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Fabrication of curved micro structures on photoresist layer

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 100-103页

作者： Jae Sung yoon tae-Jin JE Doo-Sun CHOI Sung Hwan CHANG Kyung-Hyun WHANG Nano Mechanical Systems Research Division Korea Institute of Machinery and Materials (KIMM) Daejeon 305-343 Korea

A novel fabrication process for micro patterns with curvature was introduced. The curved structures were made by compensating rectangular micro structures with liquid photoresist layer. Because of the surface tension of the liquid in micro scale, various shapes of meniscus can he made on the micro channels. The micro channels were made on the silicon suhstrate in advance, and then the liquid layer was coated on the micro channels. From the nature of liquid behavior, the curved patterns with smooth surface are obtained, which cannot be made easily with the conventional mechanical machining, as well as with the microfabrication processes, such as wet and dry etching. With this principle, it is expected that the smooth and curved surfaces can be made by simple processes and the results can be applied widely, such as optical patterns.

关键词： micro pattern liquid layer MEMS micro channel silicon substrate

Linearization of T-S fuzzy systems and robust H_∞ control

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Journal of Central South University 2011年第1期18卷 140-145页

作者： yoon tae-Sung 王法广 PARK Seung-Kyu KWAK Gun-Pyong AHN Ho-Kyun School of Mechatronics Changwon National University

Takagi-Sugeno(T-S) fuzzy model is difficult to be linearized because of membership functions ***,novel T-S fuzzy state transformation and T-S fuzzy feedback are proposed for the linearization of T-S fuzzy *** novel T-S fuzzy state transformation is the fuzzy combination of local linear transformation which transforms local linear models in the T-S fuzzy model into the local linear controllable canonical *** fuzzy combination of local linear controllable canonical model gives controllable canonical T-S fuzzy model and then nonlinear feedback is obtained *** the linearization of T-S fuzzy model,a robust H∞ controller with the robustness of sliding model control(SMC) is *** a result,controlled T-S fuzzy system shows the performance of H∞ control and the robustness of SMC.

关键词： T-S fuzzy control linearization H∞ control sliding mode control

Recurrent basal cell carcinoma of lower lid invading the orbit and whole hemiface reconstructed by rectus abdominis free flap

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 413-414页

作者： Dong Hyun Ji Ha Na Park tae yoon La Department of Ophthalmology St. Vincent's Hospital College of Medicine the Catholic University of Korea

Dear Sir, I am Dong Hyun Ji, from the Department of Ophthalmology of St. Vincent’s Hospital, Suwon, Korea. I write to present a very severely recurrent basal cell carcinoma (BCC) in lower lid invading left orbit and ... 详细信息

关键词： Figure Recurrent basal cell carcinoma of lower lid invading the orbit and whole hemiface reconstructed by rectus abdominis free flap free BCC cell

A case of unsuspected trans-orbital-cranial penetrating injury by a wooden chopstick in a one-year-old infant

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 523-526页

作者： Yeon Woong Chung Soon Young Lee tae yoon La Department of Ophthalmology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 16247Korea

Dear Editor,Transorbital penetrating injury is one emergency faced by ophthalmologists during primary care that requires special attention because it can lead to serious ophthalmic and neurological *** all head injuries, intracranial penetrating injuries occur at a low rate of 0.4%[1], and transorbital-cranial penetrating injuries are even more rare, but do occur more frequently in young children than in adults[2-3].

关键词： injuries infant orbital

Optimal biliary drainage for inoperable Klatskin's tumor based on Bismuth type

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World Journal of Gastroenterology 2007年第29期13卷 3948-3955页

作者： Sang Hyub Lee Joo Kyung Park Won Jae yoon Jun Kyu Lee Ji Kon Ryu Yong Bum yoon Yong-tae kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul South Korea

AIM： To investigate differences in the effects of biliary drainage procedures in patients with inoperable Klatskin＇s tumor based on Bismuth type, considering endoscopic retrograde biliary drainage （ERBD）, external percutaneous transhepatic biliary drainage （EPTBD） and internal biliary stenting via the PTBD tract （IPTBD）. METHODS： The initial success rate, cumulative patency rate, and complication rate were compared retrospectively, according to the Bismuth type and ERBD, EPTBD, and IPTBD. Patency was defined as the duration for adequate initial bile drainage or to the point of the patient＇s death associated with inadequate drainage. RESULTS： One hundred thirty-four patients （93 men, 41 women; 21 Bismuth type Ⅱ, 47Ⅲ, 66 Ⅳ; 34 ERBD, 66 EPTBD, 34 IPTBD） were recruited. There were no differences in demographics among the groups. Adequate initial relief of jaundice was achieved in 91% of patients without a significant difference in the results among different procedures or Bismuth types. The cumulative patency rates for ERBD and IPTBD were better than those for EPTBD with Bismuth type Ⅲ. IPTBD provided an excellent response for Bismuth type IV. However, there was no difference in the patency rate among drainage procedures for Bismuth type Ⅱ. Procedure-related cholangitis occurred less frequently with EPTBD than with ERBD and IPTBD. CONCLUSION： ERBD is recommended as the firstline drainage procedure for the palliation of jaundice in patients with inoperable Klatskin＇s tumor of Bismuth type Ⅱ or Ⅲ, but IPTBD is the best option for Bismuth type Ⅳ.

关键词： Klatskin's tumor Palliation Drainage Bile ducts Intervention

Calcium-dependent proteasome activation is required for axonal neurofilament degradation

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Neural Regeneration Research 2013年第36期8卷 3401-3409页

作者： Joo Youn Park So Young Jang yoon Kyung Shin Duk Joon Suh Hwan tae Park Department of Physiology Mitochondria Hub Regulation Center College of Medicine Dong-A University

Even though many studies have identified roles of proteasomes in axonal degeneration, the mo- lecular mechanisms by which axonal injury regulates proteasome activity are still unclear. In the present study, we found evidence indicating that extracellular calcium influx is an upstream regulator of proteasome activity during axonal degeneration in injured peripheral nerves. In degenerating axons, the increase in proteasome activity and the degradation of ubiquitinated proteins were sig- nificantly suppressed by extracellular calcium chelation. In addition, electron microscopic findings revealed selective inhibition of neurofilament degradation, but not microtubule depolymerization or mitochondrial swelling, by the inhibition of calpain and proteasomes. Taken together, our findings suggest that calcium increase and subsequent proteasome activation are an essential initiator of neurofilament degradation in Wallerian degeneration.

关键词： neural regeneration peripheral nerve injury neurofilament degradation sciatic nerve calcium calpain mitochondria microtubule depolymerization axon axon degeneration neuroregeneration

Prognostic implications of FGFR1 and MYC status in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2016年第44期22卷 9803-9812页

作者： Dohee Kwon Ji Yun Yun Bhumsuk Keam Young tae kim yoon Kyung Jeon Department of Pathology Seoul National University Hospital Seoul National University College of Medicine Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Department of Thoracic Surgery Seoul National University Hospital Cancer Research Institute Genomic Medicine Institute Seoul National University College of Medicine Seoul National University College of Medicine

AIM To investigate the clinicopathological features and prognostic implications of combined MYC and fibroblast growth factor receptor 1(FGFR1) status in esophageal squamous cell carcinomas(ESCCs). METHODS All patients with ESCC(n = 180) underwent surgical resection at Seoul National University Hospital sometime between 2000 and 2013. A tissue microarray was constructed using cores obtained from representative tumor areas of formalin-fixed, paraffin-embedded tissue blocks. FGFR1 and MYC copy numbers were quantified using fluorescence in situ hybridization. The level of MYC expression was determined using immunohistochemistry. FGFR1 and MYC amplification status was compared between primary and metastatic lymph nodes. Univariate and multivariate survival analyses were performed according to adjuvant therapy *** FGFR1 and MYC amplifications were observed in 21.4%(37/173) and 54.2%(91/168) of patients, respectively, while MYC expression was observed in 58.9%(106/180) of patients. There was a positive correlation between MYC amplification and overexpression(P = 0.002). Although FGFR1 amplification was not associated with MYC amplification or expression, 12.3%(20/163) of patients exhibited both FGFR1 amplification and MYC expression. There was also a correlation in FGFR1 amplification status between matched primary tumors and metastatic lymph nodes(P < 0.001). MYC expression was higher in ESCCs with p T1(P < 0.001) and in those with no lymph node metastasis(P = 0.023). MYC expression was associated with prolonged diseasefree survival(P = 0.036) and overall survival(OS)(P = 0.017) but was not an independent prognostic factor. FGFR1 amplification was an independent predictor for prolonged OS in all patients(P = 0.029) and in those who did not receive adjuvant therapy(P = 0.013). Combined FGFR1 amplification and MYC expression predicted better OS in patients who did not receive adjuvant therapy(P = 0.034) but not in those who did receive adjuvant ***

关键词： Receptor tyrosine kinase Fibroblast growth factor receptor 1 MYC Esophageal squamous cell carcinoma Gene amplification Prognosis Fluorescent in situ hybridization

Refractive errors in high myopic eyes after phacovitrectomy for macular hole

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 369-373页

作者： Donghyun Jee Yi-Ryeung Park Kyoung In Jung Eunchul kim tae yoon La Department of Ophthalmology and Visual Science College of Medicine Catholic University of Korea St. Vincent Hospital Department of Ophthalmology and Visual Science College of Medicine Catholic University of Korea Seoul St. Mary's Hospital Department of Ophthalmology and Visual Science College of Medicine Catholic University of Korea Bucheon St.Mary's Hospital

AIM: To examine the refractive prediction error in high myopic eyes after ***: This retrospective comparative case series included 91 eyes(18 high myopic eyes and 73 non-high myopic eyes) of 91 patients who underwent successful phacovitrectomy(phacoemulsification, intraocular lens implantation, and pars plana vitrectomy). The high myopic eyes were defined as the eye with more than 26.0mm of axial length. The postoperative prediction error of mean error and mean absolute error were evaluated at4 mo postoperatively. Axial length and keratometry measurement were performed preoperatively and 4mo postoperatively using the IOL ***: The refractive outcome after phacovitrectomy showed significantly greater myopic shift in the high myopic eyes [-1.08 ±0.87 diopters(D)] than that in the non-high myopic eyes(-0.43 ±0.63 D, P =0.004). Axial length and keratometric value in the high myopic eyes were significantly increased(P =0.043, 0.037 respectively),whereas those in the non-high myopic group were not significantly increased(P =0.135, 0.347 respectively). The change of the axial length in the myopic eye(0.46±0.28 mm)was greater than that in the non- high myopic eye(0.11 ± 0.34 mm; P <0.001).CONCLUSION: High myopic eyes showed more myopic shift than non-high myopic eyes after *** cause of myopic shift in high myopic eyes seems tobe attributed to actual elongation of the axial length in high myopia.

关键词： axial length high myopic eyes keratometry phacovitrectomy refractive errors

Growth of BaTiO_3-Ag hybrid composite films at room temperature by aerosol deposition

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中国有色金属学会会刊：英文版 2012年第S3期22卷 735-739页

作者： Young Joon yoon Sung Hwan CHO Jihoon kiM Hyo tae kiM Hong Koo BAIK Jong-Hee kiM Nano-Convergence Intelligence Material Team Korea Institute of Ceramic Engineering and Technology Division of Advanced Materials Engineering Kongju National University Department of Materials Science and Engineering Yonsei University

Barium titanate (BaTiO3) and silver (Ag) composite film with high dielectric constant was grown at room temperature by an aerosol deposition *** dielectric constant increases by 0.5 times after adding Ag to the BaTiO3 matrix,compared with pure *** high dielectric constant can be attributed to the percolation effect of Ag inclusions in the BaTiO3 *** Ag was present in the form of discrete layer in the BaTiO3 *** dielectric properties of BaTiO3 Ag were discussed in detail taking into account the changes in microstructures.

关键词： composites percolation aerosol deposition BaTiO3 Ag