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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young yoon Hyun-Woo Moon Chonsaeng kim Mi-Hwa kim yoon-Sun Yi Sangmi Jun Bum-tae kim Jong-Won Oh Aleem Siddiqui Seong-Jun kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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Clinical outcomes and predictive factors in oral corticosteroid-refractory active ulcerative colitis

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World Journal of Gastroenterology 2013年第2期19卷 265-273页

作者： Han Ho Jeon Hyun Jung Lee Hui Won Jang Jin Young yoon yoon Suk Jung Soo Jung Park Sung Pil Hong tae Il kim Won Ho kim Jae Hee Cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Brain Korea 21 Project for Medical Science Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To evaluate the clinical outcomes and prognostic factors after intravenous corticosteroids following oral corticosteroid failure in active ulcerative colitis ***:Consecutive patients with moderate to severe ulcerative colitis who had been treated with a course of intravenous corticosteroids after oral corticosteroid therapy failure between January 1996 and July 2010 were recruited at Severance Hospital,Seoul,South *** disease activity was measured by the Mayo score,which consists of stool frequency,rectal bleeding,mucosal appearance at flexible sigmoidoscopy,and Physician Global *** retrospectively evaluated clinical outcomes at two weeks,one month,three months,and one year after the initiation of intravenous corticosteroid *** weeks outcomes were classified as responders or *** month,three month and one year outcomes were classified into prolonged response,steroid dependency,and ***:Our study included a total of 67 eligible *** two weeks,56(83.6%) patients responded to intravenous *** one month,complete remission was documented in 18(32.1%) patients and partial remission in 26(46.4%).Eleven patients(19.7%) were refractory to the *** three months and one year,we found 37(67.3%) and 25(46.3%) patients in prolonged response,ten(18.2%) and 23(42.6%) patients in corticosteroid dependency,8(14.5%) and 6(11.1%) patients with no response,*** 9 patients were underwent elective proctocolectomy within 1 *** duration of oral corticosteroid therapy(> 14 d vs ≤ 14 d,P = 0.049) and lower hemoglobin level(≤ 11.0 mg/dL vs >11.0 mg/dL,P = 0.02) were found to be poor prognostic factors for response at two *** one year outcome,univariate analysis revealed that only a partial Mayo score(≥ 6 vs <6,P = 0.057) was found to be associated with a poor ***:The duration of oral corticosteroid therapy and lower hemoglobin level were strongly associ

关键词： Clinical outcome Prognosis Corticosteroid Ulcerative colitis

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Management of post-gastrectomy anastomosis site obstruction with a self-expandable metallic stent

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World Journal of Gastroenterology 2015年第16期21卷 5110-5114页

作者： Ra Ri Cha Sang Soo Lee Hyunjin kim Hong Jun kim tae-Hyo kim Woon tae Jung Ok Jae Lee Kyung Soo Bae Sang-Ho Jeong Chang yoon Ha Department of Internal Medicine Gyeongsang National University School of Medicine Department of Radiology Gyeongsang National University School of Medicine Department of Surgery Gyeongsang National University School of Medicine

Post-gastrectomy anastomosis site obstruction is a relatively rare complication after a subtotal *** present a case of a 75-year-old man who underwent a truncal vagotomy, omental patch, gastrojejunostomy, and Braun anastomosis for duodenal ulcer perforation and a gastric outlet *** the 10 th postoperative day, the patient complained of abdominal discomfort and *** diagnosed post-gastrectomy anastomosis site obstruction by an upper gastrointestinal series and an upper endoscopic *** inserted a self-expandable metallic stent(SEMS) at the anastomosis *** stent was fully expanded after *** the day following the stent insertion, the patient began to eat, and his abdominal discomfort was *** paper describes the successful management of post-gastrectomy anastomosis site obstruction with temporary placement of a SEMS.

关键词： Efferent loop syndrome Postgastrectomysyndrome self-expandable metallic stent

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Recent advances in photoacoustic endoscopy

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World Journal of Gastrointestinal Endoscopy 2013年第11期5卷 534-539页

作者： tae-Jong yoon Young-Seok CHo Department of Applied Bioscience CHA University Division of Gastroenterology Department of Internal MedicineUijeongbu St. Mary’s HospitalThe Catholic University of Korea College of Medicine

Imaging based on photoacoustic effect relies on illuminating with short light pulses absorbed by tissue absorbers, resulting in thermoelastic expansion, giving rise to ultrasonic waves. The ultrasonic waves are then detected by detectors placed around the sample. Photoacoustic endoscopy(PAE) is one of four major implementations of photoacoustic tomography that have been developed recently. The prototype PAE was based on scanning mirror system that deflected both the light and the ultrasound. A recently developed mini-probe was further miniaturized, and enabled simultaneous photoacoustic and ultrasound imaging. This PAE-endoscopic ultrasound(EUS) system can offer high-resolution vasculature information in the gastrointestinal(GI) tract and display differences between optical and mechanical contrast compared with single-mode EUS. However, PAE for endoscopic GI imaging is still at the preclinical stage. In this commentary, we describe the technological improvements in PAE for possible clinical application in endoscopic GI imaging. In addition, we discuss thetechnical details of the ultrasonic transducer incorporated into the photoacoustic endoscopic probe.

关键词： Photoacoustic techniques Tomography Endoscopy Endosonography Gastrointestinal neoplasm

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Single omental metastasis of renal cell carcinoma after radical nephrectomy:A case report

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World Journal of Clinical Cases 2023年第25期11卷 5994-5999页

作者： Jae-Wook Chung Jun-Koo Kang Eun Hye Lee So Young Chun Yun-Sok Ha Jun Nyung Lee tae-Hwan kim tae Gyun Kwon Ghil Suk yoon Department of Urology Kyungpook National University HospitalDaegu 41404South Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41404South Korea Biomedical Research Institute Kyungpook National UniversityDaegu 41404South Korea Joint Institute for Regenerative Medicine Kyungpook National UniversityDaegu 41404South Korea Department of Pathology Kyungpook National University HospitalDaegu 41404South Korea Department of Pathology School of MedicineKyungpook National UniversityDaegu 41404South Korea

BACKGROUND Renal cell carcinoma(RCC)is the third most common malignancy in the genitourinary *** lungs,bone,lymph nodes,liver,and brain are common metastatic sites of ***,there is limited literature on single omental metastasis of *** SUMMARY We present the case of a 44-year-old man with single omental metastasis of RCC after laparoscopic radical *** diagnosis of the resected left kidney revealed pT3a clear cell RCC(Fuhrman grade III).At 6 mo postoperatively,abdominal computed tomography revealed a 12-mm enhancing nodule in the left lower *** 7 mo after initial operation,laparoscopic removal of the left omental nodule was *** pathological results indicated metastatic clear cell ***,the patient is being treated with adjuvant *** Omental metastasis of RCC owing to laparoscopic radical nephrectomy is *** should be aware of the diverse nature of RCC.

关键词： Metastasis Omentum Renal cell carcinoma Radical nephrectomy Case report

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Ceramic-metal package for high power LED lighting

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Frontiers of Optoelectronics 2012年第2期5卷 133-137页

作者： Yu Jin HEO Hyo tae kiM Sahn NAHM Jihoon kiM Young Joon yoon Jonghee kiM Korea Institute of Ceramic Engineering and Technology Seoul 153-801 Korea Department of Materials Science and Engineering Korea University Seoul 136 701 Korea

High power light-emitting diodes （LEDs） lighting has drawn a great interest in the field of street light system in recent years. Key parameters for successful launching of LED street light in the commercial market are price and light efficiency, respectively, and they are greatly influenced by the materials and design factors used in high power LED package. This article presents a new design and materials processing technology to realize the solution of LED packaging with advantageous in price and performance. Cost effective materials and processing technology can be realized via thick film glass-ceramic insulating layer and silver conductor. Highly effective thermal design using direct heat dissipation to heat sink in LED package is demonstrated.

关键词： light-emitting diodes (LEDs) package high-power thick film heat dissipation thermal resistance

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Low grade chondrosarcoma of the nasal septum

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World Journal of Clinical Cases 2013年第1期1卷 64-66页

作者： Dong Hoon Lee Se Hee Jung tae Mi yoon Joon Kyoo Lee Young Eun Joo Sang Chul Lim Department of Otolaryngology-Head and Neck Surgery Chonnam National University Medical School and Hwasun Hospital Hwasun Jeonnam 519-809 South Korea Department of Radiology Chonnam National University Medical School and Hwasun Hospital Hwasun Jeonnam 519-809 South Korea Department of Research Institute of Medical Sciences Chonnam National University Medical School and Hwasun Hospital Hwasun Jeonnam 519-809 South Korea

Chondrosarcoma of the nasal septum is extremely rare. In some cases, it may be diff icult to preoperatively differentiate low grade chondrosarcoma from benign cartilaginous tumors such as chondroma. We report a case of low grade chondrosarcoma of the nasal septum with characteristic radiologic f indings. Characteristic radiologic f indings such as calcif ications on computed tomography scan and a ring-and-arc pattern on enhanced T1 weighted image were useful in the preoperative diagnosis of low grade chondrosarcoma of the septum. Awareness of radiologic f indings of low grade chondrosarcoma can help to make an accurate diagnosis and perform appropriate excision, leading to successful local control.

关键词： Chondrosarcoma Nasal septum Endoscopic surgical procedure Computed tomography Radiology

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RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model

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Journal of Genetics and Genomics 2024年第12期51卷 1389-1403页

作者： Ji-Won Park tae-Ik Choi tae-yoon kim Yu-Ri Lee Dilan Wellalage Don Jaya K.George-Abraham Laurie A.Robak Cristina C.Trandafir Pengfei Liu Jill A.Rosenfeld tae Hyeong kim Florence Petit Yoo-Mi kim Chong Kun Cheon yoonsung Lee Cheol-Hee kim Department of Biology Chungnam National UniversityDaejeon 34134Republic of Korea Department of Pediatrics The University of Texas at Austin Dell Medical SchoolAustinTX 78723USA Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Baylor Genetics Laboratories HoustonTX 77021USA Department of Pediatrics Kyung Hee University Hospital at GangdongSeoul 05278Republic of Korea Univ.Lille CHU LilleClinique de g en etique Guy FontaineF-59000 LilleFrance Department of Pediatrics Chungnam National University Sejong HospitalSejong 30099Republic of Korea Department of Pediatrics Pusan National University Children’s HospitalYangsan 50612Republic of Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsan 50612Republic of Korea Clinical Research Institute Kyung Hee University Hospital at GangdongSchool of MedicineKyung Hee UniversitySeoul 05278Republic of Korea

Williams syndrome(WS)is a rare multisystemic disorder caused by recurrent microdeletions on 7q11.23,characterized by intellectual disability,distinctive craniofacial and dental features,and cardiovascular *** studies have explored the roles of individual genes within these microdeletions in contributing to WS ***,we report five patients with WS with 1.4 Mb-1.5 Mb microdeletions that include RFC2,as well as one patient with a 167-kb microdeletion involving RFC2 and six patients with intragenic variants within *** investigate the potential involvement of RFC2 in WS pathogenicity,we generate a rfc2 knockout(KO)zebrafish using CRISPR-Cas9 ***,we generate a KO zebrafish of its paralog gene,rfc5,to better understand the functions of these RFC genes in development and *** rfc2 and rfc5 KO zebrafish exhibit similar phenotypes reminiscent of WS,including small head and brain,jaw and dental defects,and vascular ***-seq analysis reveals that genes associated with neural cell survival and differentiation are specifically affected in rfc2 KO *** addition,heterozygous rfc2 KO adult zebrafish demonstrate an anxiety-like behavior with increased social *** results suggest that RFC2 may contribute to the pathogenicity of WS,as evidenced by the zebrafish model.

关键词： Williams syndrome RFC2 RFC5 Zebrafish Knockout CRISPR-Cas9

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Friction stir butt welding of A5052-O aluminum alloy plates

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中国有色金属学会会刊：英文版 2012年第S3期22卷 619-623页

作者： Sung-Ook yoon Myoung-Soo KANG Hyun-Bin NAM Yong-Jai KWON Sung-tae HONG Jin-Chun kiM Kwang-Hak LEE Chang-Yong LIM Jong-Dock SEO School of Materials Science and Engineering University of Ulsan School of Mechanical Engineering University of Ulsan Technical Research Laboratories Shin Young Co.Ltd.

Friction stir butt welding (FSW) between A5052-O aluminum alloy plates with a thickness of 2 mm was *** rotation speeds of the welding tool were 2000 and 3000 r/min,*** traverse speed was ranged from 100 mm/min to 900 mm/*** defect-free welds with the very smooth surface morphology were successfully obtained,except for at the welding condition of 3000 r/min and 100 mm/*** onion ring structure was observed in the friction-stir-welded zone (SZ) at the condition of 2000 r/min and 100 mm/*** all the welding conditions,the grain size of the SZ was smaller than that of the base metal,and was decreased with the decrease of the tool rotation speed and with the increase of the tool traverse *** stir zone exhibited higher average hardness than the base *** decrease of the tool rotation speed and the increase of the tool traverse speed resulted in the increase in the average hardness of the *** tensile strength of the FSWed plates was similar to that of the base metal,except for at the welding condition of 3000 r/min and 100 mm/*** total elongation of the FSWed plates was lower than that of the base metal.

关键词： friction stir butter welding A5052-O aluminum alloy microstructure mechanical property

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Biliary drainage for obstructive jaundice caused by unresectable hepatocellular carcinoma: the endoscopic versus percutaneous approach

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 636-642页

作者： Jongkyoung Choi Ji Kon Ryu Sang Hyub Lee Dong-Won Ahn Jin-Hyeok Hwang Yong-tae kim Yong Bum yoon Joon Koo Han Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea Department of Internal Medicine National Medical Center Seoul Korea Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Korea Department of Internal Medicine Seoul National University Boramae Medical Center Seoul Korea Department of Radiology Seoul National University College of Medicine Seoul Korea

BACKGROUND: For palliative treatment of the obstructive jaundice associated with unresectable hepatocellular carcinoma (HCC), percutaneous transhepatic biliary drainage (PTBD) or endoscopic retrograde biliary drainage (ERBD) has been performed. PTBD is preferred as an initial procedure. Little is known about the better option for patients with obstructive jaundice caused by unresectable HCC. METHODS: Sixty patients who had received ERBD or PTBD for the palliative treatment of obstructive jaundice caused by unresectable HCC between January 2006 and May 2010 were included in this retrospective study. Successful drainage, drainage patency, and the overall survival of patients were evaluated. RESULTS: Univariate analysis revealed that the overall frequency of successful drainage was higher in the ERBD group (22/29, 75.9%) than in the PTBD group (15/31, 48.4%) (P=0.029); but multivariate analysis showed marginal significance (P=0.057). The duration of drainage patency was longer in the ERBD group than in the PTBD group (82 vs 37 days, respectively, P=0.020). Regardless of what procedure was performed, the median survival time of patients who had a successful drainage was much longer than that of the patients who did not have a successful drainage (143 vs 38 days, respectively, P<0.001).CONCLUSION: Besides PTBD, ERBD may be used as the initial treatment option to improve obstructive jaundice in patients with unresectable HCC if there is a longer duration of drainage patency after a successful drainage.

关键词： hepatocellular carcinoma obstructive jaundice endoscopic retrograde biliary drainage percutaneous transhepatic biliary drainage

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