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Amphiphilic amino-acid derivatives promote gram-scale single-crystal COFs synthesis

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Science China Chemistry 2024年第2期67卷 415-416页

作者： Yijia Yuan kian Ping Loh Department of Chemistry National University of SingaporeSingapore117543Singapore

Covalent organic frameworks(COFs) are crystalline organic compounds synthesized from covalently linked building blocks that extend in space to form a framework structure with periodic pores. The covalent linkages used... 详细信息

关键词： synthesis correction reversible

Polymer transfer film formation from cryogenic to elevated temperatures

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Friction 2024年第9期12卷 2018-2032页

作者： kian BASHANDEH Vasilis TSIGKIS Ahmad AMIRI Pixiang LAN Andreas A.POLYCARPOU J.Mike Walker’66 Department of Mechanical Engineering Texas A&M UniversityCollege StationTexas 77843USA ATSP Innovations Inc.HoustonTexas 77055USA Russell School of Chemical Engineering The University of TulsaTulsaOklahoma 74104USA Department of Mechanical Engineering The University of TulsaTulsaOklahoma 74104USA

This study reports on the tribological performance of aromatic thermosetting co-polyester(ATSP)and polyether ether ketone(PEEK)-based polymer composite coatings mixed with PTFE *** coatings were tested across a wide temperature range from−180 to 110℃ to simulate the environmental temperatures on Titan,Moon,and Mars,which are of particular interest for NASA’s future exploratory *** experimental setup was developed to conduct the pin-on-disk experiments under dry sliding conditions and extreme temperature and contact *** film formation and its characteristics were found to play significant roles in the tribological performance,and the characteristics of the film were *** XPS and SEM analysis indicated the increase of the PTFE content in the transfer film as the temperature decreased to cryogenic *** coefficient of friction did not follow a linear trend with temperature and was minimum at 110℃ and maximum at−180℃.ATSP coating showed superior performance with lower friction and unmeasurable wear at all temperatures,whereas PEEK coating exhibited maximum wear at 25℃ followed by−180,and 110℃.

关键词： transfer film cryogenic high temperature tribology space tribology polymer coating

NeurDB: an AI-powered autonomous data system

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Science China(Information Sciences) 2024年第10期67卷 129-150页

作者： Beng Chin OOI Shaofeng CAI Gang CHEN Yanyan SHEN kian-Lee tan Yuncheng WU Xiaokui XIAO Naili XING Cong YUE Lingze ZENG Meihui ZHANG Zhanhao ZHAO School of Computing National University of Singapore College of Computer Science and Technology Zhejiang University Department of Computer Science and Engineering Shanghai Jiao Tong University School of Information Renmin University of China School of Computer Science and Technology Beijing Institute of Technology

In the wake of rapid advancements in artificial intelligence(AI), we stand on the brink of a transformative leap in data systems. The imminent fusion of AI and DB(AI×DB) promises a new generation of data systems, which will relieve the burden on end-users across all industry sectors by featuring AI-enhanced functionalities, such as personalized and automated in-database AI-powered analytics, and selfdriving capabilities for improved system performance. In this paper, we explore the evolution of data systems with a focus on deepening the fusion of AI and DB. We present NeurDB, an AI-powered autonomous data system designed to fully embrace AI design in each major system component and provide in-database AI-powered analytics. We outline the conceptual and architectural overview of NeurDB, discuss its design choices and key components, and report its current development and future plan.

关键词： AI$\times$DB in-database AI intelligent data system

Bilayer separator enabling dendrite-free zinc anode with ultralong lifespan >5000 h

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Green Energy & Environment 2024年第4期9卷 771-776页

作者： Lu Wang Feifei Wang Zhe Ding Yingxin Liu Ziyi Zhang Chunpeng Yang kian Ping Loh Quan-Hong Yang Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China Nanoyang Group State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China Department of Chemistry National University of Singapore117543Singapore Institute of Process Engineering Chinese Academy of SciencesBeijing100190China

Aqueous zinc(Zn)batteries with Zn metal anodes are promising clean energy storage devices with intrinsic safety and low ***,Zn dendrite growth severely restricts the use of Zn *** effectively suppress Zn dendrite growth,we propose a bilayer separator consisting of commercial butter paper and glassfiber *** dense cellulose-based butter paper(BP)with low zincophilicity and high mechanical properties prevents the pore-filling behavior of deposited Zn and related separator piercing,effectively suppressing the Zn dendrite *** a result,the bilayer separators endow the ZnjjZn symmetrical batteries with a superlong cycling life of Zn anodes(over 5000 h)at 0.5 mA cm^(-2) and the full batteries enhanced capacity retention,demonstrating the advancement of the bilayer separator to afford excellent cyclability of aqueous metal batteries.

关键词： Zn battery Bilayer separator Butter paper Zn metal anode Zn dendrite

Guest Editorial:Special issue on advances in representation learning for computer vision

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 1-3页

作者： Andrew Beng Jin Teoh Thian Song Ong kian Ming Lim Chin Poo Lee Electrical and Electronic Engineering Department Yonsei UniversitySeoulSouth Korea Faculty of Information Science and Technology Multimedia UniversityMelakaMalaysia

Deep learning has been a catalyst for a transformative revo-lution in machine learning and computer vision in the past *** these research domains,methods grounded in deep learning have exhibited exceptional performance across a spectrum of *** success of deep learning methods can be attributed to their capability to derive potent representations from data,integral for a myriad of downstream *** representations encapsulate the intrinsic structure,fea-tures,or latent variables characterising the underlying statistics of visual *** these achievements,the challenge per-sists in effectively conducting representation learning of visual data with deep models,particularly when confronted with vast and noisy *** special issue is a dedicated platform for researchers worldwide to disseminate their latest,high-quality articles,aiming to enhance readers'comprehension of the principles,limitations,and diverse applications of repre-sentation learning in computer vision.

关键词： spite computer representation

Developing a Clang Libtooling-Based Refactoring Tool for CUDA GPU Programming

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Journal of Software Engineering and Applications 2024年第2期17卷 89-108页

作者： kian Nejadfard Janche Sang Champ Titles Inc. Cleveland USA Department of Computer Science Cleveland State University Cleveland USA

Refactoring tools, whether fully automated or semi-automated, are essential components of the software development life cycle. As software libraries and frameworks evolve over time, it’s crucial for programs utilizing them to also evolve to remain compatible with modern advancements. Take, for example, NVIDIA CUDA’s platform for general-purpose GPU programming. Embracing the more contemporary unified memory architecture offers several benefits, such as simplifying program source code, reducing bugs stemming from manual memory management between host and device memory, and optimizing memory transfer through automated memory handling. This paper describes our development of a refactoring tool based on Clang’s Libtooling to facilitate this transition automatically, thereby relieving developers from the burden and risks associated with manually refactoring large code bases.

关键词： Refactoring CUDA Unified Memory Clang Libtooling

Collaborative Simulation Method with Spatiotemporal Synchronization Process Control

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1074-1082页

作者： ZOU Yisheng DING Guofu ZHANG Weihua ZHANG Jian QIN Shengfeng tan John kian School of Mechanical Engineering Southwest Jiaotong University Chengdu 610031 China State Key Laboratory of Traction Power Southwest Jiaotong University Chengdu 610031 China Northumbria School of Design Northumbria University Newcastle upon Tyne NE1 8ST UK School of Mechanical and Construction Engineering Northumbria University Newcastle upon Tyne NE1 8ST UK

When designing a complex mechatronics system, such as high speed trains, it is relatively difficult to effectively simulate the entire system＇s dynamic behaviors because it involves multi-disciplinary subsystems. Currently, a most practical approach for multi-disciplinary simulation is interface based coupling simulation method, but it faces a twofold challenge： spatial and time unsynchronizations among multi-directional coupling simulation of subsystems. A new collaborative simulation method with spatiotemporal synchronization process control is proposed for coupling simulating a given complex mechatronics system across multiple subsystems on different platforms. The method consists of 1） a coupler-based coupling mechanisms to define the interfacing and interaction mechanisms among subsystems, and 2） a simulation process control algorithm to realize the coupling simulation in a spatiotemporal synchronized manner. The test results from a case study show that the proposed method 1） can certainly be used to simulate the sub-systems interactions under different simulation conditions in an engineering system, and 2） effectively supports multi-directional coupling simulation among multi-disciplinary subsystems. This method has been successfully applied in China high speed train design and development processes, demonstrating that it can be applied in a wide range of engineering systems design and simulation with improved efficiency and effectiveness.

关键词： design automation collaborative simulation space and time synchronization process control coupling algorithms mechatronic system design

Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam E.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann Eva Pawlus kian Eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David J.Beech Frank Timo Beil Michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

Capecitabine with radiation is an effective adjuvant therapy in gastric cancers

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World Journal of Gastroenterology 2010年第29期16卷 3709-3715页

作者： Chee kian Tham Su Pin Choo Donald Yew Hee Poon Han Chong Toh Simon Yew Kuang Ong Sze Huey tan Michael Lian Chek Wang kian Fong Foo Department of Medical Oncology National Cancer Centre Singapore Department of Clinical Trials and Epidemiological Sciences National Cancer Centre Singapore Department of Radiation Oncology National Cancer Centre Singapore

AIM:To analyze the outcome of patients who received concurrent capecitabine(Xeloda) and radiation(XRT) compared to the established concurrent 5-fluorouracil(5-FU) with radiation(5FU-RT) and fluoropyrimidine-based chemotherapy alone as adjuvant treatment in gastric ***:All patients with gastric cancers who received adjuvant treatment at the National Cancer Centre Singapore between 1996 and 2006 were *** outcomes of patients who received XRT were compared with those who had 5FU-RT or chemotherapy alone as adjuvant therapy for gastric ***:A total of 108 patients were *** age at diagnosis was *** majority of the patients(64.8%) had advanced stage Ⅲ and Ⅳ disease(with no distant metastasis).All except 4 patients had D2 *** one patients(19.4%) had positive surgical resection *** three patients received XRT compared with 52 who had 5FU-RT and 23 who received chemotherapy *** the patients in the chemotherapy-only group,all had fluoropyrimidine-based therapy,with added cisplatin in 7 patients and epirubicin in 2 *** recurrence-free survival was longer for the XRT group(52 mo) compared to the 5FU-RT(35 mo) and chemotherapy-only groups(25 mo)(P=0.48).The patients in the XRT group achieved similar median overall survival(53 mo) as the 5FU-RT(54 mo) and the chemotherapy-only groups(44 mo)(P=0.5).CONCLUSION:Capecitabine with concurrent radiation was as effective as concurrent 5FU with radiation or fluoropyrimidine-based chemotherapy alone when used as adjuvant treatment in patients with gastric cancers.

关键词： Capecitabine Radiation Gastric cancer Adjuvant chemotherapy