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Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis

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Cellular & Molecular Immunology 2024年第3期21卷 227-244页

作者： Kang-Gu Lee Bong-ki Hong Saseong Lee Naeun Lee Seung-whan kim Donghyun kim Wan-Uk kim Center for Integrative Rheumatoid Transcriptomics and Dynamics The Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Department of Pharmacology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medical Institute of Technology University of UlsanSeoul 05505Republic of Korea Department of Microbiology and Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Diseases Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheumatology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Transcriptional coactivators regulate the rate of gene expression in the *** receptor coactivator 6(NCOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but its role in innate immunity and inflammatory diseases remains ***,we demonstrated that NCOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory ***,nuclear NCOA6 was found to translocate to the cytoplasm in activated monocytes and then become incorporated into the inflammasome with NLRP3 and ASC,forming cytoplasmic ***,NCOA6 associated with the ATP hydrolysis motifs in the NACHT domain of NLRP3,promoting the oligomerization of NLRP3 and ASC and thereby instigating the production of IL-1βand active *** note,Ncoa6 deficiency markedly inhibited NLRP3 hyperactivation caused by the Nlrp3^(R258W) gain-of-function mutation in *** ablation of Ncoa6 substantially attenuated the severity of two NLRP3-dependent diseases,folic-induced acute tubular necrosis and crystal-induced arthritis,in *** with these findings,NCOA6 was highly expressed in macrophages derived from gout patients,and NCOA6-positive macrophages were significantly enriched in gout macrophages according to the transcriptome profiling ***,NCOA6 is a critical regulator of NLRP3 inflammasome activation and is therefore a promising target for NLRP3-dependent diseases,including gout.

关键词： Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NACHT domain Gouty arthritis

Divisibility Proper ties of the Semiring of Ideals of an Integral Domain

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Algebra Colloquium 2020年第3期27卷 369-380页

作者： Gyu whan Chang HwanKoo kim Department of Mathematics Education Incheon National University Incheon 22012Korea Division of Computer and Information Engineering Hoseo University Asan 336-795Korea

Let D be an integral domain,F^(+)(D)(resp.,f^(+)(D))be the set of nonzero(resp.,nonzero finitely generated)ideals of D,R_(1)=f+(D)∪{(0)},and R_(2)=F+(D)∪{(0)}.Then(R_(i),㊉,■)for i=1,2 is a commutative semiring with identity under I㊉J=I+J and I■J=ZJ for all I,J∈R_(i).In this paper,among other things,we show that D is a Priifer domain if and only if every ideal of R_(1)is a k-ideal if and only if R_(1)is *** also show that D is a Dedekind domain if and only if R_(2)is a unique factorization semidomain if and only if R_(2)is a principal ideal *** results are proved in a more general setting of star operations on D.

关键词： star operation P*MD *-Dedekind domain Gaussian semiring Bezout semiring unique factorization semidomain principal ideal semidomain

Weldability evaluation and tensile strength estimation model for aluminum alloy lap joint welding using hybrid system with laser and scanner head

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中国有色金属学会会刊：英文版 2012年第S3期22卷 596-604页

作者： Dong-Yoon kim Young-whan PARK Department of Mechanical Engineering Pukyong National University

Aluminum welding using a hybrid system with a laser and scanner welding head was performed under various welding conditions to verify the feasibility of applying an aluminum alloy to a car *** experimental material was 5J32 aluminum alloy,and the laser power,welding speed,and laser incidence angle were used as the control *** weld bead shape and the tensile shear strength were evaluated in order to understand the aluminum lap joint weld *** of variance (ANOVA) was conducted to identify the effect of the process variables on the tensile shear *** strength estimation models using three different regression models were also *** input variables were the laser power,welding speed,and laser incidence angle,and the output was the tensile shear *** the models,the second-order polynomial estimation model had the best estimation performance,and the average error rate of this model was 0.058.

关键词： laser welding scanner remote welding 5J32 aluminum alloy regression model

Integral Domains Whose ω-Integral Closures Are Krull Domains

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Algebra Colloquium 2020年第2期27卷 287-298页

Let D be an integral domain with quotient field K,D be the integral closure of D in K,and D^[w] be the ω-integral closure of D in K;so D ■ D^[w],and equality holds when D is Noetherian or dim(D)=*** Mori-Nagata theorem states that if D is Noetherian,then D is a Krull domain;it has also been investigated when D is a Dedekind *** study integral domains D such that D^[w] is a Krull *** also provide an example of an integral domain D such that D ■ D ■ D^[w],t-dim(D)=1,D is a Priifer multiplication domain with v-dim(D)=2,and D^[w] is a UFD.

关键词： Krull domain ω-integral closure PvMD t-Nagata ring weakly Dedekind domain

ψValuation ideals and primary w-ideals

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Frontiers of Mathematics in China 2016年第4期11卷 829-844页

作者： Gyu whan CHANG Hwaukoo kim Department of Mathematics Education Incheon National University Incheon 406-772 Republic of Korea Department of Information Security Hoseo University Asan 336-795 Republic of Korea

Let D be an integral domain, ψ（D）（resp., t-ψ（D）） be the set of all valuation （resp., t-valuation） ideals of D, and w-P（D） be the set of primary w-ideals of D. Let D[X] be the polynomial ring over 19, c（f） be the ideal of D generated by the coefficients of f ∈ D[X], and Nv = {f∈ D[X] ｜ c（f）v = D}. In this paper, we study integral domains D in which w-P（D） t-ψ（D）, t-ψ（D） w-P（D）, or t-ψ（D） = w-P（D）. We also study the relationship between t-ψ（D） and ψ（D[X]Nv）, and characterize when t-ψ（A ＋ XB[X]） w-P（A ＋ XB[X]） holds for a proper extension A c B of integral domains.

关键词： t-Valuation ideal primary w-ideal PvMD UMT-domain D[X]Nv

Comparison of CT and MRI for presurgical characterization of paraaortic lymph nodes in patients with pancreatico-biliary carcinoma

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World Journal of Gastroenterology 2008年第14期14卷 2208-2212页

作者： Young Chul kim Mi-Suk Park Seung-whan Cha Yong Eun Chung Joon Suk Lim Myeong-Jin kim ki whang kim Kyung Sik kim Department of Diagnostic Radiology and Institute of Gastroenterology Severance Hospital Research Institute of Radiological Science Yonsei University College of Medicine Seoul 120-752 Korea Department of Diagnostic radiology and Institute of Gastroenterology Yonsei University Wonju College of Medicine Wonju 220-701 Korea Department of General surgery and Institute ofGastroenterology Severance Hospital Yonsei University Collegeof Medicine Seoul 120-752 Korea

AIM:To determine the accuracy of computed tomography (CT) and magnetic resonance (MR) for presurgical characterization of paraaortic lymph nodes in patients with pancreatico-biliary carcinoma. METHODS:Two radiologists independently evaluated CT and MR imaging of 31 patients who had undergone lymphadenectomy (9 metastatic and 22 non-metastatic paraaortic nodes). Receiver operating characteristic (ROC) curve analysis was performed using a five point scale to compare CT with MRI. To re-define the morphologic features of metastatic nodes, we evaluated CT scans from 70 patients with 23 metastatic paraaortic nodes and 47 non-metastatic ones. The short axis diameter, ratio of the short to long axis, shape, and presence of necrosis were compared between metastatic and non-metastatic nodes by independent samples t-test and Fisher's exact test. P 5.3 mm), irregular margin, and presence of central necrosis are the suggestive morphologic features of metastatic paraaortic nodes.

关键词： Paraaortic lymph node Pancreatico-biliary carcinoma Computed tomography Magnetic resonance imaging

Characterization of lattice parameters gradient of Cu(In1-xGax)Se2 absorbing layer in thin-film solar cell by glancing incidence X-ray diffraction technique

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Journal of Materials Science & Technology 2020年第16期47卷 193-201页

作者： Yong-Il kim ki-Bok kim Miso kim Department of Nano Science University of Science and Technology217GajeongYuseongDaejeon34113Republic of Korea Korea Research Institute of Standards and Science 267GajeongYuseongDaejseon34113Republic of Korea

In or Ga gradients in the Cu(In1-xGax)Se2(CIGS)absorbing layer lead to change the lattice parameters of the absorbing layer,giving rise to the bandgap grading in the absorbing layer which is directly associated with the degree of absorbing ability of the CIGS solar *** tried to characterize the depth profile of the lattice parameters of the CIGS absorbing layer using a glancing incidence X-ray diffraction(GIXRD)technique,and then investigate the bandgap grading of the CIGS absorbing *** the glancing incident angle increased from 0.50 to 5.00°,the a and c lattice parameters of the CIGS absorbing layer gradually decreased from 5.7776(3)to 5.6905(2)?,and 11.3917(3)to 11.2114(2)?,*** depth profile of the lattice parameters as a function of the incident angle was consistent with vertical variation in the compositionof In or Ga with depth in the absorbing *** variation of the lattice parameters was due to the difference between the ionic radius of In and Ga co-occupying at the same crystallographic *** to the results of the depth profile of the refined parameters using GIXRD data,the bandgap of the CIGS absorber layer was graded over a range of 1.222-1.532 *** approach allows to determine the In or Ga gradients in the CIGS absorbing layer,and to nondestructively guess the bandgap depth profile through the refinement of the lattice parameters using GIXRD data on the assumption that the changes of the lattice parameters or unit-cell volume follow a good approximation to Vegard’s law.

关键词： Cu(In1-xGax)Se2 absorbing layer Depth profile Glancing incidence X-ray diffraction technique Bandgap grading Vegard’s law

Fabrication and Mechanical Properties of Sm2O3 Doped CeO2 Reinforced Ti3AlC2 Nano Composite

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Journal of Rare Earths 2004年第Z2期22卷 85-88页

作者： Jae Ho Han Sang whan Park Young Do kim Division of Materials Science & Engineering Hanyang UniversitySeoul133-791Korea Korea Institute of Science and TechnologyMulti-Functional Ceramics Research CenterSeoul136-791Korea Division of Materials Science & EngineeringHanyang UniversitySeoul133-791Korea

The fabrication process of Sm2O3 doped CeO2 reinforced Ti3AlC2 nano composites including the nano particle dispersion process by a hetero-coagulation process was developed using in-situ synthesis and densification process of Ti3AlC2. The effects of Sm2O2 doped CeO2 nano particles on mechanical properties of Ti3AlC2 were investigated. It was found that the presence of 20SDC nano particles in Ti3AlC2 was very effective to improve the mechanical properties of Ti3AlC2 without spoiling the unique characteristics of Ti3AlC2temary carbide.

关键词： nano ceramic composite Ti3AlC2 CeO2 fabrication rare earths

Effect of reduction in area per pass on strain distribution and microstructure during caliber rolling in twinning-induced plasticity steel

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Journal of Iron and Steel Research International 2020年第1期27卷 62-74页

作者： Joong-ki Hwang Sung Jin kim School of Mechanical Engineering Tongmyong UniversityBusan 48520Republic of Korea Department of Advanced Materials Engineering Sunchon National UniversitySuncheon 57922Republic of Korea

The effects of reduction in area(RA)per pass during caliber rolling on microstructure and strain distribution of twinninginduced plasticity steel have been investigated to find solutions to make a more homogeneous material along the radial direction for wire rod *** steel wires subjected to an average RA per pass of 2.5%(skin pass caliber rolling)and 10.0%(conventional caliber rolling)were *** skin pass caliber-rolled wire was characterized as a duplex fiber texture of majorand minor.and the textures were almost same at/between center and surface area,which is totally different from those of conventional caliber rolling and wire *** skin pass caliber rolling led to more homogeneous microstructure and mechanical properties along the radial direction in comparison with the conventional caliber rolling and wire drawing due to the more homogeneous Hall-Petch hardening,dislocation hardening,and texture behavior with area,resulting in higher formability.

关键词： Twinning-induced plasticity steel Caliber rolling Deformation twin Reduction in area Skin pass