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Photodynamic therapy prolongs metal stent patency in patients with unresectable hilar cholangiocarcinoma

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World Journal of Gastroenterology 2012年第39期18卷 5589-5594页

作者： tae yoon Lee Young Koog Cheon Chan Sup Shim Young Deok Cho Digestive Disease Center Department of Internal MedicineKonkuk University Medical CenterKonkuk University School of MedicineSeoul 143-729South Korea Institute for Digestive Research and Digestive Disease Center Soonchunhyang University College of MedicineSeoul 140-743South Korea

AIM:To evaluate the effect of photodynamic therapy (PDT) on metal stent patency in patients with unresectable hilar cholangiocarcinoma (CC). METHODS:This was a retrospective analysis of patients with hilar CC referred to our institution from December, 1999 to January, 2011. Out of 232 patients, thirty-three patients with unresectable hilar CC were treated. Eighteen patients in the PDT group were treated with uncovered metal stents after one session of PDT. Fifteen patients in the control group were treated with metal stents alone. Porfimer sodium (2 mg/kg) was administered intravenously to PDT patients. Fortyeight hours later, PDT was administered using a diffusing fiber that was advanced across the tumor by either endoscopic retrograde cholangiopancreatography or percutaneous cholangiography. After performance of PDT, uncovered metal stents were inserted to ensure adequate decompression and bile drainage. Patient survival rates and cumulative stent patency were calculated using Kaplan-Meier analysis with the log-rank test. RESULTS:The PDT and control patients were comparable with respect to age, gender, health status, pretreatment bilirubin, and hilar CC stage. When compared to control, the PDT group was associated with significantly prolonged stent patency (median 244 ± 66 and 177 ± 45 d, respectively, P = 0.002) and longer patient survival (median 356 ± 213 and 230 ± 73 d, respectively, P = 0.006). Early complication rates were similar between the groups (PDT group 17%, control group 13%) and all patients were treated conservatively. Stent malfunctions occurred in 14 PDT patients (78%) and 12 control patients (80%). Of these 26 patients, twenty-two were treated endoscopically and four were treated with external drainage. CONCLUSION:Metal stenting after one session of PDT may be safe with acceptable complication rates. The PDT group was associated with a significantly longer stent patency than the control group in patients with unresectable hilar CC.

关键词： Bile duct cancer Palliative endoscopic stent-ing Photodynamic therapy Outcome

One-year clinical outcomes in invasive treatment strategies for acute ST-elevation myocardial infarction complicated by cardiogenic shock in eld-erly patients

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Journal of Geriatric Cardiology 2013年第3期10卷 235-241页

作者： Yeon Pyo Yoo ki-Woon Kang Hyeon Soo yoon Jin Cheol Myung Yu Jeong Choi Won Ho kim Sang Hyun Park Kyung tae Jung Myung Ho Jeong Division of Cardiology Hyosung General Hospital 162-90 Sandang dong Chungju 360-802 South Korea Division of Cardiology Eulji University Hospital Eulji University School of Medicine 1306 Dunsan dong Seogu Daejeon 302-120 South Korea Division of Cardiology Worker`s Compensation&Welfare Service Hospital 833 Gaejok-ro Daejeon 306-060 South Korea Division of Cardiology Chunman National University Hospital 42 Jaebong-ro Kwangju 501-757 South Korea

Objective To investigate the clinical outcomes of an invasive strategy for elderly (aged≥75 years) patients with acute ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Methods Data on 366 of 409 elderly CS patients from a total of 6,132 acute STEMI cases enrolled in the Korea Acute Myocardial Infarction Registry between January 2008 and June 2011, were collected and analyzed. In-hospital deaths and the 1-month and 1-year survival rates free from major adverse cardiac events (MACE;defined as all cause death, myocardial infarction, and target vessel revascularization) were reported for the patients who had undergone invasive (n=310) and conservative (n=56) treatment strategies. Results The baseline clinical characteristics were not significantly different between the two groups. There were fewer in-hospital deaths in the invasive treatment strategy group (23.5%vs. 46.4%, P<0.001). In addition, the 1-year MACE-free survival rate after invasive treatment was significantly lower compared with the conservative treatment (51%vs. 66%, P=0.001). Conclusions In elderly patients with acute STEMI complicated by CS, the outcomes of invasive strategy are similar to those in younger patients at the 1-year follow-up.

关键词： Acute myocardial infarction Cardiogenic shock Elderly patients

Effects of Initial and Boundary Conditions on Heavy Rainfall Simulation over the Yellow Sea and the Korean Peninsula:Comparison of ECMWF and NCEP Analysis Data Effects and Verification with Dropsonde Observation

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Advances in Atmospheric Sciences 2024年第9期41卷 1787-1803页

作者： Jiwon HWANG Dong-Hyun CHA Donghyuck yoon tae-Young GOO Sueng-Pil JUNG Department of Civil Urban Earth and Environmental Engineering Ulsan National Institute of Science and TechnologyUlsan 44919South Korea Program in Atmospheric and Oceanic Sciences Princeton UniversityPrincetonNew Jersey 08544USA National Institute of Meteorological Sciences NIMSJeju 63568South Korea

This study evaluated the simulation performance of mesoscale convective system(MCS)-induced precipitation,focusing on three selected cases that originated from the Yellow Sea and propagated toward the Korean *** evaluation was conducted for the European Centre for Medium-Range Weather Forecasts(ECMWF)and National Centers for Environmental Prediction(NCEP)analysis data,as well as the simulation result using them as initial and lateral boundary conditions for the Weather Research and Forecasting ***,temperature and humidity profiles from 3D dropsonde observations from the National Center for Meteorological Science of the Korea Meteorological Administration served as validation *** showed that the ECMWF analysis consistently had smaller errors compared to the NCEP analysis,which exhibited a cold and dry bias in the lower levels below 850 *** model,in terms of the precipitation simulations,particularly for high-intensity precipitation over the Yellow Sea,demonstrated higher accuracy when applying ECMWF analysis data as the initial *** advantage also positively influenced the simulation of rainfall events on the Korean Peninsula by reasonably inducing convective-favorable thermodynamic features(i.e.,warm and humid lower-level atmosphere)over the Yellow *** conclusion,this study provides specific information about two global analysis datasets and their impacts on MCS-induced heavy rainfall simulation by employing dropsonde observation ***,it suggests the need to enhance the initial field for MCS-induced heavy rainfall simulation and the applicability of assimilating dropsonde data for this purpose in the future.

关键词： initial conditions dropsonde heavy rainfall forecast global model analysis evaluation

Soybean isoflavones alter parvalbumin in hippocampus of mid-aged normal female,ovariectomized female,and normal male rats

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Acta Pharmacologica Sinica 2006年第1期27卷 59-65页

作者： In Koo HWANG yoon-bok LEE ki-yeon YOO tae-cheon KANG Soon Sung LIM Sang Moo kiM Heon-soo SOHN Woo-jung kiM Hyun Kyung SHIN Moo Ho WON Department of Anatomy College of MedicineHallym UniversityChunchon 200-702Korea Department of Laboratory Animal Research.Central Research Institute Dr Chung's Food Co Ltd.Cheongju 361-782Korea Division of Life Science and Silver Biotechnology Research Center Korea Faculty of Marine Bioseience and Technology.Kangneung National University Kangneung 210-702Korea Faculty of Food Science and Technology College of Life SciencesSejong UniversitySejong 143-747Korea

Aim:To investigate the long-term effect of soybean isoflavones on changes inparvalbumin (PV) immunoreactivity in the hippocampus in normal female,ovariec-tomized (OVX) female and normal male ***:Ten-month-old rats wereassigned to one of 9 groups (n=7 in each group) based on body weight using arandomized complete-block *** groups were:control diet-treated females,OVX females,and males;0.3g/kg isoflavone-treated females,OVX females,andmales;and 1.2g/kg isoflavone-treated females,OVX females,and *** PVimmunostaining was conducted by using the standard avidin-biotin ***:PV immunoreactivity and the number of PV-immunoreactiveneurons in all the groups after isoflavone treatment were significantly changed inthe hippocampal CA1 region and in the dentate gyrus,but not in the hippocampalCA2/3 *** immunoreactivity and the number of PV-immunoreactive neu-rons in the control diet OVX females were similar to those in the control diet,andwere greater than those in the control diet normal *** immunoreactivityand the number of PV-immunoreactive neurons in all the isoflavone-treated groupsdecreased dose-dependently after isoflavone ***:Long-termadministration of isoflavones may induce a reduction of PV in interneurons in thehippocampal CA1 region and in the dentate *** reduction of PV in theseregions suggests that the long-term administration of isoflavones may cause achange in calcium homeostasis in the hippocampal CA1 region and in the dentategyrus.

关键词： isoflavones ovariectomy hippocampus immunohistochemistry

A Study on Energy Saving Rate for Variable Speed Condition of Multistage Centrifugal Pump

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Journal of Thermal Science 2015年第6期24卷 566-573页

作者： Sang-Ho Suh Rakibuzzaman Kyung-Wuk kim Hyoung-Ho kim In Sik yoon Min-tae Cho Department of Mechanical Engineering Soongsil University Dooch Co. 295 Sagok-ri Jangan- Myeon Hwaseong-si Gyeonggi-do 445-942 South Korea

Centrifugal pumps are being widely used in many industrial and commercial *** of these pumps are being operated at constant speed but could provide energy savings through adjustable speed *** purpose of this study was to get the energy saving rates of the multistage centrifugal pump with variable speed *** this investigation an experimental set up of variable flow and pressure system was made to get energy saving rates and numerical analyses are applied to validate the pump *** energy saving and therefore the cost saving depends on the specific duty cycle of which the machine *** cycle is the proportion of time during which a component,device and system is *** duty cycle segmented into different flow rates and weighting the average value for each segment by the interval *** system was operated at 50%or less of the pump *** input power of the system was carried out by pump characteristics curve of each operating *** energy consumption was done by the product of specific duty cycle and the input power of the system for constant speed and variable speed drive *** total energy consumed for constant speed drive pump was 75,770 k *** and for variable speed drive pump was 31,700 k *** total energy saving of the system was 44,070 k *** or 58.16%***,this paper suggests a method of implementing an energy saving on variable-flow and pressure system of the multistage centrifugal pump.

关键词： Multistage Centrifugal Pump Performance Analysis Energy saving rate SST Model Duty Cycle

Rapid assessment checklist for green roof ecosystem services in Bangkok,Thailand

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Ecological Processes 2020年第1期9卷 205-221页

作者： Rattanapan Phoomirat Nipada Ruankaew Disyatat tae yoon Park Dong Kun Lee Pongchai Dumrongrojwatthana Biological Sciences Program Faculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Department of Biology Faculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Graduate School of Education Yonsei UniversitySeoul 03722Republic of Korea Department of Landscape Architecture and Rural System Engineering Seoul National UniversitySeoul 08826Republic of Korea

Background:A green roof is a man-made ecosystem created when a rooftop is covered with substrate and *** green roof ecosystems(GREs)are able to provide ecosystem services,there is currently no assessment tool available to specifically evaluate ***,the aim of this study was to develop a rapid assessment checklist(RAC)to assess GRE services(GRES),which was developed and tested on 10 green roofs in Bangkok,***:The RAC consisted of 46 proxy indicators(33 qualitative and 13 quantitative indicators)encompassing various aspects of *** GRES values or scores varied according to structural differences in the green *** average score(from a maximum of 100)of total ecosystem services was 61±7,which could be inferred as a good performance in ecosystem service *** highest scores were obtained from the regulating services at 68±*** lowest average score was 53±11 from the provisioning ***:The RAC was able to evaluate the levels of GRES provided by the selected green roofs,enabling the meaningful comparison of their potential capability to provide ***,this RAC could be an innovative tool for evaluation of four categories of GRES.

关键词： Vegetated roof Evaluation Composite indicator Urban ecosystem Ecosystem management

Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 384-386页

作者： Jin A Choi Yi Ryeung Park tae yoon La Department of Ophthalmology St.Vincent Hospital College of Medicine Catholic University of Korea SuwonKyonggi-do 442-060 Korea

Dear Sir,Iam Jin A Choi,from the Department of Ophthalmology of *** Hospital of Suwon,Kyungki-do,South Korea.I write to present a case report of a young female treated with the diagnosis of Posner-Schlossman syndrome for several years,in which she was ultimately proved to have iridocorneal endothelial(ICE)***-Schlossman syndrome(PS syndrome)is characterized by recurrent attacks of mild anterior uveitis with marked elevation of intraocular pressure(IOP)[1].The exact etiology of this syndrome is not fully established ***,the possible role of herpes simplex virus(HSV)is suggested by a study that revealed DNA evidence of the virus in all aqueous specimens of patients during acute attacks in PS syndrome[1,2].ICE is a spectrum of disease that

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Osteoporosis and bone fractures in alcoholic liver disease:A meta-analysis

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World Journal of Gastroenterology 2015年第13期21卷 4038-4047页

作者： Chang Seok Bang In Soo Shin Sung Wha Lee Jin Bong kim Gwang Ho Baik ki tae Suk Jai Hoon yoon Yeon Soo kim Dong Joon kim Department of Internal Medicine Hallym University College of MedicineChuncheon 200-704South Korea College of Education Jeonju UniversityJeonju 560-759South Korea

AIM: To evaluate the association between alcoholic liver disease(ALD) and bone fractures or osteoporosis. METHODS: Non-randomized studies were identified from databases(Pub Med, EMBASE, and the Cochrane Library). The search was conducted using Boolean operators and keywords, which included "alcoholic liver diseases", "osteoporosis", or "bone fractures". The prevalence of any fractures or osteoporosis, and bone mineral density(BMD) were extracted and analyzed using risk ratios and standardized mean difference(SMD). A random effects model was applied. RESULTS: In total, 15 studies were identified and analyzed. Overall, ALD demonstrated a RR of 1.944(95%CI: 1.354-2.791) for the development of bone fractures. However, ALD showed a RR of 0.849(95%CI: 0.523-1.380) for the development of osteoporosis. BMD was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD(SMD in femur-BMD:-0.172, 95%CI:-0.453-0.110; SMD in spine-BMD:-0.169, 95%CI:-0.476-0.138). Sensitivity analyses showed consistent results. CONCLUSION: Current publications indicate significant associations between bone fractures and ALD, independent of BMD or the presence of osteoporosis.

关键词： Alcoholic liver diseases Bone fractures Osteoporos

Fabrication of curved micro structures on photoresist layer

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 100-103页

作者： Jae Sung yoon tae-Jin JE Doo-Sun CHOI Sung Hwan CHANG Kyung-Hyun WHANG Nano Mechanical Systems Research Division Korea Institute of Machinery and Materials (KIMM) Daejeon 305-343 Korea

A novel fabrication process for micro patterns with curvature was introduced. The curved structures were made by compensating rectangular micro structures with liquid photoresist layer. Because of the surface tension of the liquid in micro scale, various shapes of meniscus can he made on the micro channels. The micro channels were made on the silicon suhstrate in advance, and then the liquid layer was coated on the micro channels. From the nature of liquid behavior, the curved patterns with smooth surface are obtained, which cannot be made easily with the conventional mechanical machining, as well as with the microfabrication processes, such as wet and dry etching. With this principle, it is expected that the smooth and curved surfaces can be made by simple processes and the results can be applied widely, such as optical patterns.

关键词： micro pattern liquid layer MEMS micro channel silicon substrate