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Incidence, Mortality and Predictors of Acute Kidney Injury in Patients with cirrhosis:A Systematic Review and Meta-analysis

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Journal of clinical and Translational Hepatology 2020年第2期8卷 135-142页

作者： Raseen Tariq Yousaf Hadi khusdeep c.ahal Sivani Reddy Habeeb Salameh Ashwani K.Singal Department of Medicine Rochester General HospitalRochesterNYUSA Department of Medicine University of West VirginiaMorgantownWVUSA University of Alabama at Birmingham BirminghamALUSA Department of Gastroenterology University of Texas Medical BranchGalvestonTXUSA Division of Gastroenterology and Hepatology University of South DakotaSanford School of MedicineSioux FallsSDUSA

Background and Aims:Acute kidney injury(AKI)is com-mon in patients with cirrhosis but the incidence is heteroge-neous among *** performed a meta-analysis to describe the incidence of AKI and its impact on patient mor-tality in patients with *** also evaluated the admis-sion variables predicting development of ***:A systematic search of various databases was performed up to November ***-analyses were performed using ran-dom effects ***:Of 18,474 patients with cirrho-sis from 30 selected studies,5,648 developed AKI,with a pooled incidence of 29%(95% confidence interval[cI]:28-30%,I2 of 99%).In-hospital mortality assessed in eight stud-ies was six-fold higher among AKI patients,as compared to those without AKI(odds ratio[OR]6.72,95%cI:3.47-13,pcare showed about six-fold higher mortality among AKI patients(OR 5.90,95%cI:3.21-10.85,p>0.0001).Mor-tality remained significantly high,at days 30 and 90 and even at 1-year follow up after development of *** 12 admission variables analyzed,model for end-stage liver disease score,child-Pugh-Turcotte stage c,presence of ascites,and pres-ence of sepsis/septic shock were statistically significant risk factors for ***:AKI occurred in about 29% of patients with cirrhosis and is associated with a six-fold in-creased risk of in-hospital *** remained high even in long-term follow-up of 1 *** at risk for AKI development can be recognized at *** studies are needed to develop strategies for improving out-come of these patients.

关键词： Acute kidney injury cirrhosis Mortality Outcomes

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