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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Synergistic passivation of MAPbI_(3) perovskite solar cells by compositional engineering using acetamidinium bromide additives

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Journal of Energy Chemistry 2021年第8期30卷 755-762,I0016页

作者： Kyungeun Jung Weon-Sik Chae Jae won Choi ki Chul kim Man-Jong Lee Department of Chemistry Konkuk University143-701 SeoulSouth Korea Department of Advanced Technology Fusion Konkuk University143-701 SeoulSouth Korea Analysis Research Division Daegu CenterKorea Basic Science Institute702-701 DaeguSouth Korea Division of Chemical Engineering Konkuk University05029 SeoulSouth Korea

For the global commercialization of highly efficient and stable perovskite solar cells(PSCs),it is necessary to effectively suppress the formation of various defects acting as nonradiative recombination sources in perovskite light-harvesting *** defects between the charge-selective layer and the perovskite are easily formed in the solution process used to fabricate perovskite *** addition,owing to the difference in thermal expansion coefficients between the substrate and the perovskite film,internal residual tensile stress inevitably occurs,resulting in increased nonradiative ***,a simple compositional engineering scheme for realizing efficient and stable PSCs,which incorporates acetamidinium bromide(AABr)as an additive into the MAPbI_(3) lattice,is *** an additive,AABr has been found to provide synergistic multiple passivation for both internal and interfacial *** was found to effectively release the tensile strain of the MAPbI_(3) film by forming a structure stabilized by NH-I hydrogen bonds,as evidenced by calculations based on density functional theory(DFT).Furthermore,the incorporated AABr additives created a charge carrier recombination barrier to enhance charge collection capability by reducing interfacial ***,a power conversion efficiency(PCE)of 20.18%was achieved using a planar device employing AABr-incorporated MAPbI_(3).This was substantially higher than the 18.32% PCE of a pristine MAPbI_(3)-based ***,unencapsulated PSCs using AABr-incorporated MAPbI_(3) absorbers exhibited excellent long-term stability,maintaining>95% of initial PCE up to 1200 hours in ambient air.

关键词： Acetamidinium bromide Planar perovskite solar cell Tensile stress Interface passivation Recombination barrier

Memristive Devices Based on Two-Dimensional Transition Metal Chalcogenides for Neuromorphic Computing

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Nano-Micro Letters 2022年第4期14卷 29-58页

作者： ki Chang Kwon Ji Hyun Baek Kootak Hong Soo Young kim Ho won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34133Republic of Korea Department of Materials Science and Engineering Institute of Green Manufacturing TechnologyKorea UniversitySeoul 02841Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Two-dimensional(2D)transition metal chalcogenides(TMC)and their heterostructures are appealing as building blocks in a wide range of electronic and optoelectronic devices,particularly futuristic memristive and synaptic devices for brain-inspired neuromorphic computing *** distinct properties such as high durability,electrical and optical tunability,clean surface,flexibility,and LEGO-staking capability enable simple fabrication with high integration density,energy-efficient operation,and high *** review provides a thorough examination of high-performance memristors based on 2D TMCs for neuromorphic computing applications,including the promise of 2D TMC materials and heterostructures,as well as the state-of-the-art demonstration of memristive *** challenges and future prospects for the development of these emerging materials and devices are also *** purpose of this review is to provide an outlook on the fabrication and characterization of neuromorphic memristors based on 2D TMCs.

关键词： Two-dimensional materials Memristors Neuromorphic computing Artificial synapses Transition metal chalcogenides

Influence of a UV-ozone treatment on amorphous SnO_(2) electron selective layers for highly efficient planar MAPbI3 perovskite solar cells

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Journal of Materials Science & Technology 2020年第24期59卷 195-202页

作者： Kyungeun Jung Du Hyeon kim Jaemin kim Sunglim Ko Jae won Choi ki Chul kim Sang-Geul Lee Man-Jong Lee Department of Advanced Technology Fusion Konkuk UniversitySeoul05029Republic of Korea a Department of Chemistry Konkuk UniversitySeoul05029Republic of Korea Department of Mechanical Design and Production Engineering Konkuk UniversitySeoul05029Republic of Korea Division of Chemical Engineering Konkuk UniversitySeoul05029Republic of Korea Daegu Center Korea Basic Science InstituteDaegu41566Republic of Korea

The effect of ultraviolet-ozone(UVO)irradiation on amorphous(am)SnO_(2) and its impact on the photoconversion efficiency of MAPbI3-based perovskite solar cells were investigated in *** treatment was found to increase the amount of chemisorbed oxygen on the am-SnO_(2) surface,reducing the surface energy and contact *** changes in the am-SnO_(2) surface lowered the Gibbs free energy for the densification of perovskite films and facilitated the formation of homogeneous perovskite *** addition,the Fermi energy of the UVO-treated am-SnO_(2) shifted upwards to achieve an ideal band offset for MAPbI3,which was verified by theoretical calculations based on the density functional *** achieved a champion efficiency of 19.01% with a statistical reproducibility of 17.01±1.34% owing to improved perovskite film densification and enhanced charge transport/extraction,which is considerably higher than the 13.78±2.15% of the ***,UVO-treated,am-SnO_(2)-based devices showed improved stability and less hysteresis,which is encouraging for the future application of up-scaled perovskite solar cells.

关键词： UV-ozone Amorphous SnO_(2) Electron selective layers Planar perovskite solar cells Hysteresis

A New Encryption Mechanism Supporting the Update of Encrypted Data for Secure and Efficient Collaboration in the Cloud Environment

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 813-834页

作者： Chanhyeong Cho Byeori kim Haehyun Cho Taek-Young Youn Department of Cyber Security Dankook UniversityYongin16890Republic of Korea Department of Software Soongsil UniversitySeoul07027Republic of Korea

With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly ***,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient *** paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative *** bundle includes updated information,allowing only the updated portions to be reencrypted when changes *** encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates *** proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext *** utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those *** approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data *** validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size *** show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size ***,our security evaluation confirms that this method provides robust protection against both passive and active attacks.

关键词： Cloud collaboration mode of operation data update efficiency

Unlocking power of neighboring vacancies in boosting hydrogen evolution reactions on two-dimensional NiPS3 monolayer

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eScience 2024年第3期4卷 104-115页

作者： Hyun Gu Han Jae won Choi Minsu Son ki Chul kim Computational Materials Design Laboratory Department of Chemical EngineeringKonkuk UniversitySeoul 05029The Republic of Korea Division of Chemical Engineering Konkuk UniversitySeoul 05029The Republic of Korea

This study investigates the effect of defect engineering on the catalytic activity of a NiPS3 monolayer catalyst for the hydrogen evolution reaction(HER).Three different types of vacancies on the basal plane of the monolayer are explored through a multi-step mechanism involving the dissociative adsorption of a water molecule and subsequent electrochemical adsorption of the dissociated ***-formation of vacancies in both Ni and S sites is found to be the most effective in enhancing the catalytic performance of the monolayer.A key resource for the reaction thermodynamics is the S-substitution-like physisorption of a water molecule on a vacant S site,followed by the dissociative occupation of OH and H into vacant sites of S and Ni elements,boosted by the NiS di-vacancy configuration with low activation energy *** reveals the highest contribution of bonding orbitals to the monolayer-H bond makes it the most desirable defect engineering approach for transition metal phosphorus chalcogenides with high HER ***,this study highlights the significance of controlled defect engineering in augmenting the catalytic performance of NiPS3 monolayer catalysts for HER.

关键词： Hydrogen evolution reaction Defect engineering Transition metal phosphorus trichalcogenide Density functional theory Reaction thermodynamics

Optimization of rotor shape for constant torque improvement and radial magnetic force minimization

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Journal of Central South University 2012年第2期19卷 357-364页

作者： CHO Gyu-won WOO Seok-hyun JI Seung-hun PARK Kyoung-won JANG ki-bong kim Gyu-tak School of Mechatronics Changwon National University

The design of notch and barrier was optimized in order to improve the characteristics of constant torque while minimizing the cogging torque that occurs as a result of teeth and slot structure. The barrier was installed in order to minimize the cogging torque and torque ripple by finite element method (FEM) with a reduced barrier width toward the center of magnetic pole. The position and width of notch, which can offset cogging torque, can be calculated with energy distribution of air-gap using Fourier series. The optimized model demonstrates a 60% decrease in the cogging torque, a 75.3% decrease in the torque ripple and a 3% increase in the operating torque when compared with the basic model.

关键词： permanent magnet synchronous motor barrier notch radial magnetic force cogging torque

Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-na?ve Korean patients infected with genotype C2

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World Journal of Gastroenterology 2017年第23期23卷 4222-4232页

作者： Ji-Eun kim So-Young Lee Hong kim ki-Jeong kim won-Hyeok Choe Bum-Joon kim Department of Biomedical Sciences Microbiology and Immunologyand Liver Research InstituteSeoul National University College of Medicine Department of Microbiology School of MedicineJoong-Ang University Department of Internal Medicine Konkuk University School of Medicine

AIM To report naturally occurring mutations in the reverse transcriptase region(RT) of hepatitis B virus(HBV) polymerase from treatment na?ve Korean chronic patients infected with genotype *** Here, full-length HBV reverse transcriptase RT sequences were amplified and sequenced from 131 treatment na?ve Korean patients chronically infected with hepatitis B genotype C2. The patients had two distinct clinical statuses: 59 patients with chronic hepatitis(CH) and 72 patients with hepatocellular carcinoma(HCC). The deduced amino acids(AAs) at42 previously reported potential nucleos(t)ide analog resistance(NAr) mutation positions in the RT region were analyzed. RESULTS Potential NAr mutations involving 24 positions were found in 79 of the 131 patients(60.3%). Notably, AA substitutions at 2 positions(rt184 and rt204) involved in primary drug resistance and at 2 positions(rt80 and rt180) that functioned as secondary/compensatory mutations were detected in 10 patients(1 CH patient and 9 HCC patients) and 7 patients(1 CH and 6 HCC patients), respectively. The overall mutation frequencies in the HCC patients(3.17%, 96/3024 mutations) were significantly higher than the frequencies in the CH patients(2.09%, 52/2478 mutations)(P = 0.003). In addition, a total of 3 NAr positions, rt80, rt139 and rt204 were found to be significantly related to HCC from treatment na?ve Korean patients. CONCLUSION Our data showed that naturally occurring NAr mutations in South Korea might contribute to liver disease progression(particularly HCC generation) in chronic patients with genotype C2 infections.

关键词： Hepatitis B virus Polymerase Reverse transcriptase Potential nucleos(t)ide analog resistance Chronic hepatitis Hepatocellular carcinoma

Self-supported VO_(2) on polydopamine-derived pyroprotein-based fibers for ultrastable and flexible aqueous zinc-ion batteries

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Carbon Energy 2024年第7期6卷 1-13页

作者： Jeong Seok Yeon Sul ki Park Shinik kim Santosh VMohite won Il kim Gun Jang Hyun-Seok Jang Jiyoung Bae Sang Moon Lee won GHong Byung Hoon kim Yeonho kim Ho Seok Park School of Chemical Engineering College of EngineeringSungkyunkwan UniversityGyeonggi-doRepublic of Korea Department of Engineering University of CambridgeCambridgeUK Department of Applied Chemistry Konkuk UniversityChungjuRepublic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)College of Natural SciencesUlsanRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Intelligent Sensor Convergence Research Center Incheon National UniversityIncheonRepublic of Korea Institute of Basic Science Incheon National UniversityIncheonRepublic of Korea Division of Material Analysis and Research Korea Basic Science InstituteDaejeonRepublic of Korea

A conventional electrode composite for rechargeable zinc-ion batteries(ZIBs)includes a binder for strong adhesion between the electrode material and the current ***,the introduction of a binder leads to electrochemical inactivity and low electrical conductivity,resulting in the decay of the capacity and a low rate *** present a binder-and conducting agent-free VO_(2) composite electrode using in situ polymerization of dopamine on a flexible current collector of pyroprotein-based *** as-fabricated composite electrode was used as a substrate for the direct growth of VO_(2) as a self-supported form on polydopamine-derived pyroprotein-based fibers(pp-fibers@VO_(2)(B)).It has a high conductivity and flexible nature as a current collector and moderate binding without conventional binders and conducting agents for the VO_(2)(B) *** addition,their electrochemical mechanism was *** energy storage is induced by Zn^(2+)/H^(+) coinsertion during discharging,which can be confirmed by the lattice expansion,the formation of by-products including Zn_(x)(OTf)_(y)(OH)_(2x−y)·nH_(2)O,and the reduction of V^(4+)to V^(3+).Furthermore,the assembled Zn//pp-fibers@VO_(2)(B) pouch cells have excellent flexibility and stable electrochemical performance under various bending states,showing application possibilities for portable and wearable power sources.

关键词： aqueous battery binder free conducting agent‐free flexible electrode zinc‐ion battery