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Dietary modification in the treatment of schizophrenia spectrum disorders: A systematic review

World Journal of Psychiatry 2020年第8期10卷 187-201页

作者： Monique Aucoin Laura LaChance Sam N Clouthier kieran cooley Department of Research and Clinical Epidemiology Canadian College of Naturopathic MedicineToronto M2K 1E2Canada Department of Psychiatry McGill UniversityMontreal H3A 0G4Canada Centre for Addiction and Mental Health Toronto M6R 1A1Canada Department of Doctoral Acupuncture and Chinese Medicine Pacific College of Health ScienceSan DiegoCA 92108United States

BACKGROUND Schizophrenia spectrum disorders impact functioning,reduce quality of life and increase the risk of physical illness and premature *** intervention studies aimed at decreasing body weight have demonstrated efficacy in improving metabolic outcomes;however,few studies have explored the impact of interventions designed to modify diet on mental health *** To synthesize the existing experimental studies of adjunctive diet modification as an intervention in the treatment of psychotic disorders,analyze findings related to effectiveness and safety,highlight knowledge gaps and limitations,and set forward recommendations for future research *** An extensive a priori search strategy was developed and the databases Embase,Embase Classic,Ovid MEDLINE were *** and data extraction were completed in *** included in this analysis were experimental studies of an adjunctive dietary intervention(overall dietary pattern or education on dietary change)for treatment of schizophrenia spectrum *** restrictions were placed on control groups or *** studies were required to report a mental health *** Twenty-five clinical trials were identified,along with two additional protocols and two *** of the clinical trials reported improvement in one or more mental health domain including psychosis symptoms,cognition,and quality of life.A high level of heterogeneity was found with respect to patient population,intervention,and study *** of the studies included lifestyle or psychosocial components in addition to dietary *** nutrition advice provided to participants was poorly described overall and compliance was not *** studies that showed benefit tended to have a smaller sample size and were less likely to be randomized but were more likely to use a group delivery *** Further research assessing effectiveness and efficacy of clear

关键词： Nutrition Psychosis Schizophrenia Diet

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Fission gas released from molten salt reactor fuel:the case of noble gas short life radioisotopes for radiopharmaceutical application

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Medicine in Novel Technology and Devices 2021年第2期10卷 25-32页

作者： Claude Degueldre Richard Dawson Isabel cooley Elena Besley Engineering Department Lancaster UniversityLA14YWUK School of Chemistry University Park NottinghamNG72RDUK

The present study explores the potential of fission gas(Kr and Xe short life radioisotopes)released from a molten salt reactor,the separation of these noble gases using specific absorbents under well fixed conditions and the utilisation of these radioisotopes for *** operation,a molten salt reactor produces noble gas radioisotopes that bubble out from the liquid fuel and that can be sampled and treated for radiopharmaceutical applications including as tols for diagnostics using radioisotopes and/or potentially in radiotherapy for specific Vviral diseases usingβ^(-)*** them^(133)Xe is currenty used fr ung diagnostics thanks to its 132.9 keγ.The use of^(85)Kr for diagnostics is also *** 514 keγcpuld be used for scintigraphy,However^(133)Xe utilisation imply also itsβ^(-)(E_(mean)≈100 kev)whose mean fre pathway of 100 nm in biological tissue or in wateris much smalier than the mean pathway of the^(95)Krβ^(-).Emphasis is placed on^(133)Xe because of its potential dual ability of imag ing and as a suggested therapeutic tool of viral lung diseases.

关键词： Molten salt reactor Noble gas radioisotopes Radio-diagnostics Radiotherapy

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Adventures of Huckleberry Finn

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作者： Mark Twain edited by Thomas cooley.

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Taking the pulse of a plant:dynamic laser speckle analysis of plants

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红外与激光工程 2016年第9期45卷 7-18页

作者： Zhong Xu Wang Xuezhi cooley Nicola Farrell Peter Moran Bill Department of Infrastructure Engineering University of Melbourne School of Electrical and Computer Engineering Royal Melbourne Institute Technology Higher Education-Primary Industy NMIT and Melbourne PolytechnicNMIT Epping Campus Department of Electrical and Electronic Engineering University of Melbourne

Ideally, to achieve optimal production in agriculture, crop stress needs to be measured in real-time, and plant inputs managed in response. However, many important physiological responses like photosynthesis are difficult to measure, and current trade-offs between cost, robustness, and spatial measurement capacity of available plant sensors may prevent practical in-field application of most current sensing techniques. This paper investigates a novel application of laser speckle imaging of a plant leaf as a sensor with an aim, ultimately, to detect indicators of crop stress: changes to the dynamic properties of leaf topography on the scale of the wavelength of laser light. In our previous published work, an initial prototype of the laser speckle acquisition system specific for plant status measurements together with data processing algorithms were developed. In this paper, we report a new area based statistical method that improves robustness of the data processing against disturbances from various sources. Water and light responses of the laser speckle measurements from cabbage leaves taken by the developed apparatus are exhibited via growth chamber experiments. Experimental evidence indicates that the properties of the laser speckle patterns from a leaf are closely related to the physiological status of the leaf. This technology has the potential to be robust, cost effective, and relatively inexpensive to scale.

关键词：磁光阵列光存储融合存储

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Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components

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Bioactive Materials 2023年第1期19卷 642-652页

作者： Michaela B.cooley Eric C.Abenojar Dana Wegierak Anirban Sen Gupta Michael C.Kolios Agata A.Exner Department of Biomedical Engineering Case Western Reserve UniversityClevelandOH44106United States Department of Radiology Case Western Reserve UniversityClevelandOH44106United States Department of Physics Ryerson UniversityTorontoOntarioM5B 2K3Canada Institute for Biomedical Engineering and Science Technology A Partnership Between Ryerson University and St.Michael’s HospitalTorontoOntarioM5B 1T8Canada

Nanoscale ultrasound contrast agents,or nanobubbles,are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in *** sub-micron particles are approximately 10x smaller than clinically available *** allows them to effectively traverse compromised physiological barriers and circulate for extended periods of *** various aspects of nanobubble behavior have been previously examined,their behavior in human whole blood has not yet been ***,herein we examined,for the first time,the short and long-term effects of blood components on nanobubble acoustic *** observed differences in the kinetics of backscatter from nanobubble suspensions in whole blood compared to bubbles in phosphate buffered saline(PBS),plasma,or red blood cell solutions(RBCs).Specifically,after introducing nanobubbles to fresh human whole blood,signal enhancement,or the magnitude of nonlinear ultrasound signal,gradually increased by 22.8±13.1%throughout our experiment,with peak intensity reached within 145 *** contrast,nanobubbles in PBS had a stable signal with negligible change in intensity(􀀀1.7±3.2%)over 8 *** the same conditions,microbubbles made with the same lipid formulation showed a􀀀56.8±6.1%decrease in enhancement in whole *** confocal,fluorescent,and scanning electron microscopy analysis revealed attachment of the nanobubbles to the surface of RBCs,suggesting that direct interactions,or hitchhiking,of nanobubbles on RBCs in the presence of plasma may be a possible mechanism for the observed *** phenomenon could be key to extending nanobubble circulation time and has broad implications in drug delivery,where RBC interaction with nanoparticles could be exploited to improve delivery efficiency.

关键词： Nanobubbles Ultrasound contrast agents Red blood cells Hitchhiking Ultrasound Drug delivery

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感染性心内膜炎的手术问题

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国外医学（心血管疾病分册） 1990年第6期17卷 337-339页

作者： cooley DA 周珉

本文报告得克萨斯心脏病研究所外科治疗感染性心内膜灸的经验。早期手术治疗的良好效果。重点讨论了外科手术的指证、时机、人造代用品的选择和术后并发症等问题。

关键词：感染性心内膜炎手术

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Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral

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International Journal of Oral Science 2023年第4期15卷 676-690页

作者： Hyun-Yi Kim Victoria cooley Eun-Jung Kim Shujin Li Jong-Min Lee Dina Sheyfer Wenjun Liu Ophir D.Klein Derk Joester Han-Sung Jung NGeneS Inc. Ansan-siGyeonggi-doKorea Department of Materials Science and Engineering Northwestern UniversityEvanstonILUSA X-ray Science Division Advanced Photon SourceArgonne National LaboratoryLemontILUSA Division in Anatomy and Developmental Biology Department of Oral BiologyOral Science Research CenterBK21 FOUR ProjectYonsei University College of DentistrySeoulKorea Department of Orofacial Sciences and Program in Craniofacial Biology University of CaliforniaSan FranciscoCAUSA Department of Pediatrics Cedars-Sinai Guerin Children’sLos AngelesCAUSA

Ameloblasts are specialized cells derived from the dental epithelium that produce enamel,a hierarchically structured tissue comprised of highly elongated hydroxylapatite(OHAp)*** unique function of the epithelial cells synthesizing crystallites and assembling them in a mechanically robust structure is not fully elucidated yet,partly due to limitations with in vitro experimental ***,we demonstrate the ability to generate mineralizing dental epithelial organoids(DEOs)from adult dental epithelial stem cells(aDESCs)isolated from mouse incisor *** expressed ameloblast markers,could be maintained for more than five months(11 passages)in vitro in media containing modulators of Wnt,Egf,Bmp,Fgf and Notch signaling pathways,and were amenable to *** transplanted underneath murine kidney capsules,organoids produced OHAp crystallites similar in composition,size,and shape to mineralized dental tissues,including some enamel-like elongated *** are thus a powerful in vitro model to study mineralization process by dental epithelium,which can pave the way to understanding amelogenesis and developing regenerative therapy of enamel.

关键词： epithelium maintained specialized

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Athletes Who Sparkle： Stereotypes in the Televised Coverage of the 2010 Olympic Figure Skating Events

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Journalism and Mass Communication 2013年第5期3卷 292-303页

作者： Amy H. Jones Skye C. cooley Department of Languages and Literature University of West Alabama Department of Communication Mississippi State University

A vast amount of research has been devoted to gender roles in mass media. Prior studies relating to gender roles in media coverage of sports have been typically centered on underrepresentation, negative stereotypical portrayals of female athletes, and iconic heroic portrayals of male athletes. However, few studies have examined media coverage of male participation in so-called ＂gender inappropriate＂ sports. This research seeks to fill a gap in literature by exploring gender cues presented in the televised coverage of male and female figure skating events in the 2010 Winter Olympic Games. The findings from this research indicate that male athletes who cross gender barriers to participate in a feminine sport are likely to receive gender-marked stereotypical televised coverage. Much of the significant findings indicate that male figure skaters were visually and verbally portrayed as more feminine than the female figure skaters. The study opens lines of research into how sports are portrayed and could potentially influence sport marketing, athlete endorsements, athlete wardrobe, and other decisions made by the media, athletes, and individuals working in the sport industry.

关键词： gender stereotypes athletes figure skating televised coverage

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Delivering an mRNA vaccine using a lymphatic drug delivery device improves humoral and cellular immunity against SARS-CoV-2

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Journal of Molecular Cell Biology 2022年第6期14卷 47-56页

作者： Runqiang Chen Hui Xie Sahba Khorsandzadeh Madison Smith Namir Shaabani Qidong Hu Xiaoxuan Lyu Hua Wang Wan-lin Lim Haotian Sun Henry Ji Brian cooley Russell Ross David M.Francis Sorrento Therapeutics Inc.San DiegoCA 92121USA Sofusa a Division of Sorrento TherapeuticsAtlantaGA 30350USA

The exploration and identification of safe and effective vaccines for the SARS-CoV-2 pandemic have captured the world's attention and remains an ongoing issue due to concerns of balancing protection against emerging variants of concern while also generating long-lasting immunity. Here, we report the synthesis of a novel messenger ribonucleic acid encoding the spike protein in a lipid nanoparticle formulation (STI-7264) that generates robust humoral and cellular immunity following immunization of C57Bl6 mice. In an effort to improve immunity, a clinically focused lymphatic drug delivery device (MuVaxx) was engineered to modulate immune cells at the injection site (epidermis and dermis) and draining lymph node (LN) and tested to measure adaptive immunity. Using MuVaxx, immune responses were elicited and maintained at a 10-fold dose reduction compared to traditional intramuscular (IM) administration as measured by anti-spike antibodies, cytokine-producing CD8 T cells, neutralizing antibodies against the Washington (wild type) strain and South African (Beta) variants, and LN-resident spike-specific memory B cells. Remarkably, a 4-fold-elevated T cell response was observed in MuVaxx-administered vaccination compared to that of IM-administered vaccination. Thus, these data support further investigation into STI-7264 and lymphatic-mediated delivery using MuVaxx for SARS-CoV-2 and VoC vaccines.

关键词： COVID-19 lymph nodes lymphatics vaccines drug delivery

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漫谈FPGA测试基准

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电子设计技术 1995年第4期 18-22+24-25+27-28+30-31页

作者： John cooley

对偶尔关心软件的人来说,在鉴定任河软件包时,给FPGA(现场可编程门阵列)—合成软件定出测试基准,尽管似乎是沉闷但却可以有所预见的步骤。透过表面再深入下去,就会发现在一幅幅电影画面的背后,还有更多的戏剧性的情节。

关键词： FPGA 门阵列合成软件 PREP 测试基准软件工具软件工程

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