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Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma

World Journal of Gastroenterology 2015年第14期21卷 4268-4274页

作者： Min-Young Lee ki Sun Jung Hae Su kim Ji Yun Lee Sung Hee Lim Moonjin kim Hyun Ae Jung Sung Min kim Jong Mu Sun Myung-Ju Ahn Jeeyun Lee Se hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung Ahn Do Hyoung Lim Soon Il Lee Keon Woo Park Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine Division of Hematology-Oncology Department of Internal MedicineInje University Ilsan-Paik Hospital Division of Hematology-Oncology Department of Internal MedicineChung-Ang University Hospital Division of Hematology-Oncology Department of Internal MedicineSoonchunhyang University Hospital Division of Hematology-Oncology Department of Internal MedicineGachon University Gil Hospital Division of Hematology-Oncology Department of Internal MedicineDankook University College of Medicine

AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was ***-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and *** was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent *** primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely *** control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), ***: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC.

关键词： Clinical trial Phase Ⅱ Chemotherapy Carcinoma,Esop

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Angiosarcoma Following Radiation Therapy for Breast Cancer:Case Presentation and Clinical Management Considerations

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Open Journal of Pathology 2013年第4期3卷 180-185页

作者： Joseph R. Scalea Branko Bojovic Robin Legros Julia choi Andrea Hebert Nader Hanna Division of General & Oncologic Surgery University of Maryland School of Medicine Baltimore USA

A 59-year-old woman presented with erythema and pruritis of the breast 4.5 years after undergoing lumpectomy and radiation for breast cancer. Biopsy confirmed a diagnosis of angiosarcoma. This tumor stained positive for CD34 as well as 70% ki67 prior to therapy initiation. A multidisciplinary approach yielded a plan for neoadjuvant chemoradiation and surgical resection including delayed completion transverse rectus abdominis flap for tissue coverage. Neoadjuvant therapy successfully decreased rates of cellular proliferation, as reflected by a ki67 of 5%, at the time of resection. Pathophysiologically, angiosarcomas may be very aggressive and may develop following radiation for breast cancer. Such tumors may become more common as breast cancer therapies, which frequently include radiation therapy, improve with time. Early recognition of angiosarcoma is imperative for successful therapy. These tumors may present with a wide range of symptoms, but may be asymptomatic. Surgical resection is the preferred therapy, but early recognition is critical.

关键词： Angiosarcoma Breast Cancer Radiation Therapy Immunohistochemistry TRAM Flap

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钢结构非弹性屈曲分析的新方法

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钢结构(中英文) 2008年第10期 77-77页

作者： hoon Yoo Dong-Ho choi

通常而言,很少使用分歧稳定概念评价钢结构临界荷载,这类钢结构具有几何缺陷,并处于横向荷载导致的主弯矩作用下。这些案例中采用了基于极限荷载稳定性概念上的塑性区域和塑性铰分析。然而,这类分析需要大量的计算时间和复杂的理论,不... 详细信息

通常而言,很少使用分歧稳定概念评价钢结构临界荷载,这类钢结构具有几何缺陷,并处于横向荷载导致的主弯矩作用下。这些案例中采用了基于极限荷载稳定性概念上的塑性区域和塑性铰分析。然而,这类分析需要大量的计算时间和复杂的理论,不适合实际设计。为此,提出一种弹塑性屈曲分析的新方法,旨在确定钢结构的临界荷载。此方法基于修正分歧稳定概念(运用切线模量方法确定)和柱强度曲线,运用梁柱交互作用公式,提出迭代特征值分析方法,计算主弯矩及轴力。该法的有效性和适用性,通过弹性屈曲分析和精细塑性铰分析进行评估。以具有几何缺陷的简支柱和4层板结构作为分析基准。结果显示:所提议的非弹性屈曲分析适用于评估钢结构的临界荷载和失效模式,可用于钢结构设计中临界荷载的确定。

关键词：弹性屈曲分析非弹性屈曲分析精细塑性铰分析临界荷载钢结构

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Proposal of new expanded selection criteria using total tumor size and ^(18)F-fluorodeoxyglucose- positron emission tomography/computed tomography for living donor liver transplantation in patients with hepatocellular carcinoma:The National Cancer Center K

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World Journal of Transplantation 2016年第2期6卷 411-422页

作者： Seung Duk Lee Bora Lee Seong hoon kim Jungnam Joo Seok-ki kim Young-Kyu kim Sang-Jae Park Center for Liver Cancer Research Institute and HospitalNational Cancer Center Biometric Research Branch Research Institute and HospitalNational Cancer Center Department of Nuclear Medicine Research Institute and HospitalNational Cancer Center Department of Surgery College of MedicineJeju National University

AIM: To expand the living donor liver transplantation(LT) pool of eligible patients with hepatocellular carcinoma(HCC) using new morphological and biological ***: Patients with HCC who underwent living donor LT(LDLT) from March 2005 to May 2013 at the National Cancer Center Korea(NCCK) were enrolled. We performed the 18F-fluorodeoxyglucose positron emission tomography/computed tomography(PET/CT)before LDLT. Overall and disease-free survival analysis was done in patients to evaluate the usefulness of new NCCK criteria using PET/CT and total tumor size(10 cm).RESULTS: We enrolled a total of 280 patients who pathologically confirmed to have HCC and performed the PET/CT before transplantation. Among them, 164(58.6%) patients fulfilled the NCCK criteria and 132 patients(47.1%) met the Milan criteria. Five-year overall and disease-free survival rates for patients who fulfilled the NCCK criteria showed 85.2% and 84.0%, respectively, and were significantly higher than those beyond the NCCK criteria(60.2% and 44.4%, respectively; P < 0.001). The correlation analysis between preoperative imaging tests and pathologic reports using Cohen's Kappa demonstrated the better results in the NCCK criteria than those in the Milan criteria(0.850 vs 0.583). The comparison of diseasefree analysis among the NCCK, Milan, and University of California, San Francisco(UCSF) criteria using the receiver operating characteristics curves revealed the similar area under the curve value criteria(NCCK vs Milan, P = 0.484; NCCK vs UCSF, P = 0.189 at 5-years).CONCLUSION: The NCCK criteria using hybrid concept of both morphological and biological parameters showed an excellent agreement between preoperative imaging and pathological results, and favorable survival outcomes. These new criteria might select the optimal patients with HCC waiting LDLT and expand the selection pool.

关键词： Hepatocellular carcinoma Living donor Liver transplantation Selection criteria

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Development of Value-Added Chocolate with Oat and Evaluation of Its Physiological Properties

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Journal of Agricultural Science and Technology(B) 2018年第1期8卷 60-70页

作者： In-Sok Lee Young-Eun Song Eun-Ju Song So-Ra choi Hyun-Ah Han ki-Kwon Lee Jeollabuk-do Agricultural Research and Extension Services Iksan-si 54591Korea

This study was performed to investigate the physicochemical properties of oat *** samples were roasted at various temperatures(0,80,120,160 and 200°C)for 15 *** chocolates were made by using three natural antioxidants(green tea,lavender and cactus).The acid value,Hunter’s color,pH,total acidity and sensory evaluation of oat chocolates were *** showed that the acid value of roasted oat flour significantly decreased with increasing roasting *** sensorial characteristics,such as color,taste,smell and overall preference were increased relative to a temperature *** for oat chocolate mixture,its acid value significantly decreased as more antioxidants were added(p<0.05).The lowest acid value was recorded with chocolate lavender flour after 7 d at 1%.Findings showed that the sensory characteristics of products containing antioxidants,such as green tea and cactus,were superior to the control treatment within 7 d.A product including 0.5%green tea marked the best sensory score among *** cost among three antioxidants,green tea was the *** the end,0.5%green tea was selected as the optimal antioxidant to make high-quality oat *** end product by mixing green tea(0.5%)and oat was *** respect to Hunter’s color L(whiteness),a(redness)and b(yellowness),L and a levels were higher when green tea was ***,an opposite result was expressed in b *** terms of pH value and total acidity,the control(without antioxidant)and product with 0.5%green tea(G-0.5)were statistically identical with each *** was difference in acid value among *** acid value of G-0.5 was lower than that of the control up to 7 d,resulting in lower acid value than the ready-made product(D-Co.).When sensory characteristics were assessed,G-0.5 scores were higher than other specimens,including the control and ready-made products(*** H-Co.)up to 6 d after the manufacturing *** a result,the addition of 0

关键词： Oat chocolate antioxidants sensory evaluation

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Enantiomeric characterization and structure elucidation of Otamixaban

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Journal of Pharmaceutical Analysis 2014年第3期4卷 197-204页

作者： Jian Shen Jiping Yang Winfried Heyse Harald Schweitzer Norbert Nagel Doris Andert Chengyue Zhu Vincent Morrison Gregory A.Nemeth Teng-Man Chen Zhicheng Zhao Timothy A.Ayers Yong-Mi choi Sanofi 1041 Route 202-206BridgewaterNJ 08807United States Sanofi Industriepark Hoechst Bldg.D-65926 FrankfurtGermany

Otamixaban is a potent （ki=0.5 nM） fXa inhibitor currently in late-stage clinical develop-ment at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric characterization has been accomplished using vibrational circular dichroism （VCD） spectroscopy. Selected by a spectrum similarity index, the calculated spectra of several higher energy conformers were found to match well with the observed spectra. The characteristic IR bands of these conformers were also identified and attributed to the solvation effect. Combined with both the single crystal x-ray diffraction results for an intermediate and the proton NMR study, the absolute configuration of Otamixaban is unambiguously determined to be （R,R）.

关键词： Vibrational circular dichroism DFT IR Absolute configuration Vicinal proton-proton coupling scXRD

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共面转换液晶显示器中获得对比度高于1:600的新技术

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现代显示 2004年第5期 31-33页

作者： Jae Hyun kim Joun Ho Lee Ji Chul Lim Chang hoon Lee Moo Hyoung Song Ju Yeon Yoon Hee Dong choi Jeom Jae kim Chang Ho Oh Sang Deog Yeo 李路海 LG菲利普液晶显示电视开发部乐凯胶片厂

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树... 详细信息

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树脂、电极锥角和摩擦条件等都进行了研究。优化的背光板组合,光滑的电极锥角和摩擦方法的控制是提高对比度的主要控制因素。应用新开发的滤色片树脂,对获得高对比度最为有效。

关键词：高对比度共面转换液晶显示器薄膜晶体管背光 TFT-LCD 滤色片光板偏振片紧凑

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柔性有源OLED显示器制造几点技术方面的考虑

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现代显示 2009年第2期 21-24,49页

作者： Juhn S.Yoo Nackbong choi Yong-Chul kim In-Hwan kim Seung-Chan Byun Sang-hoon Jung Jong-Moo kim Soo-Young Yoon Chang-Dong kim In-Byeong Kang In-Jae Chung 代永平 LG显示公司南开大学

AMOLED在柔性显示领域前途似锦。LG显示展示了一款全彩4in柔性AMOLED样机,衬底为80μm厚的不锈钢薄片,曲率达到5cm弯曲半径。本文就此项柔性显示技术所面临的挑战进行了探讨,包括柔性衬底衬底的传送、如何获得特性稳定可靠的TFT以使OLE... 详细信息

AMOLED在柔性显示领域前途似锦。LG显示展示了一款全彩4in柔性AMOLED样机,衬底为80μm厚的不锈钢薄片,曲率达到5cm弯曲半径。本文就此项柔性显示技术所面临的挑战进行了探讨,包括柔性衬底衬底的传送、如何获得特性稳定可靠的TFT以使OLED的亮度和一致性适用于此项技术的商业化推广。

关键词：有源有机发光二极管柔性显示器电泳显示器

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卵巢恶性肿瘤患者治疗后FDGPET/CT显像的临床意义

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中华核医学与分子影像杂志 2017年第6期37卷 382-382页

作者：唐军 Eun Ji Han Hye Lim Park Yong Seok Lee Eun Kyung Park Min Jong Song Ie Ryung Yoo Sung hoon kim Woo Hee choi 苏州大学附属第二医院核医学科 Department of Radiology Daejeon St.Mary's HospitalCollege of MedicineThe Catholic University of Korea

目的评价卵巢恶性肿瘤患者治疗后;F-FDG PET/CT显像的诊断和预后价值。方法回顾性分析卵巢恶性肿瘤患者治疗后的FDG PET/CT显像结果,计算PET/CT诊断肿瘤复发或第二原发肿瘤的准确性,并评价其对患者诊疗过程的影响。用Cox回归分析PET/CT... 详细信息

目的评价卵巢恶性肿瘤患者治疗后;F-FDG PET/CT显像的诊断和预后价值。方法回顾性分析卵巢恶性肿瘤患者治疗后的FDG PET/CT显像结果,计算PET/CT诊断肿瘤复发或第二原发肿瘤的准确性,并评价其对患者诊疗过程的影响。用Cox回归分析PET/CT显像结果与患者总体生存率的关系。结果 268例卵巢恶性肿瘤患者[平均年龄（50±13）岁]共行416次PET/CT显像,其中87次（21%）结果阳性,329次结果阴性;灵敏度、特异性、准确性、阳性预测值和阴性预测值分别为98.8%、98.2%、98.3%、93.1%和99.7%。362次随访显像中,38次（11%）的显像结果使患者治疗决策发生了改变;54次因临床有可疑征象而进行的PET/CT显像中,9次（17%）显像排除了肿瘤复发。PET/CT显像后进行了中位时间26.7个月的随访,24例（9%）患者在随访期内死亡。单因素分析结果发现,患者年龄、国际妇产科联盟（FIGO）分期、复发病史和PET/CT显像结果均与患者的总体生存率相关。多因素分析结果显示,PET/CT显像结果与患者的总体生存率相关（P<0.05）。结论卵巢恶性肿瘤治疗后FDG PET/CT是诊断复发和第二原发肿瘤的有效方法,其便于对患者采用更合适的治疗手段,并能帮助预测预后。

关键词： FDG PET/CT 复发性卵巢恶性肿瘤诊断准确性预后

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猪苓的人工培养条件研究(英文)

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安徽农业大学学报 1999年第3期 50-57页

作者： choi Kyoung dal Lee Kyoung tae Ban ki won Son Seo gyu Shim Jae ouk Lee Sang sun 1 Lee Tae soo 2 Lee Youn su 3 Lee Min woong (1 Department of Biological Science and Education,Korean National University of Education, Chungwon 363

猪苓的白色长菌丝在ＰＤＡ培养基上能够形成厚实可剥的菌丝块。猪苓生长菌丝可形成锁状联结、顶端膨大，菌丝直径０．９５～２．８０μｍ，适宜生长条件为２０℃、ｐＨ４。振荡培养下，形成１５～２０μｍ大小的菌丝块，颜色如潜伏期菌... 详细信息

猪苓的白色长菌丝在ＰＤＡ培养基上能够形成厚实可剥的菌丝块。猪苓生长菌丝可形成锁状联结、顶端膨大，菌丝直径０．９５～２．８０μｍ，适宜生长条件为２０℃、ｐＨ４。振荡培养下，形成１５～２０μｍ大小的菌丝块，颜色如潜伏期菌核的灰黄色。在６种生长原木上，猪苓形成菌丝块大小为３～５μｍ。在ＰＤＡ培养基上猪苓与蜜环菌混合培养比单独培养的菌丝粗，菌丝密度大。在原木上，猪苓菌丝与蜜环菌菌丝形成共生联结，同时在与蜜环菌紧连的菌丝块边缘，有多点状的自我防御结构。木质素降解活性检测表明，４个菌株中的Ａ、Ｂ、Ｃ使澳酚蓝脱色后的吸光度为０．０６３５～０．０９０２，而菌株Ｄ的活性可以忽略。

关键词：猪苓蜜环菌培养形态培养条件

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