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Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

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Journal of Integrative Medicine 2024年第5期22卷 600-613页

作者： Mijung Yeom Sora Ahn Dae-Hyun Hahm sun-Young Jang Se Hoon Jang Su-Yang Park Jae-Hwan Jang Jihan Park Ju-Young Oh In-Seon Lee Kyuseok kim Soon-Kyeong kwon Hi-Joon Park Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee University Department of Physiology School of MedicineKyung Hee University BioNanocomposite Research Center Kyung Hee University Department of Science in Korean Medicine College of Korean MedicineGraduate SchoolKyung Hee University College of Korean Medicine Kyung Hee University Department of Ophthalmology Otorhinolaryngology and Dermatology of Korean MedicineCollege of Korean MedicineKyung Hee University Division of Applied Life Science (BK21) Gyeongsang National University Department of Anatomy & Information Sciences College of Korean MedicineKyung Hee University

Objective: Atopic dermatitis(AD) is a chronic inflammatory skin disease that may be linked to changes in the gut microbiome. Acupuncture has been proven to be effective in reducing AD symptoms without serious adverse events, but its underlying mechanism is not completely understood. The purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut ***: AD-like skin lesions were induced by applying MC903 topically to the cheek of the *** was done at the Gok-Ji(LI11) acupoints. AD-like symptoms were assessed by lesion scores,scratching behavior, and histopathological changes; intestinal barrier function was measured by fecal output, serum lipopolysaccharide levels, histopathological changes, and mRNA expression of markers involved in intestinal permeability and inflammation. Gut microbiota was profiled using 16S rRNA gene sequencing from fecal ***: Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening, and also significantly altered gut microbiota structure as revealed by β-diversity indices and analysis of similarities. These beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated mice. Interestingly, AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability, atrophy of the mucosal structure(reduced villus height and crypt depth), decreased expression of tight junctions and mucus synthesis genes, and increased expression of inflammatory mediators in the ileum. Acupuncture attenuated these abnormalities, which was gut ***: Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier, providing new perspective for non-phar

关键词： Acupuncture Atopic dermatitis Gut microbiota Intestinal barrier function

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A Bioprocessed Black Rice Bran Glutathione-Enriched Yeast Extract Protects Rats and Mice against Alcohol-Induced Hangovers

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Food and Nutrition Sciences（食品与营养科学） 2021年第3期

作者： sung Phil kim Ju Ryeong Lee ki sun kwon Yeo Jin Jang Jeanman kim Keun Hyung Yu sun Yeop Lee Mendel Friedman

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Bioprocessed Black Rice Bran Potentiates the Growth Inhibitory Activity of an Immune Checkpoint Inhibitor against Murine Colon Carcinoma

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Food and Nutrition Sciences（食品与营养科学） 2023年第12期

作者： Kyung Hee Lee ki sun kwon Woon Sang Hwang Wha Young Lee Jeanman kim Sang Jong Lee sung Phil kim Mendel Friedman

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Inetetamab combined with pyrotinib and chemotherapy in the treatment of breast cancer brain metastasis: A case report

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World Journal of Clinical Cases 2024年第3期12卷 575-581页

作者： Qing-Qing Dou Ting-Ting sun Guo-Qiang Wang Wei-Bing Tong Graduate Student Institute Inner Mongolia Medical UniversityHohhot 010000Inner Mongolia Autonomous RegionChina Central Breast Area B Beijing University Cancer Hospital Inner Mongolia HospitalHohhot 010000Inner Mongolia Autonomous RegionChina

BACKGROUND Breast cancer brain metastasis(BCBM)is an advanced breast disease that is difficult to treat and is associated with a high risk of *** prognosis is usually poor,with reduced quality of *** this context,we report the case of a patient with HER-2-positive BCBM treated with a macromolecular mAb(ine-tetamab)combined with a small molecule tyrosine kinase inhibitor(Tki).CASE SUMMARY The patient was a 58-year-old woman with a 12-year history of type 2 *** was compliant with regular insulin treatment and had good blood glucose *** patient was diagnosed with invasive carcinoma of the right breast(T3N1M0 stage IIIa,HER2-positive type)through aspiration biopsy of the ipsilateral breast due to the discovery of a breast tumor in February *** showed ER(-),PR(-),HER-2(3+),and ki-67(55-60%+).Preoperative neoadjuvant chemotherapy,i.e.,the AC-TH regimen(epirubicin,cyclophosphamide,docetaxel-paclitaxel,and trastuzumab),was administered for 8 *** underwent modified radical mastectomy of the right breast in November 2019 and received tocilizumab targeted therapy for 1 *** metastasis was found 9 mo after *** underwent brain metastasectomy in August *** showed ER(-)and PR.(-),HER-2(3+),and ki-67(10-20%+).In November 2020,the patient experienced headache *** an examination,tumor recurrence in the original surgical region of the brain was observed,and the patient was treated with inetetamab,pyrotinib,and ***-brain radiotherapy was *** patient and her family refused radiotherapy for personal *** September 2021,a routine examination revealed that the brain tumor was considerably *** original systemic treatment was continued and combined with intensity-modulated radiation therapy for brain metastases,followed by regular hospitalization and routine *** patient’s condition is generally stable,and she has a relatively high qua

关键词： Breast cancer brain metastasis Resistance to trastuzumab Macromolecule inetetamab Small molecule tyrosine kinase inhibitor Radiation therapy HER2-positive Case report

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Salt Tolerance in Rice: Focus on Mechanisms and Approaches

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Rice science 2017年第3期24卷 123-144页

作者： Inja Naga Bheema Lingeswara REDDY Beom-ki kiM In-sun YOON Kyung-Hwan kiM Taek-Ryoun kwon Genetic Engineering Division Department of Agricultural Biotechnology National Institute of Agricultural Sciences Rural Development Administration Jeonju-54874 South Korea

Salt tolerance is an important constrain for rice, which is generally categorized as a typical glycophyte. Soil salinity is one of the major constraints affecting rice production worldwide, especially in the coastal areas. Susceptibility or tolerance of rice plants to high salinity is a coordinated action of multiple stress responsive genes, which also interacts with other components of stress signal transduction pathways. Salt tolerant varieties can be produced by marker-assisted selection or genetic engineering by introducing salt-tolerance genes. In this review, we have updated on mechanisms and genes which can help in transferring of the salt tolerance into high-yielding rice varieties. We have focused on the need for integrating phenotyping, genomics, metabolic profiling and phenomics into transgenic and breeding approaches to develop high-yielding as well as salt tolerant rice varieties.

关键词： rice mechanism salinity salt tolerance yield gene protein

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Identification of Rice Accessions Associated with K+/Na+ Ratio and Salt Tolerance Based on Physiological and Molecular Responses

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Rice science 2017年第6期24卷 360-364页

作者： Inja Naga Bheema Lingeswara REDDY sung-Mi kiM Beom-ki kiM In-sun YOON Taek-Ryoun kwon Genetic Engineering Division Department of Agricultural Biotechnology National Institute of Agricultural Sciences Rural Development Administration Jeonju 54874 South Korea

The key for rice plant survival under Na Cl salt stress is maintaining a high K^+/Na^+ ratio in its cells. Selection for salt tolerance rice genotypes based on phenotypic performance alone will delay in progress in breeding. Use of molecular markers in tandem with physiological studies will help in better identification of salt tolerant rice accessions. Eight rice accessions along with the check Dongjin were screened using 1/2 Yoshida solution with 50 mmol/L NaCl at the seedling stage. The accessions IT001158, IT246674, IT260533 and IT291341 were classified as salt tolerant based on their K^+/Na^+ ratios. Seventeen SSR markers reported to be associated with K^+/Na^+ ratio were used to screen the accessions. Five SSR markers(RM8053, RM345, RM318, RM253 and RM7075) could differentiate accessions classified based on their K^+/Na^+ ratios. Banding pattern of the accessions was scored compared to the banding pattern of Dongjin. The study differentiated accessions based on their association of K^+/Na^+ ratio with molecular markers which are very reliable. These markers can play a significant role in screening large set of rice germplasms for salt tolerance and also help in identification of high-yielding varieties with better salt tolerance. The salt tolerant accessions can be taken forward into developing better varieties by conventional breeding and exploring genes for salt tolerance.

关键词： rice salinity K+/Na+ ratio simple sequence repeat salt tolerance

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Effect of polyethylene glycol on electrochemically deposited trivalent chromium layers

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中国有色金属学会会刊：英文版 2009年第4期19卷 819-823页

作者： Joo-Yul LEE Man ki M Sik-Chol kwon Department of Surface Technology Korea Institute of Materials Science

The structural characteristics of the trivalent chromium deposits and their interfacial behavior in the plating solution with and without polyethylene glycol molecules were observed by using various electrochemical methods such as cyclic voltammetry,open circuit potential transition,electrochemical impedance spectroscopy,scanning electron microscopy and X-ray photoelectron *** is shown that the polyethylene glycol molecules make the reductive current density lower in the trivalent chromium plating system and promote a hydrogen evolution reaction through their adsorption on the electrode *** the trivalent chromium layer formed from the polyethylene glycol-containing solution has somewhat higher density of cracks on its surface and results in a lower film resistance,lower polarization resistance,and higher capacitance in a corrosive *** is also revealed that the formation of chromium carbide layer is facilitated in the presence of polyethylene glycol,which means easier electrochemical codeposition of chromium and carbon,not single chromium deposition.

关键词：聚乙二醇电沉积层三价铬扫描电子显微镜电化学阻抗谱电极表面电化学方法乙二醇溶液

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Factors associated with use of gastric cancer screening services in Korea

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World Journal of Gastroenterology 2009年第29期15卷 3653-3659页

作者： Young Min kwon Hyung Taek Lim kiheon Lee Be Long Cho Min sun Park ki Young Son Sang Min Park Department of Family Medicine Seoul National University Hospital Seoul National University College of Medicine 28 Yunkeon-dong Jongro-gu Seoul 110-744 South Korea Department of Medicine Yonsei University College of Medicine 134 Shinchon-dong Seodaemun-gu Seoul 120-752 South Korea Department of Family Medicine Seoul National University Bundang Hospital and Department of the History of Medicine and Medical Humanities Seoul National University College of Medicine 166 Gumi-ro Bundang-gu Seongnam-si Gyeonggi-do 463-707 South Korea

AIM: To identify the factors associated with participation in gastric cancer screening programs. METHODS: Using data from the Korea National Health and Nutrition Examination Survey 2005 (KNHANES Ⅲ), a nationwide health-related surveyin Korea, a cross-sectional study was performed to investigate the multiple factors associated with gastric cancer screening attendance among persons aged at least 40 years. The study population included 4593 individuals who completed a gastric cancer screening questionnaire and had no previous cancer history. Four groups ofindividual-level or environmental level covariates were considered as potential associated ***: Using KNHANES Ⅲdata, an estimated31.71% of Korean individuals aged at least 40 years adhered to gastric cancer screening recommendations. Subjects who graduated from elementary school[adjusted odds ratio (aOR), 1.66; 95% CI: 1.21-2.26], middle/high school (aOR, 1.38; 95% CI: 1.01-1.89), and university or higher (aOR, 1.64; 95% CI: 1.13-2.37) were more likely to undergo gastric cancer screening than those who received no formal education at all. The population with the highest income tertile had more attendance at gastric screening compared to those with the lowest income tertile (aOR, 1.36; 95% CI: 1.06-1.73). Gastric screening was also negatively associated with excessive alcohol consumption (aOR, 0.71; 95% CI: 0.53-0.96). A positive attitude to preventive medical evaluation was significantly associated with better participation in gastric cancer screening programs (aOR, 5.26; 95% CI: 4.35-6.35). CONCLUSION: Targeted interventions for vulnerable populations and public campaigns about preventive medical evaluation are needed to increase gastric cancer screening participation and reduce gastric cancer mortality.

关键词： Socioeconomic factors Health behavior Health status disparity Mental health Early detectionof cancer

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Development of Non-Dissipative Direct Time Integration Method for Structural Dynamics Application

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Computer Modeling in Engineering & Sciences 2019年第1期118卷 41-89页

作者： sun-Beom kwon Jae-Myung Lee Department of Naval Architecture and Ocean Engineering Pusan National UniversityJangjeon-DongGeumjeong-GuBusan 609-735Korea.

A direct time integration scheme based on Gauss-Legendre quadrature is proposed to solve problems in linear structural *** proposed method is a oneparameter non-dissipative *** stability,accuracy,and dispersion characteristics are achieved using appropriate values of the *** proposed scheme has second-order accuracy with and without physical ***,its stability,accuracy,and dispersion are *** addition,its performance is demonstrated by the two-dimensional scalar wave problem,the single-degree-of-freedom problem,two degrees-of-freedom spring system,and beam with boundary *** wave propagation problem is solved in the high frequency wave regime to demonstrate the advantage of the proposed *** the proposed scheme is applied to solve the wave problem,more accurate solutions than those of other methods are obtained by using the appropriate value of the *** the single-degree-offreedom system,two degrees-of-freedom system,and the time responses of beam,the proposed scheme can be used effectively owing to its high accuracy and lower computational cost.

关键词： Structural dynamics finite elements direct time integration Gauss-Legendre quadrature non-dissipative scheme.

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Effectiveness and safety of auriculotherapy for breastfeeding: a systematic review

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Journal of Traditional Chinese Medicine 2020年第5期40卷 721-737页

作者： Boram Lee Chan-Young kwon sun Haeng Lee Department of Clinical Korean Medicine Graduate SchoolKyung Hee UniversitySeoul 02453Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Pediatrics of Korean Medicine Kyung Hee University Korean Medicine HospitalKyung Hee University Medical CenterSeoul 02447Republic of Korea

OBJECTIVE:To summarize and critically evaluate the evidence pertaining to the effectiveness and safety of auriculotherapy for ***:We performed a systematic search of10 databases from their inception dates to May 15,*** controlled trials evaluating the effectiveness and safety of auriculotherapy for breastfeeding were *** of bias was assessed using the Cochrane risk of bias ***:This review included 31 randomized controlled trials with 5389 *** to the obvious clinical or statistical heterogeneity,a Meta-analysis was not ***-nine studies compared auriculotherapy plus routine care with routine care *** consistent adjunctive effect of auriculotherapy was observed in increasing the volume of milk production(9 studies showed significant results in favor of auriculotherapy and 5 did not)and serum prolactin level(7 studies showed significant results in favor of auriculotherapy and 2 did not),and in facilitating the initiation of milk secretion(10 studies showed significant results in favor of auriculotherapy and 7 did not).Two studies compared auriculotherapy with no *** as a monotherapy showed significant effects in increasing serum prolactin level and facilitating the onset of milk secretion;however,it was limited and inconclusive because only two studies were included in this *** subgroup analysis of women who underwent cesarean delivery showed inconsistent results with respect to all *** serious adverse events were reported with the use of *** methodological quality of the included studies was generally ***:Although some studies showed positive results,no definite conclusion about the effectiveness and safety of auriculotherapy for breastfeeding could be drawn,owing to the low methodological quality of the included studies and the heterogeneity among ***-scale,well-designed studies are warranted on this topic.

关键词： Breastfeeding Auriculotherapy Systematic review

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