检索结果-南通市图书馆

Snowstorm over the Southwestern Coast of the Korean Peninsula Associated with the Development of Mesocyclone over the Yellow Sea

引用

Advances in Atmospheric Sciences 2008年第5期25卷 765-777页

作者： ki-young heo kyung-ja ha Division of Earth Environmental System College of Natural Sciences Pusan National University Korea

This study investigates the characteristics of a heavy snowfall event over the southwestern part of the Korean Peninsula on 4 December 2005. The snowstorm was a type of mesoscale maritime cyclone which resulted from barotropic instability, and diabatic heating from the warm ocean in continental polar air masses. Based on surface observations, radiosonde soundings, MTSAT-1R satellite data and the 10-km grid RDAPS （Regional Assimilation and Prediction System based on the PSU/NCAR MM5） data, the evolution of the mesocyclone is explained by the following dynamics; （1） In the initial stage, the primary role in the cyclogenesis process of the mesocyclone is a barotropic instability in the horizontal shear zone. （2） In the developing stage, the mesocyclone moves and deepens into a baroclinic zone corresponding to the surface heating and moistening. （3） In the mature stage, it is found that the mesocyclone is intensified by the destabilization caused by enhanced low-level heating and condensation, the moisture flux convergence, and the interaction between upper and lower-level potential vorticity anomalies. We suggest that a checklist with stepwise indicators responsible for development be prepared for the forecasting of heavy snowfall over the southwestern part of the Korean Peninsula.

关键词： heavy snowfall mesocyclone baroclinic instability barotropic instability stepwise roles potential vorticity anomalies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice

引用

World Journal of Gastroenterology 2021年第23期27卷 3342-3356页

作者： Seunghun Lee Jeonghoon heo Eun-kyung Ahn jae Hyun kim young-Ho kim Hee-kyung Chang Sang-Joon Lee Jongsik kim Seun-ja Park Department of Colorectal Surgery Kosin University College of MedicineBusan 49267South Korea Department of Molecular Biology and Immunology Kosin University College of MedicineBusan 49267South Korea Department of Gastroenterology Kosin University College of MedicineBusan 49267South Korea Department of Pathology Kosin University College of MedicineBusan 49267South Korea Department of Ophthalmology Kosin University College of MedicineBusan 49267South Korea Department of Anatomy Kosin University College of MedicineBusan 49267South Korea

BACKGROUND Inflammatory bowel diseases(IBD)is related to uncontrolled immune ***,there is no successful treatment for significant improvement in *** cells display their therapeutic effects through their repopulating capacity or secreting *** To investigate the effects of conditioned mouse adipose-derived stem cells(mADSCs)secretome on colitis-induced *** mADSCs were isolated from adipose tissue of C57BL/6 *** mADSCs secrectome was obtained by culturing of mADSCs with lipopolysaccharides(LPS,1μg/mL)for 24 *** colitis was induced by 2%dextran sulfate sodium(DSS)drinking water for 7 d and then normal drinking water for 4 *** mice were treated with normal culture medium(NM group),conditioned mADSCs secretome(CM group)or mADSCs(SC group).The length of colon and histopatholgy of colon tissues were *** mRNA expression levels of inflammatory cytokines in colon tissue and the serum interleukin(IL)-6 levels were *** The isolated mADSCs maintained the mADSCs specific gene expression profiles during *** conditioned mADSCs secretome released by the treatment of mADSCs with LPS contained mainly inflammatory chemokines,colony-stimulating factors and inflammatory *** loss of body weight and reduction in colon length were ameliorated in the CM *** conditioned mADSCs secretome reduced the histological score in colon *** expression of IL-1b and IL-6 mRNAs in colon tissues significantly inhibited in the CM group compared to SC group and NM group,*** elevation of serum IL-6 levels was also ameliorated in the CM *** results indicate that the conditioned mADSCs secretome suppressed the synthesis of inflammatory cytokines in damaged colon tissue and the elevation of serum IL-6 concentration in DSS-induced mice CONCLUSION Conditioned mADSCs secretome might play regenerative roles by the suppression of IL-6 in serum and tissue during acute colitis,and may be

关键词： Adipose-derived stem cells Conditioned secretome Cytokines Interleukin-6 Colitis Regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of Pegylated Interferon Monotherapy versus Sequential Therapy of Entecavir and Pegylated Interferon in Hepatitis B e Antigen-Positive Hepatitis B Patients： A Randomized, Multicenter, Phase IIIb Open-Label Study （POTENT Study）

引用

Chinese Medical Journal 2018年第14期131卷 1645-1651页

作者： Dae Won Jun Sang Bong Ahn Tae Yeob kim Joo Hyun Sohn Sang Gyune kim Se Whan Lee Byung Ho kim Dong Joon kim ja kyung kim Hyoung Su kim Seong Gyu Hwang Won Choong Choi Won young Tak heon Ju Lee ki Tae Yoon Byung Cheol Yun Sung Wook Lee Soon Koo Baik Seung ha Park Ji Won Park Sol Ji Park Ji Sung Lee Department of Internal Medicine Hanyang University Seoul Hospital Hanyang University Seou104763 Korea Department of Internal Medicine Nowon Eulji Hospital Eulji University Seou101830 Korea Department of Internal Medicine Hanyang University Guri Hospital Hanyang University Guri 11923 Korea Department of Internal Medicine SoonChunHyang University Bucheon Hospital SoonChunHyang University Bucheon 14584 Korea Department of Internal Medicine SoonChunHyang University Cheonan Hospital SoonChunHyang University Cheonan 31151 Korea Department of Internal Medicine Kyung Hee University Hospital Kyung Hee University Seoul 02453 Korea Department of Internal Medicine Chuncheon Sacred Heart Hospital Hallym University Chuncheon 24252 Korea Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University Seou105355 Korea Department of Internal Medicine Gangnam Severance Hospital Yonsei University Seou106273 Korea Department of Internal Medicine CHA Bundang Medical Center CHA University Seongnam 13496 Korea Department of Internal Medicine Sanggye Paik Hospital Inje University Seoul 01757 Korea Department of Internal Medicine Kyungpook National University Hospital Kyungpook National University Daegu 41944 Korea Department of Internal Medicine Yeungnam University Medical Center Yeungnam University Daegu 42415 Korea Department of Internal Medicine Pusan National University Yangsan Hospital Pusan National University Yangsan 50612 Korea Department of Internal Medicine Kosin University Gospel Hospital Kosin University Pusan 49267 Korea Department of Internal Medicine Dong A University Medical Center Dong A University Pusan 49201 Korea Department of Internal Medicine Wonju Severance Christian Hospital Yonsei University Wonju 26426 Korea Department of Internal Medicine Haeundae Paik Hospital Inje University Pusan 48108 Korea Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University Anyang 14068 Korea Department of Cli

Background： Until now, various types of combined therapy with nucleotide analogs and pegylated interferon （Peg-INF） in patients with hepatitis B patients have been tried. Howe6ver, studies regarding the benefits of de novo combination, late-add on, and sequential treatmentare very limited. The objective of the current study was to identify the efficacy of sequential treatment of Peg-INF after short-term antiviral treatment. Methods： Between June 2010 and June 2015, hepatitis 13 e antigen （HBeAg）-positive patients （n = 162） received Peg-IFN for 48 weeks （mono-treatment group, n = 81） and entecavir （ETV） for 12 weeks with a 48-week course of Peg-IFN starting at week 5 of ETV therapy （sequential treatment group, n = 81）. The primary endpoint was HBeAg seroconversion at the end of follow-up period after the 24-week treatment. The primary endpoint was analyzed using Chi-square test, Fisher＇s exact test, and regression ***： HBeAg seroconversion rate （18.2% vs. 18.2%, t = 0.03, P = 1.000） and seroclearance rate （19.7% vs. 19.7%, t = 0.03, P = 1.000） were same in both mono-treatment and sequential treatment groups. The rate of alanine aminotransferase （ALT） normalization （45.5% vs. 54.5%, t = 1.12, P = 0.296） and serum hepatitis B virus （HBV）-DNA 〈2000 U/L （28.8% vs. 28.8%, t = 0.10, P = 1.000） was not different in sequential and mono-treatment groups at 24 weeks of Peg-INF. Viral response rate （HBeAg seroconversion and serum HBV-DNA 〈2000 U/L） was not different in the two groups （12.1% vs. 16.7%, t = 1.83, P = 0.457）. Baseline HBV-DNA level （7 log10 U/ml vs. 7.5 log10 U/ml, t = 1.70, P = 0.019） and hepatitis B surface antigen titer （3.6 log10 U/ml vs. 4.0 log10 U/ml, t = 2.19, P = 0.020） were lower and predictors of responder in mono-treatment and sequential treatment groups, respectively. Conclusions： The current study shows no differences in HBeAg seroconversion rate, ALT normalization, and HBV-DNA levels between mono-therapy and sequential therapy regimens.

关键词： Entecavir Hepatitis B Peginterferon Alfa-2a

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：