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World Journal of Clinical Cases 2022年第34期10卷 12665-12670页

作者： Jun-Seob Song ki-taek hong ki Jeon Song Seok Jung kim Department of Orthopedic Surgery Gangnam JS HospitalSeoul 06053South Korea Department of Orthopedic Surgery Uijeongbu Street Mary’s HospitalCollege of MedicineThe Catholic University of KoreaUijeongbu 11765GyeonggidoSouth Korea

BACKGROUND Patellar dislocation may cause cartilage defects of various *** defects commonly require surgical treatment;however,conventional treatments are *** SUMMARY A 15-year-old male with a large patellar cartilage defect due to patellar dislocation was treated via human umbilical cord blood-derived mesenchymal stem cell(hUCB-MSC)*** our knowledge,this is the first report of this treatment for this *** patient recovered well as indicated by good visual analog scale,International Knee Documentation Committee and McMaster Universities Osteoarthritis Index *** resonance imaging showed cartilage regeneration 18 mo *** Umbilical cord blood-derived hUCB-MSCs may be a useful treatment option for the repair of large patellar cartilage defects.

关键词： Cartilage defect Umbilical cord Mesenchymal stem cells Patellar dislocation Magnetic resonance imaging Case report

High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration

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World Journal of Stem Cells 2020年第6期12卷 514-526页

作者： Jun-Seob Song ki-taek hong Chae-Gwan Kong Na-Min kim Jae-Yub Jung Han-Soo Park Young Ju kim ki Bong Chang Seok Jung kim Department of Orthopedic Surgery Gangnam JS HospitalSeoul 06053South Korea Department of Orthopedic Surgery College of MedicineThe Catholic University of KoreaUijeongbu-si 11765South Korea Department of Nursing Education&Administration Uijeongbu St.Mary’s HospitalThe Catholic University of KoreaUijeongbu-si 11765South Korea

BACKGROUND High tibial osteotomy(HTO)is a well-established method for the treatment of medial compartment osteoarthritis of the knee with varus ***,HTO alone cannot adequately repair the arthritic joint,necessitating cartilage regeneration *** regeneration procedures with concomitant HTO are used to improve the clinical outcome in patients with varus *** To evaluate cartilage regeneration after implantation of allogenic human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs)with concomitant *** Data for patients who underwent implantation of hUCB-MSCs with concomitant HTO were *** patients included in this study were over 40 years old,had a varus deformity of more than 5°,and a full-thickness International Cartilage Repair Society(ICRS)grade IV articular cartilage lesion of more than 4 cm2 in the medial compartment of the *** patients underwent second-look arthroscopy during hardware *** regeneration was evaluated macroscopically using the ICRS grading system in second-look *** also assessed the effects of patient characteristics,such as trochlear lesions,age,and lesion size,using patient medical *** A total of 125 patients were included in the study,with an average age of 58.3±6.8 years(range:43-74 years old);95(76%)were female and 30(24%)were *** average hip-knee-ankle(HKA)angle for measuring varus deformity was 7.6°±2.4°(range:5.0-14.2°).In second-look arthroscopy,the status of medial femoral condyle(MFC)cartilage was as follows:73(58.4%)patients with ICRS grade I,37(29.6%)with ICRS grade II,and 15(12%)with ICRS grade *** patients were staged with ICRS grade ***,the scores[except International Knee Documentation Committee(IKDC)at 1 year]of the ICRS grade I group improved more significantly than those of the ICRS grade II and III *** Implantation of hUCB-MSCs with concomitant HTO is an effective treatment for patients wit

关键词： Allogeneic Human umbilical cord blood-derived mesenchymal stem cells Cartilage regeneration High tibial osteotomy Osteoarthritic knees Arthroscopy

Formation of photo-reactive heterostructure from a multicomponent amorphous alloy with atomically random distribution

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Journal of Materials Science & Technology 2022年第14期109卷 245-253页

作者： Hae Jin Park Hee Jin Lee Tae Kyung kim Sung Hwan hong Wei-Min Wang taek Jib Choi ki Buem kim Department of Nanotechnology and Advanced Materials Engineering Sejong University209 Neung dong-roGwangjin-guSeoul 05006Republic of Korea Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China

In this study,metallic glass is designed tunable for promising functional applications via a facile and stable,one-step *** approach about alloy design and process is based on the unique properties of the Ti-Cu-Ni-Sn metallic glass that are afforded by the varying oxygen affinities of the four constituent *** metallic glass exhibits homogeneous nucleation of oxides and uniform formation of the various metal *** alloy design and hydrothermal synthesis to customize the metallic glasses are the most critical factors that determine the characteristics of the metal oxides and the resulting nanostructures and photoelectrode *** enables the desired element to be selectively grown via a facile single-step *** results provide a promising road map for the application of metallic glasses to photoelectrochemical(PEC)solar water splitting,as well as various other new possibilities.

关键词： Metallic glass Alloy design Hydrothermal synthesis Metal oxide Water splitting

Signcryption with fast online signing and short signcryptext for secure and private mobile communication

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Science China(Information Sciences) 2012年第11期55卷 2530-2541页

作者： YOUN taek-Young hong Dowon Electronics and Telecommunications Research Institute(ETRI) Department of Applied Mathematics Kongju National University

Signcryption scheme is one of the useful tools for secure communication where authenticity and confidentiality are simultaneously ***,mobile devices are more and more widely used for communication,and thus it is desirable to design a scheme suitable to mobile *** this paper,we propose a signcryption scheme which is efficient enough to be implemented on mobile *** our scheme,we need only one multiplication in an online phase,and thus a signcryptor can generate a signcryptext very efficiently in the online ***,the size of signcryptext is very short compared with exsiting schemes,and thus our scheme is very efficient in terms of communication *** security of our signcryption scheme is proven in the random oracle model.

关键词： security privacy signcryption short signature

Improving Method of Anomaly Detection Performance for Industrial IoT Environment

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Computers, Materials & Continua 2022年第9期72卷 5377-5394页

作者： Junwon kim Jiho Shin ki-Woong Park Jung taek Seo Department of Information Security Engineering Gachon UniversitySeongnam13120Korea Police Science Institute Korea National Police UniversityAsan31539Korea SysCore Lab. Sejong UniversitySeoul05006Korea Department of Computer Engineering Gachon UniversitySeongnam13120Korea

Industrial Control System(ICS),which is based on Industrial IoT(IIoT),has an intelligent mobile environment that supports various mobility,but there is a limit to relying only on the physical security of the ICS *** to various threat factors that can disrupt the workflow of the IIoT,machine learning-based anomaly detection technologies are being presented;it is also essential to study for increasing detection performance to minimize model errors for promoting stable ICS *** this paper,we established the requirements for improving the anomaly detection performance in the IIoT-based ICS environment by analyzing the related *** that,we presented an improving method of the performance of a machine learning model specialized for IIoT-based ICS,which increases the detection rate by applying correlation coefficients and clustering;it provides a mechanism to predict thresholds on a ***,we adopted the HAI dataset environment that actively reflected the characteristics of IIoT-based ICS and demonstrated that performance could be improved through comparative experiments with the traditional method and our proposed *** presented method can further improve the performance of commonly applied error-based detection techniques and includes a primary method that can be enhanced over existing detection techniques by analyzing correlation coefficients between features to consider feedback between ICS *** can contribute to improving the performance of several detection models applied in ICS and other areas.

关键词： Industrial IoT industrial control system anomaly detection clustering algorithm correlation coefficient

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World Journal of Clinical Cases 2021年第24期9卷 7205-7211页

作者： So-My Koo ki-Up kim Yang-ki kim Soo-taek Uh Department of Internal Medicine Soonchunhyang University Seoul HospitalSeoul 04401South Korea

BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-Tkis)are tolerable drugs used for patients with EGFR-mutant advanced non-small cell lung cancer(NSCLC).Serious adverse reactions are uncommon compared with cytotoxic *** SUMMARY A 52-year-old man presented with general weakness and *** had been taking erlotinib for 11 mo to treat *** pathological diagnosis from the right upper lobe mass was adenocarcinoma with an EGFR mutation in exon 21(L858R).He had previously received paclitaxel/carboplatin,gemcitabin/vinorelbine chemotherapy,stereotactic radiosurgery for brain metastasis,and whole-brain radiotherapy as treatment for *** diagnosed the patient with acute myeloid leukemia(AML).During the induction and consolidation chemotherapy for AML,the erlotinib was *** complete remission of the AML was achieved,since the lung masses were increased,pemetrexed/cisplatin for the NSCLC was *** two cycles of chemotherapy,the cytopenia was *** relapse occurred with the same *** Therapy-related acute myeloid neoplasm(t-MN)is a rare but fatal late *** a patient may be taking EGFR-Tkis,the possibility of t-MN should be *** studies are needed to determine whether EGFR-Tki usage is a predisposing factor for t-MN.

关键词： Acute myeloid leukemia Erlotinib Neoplasm,second primary Non-small cell lung cancer Case report

Network Traffic Obfuscation System for IIoT-Cloud Control Systems

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Computers, Materials & Continua 2022年第9期72卷 4911-4929页

作者： Yangjae Lee Sung Hoon Baek Jung taek Seo ki-Woong Park SysCore Lab. Sejong UniversitySeoul05006Korea Department of Computer System Engineering Jungwon UniversityChungcheongbuk-do28024Korea Department of Computer Engineering Gachon UniversityGyeonggi-do13120Korea

One of the latest technologies enabling remote control,operational efficiency upgrades,and real-time big-data monitoring in an industrial control system(ICS)is the IIoT-Cloud ICS,which integrates the Industrial Internet of Things(IIoT)and the cloud into the *** an ICS benefits from the application of IIoT and the cloud in terms of cost reduction,efficiency improvement,and real-time monitoring,the application of this technology to an ICS poses an unprecedented security risk by exposing its terminal devices to the outside *** adversary can collect information regarding senders,recipients,and prime-time slots through traffic analysis and use it as a linchpin for the next attack,posing a potential threat to the *** address this problem,we designed a network traffic obfuscation system(NTOS)for the IIoT-Cloud ICS,based on the requirements derived from the ICS characteristics and limitations of existing NTOS *** a strategy to solve this problem wherein a decrease in the traffic volume facilitates traffic analysis or reduces the packet transmission speed,we proposed an NTOS based on packet scrambling,wherein a packet is split into multiple pieces before transmission,thus obfuscating network *** minimize the ICS modification and downtime,the proposed NTOS was designed using an agentbased *** addition,for the ICS network traffic analyzer to operate normally in an environment wherein the NTOS is applied,a rule-based NTOS was adopted such that the actual traffic flow is known only to the device that is aware of the rule and is blocked for *** experimental results verified that the same time requested for response and level of difficulty of analysis were maintained by the application of an NTOS based on packet scrambling,even when the number of requests received by the server per second was *** network traffic analyzer of the ICS can capture the packet flow by using the pre-communicated NTOS *** addition,by designing an N

关键词： Cloud computing system moving-target defense container orchestration

Rice tissue-specific promoters and conditiondependent promoters for effective translational application

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Journal of Integrative Plant Biology 2015年第11期57卷 913-924页

作者： Hee-Jeong Jeong ki-hong Jung Department of Plant Molecular Systems Biotechnology and Crop Biotech Institute Kyung Hee University Graduate School of Biotechnology Kyung Hee University

Rice （Oryza sativa） is one of the most important staple food crops for more than half of the world＇s population. The demand is increasing for food security because of population growth and environmental challenges triggered by climate changes. This scenario has led to more interest in developing crops with greater productivity and sustainability. The process of genetic transformation, a major tool for crop improvement, utilizes promoters as one of its key elements. Those promoters are generally divided into three types： constitutive, spatiotemporal, and condition-dependent. Tran- scriptional control of a constitutive promoter often leads to reduced plant growth, due to a negative effect of accumu- lated molecules during cellular functions or energy consump- tion. To maximize the effect of a transgene on transgenic plants, it is better to use condition-dependent or tissue- specific promoters. However, until now, those types have not been as widely applied in crop biotechnology. In this review, we introduce and discuss four groups of tissue-specific promoters （5o promoters in total） and six groups of condition-dependent promoters （27 promoters）. These pro- moters can be utilized to fine-tune desirable agronomic traits and develop crops with tolerance to various stresses, enhanced nutritional value, and advanced productivity.

关键词： Condition-dependent promoters crop biotechnologyapplication genetic transformation rice tissue-specific promoters

Performance Evaluation of Composite Electrolyte with GQD for All-Solid-State Lithium Batteries

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Computers, Materials & Continua 2023年第1期74卷 55-66页

作者： Sung Won Hwang Dae-ki hong Department of System Semiconductor Engineering SangMyung UniversityCheonan-si31066Korea

The use a stabilized lithium structure as cathode material for batteries could be a fundamental alternative in the development of next-generation energy storage ***,the lithium structure severely limits battery life causes safety concerns due to the growth of lithium(Li)dendrites during rapid charge/discharge *** electrolytes,which are used in highdensity energy storage devices and avoid the instability of liquid electrolytes,can be a promising alternative for next-generation ***,poor lithium ion conductivity and structural defects at room temperature have been pointed out as *** this study,through the application of a low-dimensional graphene quantum dot(GQD)layer structure,stable operation characteristics were demonstrated based on Li^(+)ion conductivity and excellent electrochemical ***,the device based on the modified graphene quantum dots(GQDs)in solid state exhibited retention properties of 95.3%for 100 cycles at 0.5 C and room temperature(RT).Transmission electronmicroscopy analysis was performed to elucidate the Li^(+)ion action mechanism in the modified GQD/electrolyte *** low-dimensional structure of theGQD-based solid electrolyte has provided an important strategy for stably-scalable solid-state lithium battery applications at room *** was demonstrated that lithiated graphene quantum dots(Li-GQDs)inhibit the growth of Li dendrites by regulating the modified Li^(+)ion flux during charge/discharge cycling at current densities of 2.2–5.5 mA cm,acting as a modified Li diffusion heterointerface.A full Li GQDbased device was fabricated to demonstrate the practicality of the modified Li structure using the Li–GQD *** study indicates that the low-dimensional carbon structure in Li–GQDs can be an effective approach for stabilization of solid-state Li matrix architecture.

关键词： Solid-state lithium batteries composite electrolyte quantum dot graphene

Flexible Memristive Devices Based on Graphene Quantum-Dot Nanocomposites

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Computers, Materials & Continua 2022年第8期72卷 3283-3297页

作者： Sung Won Hwang Dae-ki hong Department of System Semiconductor Engineering SangMyung UniversityCheonan-si31066Korea

Artificial neural networks(ANNs)are attracting attention for their high performance in various fields,because increasing the network size improves its *** large-scale neural networks are difficult to implement on custom hardware,a two-dimensional(2D)structure is applied to an ANN in the form of a *** demonstrate a synapse crossbar device from recent research by applying a memristive system to neuromorphic *** system is designed using two-dimensional structures,graphene quantum dots(GQDs)and graphene oxide(GO).Raman spectrum analysis results indicate a D-band of 1421 cm^(−1) that occurs in the disorder;band is expressed as an atomic characteristic of carbon in the sp2 hybridized *** is also a G-band of 1518 cm^(−1) that corresponds to the graphite *** G bands measured for RGO-GQDs present significant GQD edge-dependent shifts with *** avoid an abruptly-formed conduction path,effect of barrier layer on graphene/ITO interface was *** confirmed the variation in the nanostructure in the RGO-GQD layers by analyzing them using *** applying a negative bias to the electrode,a crystalline RGO-GQD region formed,which a conductive ***,a synaptic array for a neuromorphic chip with GQDs applied was demonstrated using a crossbar array.

关键词： Memristive devices neuromorphic chip resistive RAM quantum dot graphene