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Simulation of the extreme waves generated by typhoon Bolaven (1215) in the East China Sea and Yellow Sea

Acta Oceanologica Sinica 2015年第12期34卷 19-28页

作者： JUN ki Cheon JEONG Weon Mu CHOI Jin yong PARK Kwang Soon JUNG Kyung Tae kiM Mee Kyung CHAE Jang Won QIAO Fangli Coastal Disaster Research Center Korea Institute of Ocean Science and Technology Coastal & Environmental Engineering Division Korea Institute of Ocean Science and Technology Marine Radionuclide Research Center Korea Institute of Ocean Science and Technology First Institute of Oceanography State Oceanic Administration

Record-breaking high waves occurred during the passage of the typhoon Bolaven（1215）（TYB） in the East China Sea（ECS） and Yellow Sea（YS） although its intensity did not reach the level of a super *** and directional wave measurements were made using a range of in-situ instruments mounted on an ocean tower and *** order to understand how such high waves with long duration occurred,analyses have been made through measurement and numerical *** winds were generated using the TC96 typhoon wind model with the best track data calibrated with the *** then the wind fields were blended with the reanalyzed synoptic-scale wind fields for a wave *** fields were simulated using WAM4.5 with adjustment of C_d for gust of winds and bottom friction for the study *** the accuracy of simulations is considerably enhanced,and the computed results are also in better agreement with measured data than *** is found that the extremely high waves evolved as a result of the superposition of distant large swells and high wind seas generated by strong winds from the front/right quadrant of the typhoon *** the typhoon moved at a speed a little slower than the dominant wave group velocity in a consistent direction for two days,the wave growth was significantly enhanced by strong wind input in an extended fetch and non-linear interaction.

关键词： extreme waves typhoon measurements numerical simulation East China Sea

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Neoadjuvant chemoradiotherapy followed by D2 gastrectomy in locally advanced gastric cancer

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World Journal of Gastroenterology 2015年第9期21卷 2711-2718页

作者： Mi Sun kim Joon Seok Lim Woo Jin Hyung yong Chan Lee Sun Young Rha ki Chang Keum Woong Sub Koom Department of Radiation Oncology Yonsei University College of MedicineSeoul 120-752South Korea Department of Radiology Yonsei University College of MedicineSeoul 120-752South Korea Department of Surgery Yonsei University College of MedicineSeoul 120-752South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Department of Medical Oncology Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To investigate the efficacy of neoadjuvant chemoradiotherapy(NACRT) for resectability of locally advanced gastric cancer(LAGC).METHODS:Between November 2007 and January 2014,29 patients with LAGC(clinically T3 with distal esophagus invasion/T4 or bulky regional node metastasis) that were treated with NACRT followed by D2 gastrectomy were included in this *** was evaluated with radiologic and endoscopic exams before and after *** threedimensional conformal radiotherapy,patients received 45 Gy,with a daily dose of 1.8 *** entire tumor extent and the regional metastatic lymph nodes were included in the gross tumor *** presenting with a resectable tumor after NACRT received a total or subtotal gastrectomy with D2 *** pathologic tumor response was evaluated using Japanese Gastric Cancer Association histologic evaluation *** morbidity was evaluated using the National Cancer Institute-Common Terminology Criteria for Adverse Events version *** survival(OS) and progression-free survival(PFS) rates were estimated using a Kaplan-Meier analysis and compared using the log-rank ***:All patients were assessed as unresectable ***-four patients(24/29; 82.8%) showed LAGC on positron emission tomography-computed tomography(CT) and contrast-enhanced CT,whereas four patients(4/29; 13.8%) with vague invasion orabutment to an adjacent organ underwent diagnostic *** patient(1/29; 3.4%),initially assessed as a resectable case,underwent an "open and closure" after the tumor was found to be *** to an adjacent organ(34.5%) was the most common reason for *** clinical response rate one month after NACRT was 44.8%.After NACRT,69%(20/29) of patients had a resectable *** the 20 patients with a resectable tumor,18 patients(62.1%) underwent a D2 *** R0 resection rate was 94.4% and two patients(2/18; 11.1%) showed a complete *** median follow-

关键词： Advanced gastric cancer D2 gastrectomy Neoadjuvant

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Effects of fabrication methods on deformability and microstructure of Mg-Zn-Zr wrought alloy

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 68-74页

作者： ki Ho JUNG yong Bae kiM Geun An LEE Yuzheng ZHANG Byungmin AHN Metal Forming Technology R&D Group Korea Institute of Industrial Technology Department of Chemical Engineering and Materials Science University of Southern California Department of Energy Systems Research Ajou University

The effects of fabrication processing methods on the workability of Mg-Zn-Zr wrought magnesium alloy(ZK60A) were investigated based on the microstructure and inherent internal defects. Three different billets, semi-continuously cast, semi-continuously cast and subsequently extruded, and die-cast, were fabricated and uniaxially compressed at elevated temperatures and two different strain rates to determine the deformation capabilities. The grain structure of the billets was investigated using electron backscatter diffraction(EBSD) and transmission electron microscopy(TEM). The internal defects were inspected by an X-ray scanner. The enhanced deformability was observed in semi-continuously cast billet compared to the one fabricated by conventional die-casting, and the subsequent extrusion further improved the deformability.

关键词： magnesium continuous casting workability electron backscatter diffraction(EBSD)

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Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 785-789页

作者： Tae-Il Jeon Chang-Hwa Jung Jeong-yong Cho Dong ki Park Jae-Hak Moon Department of Animal Science.College of Agriculture & Life Science Chonnam National UniversityKorea Food Function Research Center Korea Food Research InstituteSeoungnamKorea Division of Food Biotechnology University of Science and TechnologyDaejeonKorea Department of Food Science & Technology and Functional Food Research Center.Chonnam National UniversityKorea Department of Bioscience and Biotechnology Konkuk UniversityKorea

Objective:To isolate and identify the anticancer compound against proliferation of human colon cancer cells from ethyl acetate(EtOAc)extract ol Phellinus linteus grown on germinated brown rice(PB).Methods:EtOAc extract of PB was partitioned with n-hexane,EtOAc,and water-saturated *** compound of n-hexane layer was isolated and identified by HPLC and NMR,*** against HT-29 cells was tested by SRB ***:The n-hexane layer obtained after solvent fractionation of PB EtOAc extracts showed a potent anticancer activity against the HT-29 cell *** I,a eudesmane-type sesquiterpene lactone,a major anticancer substance of PB,was isolated from the n-hexane layer by silica gel column chromatography and *** structure was elucidated by one-and two-dimensional NMR spectroscopic *** I has not been reported in mushrooms or rice as of *** isolated compound dose-dependently inhibited the growth of HT-29 human colon cancer ***:Atractylenolide I might contribute to the anticancer effect of PB.

关键词： Atractylenolide I Human colon cancer cells NMR Phellinus linteus Germinated brown rice

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结外组织细胞肉瘤2例临床病理学分析

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肿瘤研究与临床 2024年第5期36卷 386-389页

作者：刘燕夏成茂陈芊杏王勇自贡市第四人民医院病理科自贡643000

目的提高对结外组织细胞肉瘤(ENHS)的认识。方法回顾性分析自贡市第四人民医院2018年5月和2022年3月收治的2例ENHS患者的临床病理资料,并进行文献复习。结果例1,女性,年龄45岁,ENHS原发于脾脏;例2,男性,年龄84岁,ENHS原发于左前臂。病... 详细信息

目的提高对结外组织细胞肉瘤(ENHS)的认识。方法回顾性分析自贡市第四人民医院2018年5月和2022年3月收治的2例ENHS患者的临床病理资料,并进行文献复习。结果例1,女性,年龄45岁,ENHS原发于脾脏;例2,男性,年龄84岁,ENHS原发于左前臂。病理组织学检查:低倍镜下见肿瘤呈浸润性生长,大量单核组织样肿瘤细胞弥漫分布,间质伴有大量淋巴细胞、浆细胞浸润;高倍镜下见瘤细胞体积大,呈圆形、卵圆形或短梭形,部分瘤细胞黏附性差,胞质丰富、嗜酸性或空泡状,核仁明显,核分裂像多见,偶可见多核瘤巨细胞。2例患者免疫组织化学检测,肿瘤细胞均表达CD68、CD163、CD4、CD31、Vimentin、MLH1、PSM2、MSH2、MSH6、CD45RO,程序性死亡受体配体1(PD-L1)联合阳性分数(CPS)评分≥1分,1例表达S-100,ki-67阳性指数5%和80%。随访截至2023年12月,1例死亡,1例生存。结论ENHS是一种罕见、侵袭性强的淋巴造血源性肿瘤。其具有相似但独特的临床病理特征,诊断主要依靠组织形态学表现和免疫组织化学表型。

关键词：淋巴造血系统肿瘤组织细胞肉瘤临床病理免疫组织化学

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Hybrid Friction Stir Welding of High-carbon Steel

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Journal of Materials Science & Technology 2011年第2期27卷 127-130页

作者： Don-Hyun Choi Chang-yong Lee Byung-Wook Ahn Jung-Hyun Choi Yun-Mo Yeon Keun Song Seung-Gab Hong Won-Bae Lee ki-Bong Kang Seung-Boo Jung School of Advanced Materials Science and Engineering Sungkyunkwan University 300 Cheoncheon-dongJangan-guSuwonGyeonggi-do 440-746South Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology 335 GwahangnoYuseong-guDaejeon 305-701South Korea Department of Advanced Materials Application Suwon Science College 9-10Botong-liJeongnam-myeonHwasungGyeonggi-do 445-742South Korea Technical Research Lab POSCO Corp.Goedong-dongNam-guPohangGyeongbuk790-785South Korea

A high-carbon steel joint,SK5（0.84 wt% C）,was successfully welded by friction stir welding（FSW）,both without and with a gas torch,in order to control the cooling rate during *** welding,the weld zone comprised gray and black regions,corresponding to microstructural variation：a martensite structure and a duplex structure of ferrite and cementite,*** volume fraction of the martensite structure and the Vickers hardness in the welds were decreased with the using of the gas torch,which was related with the lower cooling rate.

关键词： Friction stir welding High-carbon steel Transformation Martensite

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知识惯性视角下跨界搜索对新产品开发绩效的影响研究

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中国科技论坛 2024年第8期 33-42页

作者：曹勇东志纯陈炳轩刘梦浛武汉纺织大学管理学院湖北武汉430200 湖北省企业决策支持研究中心湖北武汉430200

如何提高新产品开发(NPD)成功率已成为学界和业界共同关注的焦点议题。虽然已有研究认可跨界搜索带来的外部异质性知识对NPD绩效有益,但鲜有研究从知识惯性视角来深入讨论二者关系。基于华中地区制造企业大样本问卷数据,本研究实证检验... 详细信息

如何提高新产品开发(NPD)成功率已成为学界和业界共同关注的焦点议题。虽然已有研究认可跨界搜索带来的外部异质性知识对NPD绩效有益,但鲜有研究从知识惯性视角来深入讨论二者关系。基于华中地区制造企业大样本问卷数据,本研究实证检验跨界搜索对NPD绩效的影响机制,并进一步阐释知识惯性的中介作用与组织忘却的调节效应。结果表明:跨界搜索(前瞻性跨界搜索、追随性跨界搜索)对NPD绩效具有正向影响;学习惯性在前瞻性跨界搜索与NPD绩效间起部分中介作用;经验惯性在追随性跨界搜索与NPD绩效间起部分中介作用;组织忘却不仅负向调节学习惯性与NPD绩效之间的关系,还负向调节学习惯性在前瞻性跨界搜索与NPD绩效间的中介作用,但并未调节经验惯性与NPD绩效之间的关系。研究结果不仅在理论上深化知识惯性视角下跨界搜索与NPD绩效之间的关系研究,也为管理者在实践中优化跨界搜索策略,提高NPD成功率提供有益启示。

关键词：跨界搜索知识惯性组织忘却新产品开发绩效

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Comparison of brush and basket cytology in differential diagnosis of bile duct stricture at endoscopic retrograde cholangiopancreatography

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 622-627页

作者： ki Bae Bang Hong Joo kim Jung Ho Park Dong Il Park yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik kim Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital 108 Pyung-Dong Jongro-Ku Seoul 110-746 Korea

BACKGROUND： A previous report has identified a significantly higher sensitivity of cancer detection for dedicated grasping basket than brushing at endoscopic retrograde cholangiopancreato- graphy （ERCP）. This study aimed to compare the diagnostic accuracy of Geenen brush and Dormia basket cytology in the differential diagnosis of bile duct stricture. METHOD： The current study enrolled one hundred and fourteen patients who underwent ERCP with both Geenen brush and Dormia basket cytology for the differential diagnosis of bile duct stricture at our institution between January 2008 and December 2012. RESULTS： We adopted sequential performances of cytologic samplings by using initial Geenen brush and subsequent Dormia basket cytology in 59 patients and initial Dormia basket and subsequent Geenen brush cytology in 55 patients. Presampling balloon dilatations and biliary stentings for the stricture were performed in 17 （14.9%） and 107 patients （93.9%）, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of Geenen brush cytology for the diagnosis of malignant bile duct stricture were 75.0%, 100.0%, 100.0%, 66.7% and 83.3%, respectively, and those of Dormia basket cytology were 64.5%, 100.0%, 100.0%, 58.5% and 76.3%, respectively （P=0.347 and 0.827 for sensitivity and accuracy, respectively）. The good and excellent cellular yields （≥grade 2） were obtained by Geenen brush and Dormia basket cytology in 88 （77.2%） and 79 （69.3%） patients, ***： The sensitivity, specificity and accuracy of biliary sampling with a Dormia basket are comparable to those with conventional Geenen brush cytology in the detection of malignant bile duct stricture.

关键词： bile duct stricture cholangiocarcinoma brush cytology basket cytology

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Effects of Korean ginseng berry extract （GB0710） on penile erection： evidence from in vitro and in vivo studies

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Asian Journal of Andrology 2013年第4期15卷 503-507,I0008页

作者： Kang Su Cho Chan Woong Park Chun-ki kimt Hee Young Jeon Wan Gi kim Sang Jun Lee Young-Myeong kim Joo yong Lee Young Deuk Choi Department of Urology Severance Hospital Urological Science Institute Yonsei University College of Medicine Seou1120-752 Korea R&D Center Amorepacific Corporation Yongin Gyeonggi-do 446-729 Korea Vascular System Research Center and Department of Molecular and Cellular Biochemistry School of Medicine Kangwon National University Chunchon 200-701 Korea and Clinical Trial Center for Medical Devices Yonsei University College of Medicine Seoul 120-752 Korea

Several reports have promoted the root-derived Korean red ginseng （KRG; Panax ginseng） as alternative treatment for erectile dysfunction （ED）, and ginsenosides are known to be the principal active ingredients of ginseng. Recent studies showed that ginseng berries produce more ginsenosides than KRG; thus, we investigated the ability of the Korean ginseng berry extract GB0710 to relax the penile corpus cavernosum smooth muscle （CCSM） in this study. As a comparative control, the results were compared to those obtained using KRG. In addition, possible mechanisms of action for GB0710 were investigated. While KRG and GB0710 both displayed dose-dependent relaxation effects on precontracted rabbit CCSM in vitro, GB0710 was shown to be more potent than KRG. The GBO710-induced relaxation could be partially reduced by removing the endothelium. In addition, pre-treatment with several nitric oxide （NO） inhibitors significantly inhibited the relaxation of muscle strips. Furthermore, administration of GB0710 increased intracavernosal pressure （ICP） in a rat in vivo model in both a dose- and duration-dependent manner. Intracellular NO production in human microvascular endothelial cells could be induced by GB0710 and inhibited by NG-monomethyI-L-arginine. In conclusion, GB0710 had a greater relaxation effect on rabbit CCSM than did KRG extract, and increased ICP in a rat model in both a dose- and a duration-dependent manner. This relaxine effect might be mediated bv NO production.

关键词： corpus cavernosum erectile dysfunction (ED) ginseng berry nitric oxide (NO) smooth muscle

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Increased incidence of chemoport-related thrombosis in patients with colorectal cancer receiving bevacizumab: A single-institutional experience

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Chinese Journal of Cancer Research 2018年第4期30卷 460-467页

作者： Jwa Hoon kim Jeong Eun kim yong Sang Hong Sun Young kim Kyu-pyo kim ki Eun Choi Ji Hoon Shin Tae Won kim Department of Oncology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

Objective： Chemoport-related thrombosis （CRT） is a serious complication that causes morbidities and interruptsadministration of intravenous cancer therapy. We investigated the incidence and risk of CRT in colorectal cancer（CRC） patients treated with bevacizumab （BEV）.Methods： We retrospectively reviewed 1,534 CRC patients who received chemotherapy with or without BEVusing a chemoport between 2014 and ***： The participants had a median age of 58 （18-85） years, and 60.3% were male. All participants werestratified into three groups： adjuvant chemotherapy （AC）（n=670）, palliative chemotherapy （PC） without BEV（n=356）, and PC with BEV （n=508）. The median follow-up was 20.19 （interquartile range, 14.07-27.19） *** occurred in 3.8% of all patients; incidence of symptomatic and asymptomatic CRT was 2.9% and 0.9%,respectively. CRT occurred more in patients with BEV （5.7%） than in patients without BEV （2.9%, P=0.008）. Thecumulative incidence of CRT in patients administered PC with BEV was significantly higher than that in thoseadministered AC （P=0.011） and there was a trend toward increased CRY in patients administered PC with BEVcompared with those administered PC without BEV （P=0.044）. Multivariate analysis found that BEV treatment wasthe only variable that was significandy associated with CRT （hazard ratio, 2.06; 95% confidence interval, 1.24-3.43;P=0.006）.Conclusions： BEV treatment was significandy associated with increased incidence of CRT in CRC patients.

关键词： Bevacizumab central venous catheters thrombosis colorectal neoplasms

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