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血清He4、VeGF、MCP-1及CCL20与乳腺癌患者保乳术后局部复发的关系研究

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现代生物医学进展 2022年第14期22卷 2778-2783页

作者：罗洁刘世伟张蒲蓉张剑辉牟鳄贤夏莉冉冉张欣徐佳电子科技大学医学院附属肿瘤医院·四川省肿瘤医院乳腺外科中心四川成都610041

目的:探讨血清人附睾蛋白4(He4)、血管内皮生长因子(VeGF)、单核细胞趋化因子-1(MCP-1)及CC趋化因子配体20(CCL20)与乳腺癌患者保乳术后局部复发的关系。方法:选择2015年7月~2018年7月期间本院收治的乳腺癌患者312例作为研究对象,均符... 详细信息

目的:探讨血清人附睾蛋白4(He4)、血管内皮生长因子(VeGF)、单核细胞趋化因子-1(MCP-1)及CC趋化因子配体20(CCL20)与乳腺癌患者保乳术后局部复发的关系。方法:选择2015年7月~2018年7月期间本院收治的乳腺癌患者312例作为研究对象,均符合保乳术手术指征,成功实施乳腺癌保乳术,所有患者均随访3年。检测两组血清He4、VeGF、MCP-1、CCL20水平情况,单因素及多因素Logistic回归分析影响术后局部复发的因素。使用受试者工作特征(ROC)曲线分析He4、VeGF、MCP-1、CCL20水平单独及联合检测对保乳术后局部复发的预测价值。结果:随访过程中失访6例,剩余的306例患者根据随访结果,分为局部复发组27例、无局部复发组279例,局部复发率为8.82%。局部复发组的血清He4、VeGF、MCP-1、CCL20水平均高于无局部复发组(Per-2)、细胞增殖相关抗原(ki-67)、术后规范化疗、术后足程放疗有关(Pe4、VeGF、MCP-1、CCL20水平偏高,切缘状态、Her-2、ki-67阳性以及淋巴结转移是保乳术后局部复发的危险因素(Pe4、VeGF、MCP-1、CCL20联合应用预测乳腺癌患者保乳术后局部复发的效能高于单一指标应用。结论:乳腺癌保乳术后局部复发患者体内He4、VeGF、MCP-1、CCL20水平高表达,四指标联合检测可辅助预测保乳术后局部复发。且乳腺癌患者保乳术后复发还受到切缘状态、Her-2、ki-67等多种因素的影响。

关键词： He4 VeGF MCP-1 CCL20 乳腺癌保乳术局部复发影响因素

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胎儿/新生儿同种免疫性血小板减少症患儿经母体免疫球蛋白治疗和宫内血小板输注治疗后的免疫状况

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 14-14页

作者： Radder C.M. Roelen D.L. Van De Meer-Prins e.M.W. 龚雯洁 Depts.Obstet.Immunohematolog y B. Leiden Univer sity Medical CenterLeidenNetherlands Dr.

Objective The purpose of this study was to evaluate whether maternally administered intravenous immunoglobulins(IV-IG)and intrauterine platelet transfusions(IUPT)for fetal /neonatal alloimmune thrombocytopenia(FNaiT)affect the development of the fetal immune *** design The lymphocyte subset distribution of m ononuclear cells of cord blood of 20FNaiT newborns was analyzed by flowcytometry and compared with a control group of healthy newborns and a reference group treated with intra uterine erythrocyte transfusions(IUeT)for hemolytic *** The percentage of monocytes,natural ki ller(NK)cells,ratiosof mature and immature T cells and B ce lls,and resting or activated cells were not significan tly different compared to the control *** addition,the B -cell and Tcell populations showed a normal in vitro antibody production and T -cell proliferation when compared with the control *** Antenatal treatm ent for FNaiT with maternal IVIG with or without IUPT is not associated with lymphocyte activation or premature maturation of the neonatal immune system.

关键词：血小板输注免疫状况同种免疫新生儿免疫免疫球蛋白新生儿脐带血健康新生儿出生前流式细胞仪抗体产生

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前列腺癌ki-67、磷酸化Akt和雄激素受体表达与MRI及MRS表现的关系

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国际医学放射学杂志 2009年第3期 280-280页

作者： A.Shukla-Dave H.Hricak N.M.Ishill C.S.Moskowitz M.Drobnjak V.e.Reuter 谭艳 Department of Medical Physics RadiologyMemorial Sloan-Kettering Cancer Center1275 York AveNew YorkNY 10021USA

目的回顾性分析经外科病理检查证实的显著性和非显著性前列腺癌(PCa)的MRI、MRS与选定分子标记之间是否相互关联。方法本研究符合HIPAA,并得到机构审查委员会的批准,未获得知情同意书。选取89例经活检证实并在前列腺癌根治术前行直肠线... 详细信息

目的回顾性分析经外科病理检查证实的显著性和非显著性前列腺癌(PCa)的MRI、MRS与选定分子标记之间是否相互关联。方法本研究符合HIPAA,并得到机构审查委员会的批准,未获得知情同意书。选取89例经活检证实并在前列腺癌根治术前行直肠线圈MRI和MRS的男性病人(平均年龄63岁,范围46～79岁)。对可疑的临床不显著的前列腺癌采用0～3级回顾性、

关键词：前列腺癌显著性 ki-67 MRS 雄激素性甾体磷酸化 MRI Akt

Search for the doubly heavy baryons Ω^(0)_(bc) and e^(0)_(bc) decaying to Λ^(+)_(c)π^(-) and e^(+)_(c)π^(-)

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Chinese Physics C 2021年第9期45卷 10-21页

作者： R.Aaij C.Abelian Beteta T.Ackernley B.Adeva M.Adinolfi H.Afshamia C.A.aidala S.aiola Z.Ajaltouni S.Aka J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelie S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov e.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni e.Ben-Haim A.Berezhnoy *** D.Beminghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.Bjorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Camiti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.e.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan e.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Torres R.Currie C.L.Da Silva e.Dall'Occo J.Dalseno C.D'Ambrosi Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High energy Physics Tsinghua UniversityBeijingChina Institute of High energy Physics(IHeP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University ofChinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universite Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHe Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/FN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kemphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKr

The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the e^(0)_(bc)baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 fb^(-1).The baryons are reconstructed via their decays to Λ^(+)_(c)π^(-)and e^(+)_(c)π^(-).No significant excess is fbund for invariant masses between 6700 and 7300 MeV/c^(2),in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ω^(0)_(bc)and e^(0)_(bc)production cross-section times the branching fraction to Λ^(+)_(c)π^(-)(e^(+)_(c)π^(-))relative to that of the Λ^(0)_(b)(e^(0)_(b))baryon,for different lifetime hypotheses,at 95%confidence *** upper limits range from 0.5 x 10^(-4)to 2.5 x 10^(-4)for theΩ^(0)_(bc)→Λ^(+)_(c)π^(-)(e^(0)_(bc)→Λ^(+)_(c)π^(-))decay,and from 1.4x 10^(-3)to 6.9 x 10^(-3)for theΩ^(0)_(bc)→e^(+)_(c)π^(-)(e^(0)_(bc)→e^(+)_(c)π^(-))decay,depending on the considered mass and lifetime of theΩ^(0)_(bc)(e^(0)_(bc))baryon.

关键词： B physics quarkonium spectroscopy heavy quark production