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Effects of Riboflavin Interactions with 5-Methyltetrahydrofolate and Tetrahydrofolate on Changes in Homocysteine and Folate Derivative Levels, with and without Methionine Addition

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Food and Nutrition Sciences 2013年第9期4卷 956-963页

作者： Risa Araki kiho imada Makiko Hikichi Yukiko Arai Hihumi Kashima Chizuko Maruyama Department of Food and Nutrition Japan Women’s University Tokyo Japan. Department of Food and Nutrition Japan Women’s University Tokyo Japan. Email: *maruyama@fc.jwu.ac.jp

Riboflavin has been suggested to act with folate to lower homocysteine (Hcy). However, these interactions may differ among the several known forms of folate. Therefore, we examined the effects of riboflavin interactions with 5-methyltetrahydrofolate (5-MTHF) and tetrahydrofolate (THF) on changes in Hcy and folate derivative levels, under conditions with and without methionine addition. Rat hepatocytes were cultured for 48 hours in medium with or without 2.64 μM riboflavin addition, under the following conditions: 1) without the addition of either methionine or folate;2) with addition of 2 μM folate derivatives [(A): 5-MTHF, (B): THF];3) with addition of both 5 mM methionine and 2 μM folate derivatives [(A): 5-MTHF, (B): THF]. The supernatants were collected at 0, 24, and 48 hours for Hcy and folate derivative measurements. The Hcy lowering effect of 5-MTHF, as well as inhibition of 5-MTHF reduction and THF elevation, appeared to be enhanced by riboflavin addition. THF addition did not lower the Hcy level, regardless of the presence of riboflavin and/or methionine, while THF and 5,10-methenyl THF levels were maintained. Further examination is needed to elucidate the interactive effects of riboflavin and folate derivatives on Hcy and folate metabolism.

关键词： Folate Derivatives Riboflavin Interaction Homocysteine

A novel pig model capturing clinical symptoms of harlequin ichthyosis

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Journal of Molecular Cell Biology 2019年第12期11卷 1027-1028页

作者： kiho Lee Department of Animal and Poultry Sciences Virginia TechBlacksburgVA 24061USA

The application of proper animal models is essential for developing effective treatments in biomedicine. Due to practicality, rodent models have been dominantly used as a model to identify potential treatments for patients. However, differences in physiology and anatomy between rodents and humans have been an obstacle when translating the data generated from rodents to clinics. Large animal models such as pigs can recapitulate symptoms of human diseases, making pigs an ideal model for preclinical assessment of new treatments (Prather et al., 2013). For instance, symptoms of primary immunodeficiency are more accurately represented in pigs compared to mice (Suzuki et al., 2012), demonstrating their suitability as an animal model in biomedicine. Unfortunately, the number of available pig models is low, in part, because of challenges in establishing pig models through current genetic engineering technology.

关键词： anatomy establishing suitability

Light Refraction and Reflection near a Black Hole

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Journal of High Energy Physics, Gravitation and Cosmology 2022年第1期8卷 228-236页

作者： Young Hwan Yun kiho Jang Zero Theoretical Physics Laboratory Seoul Republic of Korea

In this paper, we have calculated the angle of refraction that light travels approaching to the strong gravitational field like a black hole by combining the general relativity and the classical Snell’s law, assuming that the gravitational field can act as a non-vacuum filled with medium of some coefficients. We have found that the value of refracted angle exactly coincides with the value from the Einstein’s relativity theory in a weak gravitational field. From this optical interpretation of the traveling of light near a black hole, we have suggested that there might have the reflection phenomenon and investigated that the total reflection occurs at the surface of a black hole. Regardless this might cause controversy, we can explain the recent observation that light reflects from a black hole.

关键词： Black Hole Snell’s Law Relativity Refraction Reflection

Use of gene-editing technology to introduce targeted modifications in pigs

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Journal of Animal Science and Biotechnology 2018年第2期9卷 268-277页

作者： Junghyun Ryu Randall S.Prather kiho Lee Department of Animal and Poultry Sciences Virginia Tech175 W.Campus DriveBlacksburgVA 24061USA Division of Animal Science University of Missouri-Columbia920 East Campus DriveColumbiaMO 65211USA National Swine Resource and Research Center University of Missouri-ColumbiaColumbiaMO 65211USA

Pigs are an important resource in agriculture and serve as a model for human diseases. Due to their physiological and anatomical similarities with humans, pigs can recapitulate symptoms of human diseases, making them a useful model in biomedicine. However, in the past pig models have not been widely used partially because of the difficulty in genetic modification. The lack of true embryonic stem cells in pigs forced researchers to utilize genetic modification in somatic cells and somatic cell nuclear transfer(SCNT) to generate genetically engineered(GE) pigs carrying site-specific modifications. Although possible, this approach is extremely inefficient and GE pigs born through this method often presented developmental defects associated with the cloning process. Advancement in the gene-editing systems such as Zinc-Finger Nucleases(ZFNs), Transcription activator-like effector nucleases(TALENs), and the Clustered regularly interspaced short palindromic repeat(CRISPR)/CRISPR-associated 9(Cas9) system have dramatically increased the efficiency of producing GE pigs. These gene-editing systems, specifically engineered endonucleases, are based on inducing double-stranded breaks(DSBs) at a specific location, and then site-specific modifications can be introduced through one of the two DNA repair pathways: non-homologous end joining(NHEJ) or homology direct repair(HDR).Random insertions or deletions(indels) can be introduced through NHEJ and specific nucleotide sequences can be introduced through HDR, if donor DNA is provided. Use of these engineered endonucleases provides a higher success in genetic modifications, multiallelic modification of the genome, and an opportunity to introduce site-specific modifications during embryogenesis, thus bypassing the need of SCNT in GE pig production. This review will provide a historical prospective of GE pig production and examples of how the gene-editing system, led by engineered endonucleases, have improved GE pig production. We wil also present some of our current progress relate

关键词： CRISPR/Cas9 Gene-editing Genetic engineering Knock-in Knockout Pig TALEN ZFN

Recent developments of emerging inorganic, metal and carbon- based nanomaterials for pressure sensors and their healthcare monitoring applications

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Nano Research 2021年第9期14卷 3096-3111页

作者： Kyowon Kang Jaejin Park kiho Kim Ki Jun Yu School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea

Recently,flexible pressure sensors have gained substantial research interest in bioelectronics because they can monitor the conditions of various organs,enable early diagnosis of diseases,and provide precise medical treatment by applying them to various parts of the body.In particular,inorganic materials,metal and carbon-based materials are broadly used in novel structured pressure sensors from wearable devices to implantable devices.With the excellent electronic properties,distinctive morphologies,and remarkable mechanical and chemical stability of these materials,it is expected that these flexible pressure sensors can be the basis for new methods for human healthcare.This article covers an extensive review of the inorganic,metal and carbon-based flexible pressure sensor design strategies and sensing mechanisms studied in recent years for diverse applications such as tactile sensors,arterial pulse sensors,intracranial pressure sensors,intraocular pressure sensors,and bladder pressure sensors.Each section provides an overview by introducing the recent progress in flexible pressure sensors.

关键词： nanomaterial inorganic carbon pressure sensor wearable device implantable device

国家创新系统对经济赶超绩效影响的定性比较分析——基于QCA方法的联动效应研究

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经济问题探索 2022年第10期 33-52页

作者：郝政 kiho Kwak 黄明浩张勇韩国国立釜庆大学技术经营大学院韩国山48547 重庆大学经济与工商管理学院重庆400030

为评估和揭示国家创新生态系统(NIS)要素之间的耦合联动效应及其对经济赶超的驱动机制,构建了NIS框架下“国家—行业—企业”三个层面创新要素对经济赶超绩效的联动效应模型,运用模糊集定性比较分析方法(fsQCA),检验了NIS对于经济赶超... 详细信息

为评估和揭示国家创新生态系统(NIS)要素之间的耦合联动效应及其对经济赶超的驱动机制,构建了NIS框架下“国家—行业—企业”三个层面创新要素对经济赶超绩效的联动效应模型,运用模糊集定性比较分析方法(fsQCA),检验了NIS对于经济赶超绩效的组态效应及其路径模式。研究发现:NIS中单一要素对经济赶超绩效的作用有限,存在多因素联动构成的多重等效路径;后发国家与传统高收入经济体的赶超路径存在明显差异,不可直接借鉴;识别出四类驱动经济赶超绩效的创新路径:即以短周期多样性技术为特色的技术跟随型路径、以本地化技术出口拉动的价值嵌入型路径、原始创新能力突出的极核创新路径、综合实力突出的多元对抗型路径;存在三条制约经济赶超绩效的路径,分别是资金抑制型、路径锁定型、价值依赖型三种类型,侧面说明科技自立自强对于技术持续追赶和经济不断增长的重要意义。研究结果可以为后发国家识别技术拐点,根据发展阶段调整优化国家创新系统结构,以实现可持续的技术赶超和经济跨越提供理论支撑和决策参考。

关键词：国家创新系统经济赶超联动效应模糊集定性比较分析

Sodium variability is associated with increased mortality in severe burn injury

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Burns & Trauma 2017年第4期5卷 243-248页

作者： Soman Sen Nam Tran Brian Chan Tina L. Palmieri David G. Greenhalgh kiho Cho Department of Surgery Division of Burn Surgery University of California Davis 2425 Stockton Blvd. Suite 718 Sacramento CA 95817 USA

Background:Dysnatremias are associated with increased mortality in critically ill patients. Hypernatremia in burn patients is also associated with poor survival. Based on these findings, we hypothesized that high plasma sodium variability is a marker for increased mortality in severely burn-injured patients. Methods:We performed a retrospective review of adult burn patients with a burn injury of 15%total body surface area (TBSA) or greater from 2010 to 2014. All patients included in the study had at least three serum sodium levels checked during admission. We used multivariate logistic regression analysis to determine if hypernatremia, hyponatremia, or sodium variability independently increased the odds ratio (OR) for death. Results:Two hundred twelve patients met entry criteria. Mean age and%TBSA for the study was 45 ± 18 years and 32 ± 19%. Twenty-nine patients died for a mortality rate of 14%. Serum sodium was measured 10,310 times overall. The median number of serum sodium measurements per patient was 22. Non-survivors were older (59 ± 19 vs. 42 ± 16 years) and suffered from a more severe burn injury (50 ± 25%vs. 29 ± 16%TBSA). While mean sodium was significantly higher for non-survivors (138 ± 3 milliequivalents/liter (meq/l)) than for survivors (135 ± 2 meq/l), mean sodium levels remained within the laboratory reference range (135 to 145 meq/l) for both groups. Non-survivors had a significantly higher median number of hypernatremic (>145 meq/l) measurements (2 vs. 0). Coefficient of variation (CV) was significantly higher in non-survivors (2.85 ± 1.1) than survivors (2.0 ± 0.7). Adjusting for TBSA, age, ventilator days, and intensive care unit (ICU) stay, a higher CV of sodium measurements was associated with mortality (OR 5.8 (95%confidence interval (CI) 1.5 to 22)). Additionally, large variation in sodium ranges in the first 10 days of admission may be associated with increased mortality (OR 1.35 (95%CI 1.06 to1.7)). Conclusions:Increased variability in plasma sodium may be associated with death in severe

关键词： Sodium Burns Critical illness Ions Hypernatremia Hyponatremia

Editorial: Special issue on “Internet of things and edge computing in the new 5G era”

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Digital Communications and Networks 2021年第2期7卷 167-169页

作者： Xin Su Marek R.Ogiela Chang Choi Christian Esposito kiho Lim the College of Internet of Things Engineering Hohai UniversityChina world scientific associations 不详 University of Napoli Federico II in Italy Department of Computer Science at the University of South Dakota USA.

1.Introduction Recently,edge computing has evolved from concept to early-stage implementations because new use cases require a more remote computing and networking approach than a conventional,fully cloud-based model.Many companies,network providers and cloud companies are testing and launching early commercial products in the developed markets of the United States,Europe,China and Asia Pacific.Although progress in edge trials continues,key issues remain to be resolved around the most viable location of the edge,the scale of the required edge investment,and the actual business models.

关键词： computing companies Internet

Development of a Hybrid Pin Joint with a Compressed Wooden Dowel and Metal Pipe

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Open Journal of Civil Engineering 2015年第1期5卷 84-96页

作者： kiho Jung Shunpei Nakamine Faculty of Education Shizuoka University Shizuoka Japan

A newly developed hybrid pin (HP), composed of a compressed wooden dowel inserted into a stainless steel pipe is suggested in this research. This configuration is expected to grant high stiffness by bending performance of the metal pipe and rich ductility through shear deformation of compressed wooden dowel without brittle split of the joint member. Experimental tests were performed in order to verify your assumptions and pursue an optimum design. Double shear test perpendicular to the grain of HP was conducted with parameter of thickness and loading direction for base member for pin’s diameter. Rotational test for mortise and tenon joint inserted with HP was performed in order to evaluate the moment resisting performance. Consequently, the hybrid pin showed satisfactory performance as shear type fastener by virtues of not only relatively high stiffness but also rich ductility originated from the properties of each component, stain less steel pipe and compressed wood.

关键词： Hybrid Pin Compressed Wooden Dowel Double Shear Moment Resisting Performance