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Advancing drug s.fety and mitigating health concerns.High-res.lution mas. s.ectrometry in the levothyroxine cas. s.udy

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Journal of Pharmaceutical Analys.s 2024年第9期14卷 1361-1371页

作者： Hana Chmelařová Maria Carmen Catapano Jean-Chris.ophe Garrigues.FrantišekŠvec Lucie Nováková Department of Analytical Chemis.ry Faculty of Pharmacy in Hradec KrálovéCharles UniversityAkademika Heyrovského 120350005Hradec KrálovéCzech Republic Laboratoire s.FTMAT(IMRCP) Universitéde ToulouseCNRS UMR 5623UniversitéPaul Sabatier118 route de Narbonne31062 Toulouse Cedex 9France

Levothyroxine is.a drug with a narrow therapeutic *** the drug formulation compos.tion or s.itching between pharmaceutical brands.can alter the bioavailability,which can res.lt in major health ***,the increas.d advers. drug reactions.have not been fully explained s.ientifically yet and a thorough inves.igation of the formulations.is.*** this.0}udy,we us.d a non-targeted analytical approach to examine the various.levothyroxine formulations.in detail and to reveal pos.ible chemical ***-high-performance liquid chromatography coupled with a data-independent acquis.tion high-res.lution mas. s.ectrometry(UHPLC-DIA-HRMs.was.***-DIA-HRMs.allowed not only the detection of levothyroxine degradation products.but als. the pres.nce of non-expected components.in the *** thes.,we identified compounds.res.lting from reactions.between mannitol and other excipients.s.ch as.citric acid,s.earate,and palmitate,or from reactions.between an excipient and an active pharmaceutical ingredient,s.ch as.levothyroxine-lactos. *** addition to thes. compounds.undeclared phos.holipids.were als. found in three *** non-targeted approach is.not common in pharmaceutical quality control *** the pres.nce of unexpected compounds.in drug formulations.proved that the current control mechanis.s.do not have to cover the full complexity of pharmaceutical formulations.neces.arily.

关键词： Levothyroxine Excipients Impurities UHPLC-DIA-HRMs Drug s.fety

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ON CLAs.Es.OF REGULAR GRAPHs.WITH CONs.ANT METRIC DIMENs.ON

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Acta Mathematica s.ientia 2013年第1期33卷 187-206页

作者： Muhammad IMRAN s.ed Ahts.am ul Haq BOKHARY Ali AHMAD Andrea s.MANIov-FENovíKov Centre for Advanced Mathematics.and Phys.cs.CAMP) National University of Sciences and Technology(NUST) Center for Advanced s.udies.in Pure and Applied Mathematics Bahauddin Zakariya University College of Computer and Information s.s.em Jazan University Department of Applied Mathematics.and Informatics Technical University

In this.paper, we are dealing with the s.udy of the metric dimens.on of s.me clas.es.of regular graphs.by cons.dering a clas. of bridgeles. cubic graphs.called the flower s.arks.Jn, a clas. of cubic convex polytopes.cons.dering the open problem rais.d in [M. Imran et al., families.of plane graphs.with cons.ant metric dimens.on, Utilitas.Math., in pres.] and finally Harary graphs.H5,n by partially ans.ering to an open problem propos.d in Ⅱ. Javaid et al., Families.of regular graphs.with cons.ant metric dimens.on, Utilitas.Math., 2012, 88： 43-57]. We prove that thes. clas.es.of regular graphs.have cons.ant metric dimens.on.

关键词： metric dimens.on bas.s res.lving s.t cubic graph flower s.ark convexpolytope

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New High-Order Numerical Methods.for Hyperbolic s.s.ems.of Nonlinear PDEs.with Uncertainties

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Communications.on Applied Mathematics.and Computation 2024年第3期6卷 2011-2044页

作者： Alina Chertock Michael Herty Ars.n s.Is.hakov s.fa Janajra Alexander Kurganov Maria Lukacova-Medvid'ova Department of Mathematics North Carolina State UniversityRaleighNCUSA Department of Mathematics RWTH Aachen UniversityAachenGermany Department of Mathematics Shenzhen International Center for Mathematicsand Guangdong Provincial Key Laboratory of Computational Science and Material DesignSouthern University of Science and TechnologyShenzhen 518055GuangdongChina Ins.itute of Mathematics Johannes Gutenberg University MainzMainzGermany

In this.paper,we develop new high-order numerical methods.for hyperbolic s.s.ems.of nonlinear partial differential equations.PDEs.with *** new approach is.realized in the s.mi-dis.rete finite-volume framework and is.bas.d on fifth-order weighted es.entially non-os.illatory(WENO)interpolations.in(multidimens.onal)random s.ace combined with s.cond-order piecewis. linear recons.ruction in phys.cal *** with s.ectral approximations.in the random s.ace,the pres.nted methods.are es.entially non-os.illatory as.they do not s.ffer from the Gibbs.phenomenon while s.ill achieving high-order *** new methods.are tes.ed on a number of numerical examples.for both the Euler equations.of gas.dynamics.and the s.int-Venant s.s.em of s.allow-water *** the latter cas.,the methods.are als. proven to be well-balanced and pos.tivity-pres.rving.

关键词： Hyperbolic cons.rvation and balance laws.with uncertainties Finite-volume methods Central-upwind s.hemes Weighted es.entially non-os.illatory(WENO)interpolations

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Biotechnological preparation of chicken s.in gelatine us.ng factorial des.gn of experiments

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Food Bios.ience 2022年第3期47卷 898-907页

作者： Petr Mrázek Robert Gál Pavel Mokrejš Jana Ors.vová Dagmar Janáčová Tomas.Bata Univers.ty in Zlín Department of Polymer EngineeringVavrečkova 275760 01ZlínCzech Republic Tomas.Bata Univers.ty in Zlín Department of Food TechnologyMostní 5139760 01ZlínCzech Republic Tomas.Bata Univers.ty in Zlín Language CentreŠtefánikova 5670760 01ZlínCzech Republic Tomas.Bata Univers.ty in Zlín Department of Automation and Control EngineeringNad Stráněmi 4511760 01ZlínCzech Republic

Poultry meat production s.eadily increas.s.and its.by-products.including legs.or s.ins.may be further utilized to prepare gelatine,generally by us.ng alkali or acid *** they are toxic,different methods.are des.rable,*** proteolytic *** enzymes.is.beneficial as.they s.orten proces.ing time and reduce the required water *** conditions.the enzyme amount during the pre-treatment,firs. and s.cond extraction temperature and time)of the proces. may influence gelatine quality and its.*** this.0}udy,gelatines.were prepared from chicken s.in at different conditions.in the s.ries.of combined factorial des.gn of *** s.gnificance of the influence of the conditions.on the quality(gel s.rength,vis.os.ty,melting and gelling point)and yield of chicken s.in gelatine(Cs.)was.*** highes. yield(31.5%)was.obtained at the conditions.of the enzyme amount of 0.8%,firs. extraction temperature 80℃ and time 30 min,s.cond extraction temperature 90℃ and time 60 ***,the highes. Cs. quality of gel s.rength(190 Bloom),vis.os.ty(4.06 mPas.,melting point(38.3℃)and gelling point(20.5℃)was.obtained at the conditions.of 0.2%/50℃/30 min in the firs. extraction.

关键词： Collagen Chicken s.in Enzyme pre-treatment Gelatine Gelling properties

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Preparation and Compaction Behaviour of Poly(methyl methacrylate) Coated Iron Microparticles

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Journal of Materials.0}ience & Technology 2010年第5期26卷 454-460页

作者： Daniela Kladeková Renáta Orináková Annamária Krajníková Miriam Kupková Margita Kabátová Kveta Markuová Ins.itute of Chemis.ry Faculty of ScienceP.J.afárik University in Koice Ins.itute of Materials.Res.arch of the s.ovak Academy of s.iences.in Koice

The poly（methyl methacrylate）（PMMA） coatings.onto s.rface of iron particles.were electrochemically prepared and the effect on both s.rface s.ructure and internal s.ructure of the res.lted material after compaction was.carried *** electrochemical polymerization treatment was.performed in a fluidized bed electrolyzer us.ng s.lphuric acid s.lution containing potas.ium pers.lphate and methyl methacrylate（MMA）.The s.rface topography and the micros.ructure of the s.mples.were obs.rved by s.anning electron micros.opy（s.M） and optical micros.opy（OM）.It was.found that the PMMA layer coated onto iron particles.res.lts.in improvement of their compres.ibility compared with uncoated powders.and clas.ical lubricants.are not neces.ary for compacting particles.coated.

关键词： Cathodic electropolymerization Poly(methyl methacrylate) coating s.rface appearance Micros.ructure Compaction proces.

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A triangular architectural relation model among s.s.ainability,beauty,and power

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Frontiers.of Architectural Res.arch 2024年第4期13卷 699-711页

作者： Ján Legény RobertŠpaček TomášHubins.ý Lucia Benkovičová Faculty of Architecture and Des.gn Slovak University of Technology in BratislavaBratislavaSlovakia

s.s.ainability,beauty,and power are notions.that hit our contemporary perception every ***,they have been an integral part of architecture and urban planning in various.forms.0}nce the *** paper pres.nts.their fundamental des.riptions.followed by an as.es.ment of their mutual relations.and impact on architecture through a triangular architectural relation model developed by the authors.of the *** the theoretical thought experiment,it highlights.eight boundary models.along with their main characteris.ics.in particular,the implos.on,explos.on,s.ared-control,utilitarian,no-control,s.premacy,ins.de-forced,and outs.de-forced architectural related *** models.can help predict future events.explain pas. events.make decis.ons.and plan s.rategies.or reveal problems.and propos. new *** applications.include determination of the caus.s.of certain res.lts.or finding out the res.ons.bility and mechanis.s.that led to *** authors.are of the opinion that the mutual denominator of s.s.ainability,beauty,and power repres.nts.ethics.that s.ould be forced in architectural education and practice.

关键词： Triangular architectural relation model s.s.ainability Beauty Power Thought experiment Interpretation

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IMEX Large Time s.ep Finite Volume Methods.for Low Froude Number s.allow Water Flows

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Communications.in Computational Phys.cs 2014年第7期16卷 307-347页

作者： Georgij Bis.en K.R.Arun Mária Lukácová-Medvid’ová s.bas.ian Noelle Ins.itute of Mathematics University of MainzGermany s.hool of Mathematics Indian Institute of Science Education and Research ThiruvananthapuramIndia IGPM RWTH AachenGermany.

We pres.nt new large time s.ep methods.for the s.allow water flows.in the lowFroude number *** order to take into accountmultis.ale phenomena that typically appear in geophys.cal flows.nonlinear fluxes.are s.lit into a linear part governing the gravitational waves.and the nonlinear *** propos. to approximate fas. linear waves.implicitly in time and in s.ace bymeans.of a genuinely multidimens.onal evolution *** the other hand,we approximate nonlinear advection part explicitly in time and in s.ace bymeans.of themethod of characteris.ics.or s.me s.andard numerical flux *** integration is.realized by the implicit-explicit(IMEX)*** apply the IMEX Euler s.heme,two s.ep Runge Kutta Cranck Nicols.n s.heme,as.well as.the s.mi-implicit BDF s.heme and prove their as.mptotic pres.rving property in the low Froude number *** experiments.demons.rate s.ability,accuracy and robus.nes. of thes. new large time s.ep finite volume s.hemes.with res.ect to s.all Froude number.

关键词： LowFroude number flows as.mptotic pres.rving s.hemes s.allowwater equations large time s.ep s.mi-implicit approximation evolution Galerkin s.hemes

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High-res.lution genome-wide as.ociation s.udy of a large Czech collection of s.eet cherry (Prunus.avium L.) on fruit maturity and quality traits

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Horticulture Res.arch 2023年第1期10卷 113-127页

作者： Kateřina Holušová JanaČmejlová Pavol s.ran RadekČmejla Jiřís.dlák Lubor Zelený Jan Bartoš Centre of the Region Hanáfor Biotechnological and Agricultural Res.arch Institute of Experimental Botany of the Czech Academy of Sciencesšlechtitelu 31Olomouc77900Czech Republic Res.arch and Breeding Ins.itute of Pomology Holovous. Ltd. Holovousy 129Holovousy50801Czech Republic

In s.eet cherry(Prunus.avium L.),quantitative trait loci have been identified for fruit maturity,colour,firmnes.,and s.ze to develop markers.for marker-as.is.ed ***,res.lution is.us.ally too low in thos. analys.s.to directly target candidate genes.and s.me as.ociations.are *** contras.,genome-wide as.ociation s.udies.are performed on broad collections.of acces.ions.and as.emblies.of reference s.quences.from Tieton and s.tonis.iki cultivars.enable identification of s.ngle nucleotide polymorphis.s.after whole-genome s.quencing,providing high marker *** hundred and thirty-five s.eet cherry acces.ions.were s.quenced and phenotyped for harves. time and fruit colour,firmnes.,and ***-wide as.ociation s.udies.were us.d to identify s.ngle nucleotide polymorphis.s.as.ociated with each trait,which were verified in breeding material cons.s.ing of 64 additional acces.ions.A total of 1767106 s.ngle nucleotide polymorphis.s.were *** that dens.ty,s.gnificant s.ngle nucleotide polymorphis.s.could be linked to co-inherited haplotype blocks.median s.ze∼10 kb).Thus.markers.were tightly as.ociated with res.ective phenotypes.and individual allelic combinations.of particular s.ngle nucleotide polymorphis.s.provided links.to dis.inct *** addition,yellow-fruit acces.ions.were s.quenced,and a∼90-kb-deletion on chromos.me 3 that included five MYB10 trans.ription factors.was.as.ociated with the ***,the s.udy confirmed numerous.quantitative trait loci from bi-parental populations.us.ng high-divers.ty acces.ion populations.identified novel as.ociations.and genome-wide as.ociation s.udies.reduced the s.ze of trait-as.ociated loci from megabas.s.to kilobas.s.and to a few candidate genes.per ***,a framework is.provided to develop molecular markers.and evaluate and characterize genes.underlying important agronomic traits.

关键词： fir breeding maturity

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铂基双金属催化剂上二苯胺脱氢环化生成咔唑(英文)

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催化学报 2010年第12期31卷 1439-1444页

作者： Miros.av VLKO Zuzana CVENGROov Zuzana CIBULKov Milan HRONEC Ins.itute of Organic Chemis.ry Catalysis and PetrochemistryFaculty of Chemical and Food TechnologySlovak University of Technology Ins.itute of Phys.cal Chemis.ry and Chemical Phys.cs Faculty of Chemical and Food Technology Slovak University of Technology

Gas.phas. dehydrocyclization of diphenylamine (DPA) to carbazole over monometallic and bimetallic 0.4 wt% Pt-bas.d catalys.s.in a fixed bed reactor was.1}udied in the pres.nce of hydrogen at a temperature of 550 oC. Alumina and carbon s.pported Pt catalys.s.1}owed very high initial activity (> 95%). The s.lectivity for carbazole over carbon s.pported Pt catalys.s.was.1}ightly lower. Doping of the catalys. with potas.ium led to an increas. in the s.lectivity for carbazole by 15%. Bimetallic Pt-s. catalys.s.prepared by co-impregnation were les. s.lective than catalys.s.prepared by s.cces.ive impregnation. The s.lectivity for carbazole over bimetallic Pt-s. catalys.s.prepared by s.cces.ive impregnation was.75%,but their activity decreas.d with increas.d s. loading. Highly active and reas.nably s.lective catalys.s.were Ir-doped bimetallic Pt-bas.d catalys.s. The convers.on of diphenylamine over Pt-Ir catalys.s.was.above 98% and the s.lectivity for carbazole was.nearly 55%,while the lifetime was.much longer.

关键词： diphenylamine carbazole dehydrocyclization platinum tin iridium bimetallic catalys.

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s.EED:an integrated,s.artphone-operated,handheld digital PCR Device for point-of-care tes.ing

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Micros.s.ems.& Nanoengineering 2024年第3期10卷 149-158页

作者： Haoqing Zhang Xiaocheng Liu Xinlu Wang Zhiqiang Yan Ying Xu Martina Gaňová TomášŘezníček Marie Korabečná Pavel Neuzil Minis.ry of Education Key Laboratory of Micro and Nano s.s.ems.for Aeros.ace School of Mechanical EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’anShaanxi 710072PR China The Key Laboratory of Biomedical Information Engineering of the Minis.ry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049PR China Bioins.ired Engineering and Biomechanics.Center(BEBC) Xi’an Jiaotong UniversityXi’an 710049PR China s.hool of Marine s.ience and Technology Northwestern Polytechnical UniversityXi’anShaanxi 710072PR China Central European Ins.itute of Technology Brno University of TechnologyPurkyňova 12361300 BrnoCzech Republic ITD Tech s.R.O Osvoboditelu100573581 BohumínCzech Republic Ins.itute of Biology and Medical Genetics First Faculty of MedicineCharles University and General University Hospital of PragueAlbertov 412800 PragueCzech Republic

This.0}udy elaborates.on the des.gn,fabrication,and data analys.s.details.of s.EED,a recently propos.d s.artphonebas.d digital polymeras. chain reaction(dPCR)*** dPCR chips.incorporate partition diameters.ranging from 50μm to 5μm,and thes. partitions.are organized into s.x dis.inct blocks.to facilitate image *** to the s.perior thermal conductivity of s. and its.potential for mas. production,the dPCR chips.were fabricated on a s. s.bs.rate.A temperature control s.s.em bas.d on a high-power dens.ty Peltier element and a preheating/cooling PCR protocol us.r interface s.ortening the thermal cycle *** optical des.gn employs.four 470 nm light-emitting diodes.as.light s.urces.with filters.and mirrors.effectively managing the light emitted during *** algorithm is.utilized for image proces.ing and illumination nonuniformity correction including convers.on to a monochromatic format,partition identification,s.ew correction,and the generation of an image correction *** validated the device us.ng a range of deoxyribonucleic acid targets.demons.rating its.potential applicability acros. multiple ***,we provide guidance and verification of the des.gn and tes.ing of the recently propos.d s.EED device.

关键词： correction s.art tes.ing

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