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Risk of infection with arboviruses in a healthy population in Pakistan based on seroprevalence

VIROLOGICA SINICA 2024年第3期39卷 369-377页

作者： Chen, Shengyao Saqib, Muhammad Khan, Hafiz Sajid Bai, Yuan Ashfaq, Usman Ali Mansoor, Muhammad Khalid Moming, Abulimti Liu, Jing Zhou, Min Niazi, Saifullah Khan Wu, Qiaoli Sial, Awais-Ur-Rahman Tang, Shuang Sarfraz, Muhammad Hassan Javed, Aneela Hayat, Sumreen khurshid, mohsin Khan, Iahtasham Athar, Muhammad Ammar Taj, Zeeshan Zhang, Bo Deng, Fei Zohaib, Ali Shen, Shu Chinese Acad Sci Key Lab Virol Wuhan 430071 Peoples R China Chinese Acad Sci Wuhan Inst Virol Natl Virus Resource Ctr Wuhan 430071 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Hubei Jiangxia Lab Wuhan 430200 Peoples R China Univ Agr Faisalabad Fac Vet Sci Faisalabad 38040 Pakistan Childrens Hosp Faisalabad Faisalabad 38000 Pakistan Govt Coll Univ Faisalabad Dept Bioinformat & Biotechnol Faisalabad 38000 Pakistan Islamia Univ Bahawalpur Fac Vet & Anim Sci Dept Microbiol Bahawalpur 63100 Pakistan Chinese Acad Sci Wuhan Inst Virol Ctr Biosafety Mega Sci Key Lab Special Pathogens & Biosafety Wuhan 430071 Hubei Peoples R China Armed Forces Inst Pathol AFIP Rawalpindi 46000 Pakistan Pir Mehr Ali Shah Arid Agr Univ Fac Vet & Anim Sci Dept Clin Studies Rawalpindi 46300 Pakistan Govt Coll Univ Faisalabad Inst Microbiol Faisalabad 38000 Pakistan Natl Univ Sci & Technol Atta Ur Rahman Sch Appl Biosci Islamabad 44000 Pakistan Univ Vet & Anim Sci Dept Clin Sci Lahore Subcampus Jhang 35200 Pakistan Natl Med Ctr Dept Mol Pathol DHA Phase 1 Karachi 75500 Pakistan

Infectious diseases caused by arboviruses are a public health concern in Pakistan. However, studies on data prevalence and threats posed by arboviruses are limited. This study investigated the seroprevalence of arboviruses in a healthy population in Pakistan, including severe fever with thrombocytopenia syndrome virus (SFTSV), Crimean-Congo hemorrhagic fever virus (CCHFV), Tamdy virus (TAMV), and Karshi virus (KSIV) based on a newly established luciferase immunoprecipitation system (LIPS) assays, and Zika virus (ZIKV) by enzyme-linked immunosorbent assays (ELISA). Neutralizing activities against these arboviruses were further examined from the antibody positive samples. The results showed that the seroprevalence of SFTSV, CCHFV, TAMV, KSIV, and ZIKV was 17.37%, 7.58%, 4.41%, 1.10%, and 6.48%, respectively, and neutralizing to SFTSV (1.79%), CCHFV (2.62%), and ZIKV (0.69%) were identified, as well as to the SFTSV-related Guertu virus (GTV, 0.83%). Risk factors associated with the incidence of exposure and levels of antibody response were analyzed. Moreover, co-exposure to different arboviruses was demonstrated, as thirty-seven individuals were having antibodies against multiple viruses and thirteen showed neutralizing activity. Males, individuals aged <= 40 years, and outdoor workers had a high risk of exposure to arboviruses. All these results reveal the substantial risks of infection with arboviruses in Pakistan, and indicate the threat from co-exposure to multiple arboviruses. The findings raise the need for further epidemiologic investigation in expanded regions and populations and the necessity to improve health surveillance in Pakistan.

关键词： Arbovirus Pakistan Seroprevalence Tick -borne virus Mosquito -borne virus

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Exploring the shadow of a rotating charged ModMax black hole

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Communications in Theoretical Physics 2024年第2期76卷 89-101页

作者： khurshid Karshiboev Farruh Atamurotov Ahmadjon Abdujabbarov Ali Övgün Anvar Reyimberganov Institute of Theoretical Physics National University of UzbekistanTashkent 100174Uzbekistan New Uzbekistan University Movarounnahr Street 1Tashkent 100000Uzbekistan Central Asian University Milliy Bog'Street 264Tashkent 111221Uzbekistan University of Tashkent for Applied Sciences Str.Gavhar 1Tashkent 100149Uzbekistan Tashkent State Technical University Tashkent 100095Uzbekistan Ulugh Beg Astronomical Institute Astronomy Street 33Tashkent 100052Uzbekistan Institute of Fundamental and Applied Research National Research University TIIAMEKori Niyoziy 39Tashkent 100000Uzbekistan Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkey Urgench State University Urgench 220100Uzbekistan

The research presented in this paper discusses the impact that the parameters of charge(Q)and screening factor(γ)have on properties of the horizon and silhouette of rotating charged Mod Max black holes which were reviewed in[***.J.C(2022)82:1155]recently,building upon previous findings in the ***,the study explores the behavior of null geodesics,which can help us better understand the apparent shape of the black hole’s silhouette,as well as the distortion parameter and approximate radii of the silhouette that are influenced by the aforementioned parameters,and there are some values of parameter Q which corresponds to data from the Event Horizon Telescope(EHT).Notably,we explore the distortion parameter and approximate radii of the silhouette,revealing that while an increase inγleads to a growth in silhouette radius(Rs),it simultaneously reduces the distortion rate(δs).Conversely,heightened Q charge results in a reduction of Rsaccompanied by an increase inδ***,the paper analyzes the effects of the black hole’s parameters on the effective potential and energy emission:the peak value of the energy emission rate experiences a decrease as the screening factor(γ)increases,while it increases with higher values of the charge parameter(Q).

关键词： black hole ModMax gravity rotating black hole black hole shadow

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Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M Khan Zaw Ali Khan mohsin Ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Robot-assisted uretero-enteric reimplantation for uretero-enteric anastomotic strictures following robot-assisted radical cystectomy: Surgical approach and outcomes over two decades

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Asian Journal of Urology 2024年第3期11卷 384-390页

作者： Abdul Wasay Mahmood Grace Harrington Zhe Jing Qiang Li Ahmed A.Hussein khurshid A.Guru Department of Urology Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNew YorkNYUSA

Objective:We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures(UES)following robot-assisted radical cystectomy(RARC)and urinary ***:Retrospective review of our RARC database from November 2005 to August 2023 at Roswell Park Comprehensive Cancer center was *** who developed UES and ultimately underwent robot-assisted uretero-enteric reimplantation(RUER)were *** method was used to compute the cumulative incidence recurrence rate of UES after RUER.A multivariable regression model was used to identify variables associated with UES ***:A total of 123(15%)out of 808 RARC patients developed UES,of whom 52 underwent reimplantation(45 patients underwent RUER[n=55 cases]and seven patients underwent open ureteroenteric reimplantation).The median time from RARC to UES was 4.4(interquartile range 3.0e7.0)months,and the median time between UES and RUER was 5.2(interquartile range 3.2e8.9)*** 3-year recurrence rate after RUER is about 29%.On multivariable analysis,longer hospital stay(hazard ratio 1.37,95%confidence interval 1.16e1.61,p<0.01)was associated with recurrent UES after ***:RUER for UES after RARC is feasible with durable outcomes although a notable subset of patients experienced postoperative complications and UES recurrence.

关键词： Stricture Cystectomy Reimplantation Robot-assisted

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Impact of dark current on pinned photo-diode capacitance of CMOS image sensor in low illumination regime

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Optoelectronics Letters 2024年第11期 654-657页

作者： mohsin Suharwerdi Gausia Qazi Department of Electronics & Communication Engineering National Institute of Technology

Applications for quanta and space sensing both depend on efficient low-light imaging. To precisely optimize and design image sensor pixels for these applications, it is crucial to analyze the mechanisms behind dark current generation, considering factors such as temperature, trap cross-section and trap concentration.

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用于储能应用的可生物降解的聚合物基电介质复合材料的制备

用于储能应用的可生物降解的聚合物基电介质复合材料的制备

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作者： mohsin ALI KADHIM KADHIM 北京化工大学

学位级别：硕士

由于具有宽容量范围、高工作电压、轻质、性能可靠等优点,聚合物基的电介质薄膜电容器等在现代电子学中具有重要作用。通常所研究的介电聚合物和填料都是不可生物降解的,这是产生电子废物污染的原因之一。为了解决这个问题,本研究选择... 详细信息

由于具有宽容量范围、高工作电压、轻质、性能可靠等优点,聚合物基的电介质薄膜电容器等在现代电子学中具有重要作用。通常所研究的介电聚合物和填料都是不可生物降解的,这是产生电子废物污染的原因之一。为了解决这个问题,本研究选择了可生物降解的聚酯PBAT作为基体,将其分别与两种自制的生物质衍生填料复合,制备了可生物降解的聚合物基电介质复合材料。论文主要分为以下几个主要内容:首先,以香蕉皮废弃物（BP-W）为原料,通过热解的方法,分别制备了N掺杂和非掺杂的生物质炭,N掺杂技术解决了非掺杂生物炭性能上的一些缺陷,通过透射电子显微镜（TEM）、X射线衍射（XRD）、能量色散X射线分析（EDX）、X射线光电子能谱（XPS）、傅里叶变换红外光谱（FTIR）和热重分析（TGA）等手段对产物进行了系统表征,结果证实了氮的成功掺杂。并将它们作为含碳导电有机填料分别与PBAT复合制备了复合电介质材料,掺杂N生物炭可以改善聚合物复合材料的介电性能和热稳定性,而不会牺牲力学性能和生物降解性。具体而言,含有10 wt.%N掺杂生物炭的PBAT纳米复合材料的介电常数为10.64,比纯PBAT（介电常数为5.85）增加了83%。此外,复合材料介电损耗在1000 Hz时保持在0.071以下。其次,通过对生物质废料牛骨头的热解,制备了羟基磷灰石（HAp）并将其作为陶瓷无机填料,对其进行了系统的表征。随后,利用溶液共混和热压技术制备了包含HAp和PBAT的可生物降解介电复合材料,并进行了系统的表征。结果表明了单相结晶HAp的成功制备,具有良好定义的晶界,所得到的可生物降解复合材料表现出显著的介电性能,包括高介电常数、低介电损耗和良好的低填料含量下的击穿强度。介电常数随着填料含量的增加而增加,而介电损耗保持低水平,击穿强度随着填料含量的增加而略有降低。能量储存密度的理论研究表明,PBAT/HAp-3%复合材料具有较高的能量储存密度(Ust=3.56 J/cm3),比纯PBAT(Ust=2.48J/cm3)高出43.55%。HAp/PBAT复合材料的力学性能和热稳定性均得到了不同程度的提升。此外,对两个体系的复合材料生物降解性能进行了分析,评估了介电复合材料的生物降解行为,包括在不同时间段内浸泡在谷胱甘肽溶液中以模拟酶降解。评估参数包括重量损失率、力学性能和外观检查等。对完全可生物降解的PBAT/绿色填料复合材料的生物降解性能进行了全面的评价。

关键词：聚合物基复合材料介电性能生物降解生物炭生物来源羟基磷灰石

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Recent progress in two-dimensional metallenes and their potential application as electrocatalyst

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Journal of Energy Chemistry 2024年第7期94卷 577-598页

作者： Umer Shahzad mohsin Saeed Muhammad Fazle Rabbee Hadi M.Marwani Jehan Y.Al-Humaidi Muhammad Altaf Raed H.Althomali Kwang-Hyun Baek Md.Rabiul Awual Mohammed M.Rahman Department of Chemistry Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Biotechnology Yeungnam UniversityGyeongsanSouth Korea Center of Excellence for Advanced Materials Research(CEAMR) King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of SciencePrincess Nourah Bint Abdulrahman UniversityP.O.BOX 84428Riyadh 11671Saudi Arabia Department of Chemistry Center of Excellence for Innovation in Chemistry(PERCH-CIC)Center of Excellence in Materials Science and TechnologyFaculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry College of Art and SciencePrince Sattam Bin Abdulaziz UniversityWadi Al-Dawasir 11991Saudi Arabia Western Australian School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityGPO Box U 1987PerthWA 6845Australia

In this article,we looked at metallenes,a novel class of two-dimensional(2D)metals that are attracting interest in the energy and catalysis *** is one area where their exceptional physicochemical and electrical characteristics might be *** are unique because they include several metal atoms that are not in a coordinated *** makes them more active and improves their atomic uti-lization,which in turn increases their catalytic *** article delves into the potential of two-dimensional metals as electrocatalysts for carbon dioxide reduction,fuel oxidation,oxygen evolution,and oxygen reduction reactions in the context of sustainable energy *** to the exception-ally high surface-to-volume ratio,large surface area as well as their optimized atomic use efficiency,2D materials defined by atomic layers are crucial for surface-related sustainable energy *** to its exceptional properties,such as high conductivity and the ability to enhance the exposure of active metal sites,2D metallenes have recently attracted a lot of interest for use in catalysis,electronics,and energy-related *** their highly mobility,adjustable surface states,and electrical struc-tures that can be fine-tuned,2D metallenes are promising nanostructure materials for use in energy con-version with the sustainable applications.

关键词： Metallenes Electrocatalysts Electrochemical processes Atomically thin structure

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A hyperspectral unmixing approach for ink mismatch detection in unbalanced clusters

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Journal of Information and Intelligence 2024年第2期2卷 177-190页

作者： Faryal Aurooj Nasir Salman Liaquat Khurram khurshid Nor Muzlifah Mahyuddin Department of Electrical Engineering Institute of Space TechnologyIslamabad 44000Pakistan School of Electrical and Electronic Engineering Universiti Sains MalaysiaPenang 14300Malaysia

With the rapid development of location-based services and online social networks,POI recommendation services considering geographic and social factors have received extensive ***,the vigorous development of cloud computing has prompted service providers to outsource data to the cloud to provide POI recommendation ***,there is a degree of distrust of the cloud by service *** protect digital assets,service providers encrypt data before outsourcing ***,encryption reduces data availability,making it more challenging to provide POI recommendation services in outsourcing *** privacy-preserving schemes for geo-social-based POI recommendation have been presented,but they have some limitations in supporting group query,considering both geographic and social factors,and query accuracy,making these schemes *** solve this issue,we propose two practical and privacy-preserving geo-social-based POI recommendation schemes for single user and group users,which are named GSPR-S and ***,we first utilize the quad tree to organize geographic data and the MinHash method to index social ***,we apply BGV fully homomorphic encryption to design some private algorithms,including a private max/min operation algorithm,a private rectangular set operation algorithm,and a private rectangular overlapping detection *** that,we use these algorithms as building blocks in our schemes for efficiency *** to security analysis,our schemes are proven to be secure against the honest-but-curious cloud servers,and experimental results show that our schemes have good performance.

关键词： k-means clustering Gaussian mixture model(GMM) Hyper spectral imaging(HSI) iVision handwritten hyperspectral images dataset(HHID) Document forensics

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Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction

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World Journal of Transplantation 2024年第1期14卷 154-163页

作者： Ameet Kumar Jesrani Syed M Faiq Rahma Rashid Tariq Ali Kalwar Rehan mohsin Tahir Aziz Nida Amin Khan Muhammed Mubarak Department of Radiology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Pathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Transplantation Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Urology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

BACKGROUND Detection of early chronic changes in the kidney allograft is important for timely intervention and long-term *** and novel ultrasound-based investigations are being increasingly used for this purpose with variable *** To compare the diagnostic performance of resistive index(RI)and shear wave elastography(SWE)in the diagnosis of chronic fibrosing changes of kidney allograft with histopathological *** This is a cross-sectional and comparative study.A total of 154 kidney transplant recipients were included in this study,which was conducted at the Departments of Transplantation and Radiology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from August 2022 to February *** consecutive patients with increased serum creatinine levels and reduced glomerular filtration rate(GFR)after three months of transplantation were enrolled in this *** and RI were performed and the findings of these were evaluated against the kidney allograft biopsy results to determine their diagnostic *** The mean age of all patients was 35.32±11.08 *** these,126(81.8%)were males and 28(18.2%)were *** mean serum creatinine in all patients was 2.86±1.68 mg/dL and the mean estimated GFR was 35.38±17.27 mL/min/1.73 *** allograft biopsy results showed chronic changes in 55(37.66%)*** sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of SWE for the detection of chronic allograft damage were 93.10%,96.87%%,94.73%,and 95.87%,respectively,and the diagnostic accuracy was 95.45%.For RI,the sensitivity,specificity,PPV,and NPV were 76.92%,83.33%,70.17%,and 87.62%,respectively,and the diagnostic accuracy was 81.16%.CONCLUSION The results from this study show that SWE is more sensitive and specific as compared to RI in the evaluation of chronic allograft *** can be of great help during the routine follow-up of kidney transplant recipients for screening a

关键词： Shear wave Sonoelastography Resistive index Chronic allograft changes Biopsy Histopathology

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Smart Breeding Platform:A web-based tool for high-throughput population genetics,phenomics,and genomic selection

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Molecular Plant 2024年第5期17卷 677-681页

作者： Huihui Li Xin Li Peng Zhang Yingwei Feng Junri Mi Shang Gao Lele Sheng mohsin Ali Zikun Yang Liang Li Wei Fang Wensheng Wang Qian Qian Fei Gu Wenbin Zhou State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Nanfan Research Institute CAASSanyaHainan 572024China DAMO Academy Alibaba GroupHangzhou 310023China Hupan Lab Hangzhou 310023China Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya CityHainan Province 572024China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhouZhejiang 310006China

Dear Editor,In the era of big data and artificial intelligence,"smart breeding"has become a broad conceptual framework encompassing the paradigm shift of crop breeding to relying on analysis of high-throughput population genetics and phenomics data to conduct genomic selection,allowing identification and optimal use of the genetic potential in crop species(Xiao et al.,2022;Xu et al.,2022;Wang et al.,2023).Most existing tools for analyzing high-throughput breeding data require extensive computational power,complex installation processes,and command-line expertise and are therefore challenging and inconvenient for the majority of researchers and breeders(Brandies and Hogg,2021).

关键词： breeding artificial breed

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