检索结果-南通市图书馆

Neural Regeneration Research 2011年第27期6卷 2085-2093页

作者： Sun-Hwa Lee Byung-soo Ahn Bong-soo Lim Seong-Kyu kim Sam-ki kim Dae-Il Lee Sung-Rae Cho deok-Gon kim Jae-Bok Han Byung-Il Min Department of East-West Medicine Graduate SchoolKyunghee University Department & Research Institute of Rehabilitation Medicine Yonsei University Department of Oriental Pediatrics Kyunghee Medical CenterKyunghee University Department of Physiology College of MedicineKyunghee University

We investigated the effects of ethanol extracted Scutellaria baicalensis（EESB） on spatial memory function and neurogenesis in the hippocampal dentate *** Sprague-Dawley rats were orally administered 50,100,or 200 mg/kg of EESB for 6 successive *** radial-arm maze test showed that 200 mg/kg of EESB improved the spatial memory of adult *** microscopy results showed that 100 mg/kg of EESB increased the number of bromodeoxyuridine（BrdU）-and neuron-specific nuclear protein-positive cells in the granular cell layer,and that 100 and 200 mg/kg of EESB increased the number of BrdU-/neuron-specific nuclear protein-positive cells in the sub-granular zone.200 mg/kg of EESB increased the number of BrdU-/glial fibrillary acid protein-positive cells in the subgranular *** findings indicate that EESB can effectively promote neurogenesis in the hippocampal dentate gyrus and improve spatial memory function.

关键词： Scutellaria baicalensis neurogenesis dentate gyrus hippocampus bromodeoxyuridine neuron-specific nuclear protein glial fibrillary acidic protein neural regeneration

Simultaneous Paragonimus infection involving the breast and lung:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第24期7卷 4292-4298页

作者： Moon Young Oh Ajung Chu jeong Hwan Park Jong Yoon Lee Eun Youn Roh Young Jun Chai ki-Tae Hwang Department of Surgery Seoul National University HospitalSeoul 156707South Korea Department of Radiology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 156707South Korea Department of Pathology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 156707South Korea Department of Laboratory Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 156707South Korea Department of Surgery Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 156707South Korea

BACKGROUND Paragonimiasis is a food-borne parasitic infection caused by lung flukes of the genus Paragonimus. Although the most common site of infection is the pleuropulmonary area, the parasite can also reach other parts of the body on its journey from the intestines to the lungs, ending up in locations such as the brain,abdomen, skin, and subcutaneous tissues. Ectopic paragonimiasis is difficult to diagnose due to the rarity of this *** SUMMARY Here, we report a rare case of simultaneous breast and pulmonary paragonimiasis in a woman presenting painless breast mass and lung nodule with a history of eating raw trout. To confirm the diagnosis, serologic testing and tissue confirmation of the breast mass were performed. The patient was treated with surgical resection of the mass and praziquantel *** Ectopic paragonimiasis is difficult to diagnose due to the rarity of this ***, thorough history-taking and clinical suspicion of parasitic infection are important.

关键词： Paragonimiasis Paragonimus westermani Parasitic infection Breast mass Lung nodule Case report

Simulation of the extreme waves generated by typhoon Bolaven (1215) in the East China Sea and Yellow Sea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2015年第12期34卷 19-28页

作者： JUN ki Cheon jeong Weon Mu CHOI Jin Yong PARK Kwang Soon JUNG Kyung Tae kiM Mee Kyung CHAE Jang Won QIAO Fangli Coastal Disaster Research Center Korea Institute of Ocean Science and Technology Coastal & Environmental Engineering Division Korea Institute of Ocean Science and Technology Marine Radionuclide Research Center Korea Institute of Ocean Science and Technology First Institute of Oceanography State Oceanic Administration

Record-breaking high waves occurred during the passage of the typhoon Bolaven（1215）（TYB） in the East China Sea（ECS） and Yellow Sea（YS） although its intensity did not reach the level of a super *** and directional wave measurements were made using a range of in-situ instruments mounted on an ocean tower and *** order to understand how such high waves with long duration occurred,analyses have been made through measurement and numerical *** winds were generated using the TC96 typhoon wind model with the best track data calibrated with the *** then the wind fields were blended with the reanalyzed synoptic-scale wind fields for a wave *** fields were simulated using WAM4.5 with adjustment of C_d for gust of winds and bottom friction for the study *** the accuracy of simulations is considerably enhanced,and the computed results are also in better agreement with measured data than *** is found that the extremely high waves evolved as a result of the superposition of distant large swells and high wind seas generated by strong winds from the front/right quadrant of the typhoon *** the typhoon moved at a speed a little slower than the dominant wave group velocity in a consistent direction for two days,the wave growth was significantly enhanced by strong wind input in an extended fetch and non-linear interaction.

关键词： extreme waves typhoon measurements numerical simulation East China Sea

Electrochemical and structural evolution of structured V_(2)O_(5) microspheres during Li-ion intercalation

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第4期30卷 108-113页

作者： Sul ki Park Puritut Nakhanivej jeong Seok Yeon Kang Ho Shin Wesley M.Dose Michael De Voider Jin Bae Lee Hae Jin kim Ho Seok Park School of Chemical Engineering Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea Institute for Manufacturing Department of EngineeringUniversity of CambridgeCambridge CB30FSUnited Kingdom Department of Chemistry University of CambridgeLensfield RoadCambridge CB21EWUnited Kingdom Research Center for Materials Analysis Korea Basic Science InstituteDaejeonRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University2066SeoburoJangan-guSuwon440-746South Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea

With the development of stable alkali metal anodes,V_(2)O_(5) is gaining traction as a cathode material due to its high theoretical capacity and the ability to intercalate Li,Na and K ***,we report a method for synthesizing structured orthorhombic V_(2)O_(5) microspheres and investigate Li intercalation/deintercalation into this *** industry adoption,the electrochemical behavior of V_(2)O_(5) as well as structural and phase transformation attributing to Li intercalation reaction must be further *** synthesized V_(2)O_(5) microspheres consisted of small primary particles that were strongly joined together and exhibited good cycle stability and rate capability,triggered by reversible volume change and rapid Li ion *** addition,the reversibility of phase transformation(a,e,d,c and xLixV_(2)O_(5))and valence state evolution(5+,4+,and 3.5+)during intercalation/de-intercalation were studied via in-situ X-ray powder diffraction and X-ray absorption near edge structure analyses.

关键词： Lithium ion batteries Vanadium pentoxide(V2O5) In-situ analysis Phase transformation Intercalation/de-intercalation

A Direct Link between Abscisic Acid Sensing and the Chromatin-Remodeling ATPase BRAHMA via Core ABA Signaling Pathway ComDonents

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2016年第1期9卷 136-147页

作者： Marta Peirats-Llobet Soon-ki Han Miguel Gonzalez-Guzman Cheol Woong jeong Lesia Rodriguez Borja Belda-Palazon Doris Wagner Pedro L. Rodriguez Instituto de Biologia Molecular y Celular de Plantas Consejo Superior de Investigaciones Cientfficas-Universidad Politecnica de Valencia 46022 Valencia Spain Department of Biology University of Pennsylvania Philadelphia PA 19104 USA These authors contributed equally to this article

Optimal response to drought is critical for plant survival and will affect biodiversity and crop performance during climate change. Mitotically heritable epigenetic or dynamic chromatin state changes have been implicated in the plant response to the drought stress hormone abscisic acid （ABA）. The Arabidopsis SWI/SNF chromatin-remodeling ATPase BRAHMA （BRM） modulates response to ABA by preventing pre- mature activation of stress response pathways during germination. We show that core ABA signaling pathway components physically interact with BRM and post-translationally modify BRM by phosphoryla- tion/dephosphorylation. Genetic evidence suggests that BRM acts downstream of SnRK2.2/2.3 kinases, and biochemical studies identified phosphorylation sites in the C-terminal region of BRM at SnRK2 target sites that are evolutionarUy conserved. Finally, the phosphomimetic BRMs17s^D S1762D mutant displays ABA hypersensitivity. Prior studies showed that BRM resides at target loci in the ABA pathway in the presence and absence of the stimulus, but is only active in the absence of ABA. Our data suggest that SnRK2- dependent phosphorylation of BRM leads to its inhibition, and PP2CA-mediated dephosphorylation of BRM restores the ability of BRM to repress ABA response. These findings point to the presence of a rapid phosphorylation-based switch to control BRM activity; this property could be potentially harnessed to improve drought tolerance in plants.

关键词： abscisic acid hormone signaling chromatin remodeling

Sojucktang induces apoptosis via loss of mitochondrial membrane potential and caspase-3 activation in KLE human endometrial cancer cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2009年第23期54卷 4387-4392页

作者： OH Yeon-Suk KWON Hee-Young jeong Soo-Jin PARK ki-Young kiM Sun-Young LEE Hyo-Jung LEE Hyo-jeong LEE Eun-Ok AHN Kwang Seok kiM Sung-Hoon Cancer Preventive Material Development Research Center Oriental Medical CollegeKyunghee University College of Medicine Kyunghee University

Sojucktang (SJT) has long been used for the treatment of endometrial diseases in Korea. However, the mechanisms responsible for the SJT-induced apoptosis in endometrial cancer cells remain unclear. In the present study, SJT was demonstrated to show cytotoxic effect and induce apoptotic cell death via mitochondrial regulation in KLE endometrial cancer cells. Linderae Radix, Glycyrrhizae Radix, Zedoariae Rhizoma, Trogopterorum Faeces and Agelicae Gigantis Radix were found to be the potent constituent herbs of SJT to significantly decrease the viability of KLE cells by a tetra zolium salt (XTT) assay. Apoptotic bodies were observed in SJT-treated KLE cells by 4′-6-diamidino-2-phenylindole (DAPI) and TdT-mediated-dUTP nick-end labeling (TUNEL) assay. SJT also increased sub-G1 DNA contents of the cell cycle undergoing apoptosis in a dose-dependent manner. Furthermore, it was observed that SJT activated caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), and decreased mitochondrial membrane potential in a dose-dependent manner. Taken together, this study shows that SJT exerts anti-tumor activity against KLE endometrial cancer cells via mitochondrial dependent apoptosis induction.

关键词：线粒体膜电位 caspase 子宫内膜癌细胞凋亡活化癌细胞诱导细胞毒作用

Surface elemental distribution effect of Pt-Pb hexagonal nanoplates for electrocatalytic methanol oxidation reaction

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2020年第5期41卷 813-819页

作者： Hee Jin kim Yong-deok Ahn jeonghyeon kim Kyoung-Su kim Yeon Uk jeong Jong Wook Hong Sang-Il Choi Department of Chemistry and Green-Nano Materials Research Center Kyungpook National UniversityDaegu 41566Korea Department of Chemistry University of UlsanUlsan 44610Korea School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Korea

Bimetallic Pt-based catalysts have been extensively investigated to enhance the performance of direct methanol fuel cells(DMFCs) because CO, a by-product, reduces the activity of the pure Pt catalysts. Herein, we synthesized Pt-Pb hexagonal nanoplates as a model catalyst for the methanol oxidation reaction(MOR) and further controlled the Pt and Pb distributions on the surface of the nanoplates through acetic acid(HAc) treatment. As a result, we obtained Pt-Pb nanoplates and HAc-treated Pt-Pb nanoplates with homogeneous and heterogeneous distributions of the Pt-Pb alloy surfaces, respectively. We showed that the MOR activity and stability of the Pt-Pb nanoplates improved compared to those of the HAc-treated Pt-Pb nanoplates, mainly due to the enhanced CO tolerance and the modified electronic structure of Pt under the influence of the oxophilic Pb.

关键词： Platinum Lead Nanoplate Surface atomic distribution Methanol oxidation reaction

Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 263-268页

作者： Soundharrajan Ilavenil Da Hye kim Young-Il jeong Mariadhas Valan Arasu Mayakrishnan Vijayakumar Ponnuraj Nagendra Prabhu Srisesharam Srigopalram ki Choon Choi Grassland and Forage division National Institute of Animal ScienceRDA The United Graduate School of Agricultural Sciences Tottori University School of Medicine Pusan National University Department of Botany and Microbiology Addiriyah Chair for Environmental StudiesCollege of ScienceKing Saud University Department of Animal Sciences University of Illinois Department of Horticulture Sunchon National University

Objective:To elucidate the key parameters associated with hydrogen peroxide induced oxidative stress and investigates the mechanism of trigonelline(TG)for reducing the H_2O_2induced toxicity in H9c2 ***:Cytotoxicity and antioxidant activity of TG was assessed by EZ-CYTOX *** extraction and cDNA synthesized according to the kit manufacture *** was measured by the Flowcytometry,general PCR and ***:It was found that the TG significantly rescued the morphology of the H9c2 *** of cells with TG attenuated H_2O_2 induced cell deaths and improved the antioxidant *** addition,TG regulated the apoptotic gene caspase-3,caspase-9 and anti-apoptotic gene ***-XL during H_2O_2 induced oxidative stress in H9c2 *** results were comparable with quercetin *** evident,flow cytometer results also confirmed the TG significantly reduced the H_2O_2 induced necrosis and apoptosis in H9c2 ***,further increment of TG concentration against H_2O_2 could induce the necrosis and apoptosis along with H_2O_***:It is suggested that less than 125μM of TG could protect the cells from H_2O_2 induced cell damage by down regulating the caspases and up regulating the Bcl-2 and Bcl-XL ***,we suggest the trigonelline could be useful for treatment of oxidative stress mediated cardiovascular diseases in future.

关键词： Trigonelline H9c2 cells Antioxidant Apoptosis Cardiovascular diseases

Humidity-induced synaptic plasticity of ZnO artificial synapses using peptide insulator for neuromorphic computing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第24期119卷 150-155页

作者： Min-Kyu Song Hojung Lee jeong Hyun Yoon Young-Woong Song Seok Daniel Namgung Taehoon Sung Yoon-Sik Lee Jong-Seok Lee ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983South Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826South Korea Soft Foundry Seoul National UniversitySeoul 08826South Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826South Korea

Neuromorphic devices inspired by the human brain have attracted significant attention because of their excellent ability for cognitive and parallel *** study presents ZnO-based artificial synapses with peptide insulators for the electrical emulation of biological *** demonstrated the dynamic responses of the device under various environmental *** proton-conducting property of the tyrosine-rich peptide enables time-dependent responses under ambient conditions such that various aspects of synaptic behaviors are emulated by the *** transition from short-term memory to longterm memory is achieved via electrochemical doping of ZnO by ***,we demonstrate an image classification simulation using a multi-layer perceptron model to evaluate the potential of the device for use in neuromorphic *** neural network based on our device achieved a recognition accuracy of 87.47% for the MNIST handwritten digit *** work proposes a novel device platform inspired by biosystems for brain-mimetic hardware systems.

关键词： Artificial synapse Neuromorphic computing Oxide semiconductor Proton conductor Artificial neural network

Tyrosine-mediated analog resistive switching for artificial neural networks

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song Seok Daniel Namgung Hojung Lee jeong Hyun Yoon Young-Woong Song Kang Hee Cho Yoon-Sik Lee Jong-Seok Lee ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network