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Antioxidant capacity and genoprotective effect of ethanol fruit extract from Detarium microcarpum Guill. and Perr.(Caesalpiniaceae)

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Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 32-36页

作者： AblasséRouamba Maurice Ouedraogo martin kiendrebeogo Laboratoire de Biochimie et Chimie Appliqu′ees(LABIOCA) UFR-SVTUniversit′e de Ouagadougou03 BP 7021Ouagadougou 03Burkina Faso Laboratoire de Physiologie Animale(LAPA) UFR-SVTUniversit′e de Ouagadougou09 BP 848Ouagadougou 09Burkina Faso

Objective: To evidence the ability of ethanol fruit extract from Detarium microcarpum(D. microcarpum) to preserve DNA integrity against oxidative genomic ***: Ethanol extract from D. microcarpum fruit pulp was analyzed for its antioxidant capacity using ferric reducing antioxidant power, 2,2-diphenyl-1-picrylhydrazyl,2,20-azinobis-3-ethyl-ethylbenzothiazoline-6-sulphonate, superoxide anion, deoxyribose degradation and lipid peroxidation models. The genoprotective activity was assessed ex vivo by comet assay, on liver cells of NMRI female mice using cyclophosphamide(CP) as genotoxic ***: Ethanol extract from D. microcarpum fruit pulp exhibited interesting antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl, deoxyribose degradation and lipid peroxidation assays. The extract did not present any genotoxic effect but protected DNA against CP-induced damages with a dose-dependent manner. The genoprotective effect observed was related to the antioxidant molecules of the fruit that scavenged the hydroxyl radical(generated by the metabolism of CP) as well as the peroxyl and alkoxyl radicals issued from lipid peroxidation. Other mechanisms such as inactivation of CP metabolism to genotoxic end products, induction of the expression of antioxidant and DNA repair enzymes have been ***: Our results suggest that the wild edible fruit from D. microcarpum could be beneficial on consumer's health by its antioxidant and genoprotective effects, particularly during chemotherapies exhibiting genotoxic effects like CP in cancer treatment.

关键词： Antioxidant activity Comet assay Detarium microcarpum Genoprotection

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Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana(A. Rich.) Engl.(Burseraceae) and Loeseneriella africana(Willd.)(Celastraceae) stem leaves extracts

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 665-670页

作者： Moussa Compaore Roland Nag-Tiero Meda Sahabi Bakasso Laurian Vlase martin kiendrebeogo Laboratory of Applied Biochemistry and Chemistry University of Ouagadougou Laboratory for Research and Education in Animal Health and Biotechnology Polytechnic University of Bobo-Dioulasso Chemistry Laboratory Department of Chemistry Faculty of Science and Technology Abdou Moumouni University of Niamey Department of Pharmaceutical Technology and Biofarmceutics University of Medicine and Pharmacy 《Iuliu Hatieganu》Faculty of Pharmacy Culture Platform of Cell and Tissue (PCCT) U.F.R/S.V.T. University of Ouagadougou

Objective: To assess the antioxidant and anti-inflammatory activities as well as to determine the flavonoids and phenolic acids content of active ***: Two medicinal plant samples were extracted successively in Soxhlet apparatus with n-hexane, dichloromethane, acetonitrile, ethyl acetate, methanol and n-butanol. Five methods were used to evaluate the antioxidant activity. Anti-inflammatory activity was done through the inhibition of the cyclooxygenase enzymes(COX-1 and COX-2).Polyphenolic compounds were analyzed by using a spectrophotometrical and high performance liquid chromatography-mass spectrometry(HPLC-MS) ***: The data showed that the stem leaves extracts of Commiphora africana and Loeseneriella africana possessed significant in vitro antioxidant and anti-inflammatory activities. Polar extracts had radical scavenging effects and they reduced iron(III). The prostaglandin production was significantly stopped by acetonitrile and methanol *** biological activities were supported by some bioactive compounds quantified by using the HPLC-MS. p-Coumaric acid, ferulic acid, isoquercitrin, quercitrin, quercetin,rutin, kaempferol and apigenin were the most metabolites ***: The present study may explain the effectiveness of plants in traditional medicine of Burkina Faso, singularly Commiphora africana and Loeseneriella *** next investigation was to sub-fractionate the methanol fraction in order to isolate new antioxidant and/or anti-inflammatory compounds.

关键词： Commiphora africana Loeseneriella africana Antioxidant Anti-inflammation Phenolics HPLC-MS

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Evaluation of Acute Toxicity, Antioxidant and Antibacterial Potential of Leaves Extracts from Two Anacardiaceae’s Species: Lannea microcarpa Engl. &K. Krause and Mangifera indica L.

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Journal of Biosciences and Medicines 2022年第10期10卷 125-134页

作者： Monique Brigitte Ouattara Jean Hubert Bationo martin kiendrebeogo Odile Germaine Nacoulma Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Unité de formation et de recherche en sciences de la vie et de la terre Département de Biochimie-Microbiologie Ouagadougou Burkina Faso

Background: Leaves of Mangifera indica L or Lannea microcarpa Engl. & K. Krause are used in traditional medicine in Burkina Faso to treat bacterial, parasitic or metabolic diseases. Objective: The aim of this study is to evaluate the acute general toxicity, antioxidant potential and antibacterial activitiy of leave’s aqueous extracts from Lannea microcarpa Engl. and K. Krause and Mangifera indica L. The use of these plants in traditional medicine motivated our choice to lead scientific studies. Methods: The aqueous decoction of the leaves is the form of use recommended by traditional healers. We used the same type of extracts for studies. Acute toxicity was studied in NMRI strain mice, with the dose of 2000 mg/kg body weight, for each plant species. The antioxidant activity is evaluated by the method of reduction of radical DPPH. The phytochemical compounds were detected with specific reagent: Alcaloids with Dragendorff’s reagent, Flavonoids with ammonia (NH4OH), Polyphenols and tannins are revelated by ferric chloride (FeCl3). Saponosides were revelated by their foaming power property. Bacterial inhibiting activity is tested by measuring the diameters’ inhibition of extracts on reference strains. Results: The aqueous extracts were not toxic at the maximum dose of 2000 mg/kg body weight, for each plant species. The extracts showed an antioxidant activity with an IC50, 20 μg/ml for Lannea microcarpa and 18 μg/ml for Mangifera indica. The extracts showed no bacterial activity on three strains of bacteria tested: Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The phytochemicals we have identified are for L. microcarpa: tannins and phenolics compounds, triterpenes, saponosides. We identified in M. indica’s extracts: tannins and phenolics compounds, triterpenes, saponosides and flavonoids.

关键词： Lannea microcarpa Mangifera indica Toxicity Antioxidant Activity DPPH Antibacterial Activity Phytochemical Compounds

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Phytochemical Screening and Acute Toxicity Evaluation of Leaves Extract of Two Fabaceae’s Species: Sesbania pachycarpaDC. and Indigofera berhautianaGillett

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Journal of Biosciences and Medicines 2020年第7期8卷 28-34页

作者： Monique Brigitte Ouattara Jean Hubert Bationo martin kiendrebeogo Odile Germaine Nacoulma Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Unité de Formation et de Recherche en Sciences de la Vie et de la Terre Département de Biochimie-Microbiologie Ouagadougou Burkina Faso

Objective: The aim of this study is to screen chemical composition and to evaluate the acute general toxicity of leaves aqueous extracts from Sesbania pachycarpa DC. (Fabaceae), used in traditional medicine in Burkina Faso to treat malaria, helminthiasis, and aqueous extracts of the leaves from Indigofera berhautiana Gillet (Fabaceae) used to treat hepatitis and typhoid fever. Methods: Aqueous decoction of leaves from Sesbania pachycarpa DC. or Indigofera berhautiana Gillett which are the form of use recommended by traditional health practitioners, were used for tests. Aqueous extracts used to evaluate the acute toxicity, were studied on mice of strain NMRI. For the toxicity study, the doses of the aqueous extracts were respectively 5 mg/kg, 50 mg/kg, 300 mg/kg and 2000 mg/kg of body weight. Phytochemical screening was done to identify the phytochemicals contained in extracts. Results: Aqueous extracts of two species: Sesbania pachycarpa DC., Indigofera berhautiana Gillet were not toxic at the maximum dose of 2000 mg/kg of body weight. Phytochemical screening, showed coumarins, flavonoids, tannins, polyphenols compounds, steroids and/or triterpenes and saponosides in the aqueous extracts of the two species. Alkaloids were identified in Sesbania pachycarpa aqueous extract.

关键词： Sesbania pachycarpa DC. Indigofera bergautiana Gillet Aqueous Extracts Acute General Toxicity NMRI Strain Phytochemicals Compounds

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Physicochemical and Biochemical Composition of Balanites aegyptiaca Seed and Seed Oil from Burkina Faso

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Food and Nutrition Sciences 2023年第12期14卷 1206-1220页

作者： Patrice Bazongo Lassané Ouédraogo Pingdwindé Marie Judith Samadoulougou-Kafando martin kiendrebeogo Nicolas Barro Laboratoire de Biologie Moleculaire d’Epidemiologie et de Surveillance des Bacteries et Virus transmis par les aliments et l’eau (LaBESTA) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre National de la Recherche Scientifique et Technologique (CNRST) Institut de l’Environnement et de Recherches Agricoles (INERA)/Laboratoire de l’Environnement et des Ecosystèmes Forestiers Agroforestiers et Aquatiques (LaboEcoFAA) Ouagadougou Burkina Faso Centre National de la Recherche Scientifique et Technologique (CNRST)/Institut de Recherche en Sciences Appliquées et Technologies (IRSAT)/Laboratoire des Sciences et Technologies des Aliments et Nutrition (LabSTAN) Ouagadougou Burkina Faso Laboratoire de Biochimie & Chimie Appliquées Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

In Burkina Faso, the seeds of Balanites aegyptiaca have been considered to be potentially high lipid, protein and mineral sources but seem to be neglected and sometimes unknown by communities. This study aims to complete data on seed oil and detail on amino acids and minerals composition of the seed of B. aegyptiaca for better use. Physicochemical parameters such as moisture and ash content, saponification index, iodine, acid value, peroxide value and the melting point were determined. Seed oil triglycerides, fatty acids and amino acids have been estimated throughout this study. The moisture and ash content were 3.70% ± 0.1% and 2.90% ± 0.2%, respectively. The saponification and iodine values were respectively 181.96 ± 0.4 mg KOH/g of oil and 104.86 ± 0.6 g of iodine/100 g of oil. Polyunsaturated fatty acid content (50.94%) was the most important. Triglyceride (LLO, 22.4%) was the major triglyceride. 9 essential amino acids and 9 non-essential amino acids were identified. Phenylalanine (11697.82 ± 0.00 mg/kg) was the most important essential amino acid. The content of 21 minerals was determined and the most important was potassium (9323.13 ± 0.01 mg/kg). Ca/P, Ca/Mg, Ca/Mg and Na/K ratios were 0.34;1.18;0.04 and 0.19 respectively. B. aegyptiaca seed oil is a source of multiple nutritional values and can be used by the population for multipurpose.

关键词： Seed Seed Oil Fatty Acids Amino Acids Minerals Balanites aegyptiaca Burkina Faso

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Anti-Melanogenesis Effect of Daniellic Acid Isolated from Daniellia oliveri(Rolfe) Hutch. &Dalziel (Leguminosae) Oleoresin of Burkina Faso

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Open Journal of Medicinal Chemistry 2021年第4期11卷 41-57页

作者： Aminata P. Nacoulma Moussa Compaoré Naamwin-so-Bawfu Romaric Meda Laurent Pottier Véronique Megalizzi Issa Some martin kiendrebeogo Laboratoire de Toxicologie Environnement et Santé Université Joseph KI-ZERBO Ouagadougou Burkina Faso Microbiology Bioorganic and Macromolecular Chemistry and RD3—Pharmacognosy Bioanalysis & Drug Discovery Units Université libre de Bruxelles Brussels Belgium Laboratoire de Biochimie et de Chimie Appliquées Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, Daniellia oliveri which was a potential source of cosmeceutical agent was selected to investigate its active components. Daniellic acid isolated from the oleoresin was characterized by using data from 1H-NMR, 13C-NMR, HSQC, IR, and online chemo-informatic analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase inhibition capabilities were evaluated. This compound possessed an anti-DPPH and iron (III) reducing effect compared to quercetin. It was able to inhibit 9 tumor cells with IC50 going from 0.03 mM (U373) to 0.14 mM (Malme-3M). Interestingly daniellic acid inhibits tyrosinase activity with 1.20 mM as IC50. The tyrosinase inhibition mechanism was noncompetitive mixed-type with un-significant effect on cell melanogenesis. Daniellic acids induced a half-reduction of melanin production in B16F10 cell in IBMX stimulation (p

关键词： Daniellia oliveri Daniellic Acid Tyrosinase Melanogenesis Cytotoxicity

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POLYPHENOLS, CYTOTOXICITY AND ENZYMATIC ACTIVITIES OF THREE ERIACEAE SPECIES FROM ALGERIA

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 90-90页

作者： Guendouze-Bouchefa Nama Brahmi Fatiha Madani Khodir Chibane Mohamed kiendrebeogo martin Stévigny Caroline Duez Pierre Laboratoire de Biomathématique Biochimie Biophysique et Scientometrie Faculté des Sciences de la Nature et de la Vie Université de Bejaia Laboratoire de Biochimie et Chimie Appliquées(LABIOCA) Université de Ouagadougou Laboratoire de Pharmacognosie Bromatologie et Nutrition Humaine Faculte de Pharmacie Université Libre de Bruxelles (ULB) Laboratoire de Chimie Thérapeutique et de Pharmacognosie Faculté de Médecine et de PharmacieUniversité de Mons (UMONS)

In Algerian traditional medicine,Erica arborea(EA),Erica multiflora(EM)and Arbutus unedo(AU)are reported as antiseptic,diuretic,astringent,depurative,and to treat scalds and *** methanolic extracts of their leaves and aerial parts were screened for enzyme inhibitory and cytotoxic *** and HPLC chromatographic profiles based on flavonoids allowed to easily distinguish between the three investigated ***

关键词： CYTOTOXICITY AND ENZYMATIC ACTIVITIES OF THREE ERIACEAE SPECIES FROM ALGERIA POLYPHENOLS EM

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PHENOLIC PROFILE, ANTIBACTERIAL,NEUROPROTECTIVE AND CYTOTOXIC PROPERTIES OF THREE ALGERIAN MENTHA SPECIES

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 87-87页

作者： Brahmi Fatiha Guendouze Naima Madani Khodir PhillipeN.Okusa martin kiendrebeogo Kamagaju Léocadie Stévigny Caroline Chibane Mohamed Duez Pierre Laboratoire de Biomathématique Biochimie Biophysique et Scientom6trie Université de Bejaia Laboratoire de Pharmacognosie Bromatologie et Nutrition Humaine Université Libre de Bruxelles (ULB) Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) UFR/SVT Université de Ouagadougou Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre Université Akli Mohand Oulhadj Service de Chimie Thérapeutique et de Pharmacognosie Faculté de Medecine et de Pharmacie Université de Mons(UMONS)

This study was designed to evaluate the antibacterial(direct effect and reversal of antibiotics-resistance),neuroprotective(acetylcholinesterase and carboxylesterase inhibition)and cytotoxic(MTT assay on 2 human cancer cell lines)properties of three Mentha species[*** L.(MP),***(L.)Huds(MR),and *** L.(MS)]harvested in Bejaia(Algeria).The phenolic

关键词： MR MS PHENOLIC PROFILE ANTIBACTERIAL,NEUROPROTECTIVE AND CYTOTOXIC PROPERTIES OF THREE ALGERIAN MENTHA SPECIES

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