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Identification of factors associated with sedation tolerance in 5000 patients undergoing outpatient colonoscopy:Canadian tertiary center experience

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World Journal of Gastrointestinal Endoscopy 2016年第20期8卷 770-776页

作者： Alexandra Shingina George Ou Oliver Takach Sigrid Svarta Ricky Kwok Jessica Tong kieran donaldson Eric Lam Robert Enns Department of Gastroenterology Faculty of MedicineUniversity of TorontoToronto General Hospital Department of Gastroenterology Faculty of MedicineUniversity of British Columbia Division of Gastroenterology Saint Paul Hospital

AIM To develop a prediction model aimed at identifying patients that may require higher than usual sedation doses during *** A retrospective chart review on 5000 patients who underwent an outpatient colonoscopy at ***'s Hospital from 2009 to 2010 was conducted in order to develop a model for identifying patients who will require increased doses of *** predictor variables including age,gender,endoscopy indication,high sedation requirements during previous endoscopies,difficulty of the procedure,bowel preparation quality,interventions,findings as well as current use of benzodiazepines,opioids and alcohol were *** outcome of study was the use ofhigh dose of sedation agents for the *** particular,the high dose of sedation was defined as fentanyl greater than 50 mcg and midazolam greater than 3 *** Analysis of 5282 patients(mean age 57 ± 12,49% female) was *** common indication for the procedure was screening colonoscopy(57%).Almost half of our patients received doses exceeding Fentanyl 50 mcg and Midazolam 3 *** regression models identified the following variables associated with high sedation:Younger age(OR=0.95 95%CI:0.94-0.95;P < 0.0001);abdominal pain(OR=1.45,95%CI:1.08-1.96);P=0.01) and Inflammatory Bowel Disease(OR=1.45,95%CI:1.04-2.03;P=0.02) as indications for the procedure;difficult procedure as defined by gastroenterologist(OR=1.73,95%CI:1.48-2.03;P < 0.0001);past history of abdominal surgery(OR=1.33,95%CI:1.17-1.52;P <0.0001) and previous colonoscopy(OR=1.39,95%CI:1.21-1.60;P=0.0001) and alcohol use(OR=1.26,95%CI:1.03-1.54;P=0.02).Age and gender adjusted analysis yielded inflammatory bowel disease as an indication(OR=3.17,95%CI:1.58-6.37;P=0.002);difficult procedure as defined by an endoscopist(OR=5.13 95%CI:2.97-8.85;P=0.0001) and current use of opioids,benzodiazepines or antidepressants(OR=2.88,95%CI:1.74-4.77;P=0.001) having the highest predictive value of high sedation require

关键词： Colonoscopy Sedation Sedation tolerance Fentanyl Midazolam Predictive model

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Biomimetic Composite Structural T-joints

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Journal of Bionic Engineering 2012年第3期9卷 377-384页

作者： Vimal Kumar Thummalapalli Steven L. donaldson University of Dayton 300 College Park Dayton Ohio 45469-0243 USA

Biological structural fixed joints exhibit unique attributes, including highly optimized fiber paths which minimize stress concentrations. In addition, since the joints consist of continuous, uncut fiber architectures, the joints enable the organism to transport information and chemicals from one part of the body to the other. To the contrary, sections of man-made composite material structures are often joined using bolted or bonded joints, which involve low strength and high stress concentrations. These methods are also expensive to achieve. Additional functions such as fluid transport, electrical signal delivery, and thermal conductivity across the joints typically require parasitic tubes, wires, and attachment clips. By using the biomimetic methods, we seek to overcome the limitations which are present in the conventional methods. In the present work, biomimetic co-cured composite sandwich T-joints were constructed using unidirectional glass fiber, epoxy resin, and structural foam. The joints were fabricated using the wet lay-up vacuum bag resin infusion method. Foam sandwich T-joints with multiple continuous fiber architectures and sandwich foam thickness were prepared. The designs were tested in quasi-static bending using a mechanical load frame. The significant weight savings using the biomimetic approaches is discussed, as well as a comparison of failure modes versus architecture is described.

关键词： composites T-joints biomimetic fiberglass epoxy sandwich foam

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Ringing cancellation in Carr-Purcell-Meiboom-Gill-type sequences

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Magnetic Resonance Letters 2022年第4期2卷 233-242页

作者： Shin Utsuzawa Marcus donaldson Yi-Qiao Song Schlumberger-Doll Research CambridgeMA02139USA John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138USA Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General HospitalCharlestownMA02129USA

We propose a four-step phase cycling scheme that can cancel ringings from both the excitation and the refocusing pulses in Carr-Purcell-Meiboom-Gill(CPMG)*** allows accurate measurements of the first echo with short echo spacing tE,yielding improved precision of porosity,permeability,and fluid type identification in porous media study,at a cost of~25%signal *** our example,we achieved tE=100 ms on a 6.8 MHz unilateral NMR sensor without using a *** methods can be integrated in all nuclear magnetic resonance(NMR)protocols using CPMG,such as relaxation(T1,T2)and diffusion measurements,and do not require additional hardware(e.g.,Qswitches)to cancel ringing(although it can be used with a Q-switch to further reduce residual ringing).

关键词： CPMG Ringing cancellation Phase cycling

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Coupled Transport Phenomena in Corrugated Photocatalytic Reactors

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Chinese Journal of Chemical Engineering 2011年第5期19卷 763-772页

作者： Adam A. donaldson ZHANG Zisheng Department of Process Engineering and Applied Science Dalhousie University P.O. Box 15000 Halifax NovaScotia Canada B3H 4R2 Department of Chemical and Biological Engineering University of Ottawa 161 Louis Pasteur Street OttawaCanada K1N 6N5

Corrugated reactors are known for their use in applications requiring UV-exposure, whereby media flowing within the corrugated channel react with a photo-active catalyst impregnated on the surface （i.e. TiO2）. The performance in these systems is dependent on catalyst properties and reactivity for a given light source, in conjunc-tion with the coupled transport of reactants within the media and photons falling incident to the catalyst surface. Experimental and computational analyses of local mass transfer and radiation pattems for a broad range of corrugation angles, depths, and non-idealities introduced during manufacture （i.e. fold curvature） are thus integrated to the design and optimization of these systems. This work explores techniques for determining incident energy distribu-tions on the surface of corrugated reactor geometries with non-ideal cross-sectional profiles, and the local and overall mass transfer rates obtained using computational fluid dynamics and experimental analysis. By examining the reaction kinetics for the photo-degradation of 4-chlorophenol over a TiO2 catalyst, the effects of surface area, energy incidence with photon recapture, and local mass transfer on overall reactor performance are presented to highlight ootimization concerns for these tvoes of reactors.

关键词： photochemical reactions reactor analysis computational fluid dynamics surface chemistry/physics mass transfer

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Beowulf

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作者： translated by E. Talbot donaldson edited by Nicholas Howe.

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烈火疑云

烈火疑云

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作者： K.T.·唐纳森 K.T.·donaldson导演

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对话美国前NBA球星分享职业篮球的苦与乐

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2019年

主讲人： James donaldson

他曾获得NBA年度得分冠军，他曾入选美国全明星球队，他曾和魔术师，迈克乔丹，大鲨鱼等同场竞技，他就是James donaldson先生。这次他再度做客“饶舜英语访谈”畅谈NBA职业球员的训练与日常，以及他们获得的机遇与面临的挑战，带我们走...

他曾获得NBA年度得分冠军，他曾入选美国全明星球队，他曾和魔术师，迈克乔丹，大鲨鱼等同场竞技，他就是James donaldson先生。这次他再度做客“饶舜英语访谈”畅谈NBA职业球员的训练与日常，以及他们获得的机遇与面临的挑战，带我们走进NBA球员的真实世界。同时作为过来人，他将给新秀运动员学生推心置腹的指导和建议。（感谢Laura提供翻译校对）

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Scientific evidence is just the starting point: A generalizable process for developing sports injury prevention interventions

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Journal of Sport and Health Science 2016年第3期5卷 334-341页

作者： Alex donaldson David G.Lloyd Belinda J.Gabbe Jill Cook Warren Young Peta White Caroline F.Finch Australian Centre for Research into Injury in Sport and its Prevention (ACRISP) Federation University Australia Centre for Musculoskeletal Research Griffith Health Institute Griffith University Department of Epidemiology and Preventive Medicine Monash University La Trobe Sport and Exercise Medicine Research Centre La Trobe University School of Health Sciences Federation University Australia

Background: The 2 most cited sports injury prevention research frameworks incorporate intervention development, yet little guidance is available in the sports science literature on how to undertake this complex process. This paper presents a generalizable process for developing implementable sports injury prevention interventions, including a case study applying the process to develop a lower limb injury prevention exercise training program(Footy First) for community Australian ***: The intervention development process is underpinned by 2 complementary premises:(1) that evidence-based practice integrates the best available scientific evidence with practitioner expertise and end user values and(2) that research evidence alone is insufficient to develop implementable ***: The generalizable 6-step intervention development process involves(1) compiling research evidence, clinical experience, and knowledge of the implementation context;(2) consulting with experts;(3) engaging with end users;(4) testing the intervention;(5) using theory; and(6)obtaining feedback from early implementers. Following each step, intervention content and presentation should be revised to ensure that the final intervention includes evidence-informed content that is likely to be adopted, properly implemented, and sustained over time by the targeted intervention deliverers. For Footy First, this process involved establishing a multidisciplinary intervention development group, conducting 2targeted literature reviews, undertaking an online expert consensus process, conducting focus groups with program end users, testing the program multiple times in different contexts, and obtaining feedback from early implementers of the ***: This systematic yet pragmatic and iterative intervention development process is potentially applicable to any injury prevention topic across all sports settings and levels. It will guide researchers wishing to undertake interventio

关键词： Australian football Implementation Intervention development Lower limb injuries Research-to-practice Sports injury prevention Translation

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最后一颗蛋

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丛书名：丽声英语小剧场,外研社英语分级阅读

2015年

作者： (英)Julia donaldson

本套书通过真实、生动的剧本诵读、戏剧表演和贯穿其中的互动合作，获得语言感知、语言理解、语言运用和语言鉴赏的多种体验。本书为最后一颗蛋。

ISBN: (纸本)9787513556774;9787881044293

关键词：英语

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Protein profiles of enzymatically isolated rumen epithelium in sheep fed a fibrous diet

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Journal of Animal Science and Biotechnology 2019年第2期10卷 449-462页

作者： J.J.Bond A.J.donaldson J.V.F.Coumans K.Austin D.Ebert D.Wheeler V.H.Oddy NSW Department of Primary Industries Extensive Livestock Industry CentreUniversity of New EnglandTrevenna RdArmidaleNSW 2351Australia School of Rural Medicine University of New EnglandArmidaleNSW 2351Australia NSW Department of Primary Industries Orange Agricultural InstituteOrangeNSW 2800Australia.

Background: The rumen wall plays a major role in efficient transfer of digested nutrients in the rumen to peripheral tissues through the portal venous system. Some of these substrates are metabolised in the epithelium during this process. To identify the specific proteins involved in these processes, we used proteomic technologies. Protein extracts were prepared from ventral rumen tissue of six sheep fed a fibrous diet at 1.5× maintenance energy *** a newly developed method, we were able to enzymatically isolate the epithelial cells from underlying tissue layers, thus allowing cytosol and membrane fractions to be independently analysed using liquid chromatography tandem mass spectrometry(LC MS/MS).Results: Using our procedure we identified 570 epithelial proteins in the Ovis aries sequence database. Subcellular locations were largely cytosolic(n = 221) and extracellular(n = 85). However, a quarter of the proteins identified were assigned to the plasma membrane or organelle membranes, some of which transport nutrients and metabolites. Of these 91 were transmembrane proteins(TMHMM), 27 had an N-terminal signal peptide(signalP) and TMHMM motif,13 had a glycosylphosphatidylinositol(GPI) anchor and signalP sequence, 67 had beta(β) strands or 17 β strands and a transit peptide sequence, indicating the identified proteins were integral or peripheral membrane proteins. Subunits of the 5 protein complexes involved in mitochondrial cellular energy production were well represented. Structural proteins(15%), proteins involved in the metabolism of lipids and proteins(26%) and those with steroid or cytokine action were a feature of the ***: Our research has developed a procedure to isolate rumen epithelium proteins from the underlying tissue layers so that they may be profiled using proteomic technologies. The approach improves the number of proteins that can be profiled that are specific to the epithelium of the rumen wall. It provides new insights

关键词： Epithelium Metabolism Nutrition Proteome Rumen Sheep

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