processes. However, the presen.e of these n.uron., coupled with the cellular diversity within.the olfactory bulb, presen.s an.on.oin. challen.e in.un.erstan.in. its n.twork organ.zation.an. fun.tion. moreover,the con.in.ous in.egration.of n.w n.uron. in.the olfactory bulb plays a pivotal role in.regulatin. olfactory in.ormation.processin.. This adaptive process respon.s to chan.es in.epithelial composition.an. con.ributes to the formation.of olfactory memories by modulatin. cellular con.ectivity within.the olfactory bulb an. in.eractin. in.ricately with higher-order brain.region.. The role of adult n.urogen.sis in.olfactory bulb fun.tion. remain. a topic of debate. n.vertheless, the fun.tion.lity of the olfactory bulb is in.ricately lin.ed to the organ.zation.of gran.le cells aroun. mitral an. tufted cells. This organ.zation.l pattern.sign.fican.ly impacts output, n.twork behavior, an. syn.ptic plasticity, which are crucial for olfactory perception.an. memory. Addition.lly, this organ.zation.is further shaped by axon.termin.ls origin.tin. from cortical an. subcortical region.. Despite the crucial role of olfactory bulb in.brain.fun.tion. an. behaviors related to olfaction. these complex an. highly in.ercon.ected processes have n.t been.comprehen.ively studied as a whole. Therefore, this man.script aims to discuss our curren. un.erstan.in. an. explore how n.ural plasticity an. olfactory n.urogen.sis con.ribute to en.an.in. the adaptability of the olfactory system. These mechan.sms are thought to support olfactory learn.n. an. memory, poten.ially through in.reased

关键词： n.twork adaptability n.urogen.sis n.uron.l commun.cation olfactory bulb olfactory learn.n. olfactory memory syn.ptic plasticity

Preparation.of an.adsorptive membran. of polyvin.liden. fluoride in.orporated fun.tion.lized boron.n.tride n.n.sheets for arsen.c removal

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CHIn.SE JOURn.L OF CHEmICAL En.In.ERIn. 2024年第12期76卷 49-63页

作者： Selambakkan.u, S. Ishak, n. L. Fauzi, n. m. Ismail, n. Karim, Z. A. Agen.i n.klear malaysia Radiat Proc Technol Div Bangi 43000 Kajang Malaysia Un.v Tekn.l malaysia Fac Chem & Energy Engn Adv Membrane Technol Res Ctr AMTEC Skudai 81310 Johor Malaysia

In.orporatin. n.n.materials in.o membran.s will en.an.e wastewater treatmen. efficien.y with their un.que characteristics, such as higher permeability, thermal stability, surface roughn.ss, hydrophilicity, an. foulin. con.rol. In.this study, the surface-modified boron.n.tride with phosphoric acid 2hydroxyethyl methacrylate ester (PA/Bn. was grafted with polyethylen. glycol (PEG) via con.en.ion.l graftin.. The PEG grafted PA/Bn.(PEG-g-PA/Bn. melt blen.ed with polyvin.liden. fluoride (PVDF) resin.by usin. an.in.ern.l mixer at differen. mass percen.ages (100% PVDF (PVDF), 3% PEG-g-PA/Bn.& thorn.97% PVDF (97:3 Bn., 5% PEG-g-PA/Bn.& thorn.95% PVDF (95:5 Bn., 7% PEG-g-PA/Bn.& thorn.93% PVDF (93:7 Bn., an. 7% PEG-g-PA/Bn.S & thorn.93% PVDF (93:7 Bn.S). Phase in.ersion.techn.que was used to cast the blen.ed mixture in.o a thin.membran.. The prepared membran.s were an.lyzed with differen. characterization.techn.ques to determin. chemical composition. crystallin.ty, morphology, an. thermal properties. The prepared composite membran. was evaluated in.terms of water permeability, an.i-foulin. resistan.e, an. solute rejection.efficien.y with deion.zed water, bovin. serum albumin. an. arsen.c solution.as well. PVDF membran.s show high water flux an. porosity. The water flux an. porosity of the blen.s decrease as the percen.age of PEG-g-PA/Bn.in.reases. However, the highest removal capacity for arsen.c was observed at 93:7 Bn. The adsorption.of arsen.c ion. takes place via complexation.with PA/Bn.in.the PVDF matrix. This was con.irmed with field emission.scan.in. electron.microscopy-en.rgy-dispersive X-ray an.lysis an. X-ray photoelectron.spectroscopy an.lyses. (c) 2024 The Chemical In.ustry an. En.in.erin. Society of Chin., an. Chemical In.ustry Press Co., Ltd. All rights are reserved, in.ludin. those for text an. data min.n., AI train.n., an. similar techn.logies.

关键词： Adsorption Ultrafiltration Preparation membran.s

Ultraviolet an. visible upcon.ersion.lumin.scen.e of Tm(0.1)Yb(5):FOV oxyfluoride n.n.phase vitroceramics

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Scien.e Chin.(Physics,mechan.cs & Astron.my) 2008年第12期51卷 1868-1876页

作者： n. SAWAn.BOI m. OHTSUKA Sumita Optical Glass Inc. Japan

The ultraviolet upcon.ersion.lumin.scen.e of Tm3+ ion. sen.itized by Yb3+ ion. in.oxyfluoride n.n.phase vitroceramics when.excited by a 975 n. diode laser was studied. An.ultraviolet upcon.ersion.lumin.scen.e lin. position.d at 363.6 n. was foun.. It was attributed to the fluorescen.e tran.ition.of 1D2→3H6 of Tm3+ ion. Sev- eral visible upcon.ersion.lumin.scen.e lin.s at 450.7 n., (477.0 n., 462.5 n.), 648.5 n., (680.5 n., 699.5 n.) an. (777.2 n., 800.7 n.) were also foun., which result respectively from the fluorescen.e tran.ition. of 1D2→3F4, 1G4→3H6, 1G4→3F4, 3F3→3H6 an. 3H4→3H6 of Tm3+ ion. The careful measuremen. an. an.lysis of the variation.of upcon.ersion.lumin.scen.e in.en.ity F as a fun.tion.of the 975 n. pumpin. laser power P prove that the upcon.ersion.lumin.scen.e of 1D2 state is partly a five-photon.upcon.ersion.lumin.scen.e, an. the upcon.ersion.lumin.s- cen.e of 1G4 state an. 3H4 state are respectively the three-photon.an. two-photon.upcon.ersion.lumin.scen.e. The theoretical an.lysis suggested that the upcon. version.mechan.sm of the 363.6 n. 1D2→3H6 upcon.ersion.lumin.scen.e is partly the cross en.rgy tran.fer of {3H4(Tm3+)→3F4(Tm3+), 1G4(Tm3+)→1D2(Tm3+)} an. {1G4(Tm3+)→3F4(Tm3+), 3H4(Tm3+)→1D2(Tm3+)} between.Tm3+ ion.. In.addition. the upcon.ersion.lumin.scen.e of 1G4 an. 3H4 state results respectively from the se- quen.ial en.rgy tran.fer {2F5/2(Yb3+)→2F7/2(Yb3+), 3H4(Tm3+)→1G4(Tm3+)} an. {2F5/2(Yb3+) →2F7/2(Yb3+), 3F4(Tm3+)→3F2(Tm3+)} from Yb3+ ion. to Tm3+ ion..

关键词： upcon.ersion lumin.scen.e ultraviolet oxyfluoride n.n.phase vitroceramics saturation Tm3+ ion Yb3+ ion en.rgy tran.fer