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Frontiers of Mathematics in China 2022年第4期17卷 673-687页

作者： Qiuli LIU wai-ki CHING Junyu ZHANG Hongchu WANG School of Mathematical Sciences South China Normal UniversityGuangzhou510631China Advanced Modeling and Applied Computing Laboratory Department of MathematicsThe University of Hong KongHong KongChina School of Mathematics Sun Yat-Sen UniversityGuangzhou510275China

We study the Markov decision processes under the average-value-at-risk *** state space and the action space are Borel spaces,the costs are admitted to be unbounded from above,and the discount factors are state-action *** suitable conditions,we establish the existence of optimal deterministic stationary ***,we apply our main results to a cash-balance model.

关键词： Markov decision processes average-value-at-risk(AVaR) state-action dependent discount factors optimal policy

X-reality for phantom limb management for amputees:A systematic review and meta-analysis

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再生工程(英文) 2023年第2期4卷 134-151页

作者： James Chung-wai Cheung Daphne Sze ki Cheung Ming Ni Kam-wai Chen Ye-Jiao Mao Lin Feng Wing-Kai Lam Duo wai-Chi Wong Aaron Kam-Lun Leung Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong KongChina School of Nursing The Hong Kong Polytechnic UniversityHong KongChina Department of Orthopaedics Ruijin HospitalShanghai Jiao Tong UniversityShanghaiChina Department of Prosthetics and Orthotics Queen Mary HospitalHong KongChina Sports Information and External Affairs Centre Hong Kong Sports InstituteHong KongChina Research Institute for Sports Science and Technology The Hong Kong Polytechnic UniversityHong KongChina Department of Rehabilitation Science The Hong Kong Polytechnic UniversityHong KongChina

Phantom limb is a disabling neuropsychiatric condition among amputees resulting in pain and disturbance that impact their functions,quality of life,and *** pharmacological approaches appeared to be ineffec-tive,the emergence and integration of X-reality,including virtual reality,augmented reality,and mixed reality,might elevate the effectiveness of mirror therapy in managing phantom *** objective of this study is to review X-reality for managing phantom pain.A systematic search was conducted on PubMed,Scopus,Web of Science,PsycINFO,Embase,and ***(n=16)studies containing 66 lower-limb and 53 upper-limb amputees were included for the review over the thematic framework of amputee characteristics and intervention designs,while thirteen(n=13)studies were further proceeded for the *** found eleven studies on virtual reality(n=11),four studies on marker-based augmented reality(n=4)and one study on mixed reality(n=1)with a total of 40 game/task themes involving,motor skills,motor control,and ***,all these interventions adopted the movement representation strategies with different ***,the X-reality interventions reduced the pain level of the amputees(mean difference:-2.30,95%CI,-3.38 to-1.22),especially the virtual reality subgroup(mean difference:-2.83,95%CI,-4.43 to-1.22).However,there were substantial heterogeneity and partially explained by the subgroup analysis on publication *** strength of evidence was limited by case reports and case series in this review.

关键词： Extended reality Limb telescoping Phantom pain Phantom sensation

“Slow walk”mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel

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Bioactive Materials 2023年第7期25卷 256-272页

作者： Jing Sun Yau Tsz Chan ki wai Kevin Ho Li Zhang Liming Bian Rocky S.Tuan Yangzi Jiang Institute for Tissue Engineering and Regenerative Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongAnd Prince of Wales HospitalShatinHong Kong Special Administrative Region of China Department of Mechanical and Automation Engineering Faculty of EngineeringThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Center for Neuromusculoskeletal Restorative Medicine Hong Kong Special Administrative Region of China

Meniscus,the cushion in knee joint,is a load-bearing tissue that transfers mechanical forces to extracellular matrix(ECM)and tissue resident *** mechanoresponse of human tissue resident stem/progenitor cells in meniscus(hMeSPCs)is significant to tissue homeostasis and regeneration but is not well *** study reports that a mild cyclic tensile loading regimen of~1800 loads/day on hMeSPCs seeded in 3-dimensional(3D)photocrosslinked gelatin methacryloyl(GelMA)hydrogel is critical in maintaining cellular ***,a“slow walk”biomimetic cyclic loading regimen(10%tensile strain,0.5 Hz,1 h/day,up to 15 days)is applied to hMeSPCs encapsulated in GelMA hydrogel with a magnetic force-controlled loading *** loading significantly increases cell differentiation and fibrocartilage-like ECM deposition without affecting cell *** analysis reveals 332 mechanoresponsive genes,clustered into cell senescence,mechanical sensitivity,and ECM dynamics,associated with interleukins,integrins,and collagens/matrix metalloproteinase *** cell-GelMA constructs show active ECM remodeling,traced using a green fluorescence tagged(GFT)-GelMA *** enhances nascent pericellular matrix production by the encapsulated hMeSPCs,which gradually compensates for the hydrogel loss in the *** findings demonstrate the strong tissue-forming ability of hMeSPCs,and the importance of mechanical factors in maintaining meniscus homeostasis.

关键词： Human meniscus progenitor cells 3D cell-based constructs Biomimetic cyclic loading GelMA hydrogel Extracellular matrix

Switching-based stabilization of aperiodic sampled-data Boolean control networks with all subsystems unstable

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Frontiers of Information Technology & Electronic Engineering 2020年第2期21卷 260-267页

作者： Liang-jie SUN Jian-quan LU wai-ki CHING School of Mathematics Southeast UniversttyNanjing 210096China Department of Mathematics The University of Hong KongHong KongChina

We aim to further study the global stability of Boolean control networks(BCNs)under aperiodic sampleddata control(ASDC).According to our previous work,it is known that a BCN under ASDC can be transformed into a switched Boolean network(SBN),and further global stability of the BCN under ASDC can be obtained by studying the global stability of the transformed ***,since the major idea of our previous work is to use stable subsystems to offset the state divergence caused by unstable subsystems,the SBN considered has at least one stable *** central thought in this paper is that switching behavior also has good stabilization;i.e.,the SBN can also be stable with appropriate switching laws designed,even if all subsystems are *** is completely different from that in our previous ***,for this case,the dwell time(DT)should be limited within a pair of upper and lower *** means of the discretized Lyapunov function and DT,a sufficient condition for global stability is ***,the above results are demonstrated by a biological example.

关键词： Aperiodic sampled-data control Boolean control networks Unstable subsystem Discretized Lyapunov function Dwell time

Dual ultra-wideband(UWB)radar-based sleep posture recognition system:Towards ubiquitous sleep monitoring

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再生工程(英文) 2023年第1期4卷 36-43页

作者： Derek Ka-Hei Lai Li-Wen Zha Tommy Yau-Nam Leung Andy Yiu-Chau Tam Bryan Pak-Hei So Hyo-Jung Lim Daphne Sze ki Cheung Duo wai-Chi Wong James Chung-wai Cheung Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Bioengineering Imperial CollegeLondon SW72AZUnited Kingdom Research Institute of Smart Ageing The Hong Kong Polytechnic UniversityHong KongChina School of Nursing The Hong Kong Polytechnic UniversityHong KongChina

Sleep posture monitoring is an essential assessment for obstructive sleep apnea(OSA)*** objective of this study is to develop a machine learning-based sleep posture recognition system using a dual ultra-wideband radar *** collected radiofrequency data from two radars positioned over and at the side of the bed for 16 patients performing four sleep postures(supine,left and right lateral,and prone).We proposed and evaluated deep learning approaches that streamlined feature extraction and classification,and the traditional machine learning approaches that involved different combinations of feature extractors and *** results showed that the dual radar system performed better than either single *** statistical features with random forest classifier yielded the best accuracy(0.887),which could be further improved via an ablation study(0.938).Deep learning approach using transformer yielded accuracy of 0.713.

关键词： Obstructive sleep apnea Deep learning Sleep monitoring Feature extraction Ablation study

On Using Physico-Chemical Properties of Amino Acids in String Kernels for Protein Classification via Support Vector Machines

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Journal of Systems Science & Complexity 2015年第2期28卷 504-516页

作者： LI Limin AOki-kiNOSHITA kiyoko F CHING wai-ki JIANG Hao Institute of Information and System Science Xi'an Jiaotong University Department of Bioinformatics Faculty of EngineeringSoka University Advanced Modeling and Applied Computing Laboratory Department of MathematicsThe University of Hong Kong Department of Mathematics School of InformationRenmin University of China

String kernels are popular tools for analyzing protein sequence data and they have been successfully applied to many computational biology *** traditional string kernels assume that different substrings are ***,substrings can be highly correlated due to their substructure relationship or common physico-chemical *** paper proposes two kinds of weighted spectrum kernels:The correlation spectrum kernel and the AA spectrum *** evaluate their performances by predicting glycan-binding proteins of 12 *** results show that the correlation spectrum kernel and the AA spectrum kernel perform significantly better than the spectrum kernel for nearly all the 12 *** comparing the predictive power of AA spectrum kernels constructed by different physico-chemical properties,the authors can also identify the physicochemical properties which contributes the most to the glycan-protein *** results indicate that physico-chemical properties of amino acids in proteins play an important role in the mechanism of glycan-protein binding.

关键词：物理化学性质蛋白质序列氨基酸支持向量机内核分类预测能力计算生物学

MODELING GENETIC REGULATORY NETWORKS:A DELAY DISCRETE DYNAMICAL MODEL APPROACH

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Journal of Systems Science & Complexity 2012年第6期25卷 1052-1067页

作者： Hao JIANG wai-ki CHING kiyoko F.AOki-kiNOSHITA Dianjing GUO Advanced Modeling and Applied Computing Laboratory Department of MathematicsThe University of Hong Kong Department of Bioinformatics Faculty of EngineeringSoka University Department of Biology The Chinese University of Hong Kong

为基因规章的网络建模是在 genomic 研究和计算系统生物学的一个重要研究话题。这篇论文考虑用分离动态系统(DDS ) 构造一个基因规章的网络(GRN ) 的问题模型途径。尽管可观的研究被奉献给造 GRN，许多没工作考虑时间延期效果。这里，... 详细信息

为基因规章的网络建模是在 genomic 研究和计算系统生物学的一个重要研究话题。这篇论文考虑用分离动态系统(DDS ) 构造一个基因规章的网络(GRN ) 的问题模型途径。尽管可观的研究被奉献给造 GRN，许多没工作考虑时间延期效果。这里，作者建议一个时间延期 DDS 模型线性差别方程创作了在显著地表示的基因之中代表时间的相互作用。作者也为使相等采样时间点的不一致介绍插值计划和重新采样方法。统计意义在获得 GRN 的最佳的相互作用矩阵起一个活跃作用。与原来的数据使用线性多重回归匹配很好的构造基因网络。模拟结果被给表明建议方法和模型的有效性。

关键词：基因调控网络离散动态系统动力模型时滞模拟时间延迟线性差分方程多元线性回归

Functionalized Hydrogels for Articular Cartilage Tissue Engineering

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Engineering 2022年第6期8卷 71-90页

作者： Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao Martin J.Stoddart Gerjo J.V.M.van Osch Kevin ki-wai Ho Zhen Li Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China AO Research Institute Davos DavosCH 7270Switzerland Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518000China Department of Orthopaedics and Sports Medicine&Department of Otorhinolaryngology Erasmus MCUniversity Medical CenterRotterdam 3000 CAthe Netherlands f Department of Biomechanical EngineeringDelft University of TechnologyDelft 2600 AAthe Netherlands Centre for Translational Medicine Research and Development Shenzhen Institute of Advanced TechnologyThe Chinese Academy of SciencesShenzhen 518000China

Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial *** defects are common in the knees of young and physically active *** of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage *** rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating *** can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of *** article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC ***,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation.

关键词： Articular cartilage Functionalized hydrogels Cartilage repair Cartilage tissue engineering Clinical translation

Emerging roles of the neural adaptor FE65 in neurite outgrowth

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Neural Regeneration Research 2018年第12期13卷 2085-2086页

作者： Wen Li wai Wa Ray Chan Jacky Chi ki Ngo Kwok-Fai Lau Shenzhen Institute of Advanced Technology Chinese Academy of Sciences School of Life Sciences Chinese University of Hong Kong

The brain is the third largest organ in the human body and consists of over80 billion neurons（Herculano-Houzel,2009）.Neurons are interconnected by neurite to form a complex neural network that allows the communicati... 详细信息

关键词： FE Emerging roles of the neural adaptor FE65 in neurite outgrowth GEF