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Light(Science & Applications) 2016年第1期5卷 796-802页

作者： Hyukjin Jung Moonseong Park Minhee Kang ki-hun jeong Department of Bio and Brain Engineering KAIST Institute for Optical Science and TechnologyKorea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 305-701Korea

High-throughput small-molecule assays play essential roles in biomedical diagnosis,drug discovery,environmental analysis,and physiological function *** holds a great potential for the label-free detection of small molecules at extremely low ***,we report the development of nanoplasmonic paper(NP-paper)for the rapid separation and ultrasensitive detection of mixed small ***-paper employs nanogap-rich silver nanoislands on cellulose fibers,which were simply fabricated at the wafer level by using low-temperature solid-state dewetting of a thin silver *** nanoplasmonic detection allows for the scalable quantification and identification of small molecules over broad concentration ***,the combination of chromatographic separation and nanoplasmonic detection allows both the highly sensitive fluorescence detection of mixed small molecules at the attogram level and the label-free detection at the sub-nanogram level based on surface-enhanced Raman *** novel material provides a new diagnostic platform for the high-throughput,low-cost,and label-free screening of mixed small molecules as an alternative to conventional paper chromatography.

关键词： nanoplasmonics paper chromatography plasmon-enhanced spectroscopy silver nanoislands small-molecule assay

Biologically inspired ultrathin arrayed camera for high-contrast and high-resolution imaging

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Light(Science & Applications) 2020年第1期9卷 1742-1748页

作者： kisoo kim Kyung-Won Jang Jae-Kwan Ryu ki-hun jeong Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea KAIST Institute for Health Science and Technology KAISTDaejeon 34141Republic of Korea Unmanned/Robotic Systems Lab. LIG Nex1 Co.LtdSeongnam 13488Republic of Korea

Compound eyes found in insects provide intriguing sources of biological inspiration for miniaturised imaging ***,we report an ultrathin arrayed camera inspired by insect eye structures for high-contrast and super-resolution *** ultrathin camera features micro-optical elements(MOEs),i.e.,inverted microlenses,multilayered pinhole arrays,and gap spacers on an image *** MOE was fabricated by using repeated photolithography and thermal *** fully packaged camera shows a total track length of 740μm and a field-of-view(FOV)of 73°.The experimental results demonstrate that the multilayered pinhole of the MOE allows high-contrast imaging by eliminating the optical crosstalk between *** integral image reconstructed from array images clearly increases the modulation transfer function(MTF)by~1.57 times compared to that of a single channel image in the ultrathin *** ultrathin arrayed camera provides a novel and practical direction for diverse mobile,surveillance or medical applications.

关键词： resolution high camera

Xenos peckii vision inspires an ultrathin digital camera

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Light(Science & Applications) 2018年第1期7卷 272-278页

作者： Dongmin Keum Kyung-Won Jang Daniel S.Jeon Charles S.H.Hwang Elke K.Buschbeck Min H.kim ki-hun jeong Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Korea School of Computing Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Korea Department of Biological Sciences University of CincinnatiCincinnatiOH 45221-0006USA

Increased demand for compact devices leads to rapid development of miniaturized digital ***,conventional camera modules contain multiple lenses along the optical axis to compensate for optical aberrations that introduce technical challenges in reducing the total thickness of the camera ***,we report an ultrathin digital camera inspired by the vision principle of Xenos peckii,an endoparasite of paper *** male Xenos peckii has an unusual visual system that exhibits distinct benefits for high resolution and high sensitivity,unlike the compound eyes found in most insects and some *** biologically inspired camera features a sandwiched configuration of concave microprisms,microlenses,and pinhole arrays on a flat image *** camera shows a field-of-view(FOV)of 68 degrees with a diameter of 3.4mm and a total track length of *** biologically inspired camera offers a new opportunity for developing ultrathin cameras in medical,industrial,and military fields.

关键词： camera sandwich digital

Handheld endomicroscope using a fiber-optic harmonograph enables real-time and in vivo confocal imaging of living cell morphology and capillary perfusion

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Microsystems & Nanoengineering 2020年第1期6卷 449-459页

作者： Kyungmin Hwang Yeong-Hyeon Seo Daniel Ykim Jinhyo Ahn Soyoung Lee Kyung Hee Han Koun-Hee Lee Sangyong Jon Pilhan kim Kate EYu Hyungsin kim Shin-Hyuk Kang ki-hun jeong Department of Bio and Brain Engineering KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Graduate School of Nanoscience and Technology KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences KAIST and KAIST Institute for the BioCenturyDaejeon 34141Republic of Korea Hyunjoo In-Tech Seoul 08390Republic of Korea VPIX Medical IncDeajeon 34141Republic of Korea Graduate School of Medical Science and Engineering Daejeon 34141Republic of Korea Department of Neurosurgery Korea University Anam HospitalKorea University MedicineSeoul 02842Korea

Confocal laser endomicroscopy provides high potential for noninvasive and in vivo optical biopsy at the cellular ***,we report a fully packaged handheld confocal endomicroscopic system for real-time,high-resolution,and in vivo cellular imaging using a Lissajous scanning fiber-optic *** endomicroscopic system features an endomicroscopic probe with a fiber-optic harmonograph,a confocal microscope unit,and an image signal *** fiber-optic harmonograph contains a single mode fiber coupled with a quadrupole piezoelectric tube,which resonantly scans both axes at~1 kHz to obtain a Lissajous *** fiber-optic harmonograph was fully packaged into an endomicroscopic probe with an objective *** endomicroscopic probe was hygienically packaged for waterproofing and disinfection of medical instruments within a 2.6-mm outer diameter stainless tube capable of being inserted through the working channel of a clinical *** probe was further combined with the confocal microscope unit for indocyanine green imaging and the image signal processor for high frame rate and high density Lissajous *** signal processing unit delivers driving signals for probe actuation and reconstructs confocal images using the auto phase matching process of Lissajous fiber *** confocal endomicroscopic system was used to successfully obtain human in vitro fluorescent images and real-time ex vivo and in vivo fluorescent images of the living cell morphology and capillary perfusion inside a single mouse.

关键词： fiber processor confocal

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第01期 397-408页

作者： Md Ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar Jae-hun jeong Jihoon Lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

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Rice tissue-specific promoters and conditiondependent promoters for effective translational application

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Journal of Integrative Plant Biology 2015年第11期57卷 913-924页

作者： Hee-jeong jeong ki-Hong Jung Department of Plant Molecular Systems Biotechnology and Crop Biotech Institute Kyung Hee University Graduate School of Biotechnology Kyung Hee University

Rice （Oryza sativa） is one of the most important staple food crops for more than half of the world＇s population. The demand is increasing for food security because of population growth and environmental challenges triggered by climate changes. This scenario has led to more interest in developing crops with greater productivity and sustainability. The process of genetic transformation, a major tool for crop improvement, utilizes promoters as one of its key elements. Those promoters are generally divided into three types： constitutive, spatiotemporal, and condition-dependent. Tran- scriptional control of a constitutive promoter often leads to reduced plant growth, due to a negative effect of accumu- lated molecules during cellular functions or energy consump- tion. To maximize the effect of a transgene on transgenic plants, it is better to use condition-dependent or tissue- specific promoters. However, until now, those types have not been as widely applied in crop biotechnology. In this review, we introduce and discuss four groups of tissue-specific promoters （5o promoters in total） and six groups of condition-dependent promoters （27 promoters）. These pro- moters can be utilized to fine-tune desirable agronomic traits and develop crops with tolerance to various stresses, enhanced nutritional value, and advanced productivity.

关键词： Condition-dependent promoters crop biotechnologyapplication genetic transformation rice tissue-specific promoters

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Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports

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World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： Jin-Bok Hwang Hyo-jeong Jang Department of Pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** SUMMARY Seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

Improved Photoresponse of UV Photodetectors by the Incorporation of Plasmonic Nanoparticles on Ga N Through the Resonant Coupling of Localized Surface Plasmon Resonance

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Nano-Micro Letters 2020年第7期12卷 175-190页

作者： Sundar Kunwar Sanchaya Pandit Jae-hun jeong Jihoon Lee Department of Electronic Engineering College of Electronics and InformationKwangwoon University

Very small metallic nanostructures,i.e.,plasmonic nanoparticles(NPs),can demonstrate the localized surface plasmon resonance(LSPR)e ect,a characteristic of the strong light absorption,scattering and localized electromagnetic field via the collective oscillation of surface electrons upon on the excitation by the incident *** LSPR of plasmonic NPs can significantly improve the photoresponse of the *** this work,significantly enhanced photoresponse of UV photodetectors is demonstrated by the incorporation of various plasmonic NPs in the detector *** size and elemental composition of monometallic Ag and Au NPs,as well as bimetallic alloy Ag Au NPs,are fabricated on Ga N(0001)by the solid-state dewetting *** photoresponse of various NPs are tailored based on the geometric and elemental evolution of NPs,resulting in the highly enhanced photoresponsivity of 112 A W-1,detectivity of 2.4×1012 Jones and external quantum e ciency of 3.6×104%with the high Ag percentage of Ag Au alloy NPs at a low bias of 0.1 *** Ag Au alloy NP detector also demonstrates a fast photoresponse with the relatively short rise and fall time of less than 160 and 630 ms,*** improved photoresponse with the Ag Au alloy NPs is correlated with the simultaneous e ect of strong plasmon absorption and scattering,increased injection of hot electrons into the Ga N conduction band and reduced barrier height at the alloy NPs/Ga N interface.

关键词： UV photodetection NP-based photodetectors Nanoparticles Plasmonic enhancement

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The learning curve for transurethral enucleation with bipolar energy for benign prostate hyperplasia:a single-surgeon experience of 494 patients

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Asian Journal of Andrology 2024年第3期26卷 288-294页

作者： Byeongdo Song Sang hun Song Seong Jin jeong Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Seoul National University College of MedicineSeoul 03080Korea

This study was performed to investigate the learning curve of transurethral enucleation with bipolar energy(TUEB)for benignprostatic *** study involved 494 consecutive patients who underwent TUEB for benign prostatic hyperplasia fromAugust 2018 to March 2022 by one surgeon(SJJ,Seoul National University Bundang Hospital,Seongnam,Korea).The patientswere followed up at 1 week,1 month,3 months,and 6 months *** evaluate the learning curve of TUEB,perioperativeparameters including the enucleation ratio(enucleated tissue weight/transitional zone volume),TUEB efficiency(enucleatedtissue weight/operation time),and enucleation efficiency(enucleated tissue weight/enucleation time)were *** and postoperative complications were also assessed,including the International Prostate Symptom Score(IPSS),IPSSquality-of-life(QoL)score,and uroflowmetry *** patients’median age was 72(interquartile range[IQR]:66–78)years,and the estimated prostate volume and transitional zone volume were 63.0(IQR:46.0–90.6)ml and 37.1(IQR:24.0–60.0)ml,*** enucleation ratio,TUEB efficiency,and enucleation efficiency were 0.60(IQR:0.46–0.54)g ml−1,0.33(IQR:0.22–0.46)g min−1,and 0.50(IQR:0.35–0.72)g min−1,respectively,plateauing after 70 *** functional outcomes,including total IPSS,IPSS QoL score,and uroflowmetry outcomes,significantly improved at 6 months after TUEB(all P<0.05),but without significant differences over the learning ***-five(13.2%)patients developed complications after TUEB,21.5%of whom experienced major complications(Clavien–Dindo grade≥3).The rate of major complications declined as the number ofTUEB cases increased(P=0.013).Our results suggest that the efficiency of TUEB stabilized within 70 procedures.

关键词： benign prostate hyperplasia learning curve perioperative efficiency prostate transurethral enucleation with bipolar energy